HIGH TEMPERATURE STABLE PEPTIDE FORMULATION
    2.
    发明申请
    HIGH TEMPERATURE STABLE PEPTIDE FORMULATION 有权
    高温稳定肽配方

    公开(公告)号:US20090054331A1

    公开(公告)日:2009-02-26

    申请号:US12129504

    申请日:2008-05-29

    IPC分类号: A61K38/16 A61P43/00 B65D85/00

    摘要: A stabilized pharmaceutical composition in the form of a lyophilized product to be later reconstituted to generate an aqueous drug product is described herein. The therapeutically active ingredient in the form of a peptide of sequence TDLQERGDNDISPFSGDGQPFKD is stabilized with a buffer, carbohydrate stabilizer, a nonionic bulking agent and a surfactant to facilitate reconstitution. The preferred preparation contains a peptide of the sequence TDLQERGDNDISPFSGDGQPFKD, histidine buffer, mannitol or glycine, sucrose and/or Polysorbate 20. This combination of excipients has demonstrated exceptional stability as a lyophilized product when stored at the elevated temperature of 40° C. for at least 6 months and for at least 3 Months at 50° C. The lyophilized mixture thus formed is reconstituted to a high peptide concentration without apparent loss of stability of the peptide. Also, this combination of excipients has also enabled the ability to terminally sterilize the lyophilized product using gamma irradiation without affecting the stability of the active ingredient of the formulation.

    摘要翻译: 本文描述了待再造以产生含水药物产品的冻干产品形式的稳定化药物组合物。 序列TDLQERGDNDISPFSGDGQPFKD的肽形式的治疗活性成分用缓冲液,碳水化合物稳定剂,非离子填充剂和表面活性剂稳定以促进重构。 优选的制剂含有序列TDLQERGDNDISPFSGDGQPFKD,组氨酸缓冲液,甘露醇或甘氨酸,蔗糖和/或聚山梨醇酯20的肽。这种赋形剂的组合已经证明作为冻干产品在40℃升高的温度下储存时具有特别的稳定性, 至少6个月,并且在50℃下至少3个月。由此形成的冻干混合物重构成高肽浓度,而不会明显丧失肽的稳定性。 此外,赋形剂的这种组合也使得能够使用γ辐射对冻干产品进行终末灭菌,而不影响制剂的活性成分的稳定性。

    COMMUNICATING COMMUNITY FEATURES FOR MOBILE ELECTRONIC DEVICES
    3.
    发明申请
    COMMUNICATING COMMUNITY FEATURES FOR MOBILE ELECTRONIC DEVICES 审中-公开
    传播移动电子设备的社区功能

    公开(公告)号:US20080242277A1

    公开(公告)日:2008-10-02

    申请号:US11865604

    申请日:2007-10-01

    IPC分类号: H04M3/42

    摘要: A method for social networking includes storing at least one profile on at least one server, the profile being associated with at least one local profile on a mobile device and wherein each of the profile and the local profile includes social networking information, receiving changes to one of the profile and the local profile, and synchronizing the profile and the local profile.

    摘要翻译: 一种用于社交网络的方法包括在至少一个服务器上存储至少一个简档,所述简档与移动设备上的至少一个本地配置文件相关联,并且其中所述配置文件和所述本地配置文件中的每一个包括社交网络信息,接收到一个 的配置文件和本地配置文件,并同步配置文件和本地配置文件。

    Disk drive attenuating excitation of arm vibration mode by simultaneously driving secondary actuator for non-active head
    4.
    发明授权
    Disk drive attenuating excitation of arm vibration mode by simultaneously driving secondary actuator for non-active head 失效
    磁盘驱动器通过同时驱动非活动头的辅助执行器来衰减臂振动模式的激励

    公开(公告)号:US06972924B1

    公开(公告)日:2005-12-06

    申请号:US10816997

    申请日:2004-04-02

    IPC分类号: G11B5/48 G11B5/55 G11B5/596

    CPC分类号: G11B5/5556 G11B5/4813

    摘要: A disk drive is disclosed employing a primary actuator for rotating an actuator arm about a pivot in coarse movements, and first and second secondary actuators coupled to the actuator arm for actuating first and second heads in fine movements. A servo control system generates a first control signal applied to the first secondary actuator to position the first head over the first disk surface in fine movements while accessing the first disk surface. The servo control system phase shifts the first control signal by a predetermined phase to generate a second control signal applied to the second secondary actuator to attenuate excitation of at least one arm vibration mode.

    摘要翻译: 公开了一种磁盘驱动器,其采用主致动器,用于在粗略运动中围绕枢轴旋转致动器臂,以及联接到致动器臂的第一和第二辅助致动器,用于以精细运动致动第一和第二磁头。 伺服控制系统产生施加到第一辅助致动器的第一控制信号,以便在访问第一盘表面时以优良的运动将第一磁头定位在第一磁盘表面上。 伺服控制系统将第一控制信号相移一预定相位,以产生施加到第二辅助致动器的第二控制信号,以衰减至少一个臂振动模式的激励。

    Method of making at least one suspension load beam for an actuator assembly of a disk drive
    5.
    发明授权
    Method of making at least one suspension load beam for an actuator assembly of a disk drive 失效
    制造用于磁盘驱动器的致动器组件的至少一个悬架负载梁的方法

    公开(公告)号:US06938326B1

    公开(公告)日:2005-09-06

    申请号:US10342174

    申请日:2003-01-13

    摘要: A suspension load beam for an actuator assembly of a disk drive includes a bend radius portion with a spring rate that is less than 18 Newtons per meter, a first bending mode that is greater than 3,500 Hertz, and a first torsion mode that is greater than 5,300 Hertz. The method of making this suspension load beam includes cutting a sheet of material to form a flat suspension load beam including a bend radius portion, removing material in the bend radius portion from full thickness, inspecting the bend radius portion to determine its thickness, and removing material from the bend radius portion and/or from the main body of the suspension load beam to compromise the performance difference due to thickness variation in bend radius portion.

    摘要翻译: 用于盘驱动器的致动器组件的悬挂负载梁包括具有小于每米18牛顿的弹簧速率的弯曲半径部分,大于3,500赫兹的第一弯曲模式和大于3,500赫兹的第一扭转模式 5,300赫兹。 制造悬架载荷梁的方法包括切割一片材料以形成包括弯曲半径部分的平坦悬挂载荷梁,从弯曲半径部分全部去除材料,检查弯曲半径部分以确定其厚度,并且移除 材料从弯曲半径部分和/或来自悬挂载荷梁的主体,以损害由于弯曲半径部分的厚度变化引起的性能差异。

    Apparatus for minimizing head off-track due to disk flutter
    6.
    发明授权
    Apparatus for minimizing head off-track due to disk flutter 有权
    用于使由于磁盘颤动引起的磁头偏离磁道最小化的装置

    公开(公告)号:US06445545B1

    公开(公告)日:2002-09-03

    申请号:US09532057

    申请日:2000-03-21

    IPC分类号: G11B2116

    CPC分类号: G11B5/59627

    摘要: A slider support structure is disclosed for minimizing off-rack due to disk flutter. In one embodiment, the slider support structure includes a gimbal assembly (306). The assembly (306) includes an outer ring (500) and an inner ring (502). The outer ring (500) is connected to the inner ring (502) via narrow strips (504 and 506) adjacent to the front (508) and back (510) surfaces of the slider body (512). The inner ring (502) is attached to the left (514) and right (516) surfaces of the slider body (512) via narrow strips (518 and 520). The strips (504 and 506) interconnecting the inner ring (502) and outer ring (500) define a flexible hinge that allows the slider body (512) to pivot relative to the assembly (306) about an axis (522) which, in this case, is the roll axis. Similarly, the strips (518 and 520) define a flexible hinge which allows the slider to pivot relative to the assembly (306) about another axis (524) which, in this case, is the pitch axis. The axes (522 and 524) are disposed close to the lower surface of the slider so that head off-track associated with such pivotal is minimized.

    摘要翻译: 公开了一种滑块支撑结构,用于使由于磁盘颤动引起的离架减少。 在一个实施例中,滑块支撑结构包括万向节组件(306)。 组件(306)包括外环(500)和内环(502)。 外环(500)通过与滑块体(512)的前(508)和后(510)表面相邻的窄条(504和506)连接到内环(502)。 内环(502)经由窄条(518和520)附接到滑块体(512)的左(514)和右(516)表面。 互连内环(502)和外环(500)的条(504和506)限定了柔性铰链,其允许滑块体(512)相对于组件(306)围绕轴线(522)枢转,所述轴线(522) 这种情况下,是滚轴。 类似地,条带(518和520)限定柔性铰链,其允许滑块相对于组件(306)围绕另一个轴线(524)枢转,在这种情况下,该滑动件是俯仰轴线。 轴(522和524)设置成靠近滑块的下表面,使得与这种枢轴相关的头部偏离轨迹最小化。

    Grip for sporting equipment
    7.
    发明授权
    Grip for sporting equipment 失效
    握手体育设备

    公开(公告)号:US5435549A

    公开(公告)日:1995-07-25

    申请号:US166526

    申请日:1993-12-14

    申请人: Dennis Chen

    发明人: Dennis Chen

    摘要: A grip for sporting equipment comprises a first mat cloth strip, a foamed polyurethane strip and a second mat cloth strip sequentially adhered together in predetermined thickness. A resilient element of silicon elastoner is formed in the recesses inside the strips thereinbetween and a double faced tape is adhered on the top surface of the second mat cloth strip. So that the grip can be stuck and twined with the handle of the sporting equipments for providing shock absorbing effect thereon.

    摘要翻译: 用于运动装置的把手包括以预定厚度顺序地粘合在一起的第一垫布条,泡沫聚氨酯条和第二垫布条。 硅弹性体的弹性元件形成在其间的条带内的凹部中,并且双面胶带粘附在第二垫布条的顶表面上。 因此,可以将握把与卡在运动设备的手柄上并提供冲击吸收效果。

    Weight adjustable shock and vibration absorbing tennis racket
    8.
    发明授权
    Weight adjustable shock and vibration absorbing tennis racket 失效
    重量可调震动和减震网球拍

    公开(公告)号:US5236197A

    公开(公告)日:1993-08-17

    申请号:US752185

    申请日:1991-08-23

    申请人: Dennis Chen

    发明人: Dennis Chen

    IPC分类号: A63B49/02 A63B49/04 A63B59/00

    CPC分类号: A63B49/02 A63B60/02 A63B60/54

    摘要: A weight adjustable, shock and vibration absorbing tennis racket comprising a generally oval shaped headframe with a handle attached thereto, and a striking surface therein formed by stringing the headframe with a string in the conventional manner. A pair of elongate recesses are formed along the inner periphery of the headframe at opposed positions thereon and aligned with the center of percussion of the headframe. A pair of projections are formed on respective opposed longitudinal sides of each recess. A vibration absorbing rib can be releasably secured to each recess, with the ends thereof snap fitting into respective projections of a corresponding recess. String holes for cross strings passing through a recess are arranged in two staggered rows with a pair of adjacent cross strings diverging to a respective pair of adjacent string holes disposed on opposing rows. Adjacent cross strings pass around and contact opposite sides of the corresponding rib when attached. A shock absorbing counterweight can be inserted into each recess, snap fitting around a corresponding rib.

    摘要翻译: 一种重量可调的,减震和振动吸收的网球拍,其包括大致椭圆形的头架,其具有附接到其上的手柄,以及其中通过以常规方式用字符串串联头架而形成的打击表面。 沿着头架的内周边形成一对细长的凹槽,在其上相对的位置上形成一对细长的凹槽,并与头架的冲击中心对齐。 一对突起形成在每个凹部的相对的纵向侧上。 振动吸收肋可以可释放地固定到每个凹部,其端部卡扣配合到相应凹部的相应突起中。 用于穿过凹部的十字线的线孔布置成两个交错行,一对相邻的交叉串发散到设置在相对行上的相应的一对相邻的线孔。 当相邻的十字线条附着时,相邻的十字线条绕过并接触相应的肋条的相对两侧。 减震配重可插入每个凹槽中,卡扣配合在相应的肋条周围。

    Racket handle butt plate
    9.
    发明授权
    Racket handle butt plate 失效
    球拍手柄对接板

    公开(公告)号:US5069452A

    公开(公告)日:1991-12-03

    申请号:US574592

    申请日:1990-08-29

    申请人: Dennis Chen

    发明人: Dennis Chen

    IPC分类号: A63B49/08

    CPC分类号: A63B49/08 A63B60/16 A63B60/14

    摘要: Disclosed is a racket handle butt plate for mounting on the rear end of a racket handle, which comprises an elongated octagonal socket body made of rigid plastic injection molded material, having a single opening at one side for the insertion therein of a racket handle and being covered with a layer of resilient material of pre-determined thickness by means of a secondary injection molding process, so that the butt plate has a rigid inner structure and a soft outer surface.

    摘要翻译: 公开了一种用于安装在球拍手柄的后端上的球拍柄对接板,其包括由刚性塑料注射成型材料制成的细长八边形插座体,在一侧具有单个开口,用于插入球拍手柄,并且 通过二次注射成型工艺覆盖有预定厚度的弹性材料层,使得对接板具有刚性的内部结构和柔软的外表面。

    Structure of a composite fiber racket
    10.
    发明授权
    Structure of a composite fiber racket 失效
    复合纤维球拍的结构

    公开(公告)号:US5029858A

    公开(公告)日:1991-07-09

    申请号:US554014

    申请日:1990-07-17

    申请人: Dennis Chen

    发明人: Dennis Chen

    IPC分类号: A63B49/02 A63B49/04 A63B49/10

    CPC分类号: A63B49/02 A63B49/10 A63B60/02

    摘要: Disclosed is an improved structure of a composite fiber racket, which includes a frame comprising a head portion and a handle, wherein a catgut string is laterally and longitudinally inserted through the through-holes set around the head portion to form a taut striking surface, characterized by the head portion having thereon a plurality of reinforcement elements inset at several predetermined positions. Each of the reinforcement elements has an elongate foam piece disposed therein and is covered with a layer of composite fiber which is of the same material as used by the head portion. One side of the reinforcement element is attached to the corresponding inner side wall of the head portion, and the other side thereof has a small space separating it from the corresponding outer side wall of the head portion, so as to reinforce the strength of the head portion and increase the weight distribution around the periphery of the racket frame.

    摘要翻译: 公开了一种复合纤维球拍的改进结构,其包括一个包括一个头部和一个把手的框架,其中,一根通孔被横向和纵向插入穿过头部周围的通孔,以形成紧紧的打击表面,其特征在于 通过其上具有多个加强元件的头部在几个预定位置插入。 每个加强元件具有设置在其中的细长泡沫块,并且覆盖有与头部使用的材料相同的复合纤维层。 加强元件的一侧附接到头部的相应的内侧壁,并且其另一侧具有与头部的相应的外侧壁分离的小的空间,以便增强头部的强度 并且增加围绕球拍框架周边的重量分布。