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1.发明申请公开(公告)号：US20110195516A1
公开(公告)日：2011-08-11
申请号：US13062568
申请日：2009-09-08
CPC分类号： G01N21/648 , B82Y15/00 , B82Y20/00 , G01N21/6428 , G01N33/54393 , Y10T428/24331
摘要： The present invention relates to a multi-layered substrate structure comprising at least one carrier layer (11), a first layer (12), said carrier layer and first layer being in contact with each other, and at least one second layer with a chemical composition different from the first layer (13) said first and second layer being in contact with each other, the second layer forming apertures each having at least one in-plane dimension (W1) smaller than the diffraction limit, the diffraction limit being defined by a radiation wavelength of the excitation light. The invention further relates to the use and manufacturing process of such a substrate structure and a luminescence sensor.
摘要翻译： 本发明涉及一种多层衬底结构，其包括至少一个载体层（11），第一层（12），所述载体层和第一层彼此接触，以及至少一个具有化学物质的第二层 组成不同于第一层（13）的第一和第二层彼此接触，第二层形成孔各自具有小于衍射极限的至少一个面内尺寸（W1），衍射极限由 激发光的辐射波长。 本发明还涉及这种衬底结构和发光传感器的使用和制造过程。
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公开(公告)号：US20100044585A1
公开(公告)日：2010-02-25
申请号：US12447668
申请日：2007-10-31
CPC分类号： G01N21/648 , G01J3/26 , G01J3/4406 , G01N21/6428 , G01N2021/6469 , G02B5/204 , G02B5/284 , G02B5/3058
摘要： The invention discloses a luminescence sensor (101) for bio-sensing having an input reflector (253) and an output reflector (254). The gap (S) between the input and output reflectors constitutes an optical cavity. One or both of the input and output reflectors can be a wire-grid (270) having apertures (211,212), where at least one dimension of the apertures is below the diffraction limit. When input radiation (221) impinges the input reflector a fraction of the input radiation is transmitted into the cavity. The energy of the radiation inside the cavity is increased due to the resonance properties of the cavity. Due to the increase of the cavity excitation energy, the luminescent radiation emitted from the luminescent particles inside the cavity can be detected outside the cavity. Since the input and output reflectors have high reflection coefficients the input radiation is effectively prohibited from being transmitted through the luminescence detector. In addition, luminescence generated in the cavity is significantly higher than luminescence generated outside the cavity.
摘要翻译： 本发明公开了一种用于生物感测的发光传感器（101），其具有输入反射器（253）和输出反射器（254）。 输入和输出反射器之间的间隙（S）构成一个光腔。 输入和输出反射器中的一个或两个可以是具有孔（211,212）的线栅（270），其中孔的至少一个尺寸低于衍射极限。 当输入辐射（221）撞击输入反射器时，输入辐射的一部分被传送到空腔中。 由于空腔的共振特性，空腔内的辐射能量增加。 由于空腔激发能的增加，可以在空腔外部检测从空腔内的发光颗粒发射的发光辐射。 由于输入和输出反射器具有高反射系数，因此有效地禁止输入辐射通过发光检测器传输。 此外，在空腔中产生的发光显着高于腔外产生的发光。
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公开(公告)号：US20100001210A1
公开(公告)日：2010-01-07
申请号：US12519849
申请日：2007-12-17
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/025 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , C12Q1/6837 , G01N21/47 , G01N21/554 , G01N21/658 , G01N2021/95676
摘要： A luminescence sensor, comprising a non-transparent substrate structure (2) having at least one aperture (5) intended to comprise an analyte and a transparent substrate structure (3), which is arranged to or adjacent said first structure (2). The aperture has a smallest lateral dimension, which is smaller than half the effective wavelength of an excitation radiation, such as light at a wavelength of 700 nm, resulting in an effective wavelength in water of about 538 nm. The transparent structure has a trench (4) with a surface portion provided with ligands with an affinity towards a target molecule. The trench results in that a luminophore attached to the target molecule will be positioned at the entrance surface of the aperture, where the excitation energy is largest.
摘要翻译： 发光传感器，包括具有至少一个孔（5）的非透明衬底结构（2），所述孔旨在包括被分析物和透明衬底结构（3），所述透明衬底结构（3）布置在所述第一结构（2）上或邻近所述第一结构（2）。 孔径具有最小的横向尺寸，其小于激发辐射的有效波长的一半，例如波长为700nm的光，导致在约538nm的水中的有效波长。 透明结构具有沟槽（4），其表面部分具有对靶分子具有亲和性的配体。 沟槽导致连接到靶分子的发光体将位于孔的入射表面处，其中激发能量最大。
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公开(公告)号：US20100072397A1
公开(公告)日：2010-03-25
申请号：US12519800
申请日：2007-12-18
CPC分类号： G01N21/64 , G01N21/6445
摘要： There is provided a method of detecting a presence of a luminophore in a detection volume comprising providing excitation radiation in said detection volume. A luminophore is provided in said detection volume being excitable by said excitation radiation. The luminescent radiation is detected to identify the presence of said luminophore in said detection volume. In one aspect of the invention, said luminophore is selected to emit luminescent radiation having a wavelength in said medium that is larger than twice said smallest dimension; and wherein said luminophore is selected to be excitable by excitation radiation having a wavelength in said medium that is smaller than twice said smallest dimension. Accordingly, luminescent radiation is blocked from entering the detector but for the portion present on an interface of the aperture.
摘要翻译： 提供了一种检测检测体积中的发光体的存在的方法，包括在所述检测体积中提供激发辐射。 在所述检测体积中提供发光体，所述发光体可被所述激发辐射激发。 检测发光辐射以识别所述检测体积中所述发光体的存在。 在本发明的一个方面，所述发光体选择为发射具有大于所述最小尺寸的两倍的所述介质中的波长的发光辐射; 并且其中所述发光体被选择为通过所述介质中具有小于所述最小尺寸的两倍的波长的激发辐射来激发。 因此，阻挡发光辐射进入检测器，但是阻挡存在于孔的界面上的部分。
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5.发明申请Biosensor with One-Dimensional Sub-Diffraction-Limited Apertures Composed of a Grid and a Polarizer 有权具有由网格和偏振器组成的一维子衍射限制光圈的生物传感器公开(公告)号：US20090001284A1
公开(公告)日：2009-01-01
申请号：US12158347
申请日：2006-12-11
IPC分类号： G01J1/58
CPC分类号： G01N21/648 , Y10T436/11
摘要： A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (120) defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light (102) in a medium, a polarizer (115), and luminophores (117) positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (120), the volume in between the array of slits (120) and the polarizer (115) and a volume that extends into the polarizer (115), wherein the grid (120) providing a transmission axis extending in a first direction and the polarizer (115) providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation (102) is polarized such that it is substantially suppressed by one of the at least one grid (120) and polarizer (115) and substantially not suppressed by the other of the at least one grid (120) and polarizer (115).
摘要翻译： 公开了一种用于检测由至少一个发光体产生的发光辐射的方法和传感器。 在本发明的上下文中，生物传感器包括定义为孔阵列的格栅（120），孔格具有第一尺寸，第二维度高于介质中的激发光（102）的衍射极限，偏振器（ 115）和位于选自以下的体积中的发光体（117）：栅格（120）的孔内的体积，狭缝阵列（120）和偏振器（115）之间的体积和 延伸到偏振器（115）的体积，其中提供沿第一方向延伸的透射轴的格栅（120）和提供沿第二方向延伸的透射轴的偏振器（115），第一方向和第二方向基本上 垂直于彼此垂直，其中所述激发辐射（102）被极化，使得其基本上被所述至少一个格栅（120）和偏振器（115）中的一个所抑制，并且基本上不被所述o 该至少一个格栅（120）和偏振器（115）。
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公开(公告)号：US20100108908A1
公开(公告)日：2010-05-06
申请号：US12526547
申请日：2008-02-12
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , B82Y15/00 , G01N21/6445 , G01N21/6452
摘要： A device for monitoring radiation emitted by luminophores present in an analyte fluid of a wiregrid biosensor. The monitoring device comprises a non-polarized light source (41) for illuminating the wiregrid biosensor for exciting fluorescent labels arranged in the analyte fluid of said biosensor. A detector (71) detects radiation emitted by the labels after excitation. A polarizing filter (53) is arranged in between the transparent substrate and the detector for suppression of background emission radiation from labels positioned outside apertures in the wiregrid, in the analyte fluid.
摘要翻译： 用于监测存在于丝网生物传感器的分析物流体中的发光体发射的辐射的装置。 监测装置包括用于照亮丝网生物传感器以激发布置在所述生物传感器的分析物流体中的荧光标记的非偏振光源（41）。 检测器（71）检测激励后由标签发射的辐射。 偏振滤光器（53）布置在透明基板和检测器之间，用于抑制分析物流体中位于线网中的孔外部的标签的背景辐射辐射。
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公开(公告)号：US20100096562A1
公开(公告)日：2010-04-22
申请号：US12519834
申请日：2007-12-17
CPC分类号： G01N21/774 , G01N21/648 , G01N2021/6467
摘要： There is provided a wave guide comprising: a wave guiding medium, having an index of refraction and provided between first and second wave propagating planar structures at least said first planar structure comprises a plurality of slitted-apertures defining a length axis of the first reflective structure; the slitted apertures constructed and arranged to reflect a R-polarized component of said radiation oriented parallel to said length axis; and wherein said first planar structure is arranged between said wave guiding medium and an adjacent medium having an index of refraction equal or larger than the wave guiding medium. In one aspect of the invention, a waveguide is proposed to limit an excitation region wherein luminophores are excited; substantially independent from the surrounding media of the waveguide. Preferentially, the waveguide is used in a luminescence sensor.
摘要翻译： 提供了一种波导，包括：波导介质，具有折射率并且设置在第一和第二波传播平面结构之间，至少所述第一平面结构包括限定第一反射结构的长度轴的多个狭缝孔 ; 所述切割孔被构造和布置成反射平行于所述长度轴定向的所述辐射的R偏振分量; 并且其中所述第一平面结构布置在所述波导介质和具有等于或大于所述波导介质的折射率的相邻介质之间。 在本发明的一个方面，提出了一种波导来限制其中发光体被激发的激发区域; 基本上独立于波导的周围介质。 优选地，波导用于发光传感器。
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公开(公告)号：US20100276577A1
公开(公告)日：2010-11-04
申请号：US12810022
申请日：2008-12-18
申请人： Derk J.W. Klunder
发明人： Derk J.W. Klunder
CPC分类号： G01N21/553 , G01N21/648
摘要： The invention concerns an optical device for providing evanescent radiation, in response to incident radiation, in a detection volume for containing a target component in a medium, the detection volume having at least one in-plane dimension (W1) smaller than a diffraction limit. The diffraction limit is defined by the radiation wavelength and the medium. The evanescent radiation is provided by aperture defining structures having a smallest in plane aperture dimension W1 smaller than the diffraction limit. The detection volume is provided between said aperture defining structures. The aperture defining structures in addition define a largest in plane aperture dimension W2; wherein said largest in plane aperture dimension is larger than the diffraction limit. A source is provided for emitting a beam of radiation having a wavelength incident at the optical device and having a direction of incidence non parallel to an out of plane normal direction, for providing evanescent radiation in the detection volume, in response to the radiation incident at the optical device. The plane of incidence is parallel to the largest in plane aperture dimension.
摘要翻译： 本发明涉及一种光学装置，用于响应于入射辐射，在用于在介质中容纳目标成分的检测体积中提供ev逝辐射，所述检测体积具有小于衍射极限的至少一个面内尺寸（W1）。 衍射极限由辐射波长和介质决定。 ev逝辐射由具有小于衍射极限的最小平面孔径尺寸W1的孔限定结构提供。 检测体积设置在所述孔限定结构之间。 孔限定结构另外限定最大的平面孔尺寸W2; 其中所述最大的平面孔径尺寸大于衍射极限。 提供源，用于发射具有入射在光学装置处的波长并具有不平行于外部平面法线方向的入射方向的辐射束，用于响应于入射在...的辐射而在检测体积中提供渐逝辐射 光学装置。 入射平面平行于最大的平面孔径尺寸。
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公开(公告)号：US20080166089A1
公开(公告)日：2008-07-10
申请号：US11816291
申请日：2006-02-15
IPC分类号： G02B6/42
CPC分类号： G02B6/3538 , G02B6/122 , G02B6/3594 , G02B6/3596 , G02B2006/0325
摘要： An optical waveguide comprises a body (13), the body including an entrance window (9) and an exit window (11) defining an optical path (13) through a cavity. The cavity contains a first fluid (A) and a second fluid (B), with an interface between the first fluid and the second fluid defined by a meniscus. The meniscus lies longitudinally along the optical path. Means for adjusting the meniscus are provided, for example a voltage source and at least two electrodes. Electrowetting can be used for influencing the fluids.
摘要翻译： 光波导包括主体（13），主体包括通过空腔限定光路（13）的入口窗（9）和出口窗（11）。 空腔包含第一流体（A）和第二流体（B），在第一流体和由弯月面限定的第二流体之间具有界面。 弯液面沿光路纵向延伸。 提供了用于调节弯液面的装置，例如电压源和至少两个电极。 电润湿可用于影响流体。
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