公开(公告)号：US20080287857A1

公开(公告)日：2008-11-20

申请号：US11894653

申请日：2007-08-20

Applicant: Rune Kjeken ,  Iacob Mathiesen ,  Torunn Elisabeth Tjelle ,  George McHugh

Inventor： Rune Kjeken ,  Iacob Mathiesen ,  Torunn Elisabeth Tjelle ,  George McHugh

IPC: A61N1/30

CPC classification number: A61N1/327

Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single-needle electrode which provides for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue

公开(公告)号：US20120046598A1

公开(公告)日：2012-02-23

申请号：US13263802

申请日：2010-04-16

Applicant: Thomas Joseph Kardos ,  Stephen Vincent Kemmerer ,  Rune Kjeken ,  Kate Broderick ,  Jay McCoy ,  Michael P Fons

Inventor： Thomas Joseph Kardos ,  Stephen Vincent Kemmerer ,  Rune Kjeken ,  Kate Broderick ,  Jay McCoy ,  Michael P Fons

IPC: A61M37/00

CPC classification number: A61N1/327 ,  A61M2037/0007 ,  A61N1/0416 ,  A61N1/0476 ,  A61N1/325

Abstract: Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.

Abstract translation: 用于将电能的电能脉冲递送到组织表面以使得能够递送到组织治疗物质中的细胞的装置和方法。 该装置包含能够产生足够的电压电位的源，以在间隙上传递火花并将其传送到组织表面。

公开(公告)号：US20070287950A1

公开(公告)日：2007-12-13

申请号：US11704591

申请日：2007-02-09

Applicant: Rune Kjeken ,  Iacob Mathiesen ,  Elisabeth Tjelle ,  George McHugh

Inventor： Rune Kjeken ,  Iacob Mathiesen ,  Elisabeth Tjelle ,  George McHugh

IPC: A61N1/30

CPC classification number: A61N1/327 ,  A61N1/30

Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.

Abstract translation: 描述了用于在各种医疗应用中向体内组织施用分子的装置和方法，所述装置包括单个皮下注射针和至少两个间隔开的细长电极，其提供当针插入组织中时的能力，例如 皮肤或肌肉，以不均匀的电场脉冲组织，其足以引起沿着或靠近由针在其插入所述组织中时所制成的轨道的细胞的可逆定位。

公开(公告)号：US11565107B2

公开(公告)日：2023-01-31

申请号：US13581702

申请日：2011-03-01

Applicant: Kate Broderick ,  Jay McCoy ,  Stephen V. Kemmerrer ,  Feng Lin ,  Rune Kjeken

Inventor： Kate Broderick ,  Jay McCoy ,  Stephen V. Kemmerrer ,  Feng Lin ,  Rune Kjeken

IPC: A61N1/32 ,  A61N1/05 ,  A61K39/145 ,  A61K39/12 ,  A61K39/00

Abstract: A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.

公开(公告)号：US20120323165A1

公开(公告)日：2012-12-20

申请号：US13581700

申请日：2011-03-01

Applicant: Kate Broderick ,  Feng Lin ,  Jay McCoy ,  Stephen V. Kemmerrer ,  Rune Kjeken

Inventor： Kate Broderick ,  Feng Lin ,  Jay McCoy ,  Stephen V. Kemmerrer ,  Rune Kjeken

IPC: A61M37/00 ,  A61N1/05

CPC classification number: A61N1/327

Abstract: The present invention relates to dual depth electroporation devices capable of electorporating both muscle tissue and skin tissue in a single application in order to generate a broad immune response in a subject, and uses of the same.

Abstract translation: 本发明涉及双重深度电穿孔装置，其能够在单个应用中电连接肌肉组织和皮肤组织，以便在受试者中产生广泛的免疫应答及其用途。

公开(公告)号：US10369359B2

公开(公告)日：2019-08-06

申请号：US11704591

申请日：2007-02-09

Applicant: Rune Kjeken ,  Iacob Mathiesen ,  Elisabeth Torunn Tjelle ,  George McHugh

Inventor： Rune Kjeken ,  Iacob Mathiesen ,  Elisabeth Torunn Tjelle ,  George McHugh

IPC: A61N1/32 ,  A61N1/30

Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.

公开(公告)号：US10232173B2

公开(公告)日：2019-03-19

申请号：US13263802

申请日：2010-04-16

Applicant: Thomas Joseph Kardos ,  Stephen Vincent Kemmerer ,  Rune Kjeken ,  Kate Broderick ,  Jay McCoy ,  Michael P Fons

Inventor： Thomas Joseph Kardos ,  Stephen Vincent Kemmerer ,  Rune Kjeken ,  Kate Broderick ,  Jay McCoy ,  Michael P Fons

IPC: A61N1/32 ,  A61N1/04 ,  A61M37/00

Abstract: Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.

公开(公告)号：US11097099B2

公开(公告)日：2021-08-24

申请号：US13581700

申请日：2011-03-01

Applicant: Kate Broderick ,  Feng Lin ,  Jay McCoy ,  Stephen V Kemmerrer ,  Rune Kjeken

Inventor： Kate Broderick ,  Feng Lin ,  Jay McCoy ,  Stephen V Kemmerrer ,  Rune Kjeken

IPC: A61N1/32

Abstract: The present invention relates to dual depth electroporation devices capable of electorporating both muscle tissue and skin tissue in a single application in order to generate a broad immune response in a subject, and uses of the same.

公开(公告)号：US20130066296A1

公开(公告)日：2013-03-14

申请号：US13581702

申请日：2011-03-01

Applicant: Kate Broderick ,  Jay McCoy ,  Stephen V. Kemmerrer ,  Feng Lin ,  Rune Kjeken

Inventor： Kate Broderick ,  Jay McCoy ,  Stephen V. Kemmerrer ,  Feng Lin ,  Rune Kjeken

IPC: A61N1/04 ,  A61M37/00

CPC classification number: A61N1/327 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/53 ,  A61K2039/54 ,  A61N1/0502 ,  C12N2760/16134

Abstract: A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.

Abstract translation: 一种用于递送疫苗的新型电穿孔装置，其有效地产生保护性免疫应答并且可耐受地递送至受试者（或接近无痛）; 以及使用相同装置在接近无痛期间针对各种感染性疾病和癌症类型接种受试者的方法。

公开(公告)号：US20110009807A1

公开(公告)日：2011-01-13

申请号：US12836163

申请日：2010-07-14

Applicant: Rune KJEKEN ,  Stephen Vincent KEMMERRER ,  Feng LIN ,  Dietmar RABUSSAY ,  Thomas Joseph KARDOS

Inventor： Rune KJEKEN ,  Stephen Vincent KEMMERRER ,  Feng LIN ,  Dietmar RABUSSAY ,  Thomas Joseph KARDOS

IPC: A61N1/30

CPC classification number: A61N1/327 ,  A61N1/325 ,  C12M35/02 ,  C12N13/00 ,  C12N15/87

Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.

Abstract translation: 本发明包括改进的电穿孔电极系统，其包括单针和环形或环形电极，其中电极的表面面积的差异大大降低了处理组织表面附近的电流密度，并且更集中的电流密度足够 仅在与单针电极的末端部分相邻的组织中进行电穿孔。 因此，本发明提供靶向用于电穿孔的特定组织，并且还应当提供减少处理组织中电流的感觉。