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1.发明申请Modular electroporation device with disposable electrode and drug delivery components 审中-公开具有一次性电极和药物输送组件的模块化电穿孔装置公开(公告)号：US20060036210A1
公开(公告)日：2006-02-16
申请号：US11173176
申请日：2005-06-30
Applicant: Lei Zhang , Andre Gamelin , Dietmar Rabussay
Inventor： Lei Zhang , Andre Gamelin , Dietmar Rabussay
IPC: A61N1/30
CPC classification number: A61N1/327 , A61N1/0412
Abstract: The invention comprises a modular electroporation device for use in clinical settings. The device includes components which may be varied or adapted for application of electroporation-based delivery of therapeutic agents to cells of a subject in a variety of electroporation formats such as intratissue electroporation or transsurface electroporation. The device components include a hand-manipulable handle with activation switch and a disposable head comprising electrodes, injection port, electrode directional and depth guide, and a slideably engaged electrode safety shield
Abstract translation: 本发明包括用于临床设置的模块化电穿孔装置。 该装置包括可以变化或适于以多种电穿孔形式（例如组织间电穿孔或经表面电穿孔）将治疗剂施用于受试者细胞的电穿孔为基础的组分。 装置部件包括具有致动开关的手动操纵手柄和包括电极，注射端口，电极定向和深度引导件以及可滑动接合的电极安全屏蔽件
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2.发明申请Modular electroporation device with disposable electrode and drug delivery components 审中-公开具有一次性电极和药物输送组件的模块化电穿孔装置公开(公告)号：US20080058706A1
公开(公告)日：2008-03-06
申请号：US11784892
申请日：2007-04-10
Applicant: Lei Zhang , Andre Gamelin , Dietmar Rabussay
Inventor： Lei Zhang , Andre Gamelin , Dietmar Rabussay
IPC: A61N1/30
CPC classification number: A61N1/327 , A61N1/0412
Abstract: The invention comprises a modular electroporation device for use in clinical settings. The device includes components which may be varied or adapted for application of electroporation-based delivery of therapeutic agents to cells of a subject in a variety of electroporation formats such as intratissue electroporation or transsurface electroporation. The device components include a hand-manipulable handle with activation switch and a disposable head comprising electrodes, injection port, electrode directional and depth guide, and a slideably engaged electrode safety shield.
Abstract translation: 本发明包括用于临床设置的模块化电穿孔装置。 该装置包括可以变化或适于以多种电穿孔形式（例如组织间电穿孔或经表面电穿孔）将治疗剂施用于受试者细胞的电穿孔为基础的组分。 装置部件包括具有致动开关的可手动手柄和包括电极，注射端口，电极定向和深度引导件以及可滑动接合的电极安全屏蔽件的一次性头部。
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3.发明授权Method and device for treating microscopic tumors remaining in tissues following surgical resection 有权用于治疗手术切除后组织中剩余的微观肿瘤的方法和装置公开(公告)号：US09037230B2
公开(公告)日：2015-05-19
申请号：US11713181
申请日：2007-03-02
Applicant: Paul Goldfarb , Dietmar Rabussay
Inventor： Paul Goldfarb , Dietmar Rabussay
CPC classification number: A61N1/327 , A61K9/0009 , A61K38/14 , A61M5/19 , A61M5/20
Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
Abstract translation: 本发明涉及治疗癌性肿瘤周围部位的正常正常组织，以减少在癌组织的位点附近或其附近的癌症复发的可能性，并减少通常切除的明显健康组织的量 肿瘤，从而通过消除或延迟肿瘤复发和保持正常组织的功能并避免不必要的损伤，为癌症患者提供实质性益处。
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4.发明申请METHOD AND DEVICE FOR TREATING MICROSCOPIC TUMORS REMAINING IN TISSUES FOLLOWING SURGICAL RESECTION 审中-公开用于治疗手术后组织中的微创肿瘤的方法和装置公开(公告)号：US20120143120A1
公开(公告)日：2012-06-07
申请号：US13278721
申请日：2011-10-21
Applicant: Paul GOLDFARB , Dietmar RABUSSAY
Inventor： Paul GOLDFARB , Dietmar RABUSSAY
IPC: A61M37/00
CPC classification number: A61N1/327 , A61K9/0009 , A61K38/14 , A61M5/19 , A61M5/20
Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
Abstract translation: 本发明涉及治疗癌性肿瘤周围部位的正常正常组织，以减少在癌组织的位点附近或其附近的癌症复发的可能性，并减少通常切除的明显健康组织的量 肿瘤，从而通过消除或延迟肿瘤复发和保持正常组织的功能并避免不必要的损伤，为癌症患者提供实质性益处。
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5.发明申请Methods for particle-assisted polynucleotide immunization using a pulsed electric field 审中-公开使用脉冲电场进行颗粒辅助多核苷酸免疫的方法公开(公告)号：US20050054594A1
公开(公告)日：2005-03-10
申请号：US10498923
申请日：2002-12-16
Applicant: Lei Zhang , Georg Widera , Dietmar Rabussay
Inventor： Lei Zhang , Georg Widera , Dietmar Rabussay
IPC: A61N1/10 , A61B17/20 , A61K9/127 , A61K31/7088 , A61K35/76 , A61K39/00 , A61K39/29 , A61K39/39 , A61K45/06 , A61K47/02 , A61K47/04 , A61K47/24 , A61K47/30 , A61K48/00 , A61P31/04 , A61P31/12 , A61P31/20 , A61P35/00 , A61P37/04 , C12N15/87 , A61N1/30
CPC classification number: A61K39/292 , A61K31/7088 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K45/06 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , C12N15/87 , C12N2730/10134 , A61K2300/00
Abstract: Methods are provided for enhancing an immune response induced by administration of a DNA vaccine. In the invention methods a DNA vaccine encoding an antigen and non-chemically associated adjuvant particles are injected into muscle, dermal or mucosal tissue of a subject at substantially the same time and the tissue is subjected to a pulsed electric field of sufficient strength to result in the DNA vaccine entering cells of the target tissue. The immune response to the antigen is enhanced as compared to when the DNA vaccine is administered alone or in combination with either of the electric pulses or the adjuvant particles without the other.
Abstract translation: 提供了用于增强通过施用DNA疫苗诱导的免疫应答的方法。 在本发明方法中，将编码抗原和非化学相关佐剂颗粒的DNA疫苗基本上同时注射到受试者的肌肉，皮肤或粘膜组织中，组织经受足够强度的脉冲电场，导致 DNA疫苗进入目标组织的细胞。 与单独施用DNA疫苗或与任意一种电脉冲或佐剂颗粒组合施用时，对抗原的免疫应答增强。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20110009807A1
公开(公告)日：2011-01-13
申请号：US12836163
申请日：2010-07-14
Applicant: Rune KJEKEN , Stephen Vincent KEMMERRER , Feng LIN , Dietmar RABUSSAY , Thomas Joseph KARDOS
Inventor： Rune KJEKEN , Stephen Vincent KEMMERRER , Feng LIN , Dietmar RABUSSAY , Thomas Joseph KARDOS
IPC: A61N1/30
Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
Abstract translation: 本发明包括改进的电穿孔电极系统，其包括单针和环形或环形电极，其中电极的表面面积的差异大大降低了处理组织表面附近的电流密度，并且更集中的电流密度足够 仅在与单针电极的末端部分相邻的组织中进行电穿孔。 因此，本发明提供靶向用于电穿孔的特定组织，并且还应当提供减少处理组织中电流的感觉。
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7.发明申请Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation 有权通过非侵入性体内电穿孔增强裸DNA的表达公开(公告)号：US20060084938A1
公开(公告)日：2006-04-20
申请号：US11291459
申请日：2005-11-30
Applicant: Lei Zhang , Dietmar Rabussay
Inventor： Lei Zhang , Dietmar Rabussay
IPC: A61M31/00
Abstract: In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and systemic treatments or for immunization with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
Abstract translation: 提供体内方法，通过将非侵入性的，用户友好的电极施加到皮肤表面，使用电场来传递对受试者的治疗或免疫治疗。 因此，治疗或免疫剂可以递送到皮肤细胞中用于局部和全身治疗或用最佳基因表达和最小组织损伤进行免疫。 特别地，治疗剂包括裸体或配制的核酸，多肽和化学治疗剂。
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公开(公告)号：US06746441B1
公开(公告)日：2004-06-08
申请号：US09470567
申请日：1999-12-22
Applicant: Gunter A. Hofmann , Dietmar Rabussay
Inventor： Gunter A. Hofmann , Dietmar Rabussay
IPC: A61M3100
Abstract: A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating electric fields which introduce transient pores in the living cell without killing the cell. The rotating electric fields are provided in a flow through chamber apparatus having more than two electrodes. A three-step pulse process, e.g. collection, electroporation, electrophoresis, is used to introduce the preselected molecule into the cell. A mechanical means of repositioning cells between successive pulses is also provided. The apparatus can also provide a means to pulse cells at different temperatures and then after pulsing, let the cells recover for a specified residence time at another temperature.
Abstract translation: 一种通过使细胞与预选分子接触并向细胞施加多系列电脉冲将预选分子引入活细胞的方法和装置。 该方法可以离体使用。 多个电脉冲产生旋转电场，其在活细胞中引入瞬时孔而不杀死细胞。 旋转电场设置在具有多于两个电极的流通室装置中。 三步脉冲处理，例如 收集，电穿孔，电泳，用于将预选分子引入细胞。 还提供了在连续脉冲之间重新定位电池的机械装置。 该装置还可以提供在不同温度下脉冲细胞的手段，然后在脉冲之后，让细胞在另一个温度恢复指定的停留时间。
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公开(公告)号：US6027488A
公开(公告)日：2000-02-22
申请号：US90471
申请日：1998-06-03
Applicant: Gunter A. Hofmann , Dietmar Rabussay
Inventor： Gunter A. Hofmann , Dietmar Rabussay
Abstract: A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating electric fields which introduce transient pores in the living cell without killing the cell. The rotating electric fields are provided in a flow through chamber apparatus having more than two electrodes. A three-step pulse process, e.g. collection, electroporation, electrophoresis, is used to introduce the preselected molecule into the cell. A mechanical means of repositioning cells between successive pulses is also provided. The apparatus can also provide a means to pulse cells at different temperatures and then after pulsing, let the cells recover for a specified residence time at another temperature.
Abstract translation: 一种通过使细胞与预选分子接触并向细胞施加多系列电脉冲将预选分子引入活细胞的方法和装置。 该方法可以离体使用。 多个电脉冲产生旋转电场，其在活细胞中引入瞬时孔而不杀死细胞。 旋转电场设置在具有多于两个电极的流通室装置中。 三步脉冲处理，例如 收集，电穿孔，电泳，用于将预选分子引入细胞。 还提供了在连续脉冲之间重新定位电池的机械装置。 该装置还可以提供在不同温度下脉冲细胞的手段，然后在脉冲之后，让细胞在另一个温度恢复指定的停留时间。
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10.发明申请Method and device for treating microscopic tumors remaining in tissues following surgical resection 有权用于治疗手术切除后组织中剩余的微观肿瘤的方法和装置公开(公告)号：US20070239099A1
公开(公告)日：2007-10-11
申请号：US11713181
申请日：2007-03-02
Applicant: Paul Goldfarb , Dietmar Rabussay
Inventor： Paul Goldfarb , Dietmar Rabussay
IPC: A61N1/30
CPC classification number: A61N1/327 , A61K9/0009 , A61K38/14 , A61M5/19 , A61M5/20
Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
Abstract translation: 本发明涉及治疗癌性肿瘤周围部位的正常正常组织，以减少在癌组织的位点附近或其附近的癌症复发的可能性，并减少通常切除的明显健康组织的量 肿瘤，从而通过消除或延迟肿瘤复发和保持正常组织的功能并避免不必要的损伤，为癌症患者提供实质性益处。
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