利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.013 秒)

    DENTAL PRODUCTS COMPRISING BONE GROWTH ENHANCING PEPTIDE
    1.
    发明申请
    DENTAL PRODUCTS COMPRISING BONE GROWTH ENHANCING PEPTIDE 审中-公开
    包含骨生长增强肽的牙科产品

    公开(公告)号：US20090163413A1

    公开(公告)日：2009-06-25

    申请号：US12108374

    申请日：2008-04-23

    申请人： TOSHIYUKI YONEDA ,  Motoyoshi Nomizu ,  Yoshinari Kumagai ,  Russell Wayne Blacher

    发明人： TOSHIYUKI YONEDA ,  Motoyoshi Nomizu ,  Yoshinari Kumagai ,  Russell Wayne Blacher

    IPC分类号： A61K38/16 ,  A61K38/10

    CPC分类号： A61Q11/00 ,  A61K8/64 ,  A61K38/1709 ,  Y10S514/899 ,  Y10S514/90 ,  Y10S514/901

    摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promotes bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.

    摘要翻译： 公开了诸如牙膏，漱口剂和牙线的牙科产品，其通过在其上溶解，分散或涂覆促进骨生长的化合物来增强产品。 优选的化合物是包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，并且在基质细胞外磷酸糖蛋白中与RGD序列连续的氨基酸残基。 可以将这些序列配制成用于分散在牙膏或漱口剂中并施用以增强骨/牙齿生长。 当牙科产品随着时间的推移被多次使用时，它们可以提高牙齿健康。

    HIGH TEMPERATURE STABLE PEPTIDE FORMULATION
    2.
    发明申请
    HIGH TEMPERATURE STABLE PEPTIDE FORMULATION 有权
    高温稳定肽配方

    公开(公告)号：US20090054331A1

    公开(公告)日：2009-02-26

    申请号：US12129504

    申请日：2008-05-29

    申请人： Dennis CHEN ,  Russell Wayne BLACHER ,  Byeong CHANG

    发明人： Dennis CHEN ,  Russell Wayne BLACHER ,  Byeong CHANG

    IPC分类号： A61K38/16 ,  A61P43/00 ,  B65D85/00

    CPC分类号： A61K38/1709 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K47/183 ,  A61K47/26 ,  C07K14/4702

    摘要： A stabilized pharmaceutical composition in the form of a lyophilized product to be later reconstituted to generate an aqueous drug product is described herein. The therapeutically active ingredient in the form of a peptide of sequence TDLQERGDNDISPFSGDGQPFKD is stabilized with a buffer, carbohydrate stabilizer, a nonionic bulking agent and a surfactant to facilitate reconstitution. The preferred preparation contains a peptide of the sequence TDLQERGDNDISPFSGDGQPFKD, histidine buffer, mannitol or glycine, sucrose and/or Polysorbate 20. This combination of excipients has demonstrated exceptional stability as a lyophilized product when stored at the elevated temperature of 40° C. for at least 6 months and for at least 3 Months at 50° C. The lyophilized mixture thus formed is reconstituted to a high peptide concentration without apparent loss of stability of the peptide. Also, this combination of excipients has also enabled the ability to terminally sterilize the lyophilized product using gamma irradiation without affecting the stability of the active ingredient of the formulation.

    摘要翻译： 本文描述了待再造以产生含水药物产品的冻干产品形式的稳定化药物组合物。 序列TDLQERGDNDISPFSGDGQPFKD的肽形式的治疗活性成分用缓冲液，碳水化合物稳定剂，非离子填充剂和表面活性剂稳定以促进重构。 优选的制剂含有序列TDLQERGDNDISPFSGDGQPFKD，组氨酸缓冲液，甘露醇或甘氨酸，蔗糖和/或聚山梨醇酯20的肽。这种赋形剂的组合已经证明作为冻干产品在40℃升高的温度下储存时具有特别的稳定性， 至少6个月，并且在50℃下至少3个月。由此形成的冻干混合物重构成高肽浓度，而不会明显丧失肽的稳定性。 此外，赋形剂的这种组合也使得能够使用γ辐射对冻干产品进行终末灭菌，而不影响制剂的活性成分的稳定性。

    High temperature stable peptide formulation
    7.
    发明授权
    High temperature stable peptide formulation 有权
    高温稳定肽制剂

    公开(公告)号：US07879805B2

    公开(公告)日：2011-02-01

    申请号：US12129504

    申请日：2008-05-29

    申请人： Dennis Chen ,  Russell Wayne Blacher ,  Byeong Chang

    发明人： Dennis Chen ,  Russell Wayne Blacher ,  Byeong Chang

    IPC分类号： A61K38/16

    CPC分类号： A61K38/1709 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K47/183 ,  A61K47/26 ,  C07K14/4702

    摘要： A stabilized pharmaceutical composition in the form of a lyophilized product to be later reconstituted to generate an aqueous drug product is described herein. The therapeutically active ingredient in the form of a peptide of sequence TDLQERGDNDISPFSGDGQPFKD is stabilized with a buffer, carbohydrate stabilizer, a nonionic bulking agent and a surfactant to facilitate reconstitution. The preferred preparation contains a peptide of the sequence TDLQERGDNDISPFSGDGQPFKD, histidine buffer, mannitol or glycine, sucrose and/or Polysorbate 20. This combination of excipients has demonstrated exceptional stability as a lyophilized product when stored at the elevated temperature of 40° C. for at least 6 months and for at least 3 Months at 50° C. The lyophilized mixture thus formed is reconstituted to a high peptide concentration without apparent loss of stability of the peptide. Also, this combination of excipients has also enabled the ability to terminally sterilize the lyophilized product using gamma irradiation without affecting the stability of the active ingredient of the formulation.

    摘要翻译： 本文描述了待再造以产生含水药物产品的冻干产品形式的稳定化药物组合物。 序列TDLQERGDNDISPFSGDGQPFKD的肽形式的治疗活性成分用缓冲液，碳水化合物稳定剂，非离子填充剂和表面活性剂稳定以促进重构。 优选的制剂含有序列TDLQERGDNDISPFSGDGQPFKD，组氨酸缓冲液，甘露醇或甘氨酸，蔗糖和/或聚山梨醇酯20的肽。这种赋形剂的组合已经证明作为冻干产品在40℃升高的温度下储存时具有特别的稳定性， 至少6个月，并且在50℃下至少3个月。由此形成的冻干混合物重构成高肽浓度，而不会明显丧失肽的稳定性。 此外，赋形剂的这种组合也使得能够使用γ辐射对冻干产品进行终末灭菌，而不影响制剂的活性成分的稳定性。

    Dental products comprising bone growth enhancing peptide
    8.
    发明授权
    Dental products comprising bone growth enhancing peptide 有权
    包含骨生长增强肽的牙科产品

    公开(公告)号：US07498021B2

    公开(公告)日：2009-03-03

    申请号：US11379316

    申请日：2006-04-19

    申请人： Toshiyuki Yoneda ,  Motoyoshi Nomizu ,  Yoshinari Kumagai ,  Russell Wayne Blacher

    发明人： Toshiyuki Yoneda ,  Motoyoshi Nomizu ,  Yoshinari Kumagai ,  Russell Wayne Blacher

    IPC分类号： A61K7/16 ,  A61K38/00 ,  C07K17/00

    CPC分类号： A61Q11/00 ,  A61K8/64 ,  A61K38/1709 ,  Y10S514/899 ,  Y10S514/90 ,  Y10S514/901

    摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.

    摘要翻译： 公开了牙膏，漱口剂和牙线等牙科产品，其中通过溶解，分散或涂覆促进骨生长的化合物来增强产品。 优选的化合物是包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，并且在基质细胞外磷酸糖蛋白中与RGD序列连续的氨基酸残基。 可以将这些序列配制成用于分散在牙膏或漱口剂中并施用以增强骨/牙齿生长。 当牙科产品随着时间的推移被多次使用时，它们可以提高牙齿健康。