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1.发明授权LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies 失效三酰基甘油脂肪酶家族的LLG多肽及其用于酶水解的组合物和方法以及蛋白质和基因治疗公开(公告)号：US07056720B2
公开(公告)日：2006-06-06
申请号：US10128449
申请日：2002-04-23
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： The present invention relates to LLG polypeptides, which are polypeptides of the triacylglycerol lipase family, and fragments thereof, antibodies against such polypeptides, nucleic acids encoding such polypeptides, and antisense nucleic acids derived from such nucleic acids. The invention relates also to therapeutic compositions and methods comprising the above. In addition, the invention relates to the preparation of LLG polypeptides using recombinant technology and to the use of LLG polypeptides to screen for agonists and antagonists thereof.
摘要翻译： 本发明涉及LLG多肽，其是三酰基甘油脂肪酶家族的多肽及其片段，针对此类多肽的抗体，编码此类多肽的核酸以及衍生自该核酸的反义核酸。 本发明还涉及包含上述物质的治疗组合物和方法。 此外，本发明涉及使用重组技术制备LLG多肽，以及使用LLG多肽筛选其激动剂和拮抗剂。
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公开(公告)号：US08343494B2
公开(公告)日：2013-01-01
申请号：US12503778
申请日：2009-07-15
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
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3.发明授权LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies 失效三酰基甘油脂肪酶家族的LLG多肽及其用于酶水解的组合物和方法以及蛋白质和基因治疗公开(公告)号：US06395530B1
公开(公告)日：2002-05-28
申请号：US08985492
申请日：1997-12-05
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
IPC分类号： C12N920
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
摘要翻译： 公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。 还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。 还公开了用于治疗脂质代谢紊乱的方法和组合物。
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4.发明申请公开(公告)号：US20120114660A1
公开(公告)日：2012-05-10
申请号：US12503778
申请日：2009-07-15
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
IPC分类号： A61K39/395 , A61P3/06
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
摘要翻译： 公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。 还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。 还公开了用于治疗脂质代谢紊乱的方法和组合物。
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5.发明授权公开(公告)号：US07579447B2
公开(公告)日：2009-08-25
申请号：US11369410
申请日：2006-03-07
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
摘要翻译： 公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。 还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。 还公开了用于治疗脂质代谢紊乱的方法和组合物。
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公开(公告)号：US20130059361A1
公开(公告)日：2013-03-07
申请号：US13323731
申请日：2011-12-12
申请人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
发明人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
CPC分类号： G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
摘要： Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a member of the triacylglycerol lipase family or which effect the enzymatic activity of the enzyme.
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7.发明授权Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol 失效用于影响高密度脂蛋白（HDL）胆固醇和载脂蛋白AI极低密度脂蛋白（VLDL）胆固醇和低密度脂蛋白（LDL）胆固醇水平的组合物和方法公开(公告)号：US07008776B1
公开(公告)日：2006-03-07
申请号：US09277401
申请日：1999-03-26
申请人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
发明人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
IPC分类号： G01N33/573 , C12N9/20
CPC分类号： G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
摘要： The present invention relates to compositions for use in raising or lowering the level of LIPG polypeptide in a patient. Embodiments of the composition include compositions comprising: an anti-sense nucleic acid; a neutralizing antibody; an intracellular binding protein; an inhibitor which inhibits the enzymatic activity of LIPG polypeptide; an inhibitor which inhibits the expression of LIPG gene; a ribozyme; an LIPG polypeptide; an enhancer which increases the enzymatic activity of LIPG polypeptide; or an enhancer which increases the expression of LIPG gene. The invention relates also to methods for using the above compositions.In addition, the invention relates to a method for diagnosing a predisposition to lower cholesterol, a method for determining whether a test compound can inhibit the enzymatic reaction between LIPG polypeptide and HDL cholesterol, and methods for determining whether a test compound can enhance the enzymatic reaction between LIPG polypeptide and LDL or VLDL cholesterol.
摘要翻译： 本发明涉及用于提高或降低患者中LIPG多肽水平的组合物。 组合物的实施方案包括组合物，其包含：反义核酸; 中和抗体; 细胞内结合蛋白; 抑制LIPG多肽的酶活性的抑制剂; 抑制LIPG基因表达的抑制剂; 核酶; LIPG多肽; 增强LIPG多肽的酶活性的增强剂; 或增加LIPG基因表达的增强子。 本发明还涉及使用上述组合物的方法。 另外本发明还涉及一种用于诊断低胆固醇倾向的方法，一种测定化合物是否能抑制LIPG多肽与HDL胆固醇之间的酶反应的方法，以及用于确定测试化合物是否可以增强酶反应的方法 LIPG多肽和LDL或VLDL胆固醇之间。
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8.发明申请Compositions and Methods for Effecting the Levels of High Density Lipoprotein (HDL) Cholesterol and Apolipoprotein AI, Very Low Density Lipoprotein (VLDL) Cholesterol and Low Density Lipoprotein (LDL) Cholesterol 审中-公开用于影响高密度脂蛋白（HDL）胆固醇和载脂蛋白AI，极低密度脂蛋白（VLDL）胆固醇和低密度脂蛋白（LDL）胆固醇水平的组合物和方法公开(公告)号：US20090208479A1
公开(公告)日：2009-08-20
申请号：US12197970
申请日：2008-08-25
申请人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
发明人： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
CPC分类号： G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
摘要： Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a member of the triacylglycerol lipase family or which effect the enzymatic activity of the enzyme.
摘要翻译： 用于提高患者中HDL胆固醇和载脂蛋白AI水平以及降低患者中VLDL胆固醇和LDL胆固醇水平的组合物和方法，包括影响基因表达的组合物和方法，LIPG编码脂肪酶 其是三酰基甘油脂肪酶家族的成员或其影响酶的酶活性。
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公开(公告)号：US5541109A
公开(公告)日：1996-07-30
申请号：US230047
申请日：1994-04-19
申请人： George H. Searfoss, III , Yuri D. Ivashchenko , Michael C. Jaye , Victoria J. South , Stephen M. French , Christopher Cheadle , George A. Ricca
发明人： George H. Searfoss, III , Yuri D. Ivashchenko , Michael C. Jaye , Victoria J. South , Stephen M. French , Christopher Cheadle , George A. Ricca
摘要： This invention provides a unique SH3 binding domain core motif of the sequence RPLPXXP and cDNA clones encoding proteins which interact with the SH3 domain of c-src, as well as the amino acid sequences which mediate this binding.Another embodiment of this invention is a method of identifying SH3-binding proteins and elucidating the sequences which mediate binding. This method may be used as an assay to select compounds which bind to this site and which inhibit or enhance the binding of the SH3 domain.
摘要翻译： 本发明提供了序列RPLPXXP的独特的SH3结合域核心基序和编码与c-src的SH3结构域相互作用的蛋白质的cDNA克隆，以及介导该结合的氨基酸序列。 本发明的另一个实施方案是鉴定SH3结合蛋白并阐明介导结合的序列的方法。 该方法可用作选择结合该位点并抑制或增强SH3结构域的化合物的测定法。
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10.发明授权Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same 失效对人表皮生长因子受体特异性的单克隆抗体和使用其的治疗方法公开(公告)号：US06217866B1
公开(公告)日：2001-04-17
申请号：US08487761
申请日：1995-06-07
申请人： Joseph Schlessinger , David Givol , Francoise Bellot , Richard Kris , George A. Ricca , Christopher Cheadle , Victoria J. South
发明人： Joseph Schlessinger , David Givol , Francoise Bellot , Richard Kris , George A. Ricca , Christopher Cheadle , Victoria J. South
IPC分类号： A61K39395
CPC分类号： C07K16/2863 , A61K38/00 , A61K39/395 , A61K33/24 , A61K31/70 , A61K2300/00
摘要： Hybridoma cell lines producing monoclonal antibodies specific to the human epidermal growth factor receptor are disclosed. The antibodies are capable of inhibiting the growth of human tumor cells expressing human epidermal growth factor receptors. Therapeutic uses of these monoclonal antibodies by themselves and in combination with anti-neoplastic agents are also disclosed.
摘要翻译： 公开了产生对人表皮生长因子受体特异性的单克隆抗体的杂交瘤细胞系。 抗体能够抑制表达人表皮生长因子受体的人肿瘤细胞的生长。 还公开了这些单克隆抗体本身和与抗肿瘤剂组合的治疗用途。
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