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    Methods for optimizing and using medical diagnostic classifiers based on genetic algorithms
    1.
    发明授权
    Methods for optimizing and using medical diagnostic classifiers based on genetic algorithms 有权
    基于遗传算法优化和使用医学诊断分类器的方法

    公开(公告)号：US08798937B2

    公开(公告)日：2014-08-05

    申请号：US10597767

    申请日：2005-02-01

    申请人： J. David Schaffer ,  Mark R. Siimpson

    发明人： J. David Schaffer ,  Mark R. Siimpson

    IPC分类号： G01N33/48 ,  G06F19/24

    CPC分类号： G06F19/24 ,  G06F19/20 ,  G06N3/126

    摘要： In a genetic optimization method, the genes of a chromosome population are computationally genetically evolved. The evolving includes evolving a number of expressed genes in each chromosome and employing a fitness criterion evaluated without reference to unexpressed genes of each chromosome. An optimized chromosome produced by the genetic evolving is selected.

    摘要翻译： 在遗传优化方法中，染色体群体的基因在计算上是遗传演化的。 不断发展的包括在每个染色体中发展出许多表达基因，并采用不参照每个染色体未表达基因的适应度标准。 选择由遗传进化产生的优化染色体。

    Decision support system for acute dynamic diseases
    2.
    发明授权
    Decision support system for acute dynamic diseases 有权
    急性动态疾病决策支持系统

    公开(公告)号：US08494871B2

    公开(公告)日：2013-07-23

    申请号：US12668431

    申请日：2008-07-11

    申请人： James David Schaffer ,  Mark R. Simpson ,  Nicolas Wadih Chbat ,  Nilanjana Banerjee ,  Yasser H. Alsafadi

    发明人： James David Schaffer ,  Mark R. Simpson ,  Nicolas Wadih Chbat ,  Nilanjana Banerjee ,  Yasser H. Alsafadi

    IPC分类号： G06Q10/00

    CPC分类号： G16H50/50 ,  G06F19/00

    摘要： A medical apparatus (901, 100) assists clinicians, nurses or other users in choosing an intervention for the treatment of a patent suffering from an acute dynamic disease, e.g. sepsis. The medical apparatus is based on a method where a model of the disease is adapted or personalized to the patient. To ensure that the apparatus remains capable of predicting the health of the patient, the apparatus is continuously provided with new, more recent patient values and the model is continuously adapted to the new patient values. Since the medical apparatus is configured to be continuously adapted to current state of health, the apparatus is able to assist the user by generating disease management information, e.g. suggestions for medications, to an output device (902, 104).

    摘要翻译： 医疗器械（901,100）帮助临床医生，护士或其他用户选择治疗患有急性动态疾病的专利的干预措施，例如， 败血症 该医疗装置是基于对患者的疾病模型进行适应或个性化的方法。 为了确保该装置能够预测患者的健康状态，该装置被连续地提供有新的更新的患者值，并且该模型连续地适应于新的患者值。 由于医疗装置被配置为连续地适应当前健康状态，因此该装置能够通过产生疾病管理信息来辅助用户，例如， 对药物的建议，输出设备（902,104）。

    Method and apparatus for automatically developing a high performance classifier for producing medically meaningful descriptors in medical diagnosis imaging
    3.
    发明授权
    Method and apparatus for automatically developing a high performance classifier for producing medically meaningful descriptors in medical diagnosis imaging 有权
    用于自动开发用于在医学诊断成像中产生医学上有意义的描述符的高性能分类器的方法和装置

    公开(公告)号：US08208697B2

    公开(公告)日：2012-06-26

    申请号：US11721999

    申请日：2005-12-13

    申请人： James David Schaffer ,  Walid Ali ,  Larry J. Eshelman ,  Claude Cohen-Bacrie ,  Jean-Michel Lagrange ,  Claire Levrier ,  Nicholas Villain ,  Robert R. Entrekin

    发明人： James David Schaffer ,  Walid Ali ,  Larry J. Eshelman ,  Claude Cohen-Bacrie ,  Jean-Michel Lagrange ,  Claire Levrier ,  Nicholas Villain ,  Robert R. Entrekin

    IPC分类号： G06K9/36

    CPC分类号： G06K9/6217

    摘要： A method for determining the presence or absence of malignant features in medical images, wherein a plurality of base comparison or training images of various types of lesions taken of actual patient is examined by one or more image reading experts to create a first database array. Low-level features of each of the lesions in the same plurality of base comparisons or training images are determined using one or more image processing algorithms to obtain a second database array set. The first and second database array set are combined to create a training database array set which is input to a learning system that discovers/learns a classifier that maps from a subset of the low-level features to the expert's evaluation in the first database array set. The classifier is used to determine the presence of a particular mid-level feature in an image of lesion in a patient based solely on the image.

    摘要翻译： 一种用于确定医学图像中恶性特征的存在或不存在的方法，其中由一个或多个图像读取专家检查由实际患者取得的各种类型的损伤的多个基础比较或训练图像以创建第一数据库阵列。 使用一个或多个图像处理算法确定相同多个基本比较或训练图像中的每个病变的低级特征以获得第二数据库阵列集。 组合第一和第二数据库阵列组以创建训练数据库阵列集合，其被输入到发现/学习从低级特征的子集映射到第一数据库阵列集合中的专家评估的分类器的学习系统 。 分类器用于仅基于图像来确定患者的病变图像中特定中级特征的存在。

    Method to automatically decode microarray images
    4.
    发明授权
    Method to automatically decode microarray images 有权
    自动解码微阵列图像的方法

    公开(公告)号：US08199991B2

    公开(公告)日：2012-06-12

    申请号：US12516931

    申请日：2007-12-03

    申请人： Lalitha Agnihotri ,  James David Schaffer ,  Nevenka Dimitrova

    发明人： Lalitha Agnihotri ,  James David Schaffer ,  Nevenka Dimitrova

    IPC分类号： G06K9/36

    CPC分类号： G06K9/00134 ,  G06K9/3233 ,  G06K9/3275 ,  G06T7/70 ,  G06T2207/20056 ,  G06T2207/30072

    摘要： A method of automatically identifying the microarray chip corners and probes, even if there are no probes at the corners, in a high density and high resolution microarray scanned image having an image space, wherein the method minimizes the error distortions in the image arising in the scanning process by applying to the image a multipass corner finding algorithm comprising: (a) applying a Radon transform to an input microarray image to project the image into an angle and distance space where it is possible to find the orientation of the straight lines; (b) applying a fast Fourier transform to the projected image of (a) to find the optimal tilting angle of the projected image; (c) determining the optimal first and last local maxima for the optimal tilting angle; (d) back projecting the determined first and last local maxima to the image space to find the first approximation of the first and last column lines of the image; (e) rotating the image and repeating steps (a) through (d) to find the first approximation of the top and bottom row lines of the image; (f) determining the first approximation of the four corners of the image from the intersection of the column and row lines; (g) applying a heuristic for determining if the first approximation of step (f) is sufficient; and (h) optionally trimming the scanned image around the first approximation of the four corners and repeating steps (a) through (f).

    摘要翻译： 即使在具有图像空间的高密度和高分辨率的微阵列扫描图像中，即使在角落处没有探针也能够自动识别微阵列芯片角部和探针的方法，其中该方法使图像中产生的图像中的误差失真最小化 扫描过程，通过向图像应用多点角发现算法，包括：（a）将Radon变换应用于输入微阵列图像以将图像投影到可以找到直线的取向的角度和距离空间中; （b）对（a）的投影图像应用快速傅立叶变换以找到投影图像的最佳倾斜角; （c）确定最佳倾斜角的最佳第一和最后局部最大值; （d）将确定的第一和最后局部最大值向前投影到图像空间，以找到图像的第一列和最后一列的第一近似; （e）旋转图像并重复步骤（a）至（d）以找到图像的顶行和下行行的第一近似值; （f）从列和行之间的交点确定图像的四个角的第一近似值; （g）应用启发式来确定步骤（f）的第一近似是否足够; 和（h）可选地修整围绕四个角的第一近似的扫描图像并重复步骤（a）至（f）。

    Method and apparatus for predicting a number of individuals interested in an item based on recommendations of such item
    6.
    发明申请
    Method and apparatus for predicting a number of individuals interested in an item based on recommendations of such item 审中-公开
    根据该项目的建议预测对项目感兴趣的个人数量的方法和装置

    公开(公告)号：US20060026642A1

    公开(公告)日：2006-02-02

    申请号：US10538210

    申请日：2003-12-10

    申请人： David Schaffer ,  Yasser Alsafadi ,  Amr Yassin

    发明人： David Schaffer ,  Yasser Alsafadi ,  Amr Yassin

    IPC分类号： H04N7/025 ,  H04N7/10 ,  H04N5/445 ,  G06F13/00

    CPC分类号： G06Q30/02 ,  H04H60/33 ,  H04H60/61 ,  H04N5/44543 ,  H04N7/17318 ,  H04N21/252 ,  H04N21/2547 ,  H04N21/4532 ,  H04N21/482 ,  H04N21/6582 ,  H04N21/812

    摘要： A method (800) and apparatus (100) are disclosed for predicting a level of interest in an item, such as the size of an audience for a television program, based on the selection history (120) of multiple users and the extent to which the item is recommended (220) to the multiple users. The size of an audience for a given program can be predicted based on, for example, the percentage of users to which the given program is “highly recommended.” A method (900) for calibrating the accuracy of the predictions using measurement data indicating the actual size of the audience is also disclosed. A comparison of the predicted and actual audiences allows a correction factor to be generated to improve subsequent predictions.

    摘要翻译： 公开了一种方法（800）和装置（100），用于基于多个用户的选择历史（120）来预测项目中的兴趣水平，例如电视节目的观众的大小，以及多少用户的选择历史 该项目被推荐（220）给多个用户。 可以基于例如“强烈推荐”给定程序的用户的百分比来预测给定节目的观众的大小。 还公开了一种使用指示观众的实际大小的测量数据来校准预测精度的方法（900）。 预测和实际受众的比较允许生成修正因子以改进后续预测。

    Object proximity/security adaptive event detection
    7.
    发明授权
    Object proximity/security adaptive event detection 失效
    对象接近/安全自适应事件检测

    公开(公告)号：US06492905B2

    公开(公告)日：2002-12-10

    申请号：US09933554

    申请日：2001-08-20

    申请人： Keith E. Mathias ,  J. David Schaffer

    发明人： Keith E. Mathias ,  J. David Schaffer

    IPC分类号： G08B2100

    CPC分类号： G08B21/0227 ,  G07C9/00111 ,  G08B29/26 ,  G08B31/00

    摘要： A security system incorporating a reasoning system and security rules and processes. Transponders may be triggered and sensed from a distance to identify both items and individuals. These sensed identifiers are processed by the reasoning system to determine whether each identified item is authorized to be removed from or brought into a secured location by the identified individual. The system modifies and optimizes its rules and processes based on assessments of security events. The security system enforces these security rules and receives feedback from authorized security personnel. A learning system is configured to modify existing rules or create new rules in conformance with the feedback from the authorized security personnel.

    摘要翻译： 一个包含推理系统和安全规则和流程的安全系统。 可能会从远处触发和感测到应答器，以识别物品和个人。 这些感测的标识符由推理系统处理以确定每个被识别的物品是否被授权从被识别的个人移除或被带入安全的位置。 系统根据安全事件的评估修改和优化其规则和流程。 安全系统执行这些安全规则并从授权的安全人员接收反馈。 学习系统被配置为修改现有规则或根据授权的安全人员的反馈创建新的规则。

    Reconfiguration manager for controlling upgrades of electronic devices
    8.
    发明授权
    Reconfiguration manager for controlling upgrades of electronic devices 有权
    用于控制电子设备升级的重配置管理器

    公开(公告)号：US06467088B1

    公开(公告)日：2002-10-15

    申请号：US09343607

    申请日：1999-06-30

    申请人： Yasser alSafadi ,  J. David Schaffer

    发明人： Yasser alSafadi ,  J. David Schaffer

    IPC分类号： G06F945

    CPC分类号： G06F8/65

    摘要： A reconfiguration manager implemented on a computer or other data processing device controls the reconfiguration of software or other components of an electronic device such as a computer, personal digital assistant (PDA), set-top box, television, etc. The reconfiguration manager receives a reconfiguration request, e.g., a software upgrade request from the electronic device, and determines one or more device components that are required to implement the reconfiguration request. The reconfiguration manager also determines, e.g., from information in the request, identifiers of one or more additional components currently implemented in the electronic device. The reconfiguration manager then compares the needed and currently implemented components with previously-stored lists of known acceptable and unacceptable configurations for the electronic device. If the needed and currently implemented components correspond to a configuration on the list of acceptable configurations, the request is approved and the needed components are downloaded to the electronic device. If the needed and currently implemented components correspond to a configuration on the list of unacceptable configurations, the request is denied. Otherwise, the reconfiguration manager may indicate that the requested reconfiguration is unknown, or may take another action such as responding to the electronic device with a list of other components that would be required to implement the request.

    摘要翻译： 在计算机或其他数据处理设备上实现的重新配置管理器控制诸如计算机，个人数字助理（PDA），机顶盒，电视等的电子设备的软件或其他组件的重新配置。重新配置管理器接收 重新配置请求，例如来自电子设备的软件升级请求，并且确定实现重新配置请求所需的一个或多个设备组件。 重新配置管理器还例如从请求中的信息确定当前在电子设备中实现的一个或多个附加组件的标识符。 然后，重新配置管理器将所需和当前实现的组件与电子设备的已知可接受和不可接受的配置的先前存储的列表进行比较。 如果所需和当前实现的组件对应于可接受配置列表上的配置，则该请求被批准并且所需组件被下载到电子设备。 如果所需的和当前实现的组件对应于不可接受的配置列表中的配置，则该请求被拒绝。 否则，重新配置管理器可以指示所请求的重新配置是未知的，或者可以采取另一动作，例如响应于电子设备，其具有实现该请求所需的其他组件的列表。

    Component placement machine step size determination for improved throughput via an evolutionary algorithm
    9.
    发明授权
    Component placement machine step size determination for improved throughput via an evolutionary algorithm 失效
    组件放置机步长确定，通过进化算法提高吞吐量

    公开(公告)号：US06260178B1

    公开(公告)日：2001-07-10

    申请号：US09277636

    申请日：1999-03-26

    申请人： J. David Schaffer

    发明人： J. David Schaffer

    IPC分类号： G06F1750

    CPC分类号： H05K13/08

    摘要： The step size parameters of a component placement machine are represented as genes in a component placement chromosome, and evolutionary algorithm techniques are applied to evolve offspring that have step size parameters that provide an improved component placement throughput estimate. The offspring that have these preferential step size parameters are used to generate additional offspring that provide further improvement in the component placement throughput estimate. After a number of generations, the step size parameters of the offspring that provides the best component placement throughput are used to program the component placement machine to achieve this improved throughput.

    摘要翻译： 组件放置机器的步长参数被表示为组件放置染色体中的基因，并且应用进化算法技术来演化具有提供改进的组件放置通过量估计的步长参数的后代。 具有这些优先步长参数的后代被用于产生额外的后代，其进一步改进了组件放置通量估计。 经过几代人，使用提供最佳组件放置吞吐量的后代的步长参数用于对组件放置机进行编程，以实现这种提高的吞吐量。