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1.发明申请Biosensor with One-Dimensional Sub-Diffraction-Limited Apertures Composed of a Grid and a Polarizer 有权具有由网格和偏振器组成的一维子衍射限制光圈的生物传感器公开(公告)号：US20090001284A1
公开(公告)日：2009-01-01
申请号：US12158347
申请日：2006-12-11
IPC分类号： G01J1/58
CPC分类号： G01N21/648 , Y10T436/11
摘要： A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (120) defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light (102) in a medium, a polarizer (115), and luminophores (117) positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (120), the volume in between the array of slits (120) and the polarizer (115) and a volume that extends into the polarizer (115), wherein the grid (120) providing a transmission axis extending in a first direction and the polarizer (115) providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation (102) is polarized such that it is substantially suppressed by one of the at least one grid (120) and polarizer (115) and substantially not suppressed by the other of the at least one grid (120) and polarizer (115).
摘要翻译： 公开了一种用于检测由至少一个发光体产生的发光辐射的方法和传感器。 在本发明的上下文中，生物传感器包括定义为孔阵列的格栅（120），孔格具有第一尺寸，第二维度高于介质中的激发光（102）的衍射极限，偏振器（ 115）和位于选自以下的体积中的发光体（117）：栅格（120）的孔内的体积，狭缝阵列（120）和偏振器（115）之间的体积和 延伸到偏振器（115）的体积，其中提供沿第一方向延伸的透射轴的格栅（120）和提供沿第二方向延伸的透射轴的偏振器（115），第一方向和第二方向基本上 垂直于彼此垂直，其中所述激发辐射（102）被极化，使得其基本上被所述至少一个格栅（120）和偏振器（115）中的一个所抑制，并且基本上不被所述o 该至少一个格栅（120）和偏振器（115）。
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2.发明授权Biosensor with one-dimensional sub-diffraction-limited apertures composed of a grid and a polarizer 有权具有由栅格和偏振器组成的一维亚衍射限制孔的生物传感器公开(公告)号：US08075841B2
公开(公告)日：2011-12-13
申请号：US12158347
申请日：2006-12-11
CPC分类号： G01N21/648 , Y10T436/11
摘要： A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (120) defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light (102) in a medium, a polarizer (115), and luminophores (117) positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (120), the volume in between the array of slits (120) and the polarizer (115) and a volume that extends into the polarizer (115), wherein the grid (120) providing a transmission axis extending in a first direction and the polarizer (115) providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation (102) is polarized such that it is substantially suppressed by one of the at least one grid (120) and polarizer (115) and substantially not suppressed by the other of the at least one grid (120) and polarizer (115).
摘要翻译： 公开了一种用于检测由至少一个发光体产生的发光辐射的方法和传感器。 在本发明的上下文中，生物传感器包括定义为孔阵列的格栅（120），孔格具有第一尺寸，第二维度高于介质中的激发光（102）的衍射极限，偏振器（ 115）和位于选自以下的体积中的发光体（117）：栅格（120）的孔内的体积，狭缝阵列（120）和偏振器（115）之间的体积和 延伸到偏振器（115）的体积，其中提供沿第一方向延伸的透射轴的格栅（120）和提供沿第二方向延伸的透射轴的偏振器（115），第一方向和第二方向基本上 垂直于彼此垂直，其中所述激发辐射（102）被极化，使得其基本上被所述至少一个格栅（120）和偏振器（115）中的一个所抑制，并且基本上不被所述o 该至少一个格栅（120）和偏振器（115）。
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公开(公告)号：US20110293712A1
公开(公告)日：2011-12-01
申请号：US13132534
申请日：2009-11-26
申请人： Ralph Kurt , Emiel Peeters , Roel Penterman , Dirk J. Broer , David Halter
发明人： Ralph Kurt , Emiel Peeters , Roel Penterman , Dirk J. Broer , David Halter
CPC分类号： B01J13/04 , A61K2035/126 , A61L27/38 , A61L27/58
摘要： The present invention provides for the coaxial encapsulation of a plurality of cells in a single elongated compartment. By this encapsulation, the cells are protected by at least one layer of separation material and kept in close contact, which leads to a better vitality of the encapsulated cells and consequently results in higher chances to form microtissue. Methods and devices for the production of such encapsulated cell compartments are disclosed as well as medical uses of such compartments in cell, tissue therapy and tissue engineering.
摘要翻译： 本发明提供了在单个细长隔室中的多个电池的同轴封装。 通过这种封装，细胞被至少一层分离材料保护并保持紧密接触，这导致包封的细胞更好的活力，从而导致更高的形成微组织的机会。 在细胞，组织治疗和组织工程中公开了用于生产这种包封的细胞室的方法和装置以及这些隔室的医学用途。
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公开(公告)号：US20140113232A1
公开(公告)日：2014-04-24
申请号：US14123943
申请日：2012-06-07
CPC分类号： G03F7/004 , B82Y10/00 , B82Y40/00 , C30B19/00 , G03F7/0002
摘要： A block copolymer, adapted to self-assemble to form an ordered pattern on a substrate, has first and second blocks with a terminal moiety covalently bonded to the end of the first block. The molecular weight of the terminal moiety is 20% or less than that of the block copolymer and the terminal moiety has a low chemical affinity for the first block. The terminal moiety can assist the accurate positional placement of the domains of the ordered array and lead to improved critical dimension uniformity and/or reduced line edge roughness. The polymer may be useful in combination with a graphoepitaxy template, where the terminal moiety is chosen to associate with a sidewall of the template. This may reduce undesired aggregation of polymer domains at a sidewall and/or assist in domain placement accuracy.
摘要翻译： 适于自组装以在基底上形成有序图案的嵌段共聚物具有第一和第二嵌段，其末端部分共价键合到第一嵌段的末端。 末端部分的分子量为嵌段共聚物的分子量的20％以下，末端部分对第一嵌段具有低的化学亲和力。 末端部分可以帮助有序阵列的域的精确位置放置并且导致改进的临界尺寸均匀性和/或减少的线边缘粗糙度。 所述聚合物可以与骨架外延模板组合使用，其中末端部分被选择为与模板的侧壁缔合。 这可以减少侧壁处的聚合物域的不希望的聚集和/或有助于域放置精度。
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5.发明申请METHODS FOR PROVIDING PATTERNED ORIENTATION TEMPLATES FOR SELF-ASSEMBLABLE POLYMERS FOR USE IN DEVICE LITHOGRAPHY 审中-公开提供用于自组装聚合物的图案方向模板的方法用于器件平台的使用公开(公告)号：US20130266727A1
公开(公告)日：2013-10-10
申请号：US13994426
申请日：2011-12-09
申请人： Emiel Peeters , Wilhelmus Sebastianus Marcus Maria Ketelaars , Johan Frederik Dijksman , Sander Frederik Wuister , Roelof Koole , Christianus Martinus Van Heesch
发明人： Emiel Peeters , Wilhelmus Sebastianus Marcus Maria Ketelaars , Johan Frederik Dijksman , Sander Frederik Wuister , Roelof Koole , Christianus Martinus Van Heesch
IPC分类号： C30B19/12
CPC分类号： C30B19/12 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： A method is disclosed involving depositing a neutral orientation template layer onto a substrate after formation of chemical epitaxy or graphoepitaxy features on the substrate, but before deposition and orientation of a self-assemblable polymer. The orientation layer is arranged to bond with the substrate but not with certain features, so that it may be easily removed by vacuum or rinsing with organic solvent. The neutral orientation layer has a chemical affinity to match that of blocks in the self-assemblable polymer so that blocks of differing types wet the neutral orientation layer so that domains in the self-assembled polymer may lie side by side along the substrate surface, with interfaces normal to the substrate surface. The resulting aligned and oriented self-assembled polymer may itself be used as a resist for device lithography of the substrate.
摘要翻译： 公开了一种方法，其涉及在衬底上形成化学外延或者石墨电极特征之后，但在自组装聚合物的沉积和取向之前，将中性取向模板层沉积到衬底上。 取向层被布置成与基底结合，但不具有某些特征，使得其可以容易地通过真空或用有机溶剂漂洗除去。 中性取向层具有与自组装聚合物中的嵌段相符的化学亲和力，使得不同类型的块润湿中性取向层，使得自组装聚合物中的畴可以沿着衬底表面并排， 界面垂直于衬底表面。 所得到的对准和取向的自组装聚合物本身可以用作衬底的器件光刻的抗蚀剂。
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公开(公告)号：US20100259261A1
公开(公告)日：2010-10-14
申请号：US12665336
申请日：2008-06-16
申请人： Marc Paul Saes , Johan Samuel Van Den Brink , Filips Van Liere , Roel Penterman , Ralph Kurt , Emiel Peeters , Dirk Broer , Michel Paul Barbara Van Bruggen , Hans Van Zon , Miha Fuderer
发明人： Marc Paul Saes , Johan Samuel Van Den Brink , Filips Van Liere , Roel Penterman , Ralph Kurt , Emiel Peeters , Dirk Broer , Michel Paul Barbara Van Bruggen , Hans Van Zon , Miha Fuderer
IPC分类号： G01R33/48
CPC分类号： G01R33/341 , G01R33/3415 , G01R33/3621 , G01R33/3692
摘要： The invention relates to a nuclear magnetic resonance imaging radio frequency—receiver (112; 216; 308; 404), the receiver (112; 216; 308; 404) being adapted to receive analogue signals from at least one radio frequency receiver coil unit (106; 200; 202; 300; 400; 402), the radio frequency receiver (112; 216; 308; 404) comprising: an analogue-digital converter (118; 226) to convert the analogue pre-amplified magnetic resonance signal into a digital signal, means (120; 230) for digital down converting the digital signal and a first communication interface (130; 252) adapted for transmitting the down converted digital signal via a communication link (e.g. wireless, optical or wire-bound).
摘要翻译： 本发明涉及一种核磁共振成像射频接收器（112; 216; 308; 404），所述接收器（112; 216; 308; 404）适于接收来自至少一个射频接收器线圈单元 106; 200; 202; 300; 400; 402），所述射频接收器（112; 216; 308; 404）包括：模拟数字转换器（118; 226），用于将所述模拟预放大磁共振信号转换成 数字信号，用于数字下变频数字信号的装置（120; 230）和适于经由通信链路（例如无线，光或有线）发送经下变频的数字信号的第一通信接口（130; 252）。
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公开(公告)号：US20100252124A1
公开(公告)日：2010-10-07
申请号：US12743838
申请日：2008-11-18
IPC分类号： F16K49/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L2200/146 , B01L2200/147 , B01L2300/0627 , B01L2300/1838 , B01L2400/0638 , B01L2400/0677 , F16K99/0026 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N2035/00247 , Y10T137/6606
摘要： The invention relates to a valve for opening and closing a channel (3) of a microfluidic system, respectively. According to the invention, the valve comprises an actuation medium (2) that undergoes a volume change with changing temperature; and a heater arrangement (5) for generating a temperature gradient in the actuation medium (2) with respect to the actuation medium's (2) distance relative to the channel (3); wherein due to an expansion or a contraction of the actuation medium (2) the channel (3) is closed or opened, respectively. When the heater arrangement (5) is activated in such a way that a higher temperature is generated in the actuation medium (2) which is nearer to the channel (3) and a lower temperature is generated in the actuation medium (2) which is further away from the channel (3) the valve can be closed and vice versa. Accordingly, such a valve for a microfluidic system is provided which can be reliably actuated during a long time of use.
摘要翻译： 本发明涉及分别用于打开和关闭微流体系统的通道（3）的阀。 根据本发明，该阀包括在变化温度下经历体积变化的致动介质（2）; 以及加热器装置（5），用于相对于所述致动介质（2）相对于所述通道（3）的距离产生所述致动介质（2）中的温度梯度; 其中由于致动介质（2）的膨胀或收缩，通道（3）分别关闭或打开。 当加热器装置（5）以这样一种方式启动时，使得在更靠近通道（3）的致动介质（2）中产生较高的温度，并且在致动介质（2）中产生较低的温度 更远离通道（3），阀可以关闭，反之亦然。 因此，提供了这种用于微流体系统的阀，其可以在长时间使用期间被可靠地致动。
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公开(公告)号：US20080312106A1
公开(公告)日：2008-12-18
申请号：US12096920
申请日：2006-11-28
申请人： Ralph Kurt , Dirk Jan Broer , Roel Penterman , Emiel Peeters
发明人： Ralph Kurt , Dirk Jan Broer , Roel Penterman , Emiel Peeters
CPC分类号： G01N33/54313
摘要： The invention relates to a substrate material for analyzing fluids which has first areas with a high porosity and second areas with a lower porosity.
摘要翻译： 本发明涉及一种用于分析具有高孔隙率的第一区域和具有较低孔隙率的第二区域的流体的基底材料。
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公开(公告)号：US08828253B2
公开(公告)日：2014-09-09
申请号：US13816720
申请日：2011-07-21
IPC分类号： B44C1/22 , B81C1/00 , H01L21/033
CPC分类号： B44C1/227 , B81C1/00031 , B81C2201/0149 , B81C2201/0198 , G03F7/0002 , H01L21/0337
摘要： A method of lithography on a substrate uses a self-assembled polymer (SAP) layer deposited on the substrate, with first and second domains arranged in a pattern across the layer. A planarization layer is formed over the SAP and a development etch applied to substantially remove a portion of the planarization layer over the second domain leaving a cap of the planarization layer substantially covering the first domain. The uncapped second domain is then removed from the surface by a breakthrough etch leaving the capped first domain as a pattern feature on the surface. A transfer etch may then be used to transfer the pattern feature to the substrate using the capped first domain. The capping allows the second domain to be removed, e.g., without excessive loss of lateral feature width for the remaining first domain, even when the difference in etch resistance between the first and second domains is small.
摘要翻译： 衬底上的光刻方法使用沉积在衬底上的自组装聚合物（SAP）层，其中第一和第二畴以整个层的图案排列。 平坦化层形成在SAP之上，并且显影蚀刻被施加以在第二域上基本上去除平坦化层的一部分，留下平坦化层的盖基本覆盖第一域。 然后通过穿透蚀刻从表面除去未封端的第二结构域，留下封盖的第一结构域作为表面上的图案特征。 然后可以使用转移蚀刻来使用封盖的第一结构域将图案特征转移到衬底。 封盖允许除去第二结构域，例如即使当第一和第二畴之间的耐蚀刻性差异小时，也不会对剩余的第一区域的横向特征宽度过度损失。
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10.发明申请METHOD FOR PROVIDING AN ORDERED LAYER OF SELF-ASSEMBLABLE POLYMER FOR USE IN LITHOGRAPHY 有权用于提供自组装聚合物的订购层的方法用于LITHOGRAPHY公开(公告)号：US20130034811A1
公开(公告)日：2013-02-07
申请号：US13640293
申请日：2011-01-19
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： A method for providing an ordered polymer layer at a surface of a substrate includes depositing a self-assemblable polymer layer directly onto a primer layer on a substrate to provide an interface between the self-assemblable polymer layer and the primer layer, and treating the self-assemblable polymer layer to provide self-assembly into an ordered polymer layer, such as a block copolymer, having first and second domain types at the interface. The primer layer is adapted to improve its chemical affinity to each domain type at the interface, in response to the presence of the respective domain type in the self-assembled polymer at the interface during the self-assembly of the self-assemblable polymer layer into the ordered polymer layer. This may lead to reduction in defect levels and/or improved persistence length for the ordered polymer layer. The method may be useful for forming resist layers for use in device lithography.
摘要翻译： 在衬底的表面提供有序聚合物层的方法包括将可自组装的聚合物层直接沉积在基底上的底漆层上，以提供可自组装的聚合物层和底漆层之间的界面，以及处理自身 可以将聚合物层自组装成有序聚合物层，例如在界面处具有第一和第二域类型的嵌段共聚物。 响应于在自组装聚合物层的自组装期间在界面处的自组装聚合物中存在相应的畴型，引物层适于改善其在界面处对每种畴型的化学亲和力 有序聚合物层。 这可能导致有序聚合物层的缺陷水平和/或改善的持续长度的降低。 该方法可用于形成用于器件光刻的抗蚀剂层。
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