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公开(公告)号：US20130059361A1
公开(公告)日：2013-03-07
申请号：US13323731
申请日：2011-12-12
申请人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
发明人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
CPC分类号： G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
摘要： Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a member of the triacylglycerol lipase family or which effect the enzymatic activity of the enzyme.
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2.发明授权Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol 失效用于影响高密度脂蛋白（HDL）胆固醇和载脂蛋白AI极低密度脂蛋白（VLDL）胆固醇和低密度脂蛋白（LDL）胆固醇水平的组合物和方法公开(公告)号：US07008776B1
公开(公告)日：2006-03-07
申请号：US09277401
申请日：1999-03-26
申请人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
发明人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
IPC分类号： G01N33/573 , C12N9/20
CPC分类号： G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
摘要： The present invention relates to compositions for use in raising or lowering the level of LIPG polypeptide in a patient. Embodiments of the composition include compositions comprising: an anti-sense nucleic acid; a neutralizing antibody; an intracellular binding protein; an inhibitor which inhibits the enzymatic activity of LIPG polypeptide; an inhibitor which inhibits the expression of LIPG gene; a ribozyme; an LIPG polypeptide; an enhancer which increases the enzymatic activity of LIPG polypeptide; or an enhancer which increases the expression of LIPG gene. The invention relates also to methods for using the above compositions.In addition, the invention relates to a method for diagnosing a predisposition to lower cholesterol, a method for determining whether a test compound can inhibit the enzymatic reaction between LIPG polypeptide and HDL cholesterol, and methods for determining whether a test compound can enhance the enzymatic reaction between LIPG polypeptide and LDL or VLDL cholesterol.
摘要翻译： 本发明涉及用于提高或降低患者中LIPG多肽水平的组合物。 组合物的实施方案包括组合物，其包含：反义核酸; 中和抗体; 细胞内结合蛋白; 抑制LIPG多肽的酶活性的抑制剂; 抑制LIPG基因表达的抑制剂; 核酶; LIPG多肽; 增强LIPG多肽的酶活性的增强剂; 或增加LIPG基因表达的增强子。 本发明还涉及使用上述组合物的方法。 另外本发明还涉及一种用于诊断低胆固醇倾向的方法，一种测定化合物是否能抑制LIPG多肽与HDL胆固醇之间的酶反应的方法，以及用于确定测试化合物是否可以增强酶反应的方法 LIPG多肽和LDL或VLDL胆固醇之间。
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3.发明授权LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies 失效三酰基甘油脂肪酶家族的LLG多肽及其用于酶水解的组合物和方法以及蛋白质和基因治疗公开(公告)号：US06395530B1
公开(公告)日：2002-05-28
申请号：US08985492
申请日：1997-12-05
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
IPC分类号： C12N920
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
摘要翻译： 公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。 还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。 还公开了用于治疗脂质代谢紊乱的方法和组合物。
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公开(公告)号：US5441946A
公开(公告)日：1995-08-15
申请号：US227803
申请日：1994-04-14
申请人： Henry W. Pauls , Yong-Mi Choi , Dilip V. Amin
发明人： Henry W. Pauls , Yong-Mi Choi , Dilip V. Amin
CPC分类号： C07F9/65583 , C07F9/3808 , C07F9/3873 , C07F9/4006 , C07F9/404 , C07F9/405 , C07F9/65324
摘要： This invention relates to a class of novel phosphonate derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis aryl cycloalkylamino and azacycloalkyl phosphonates. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
摘要翻译： 本发明涉及一类表现出角鲨烯合酶抑制性质的亲脂胺的新型膦酸酯衍生物。 更具体地，化合物是双芳基环烷基氨基和氮杂环烷基膦酸酯。 本发明化合物降低体内血清胆固醇水平，而不显着降低甲羟戊酸代谢物合成。 本发明还涉及使用本发明化合物降低血清胆固醇水平的药物组合物和治疗方法。
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公开(公告)号：US5563128A
公开(公告)日：1996-10-08
申请号：US435020
申请日：1995-05-04
申请人： Henry W. Pauls , Yong-Mi Choi , Dilip V. Amin
发明人： Henry W. Pauls , Yong-Mi Choi , Dilip V. Amin
IPC分类号： C07F9/38 , C07F9/40 , C07F9/653 , C07F9/6558 , A61K31/675 , A61K31/66
CPC分类号： C07F9/65583 , C07F9/3808 , C07F9/3873 , C07F9/4006 , C07F9/404 , C07F9/405 , C07F9/65324
摘要： This invention relates to a class of novel phosphonate derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis aryl cycloalkylamino and azacycloalkyl phosphonates. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
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公开(公告)号：US08343494B2
公开(公告)日：2013-01-01
申请号：US12503778
申请日：2009-07-15
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
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7.发明申请公开(公告)号：US20120114660A1
公开(公告)日：2012-05-10
申请号：US12503778
申请日：2009-07-15
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
IPC分类号： A61K39/395 , A61P3/06
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
摘要翻译： 公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。 还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。 还公开了用于治疗脂质代谢紊乱的方法和组合物。
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8.发明授权公开(公告)号：US07579447B2
公开(公告)日：2009-08-25
申请号：US11369410
申请日：2006-03-07
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
摘要翻译： 公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。 还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。 还公开了用于治疗脂质代谢紊乱的方法和组合物。
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9.发明申请Compositions and Methods for Effecting the Levels of High Density Lipoprotein (HDL) Cholesterol and Apolipoprotein AI, Very Low Density Lipoprotein (VLDL) Cholesterol and Low Density Lipoprotein (LDL) Cholesterol 审中-公开用于影响高密度脂蛋白（HDL）胆固醇和载脂蛋白AI，极低密度脂蛋白（VLDL）胆固醇和低密度脂蛋白（LDL）胆固醇水平的组合物和方法公开(公告)号：US20090208479A1
公开(公告)日：2009-08-20
申请号：US12197970
申请日：2008-08-25
申请人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
发明人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
CPC分类号： G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
摘要： Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a member of the triacylglycerol lipase family or which effect the enzymatic activity of the enzyme.
摘要翻译： 用于提高患者中HDL胆固醇和载脂蛋白AI水平以及降低患者中VLDL胆固醇和LDL胆固醇水平的组合物和方法，包括影响基因表达的组合物和方法，LIPG编码脂肪酶 其是三酰基甘油脂肪酶家族的成员或其影响酶的酶活性。
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10.发明授权LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies 失效三酰基甘油脂肪酶家族的LLG多肽及其用于酶水解的组合物和方法以及蛋白质和基因治疗公开(公告)号：US07056720B2
公开(公告)日：2006-06-06
申请号：US10128449
申请日：2002-04-23
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： The present invention relates to LLG polypeptides, which are polypeptides of the triacylglycerol lipase family, and fragments thereof, antibodies against such polypeptides, nucleic acids encoding such polypeptides, and antisense nucleic acids derived from such nucleic acids. The invention relates also to therapeutic compositions and methods comprising the above. In addition, the invention relates to the preparation of LLG polypeptides using recombinant technology and to the use of LLG polypeptides to screen for agonists and antagonists thereof.
摘要翻译： 本发明涉及LLG多肽，其是三酰基甘油脂肪酶家族的多肽及其片段，针对此类多肽的抗体，编码此类多肽的核酸以及衍生自该核酸的反义核酸。 本发明还涉及包含上述物质的治疗组合物和方法。 此外，本发明涉及使用重组技术制备LLG多肽，以及使用LLG多肽筛选其激动剂和拮抗剂。
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