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1.发明申请Inducing cellar immune responses to hepatitis C virus using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导丙型肝炎病毒的地窖免疫应答公开(公告)号：US20090304746A1
公开(公告)日：2009-12-10
申请号：US11980348
申请日：2007-10-31
申请人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chesnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chesnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
IPC分类号： A61K39/29 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61K31/7052 , C07K14/00 , G01N33/53 , A61K38/16 , A61P31/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/70 , C07K2319/00 , C12N2770/24222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare HCV epitopes, and to develop epitope-based vaccines directed towards HCV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HCV infection.
摘要翻译： 本发明使用我们对抗原被T细胞识别和制备HCV表位的机制的知识，并开发针对HCV的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗HCV感染。
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公开(公告)号：US09340577B2
公开(公告)日：2016-05-17
申请号：US10817970
申请日：2004-04-06
申请人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
发明人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
IPC分类号： A61K38/10 , A61K39/145 , C07K7/08 , C07K7/06 , A61K39/02 , A61K39/12 , C07K14/74 , A61K38/00 , A61K39/00
CPC分类号： A61K38/00 , A61K38/10 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K39/145 , A61K2039/5158 , A61K2039/55516 , A61K2039/55566 , A61K2039/572 , C07K7/06 , C07K14/70539 , C07K2319/01 , C07K2319/33 , C07K2319/40 , C12N2710/00088 , C12N2710/20034 , C12N2730/10134 , C12N2740/16034 , C12N2770/24234
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. One such peptide, NMLSTVLGV (SEQ ID NO: 183) is useful to elicit an immune response against influenza. The present invention also provides a heteropolymer of an isolated immunogenic peptide less than 15 amino acids in length comprising the oligopeptide NMLSTVLGV (SEQ ID NO: 183) and at least one different peptide.
摘要翻译： 本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。 一种这样的肽NMLSTVLGV（SEQ ID NO：183）可用于引发针对流感的免疫应答。 本发明还提供了长度小于15个氨基酸的分离的免疫原性肽的杂聚物，其包含寡肽NMLSTVLGV（SEQ ID NO：183）和至少一种不同的肽。
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公开(公告)号：US20080260762A1
公开(公告)日：2008-10-23
申请号：US11978519
申请日：2007-10-30
申请人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
发明人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen.
摘要翻译： 本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。 所述肽可用于引发针对所需抗原的免疫应答。
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4.发明授权Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions 有权使用肽和核酸组合物诱导对人乳头瘤病毒的细胞免疫应答公开(公告)号：US07026443B1
公开(公告)日：2006-04-11
申请号：US09641528
申请日：2000-08-15
申请人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
IPC分类号： C07K7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5158 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/57 , C12N2710/20022 , C12N2710/20034
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原识别和制备人乳头状瘤病毒（HPV）表位的机制的知识，并开发针对HPV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HPV感染中的药物组合物和使用方法的发现。
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5.发明申请公开(公告)号：US20090214632A1
公开(公告)日：2009-08-27
申请号：US12292281
申请日：2008-11-14
申请人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
IPC分类号： A61K39/12 , C07K14/005 , A61K9/127 , C12N5/08 , C07H21/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5158 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/57 , C12N2710/20022 , C12N2710/20034
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
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6.发明授权Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions 有权使用肽和核酸组合物诱导对人乳头瘤病毒的细胞免疫应答公开(公告)号：US07572882B2
公开(公告)日：2009-08-11
申请号：US10149136
申请日：2000-12-11
申请人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
IPC分类号： A61K38/03
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5158 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/57 , C12N2710/20022 , C12N2710/20034
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原识别和制备人乳头状瘤病毒（HPV）表位的机制的知识，并开发针对HPV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HPV感染中的药物组合物和使用方法的发现。
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7.发明申请Inducing cellular immune responses to p53 using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导对p53的细胞免疫应答公开(公告)号：US20050196403A1
公开(公告)日：2005-09-08
申请号：US11051411
申请日：2005-02-07
申请人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Elissa Keogh
发明人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Elissa Keogh
CPC分类号： C07K14/70539 , A61K38/00 , A61K39/00 , C07K14/4746
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare p53 epitopes, and to develop epitope-based vaccines directed towards p53-bearing tumors. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of cancer.
摘要翻译： 本发明使用我们对抗原被T细胞识别和制备p53表位的机制的知识，并开发针对p53携带肿瘤的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗癌症。
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8.发明申请HLA CLASS I A2 TUMOR ASSOCIATED ANTIGEN PEPTIDES AND VACCINE COMPOSITIONS 审中-公开HLA I类A2肿瘤相关抗原肽和疫苗组合物公开(公告)号：US20140147490A1
公开(公告)日：2014-05-29
申请号：US13662906
申请日：2012-10-29
申请人： John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
发明人： John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/55516
摘要： A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译： 一种组合物或疫苗组合物，其包含至少一种具有小于600个连续氨基酸的肽，其具有与CEA，HER2 / neu，MAGE2，MAGE3或p53的天然序列具有100％同一性，所述肽还包含至少一个选自 表6。
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9.发明授权Inducing cellular immune responses to hepatitis B virus using peptide compositions 有权使用肽组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US07611713B2
公开(公告)日：2009-11-03
申请号：US10654601
申请日：2003-09-04
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
CPC分类号： C07K14/005 , A61K38/00 , C07K14/70539 , C12N2730/10122
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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10.发明申请HLA class I A2 tumor associated antigen peptides and vaccine compositions 审中-公开HLA I类A2肿瘤相关抗原肽和疫苗组合物公开(公告)号：US20080279924A1
公开(公告)日：2008-11-13
申请号：US11976908
申请日：2007-10-29
申请人： John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
发明人： John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
CPC分类号： A61K9/0019 , A61K9/127 , A61K38/08
摘要： A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译： 一种组合物或疫苗组合物，其包含至少一种具有小于600个连续氨基酸的肽，其具有与CEA，HER2 / neu，MAGE2，MAGE3或p53的天然序列具有100％同一性，所述肽还包含至少一个选自 表6。
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