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1.发明授权LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies 失效三酰基甘油脂肪酶家族的LLG多肽及其用于酶水解的组合物和方法以及蛋白质和基因治疗公开(公告)号：US06395530B1
公开(公告)日：2002-05-28
申请号：US08985492
申请日：1997-12-05
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
IPC分类号： C12N920
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
摘要翻译： 公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。 还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。 还公开了用于治疗脂质代谢紊乱的方法和组合物。
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2.发明授权LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies 失效三酰基甘油脂肪酶家族的LLG多肽及其用于酶水解的组合物和方法以及蛋白质和基因治疗公开(公告)号：US07056720B2
公开(公告)日：2006-06-06
申请号：US10128449
申请日：2002-04-23
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： The present invention relates to LLG polypeptides, which are polypeptides of the triacylglycerol lipase family, and fragments thereof, antibodies against such polypeptides, nucleic acids encoding such polypeptides, and antisense nucleic acids derived from such nucleic acids. The invention relates also to therapeutic compositions and methods comprising the above. In addition, the invention relates to the preparation of LLG polypeptides using recombinant technology and to the use of LLG polypeptides to screen for agonists and antagonists thereof.
摘要翻译： 本发明涉及LLG多肽，其是三酰基甘油脂肪酶家族的多肽及其片段，针对此类多肽的抗体，编码此类多肽的核酸以及衍生自该核酸的反义核酸。 本发明还涉及包含上述物质的治疗组合物和方法。 此外，本发明涉及使用重组技术制备LLG多肽，以及使用LLG多肽筛选其激动剂和拮抗剂。
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公开(公告)号：US08343494B2
公开(公告)日：2013-01-01
申请号：US12503778
申请日：2009-07-15
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
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4.发明申请公开(公告)号：US20120114660A1
公开(公告)日：2012-05-10
申请号：US12503778
申请日：2009-07-15
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
IPC分类号： A61K39/395 , A61P3/06
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
摘要翻译： 公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。 还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。 还公开了用于治疗脂质代谢紊乱的方法和组合物。
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5.发明授权公开(公告)号：US07579447B2
公开(公告)日：2009-08-25
申请号：US11369410
申请日：2006-03-07
申请人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
发明人： Michael C. Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
摘要翻译： 公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。 还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。 还公开了用于治疗脂质代谢紊乱的方法和组合物。
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公开(公告)号：US5541109A
公开(公告)日：1996-07-30
申请号：US230047
申请日：1994-04-19
申请人： George H. Searfoss, III , Yuri D. Ivashchenko , Michael C. Jaye , Victoria J. South , Stephen M. French , Christopher Cheadle , George A. Ricca
发明人： George H. Searfoss, III , Yuri D. Ivashchenko , Michael C. Jaye , Victoria J. South , Stephen M. French , Christopher Cheadle , George A. Ricca
摘要： This invention provides a unique SH3 binding domain core motif of the sequence RPLPXXP and cDNA clones encoding proteins which interact with the SH3 domain of c-src, as well as the amino acid sequences which mediate this binding.Another embodiment of this invention is a method of identifying SH3-binding proteins and elucidating the sequences which mediate binding. This method may be used as an assay to select compounds which bind to this site and which inhibit or enhance the binding of the SH3 domain.
摘要翻译： 本发明提供了序列RPLPXXP的独特的SH3结合域核心基序和编码与c-src的SH3结构域相互作用的蛋白质的cDNA克隆，以及介导该结合的氨基酸序列。 本发明的另一个实施方案是鉴定SH3结合蛋白并阐明介导结合的序列的方法。 该方法可用作选择结合该位点并抑制或增强SH3结构域的化合物的测定法。
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公开(公告)号：US5614496A
公开(公告)日：1997-03-25
申请号：US458634
申请日：1995-06-02
IPC分类号： G01B21/20 , A61K38/00 , A61K38/18 , A61K38/22 , A61K45/00 , A61P1/02 , A61P5/00 , A61P19/08 , A61P19/10 , A61P43/00 , C07K14/50 , C12P21/02 , G01N21/35 , G01N21/85 , G01N33/10 , A61K38/16 , C07K14/475
CPC分类号： C07K14/501 , A61K38/1825 , C07K14/50 , G01N21/85 , G01N33/10 , Y10S530/84
摘要： The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pathological conditions involving bone tissue, for example, osteoporosis, Paget's disease, osteopetrosis, and periodontal disease and fracture repair, and healing of bone defects by administering FGF-1 to an animal or human in need of treatment.
摘要翻译： 本发明提供了用于预防和治疗涉及骨和牙齿组织的病理状况的治疗组合物。 本发明还提供一种促进骨修复和/或生长的方法，用于治疗涉及骨组织的病理状况，例如骨质疏松症，佩吉特氏病，骨硬化症，牙周病和骨折修复，以及通过施用FGF来治疗骨缺损 -1给需要治疗的动物或人类。
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公开(公告)号：US4861710A
公开(公告)日：1989-08-29
申请号：US911863
申请日：1986-09-26
IPC分类号： G01N33/50 , A61K38/00 , A61P35/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/705 , C12N1/21 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/19
CPC分类号： C07K14/705 , C12Q1/6886 , A61K38/00 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , Y10S436/813
摘要： The invention provides a recombinant cDNA clone encoding cell surface receptor for laminin, as well as a probe and methods of using that probe to diagnose the aggressiveness of a carcinoma or the effectiveness of an agent for treating cancer cells.
摘要翻译： 本发明提供了编码层粘连蛋白的细胞表面受体的重组cDNA克隆，以及使用该探针诊断癌侵袭性或治疗癌细胞的药物有效性的探针和方法。
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公开(公告)号：USRE37850E1
公开(公告)日：2002-09-17
申请号：US09538857
申请日：2000-03-28
IPC分类号： A61K3827
CPC分类号： C07K14/501 , A61K38/00 , Y10S930/12
摘要： Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering ECGF protein essentially free of other proteins of human origin. The product is useful for, among other purposes, diagnostic applications and as potential in the treatment of damaged blood vessels or other endothelial cell-lined structures.
摘要翻译： 内皮细胞生长因子通过应用重组DNA技术来制备编码ECGF蛋白质的克隆载体，公开了用于回收基本上不含人源蛋白质的ECGF蛋白质的方法。 该产品除了其它目的之外还可用于诊断应用，并且用于治疗损伤的血管或其它内皮细胞内衬结构的潜力。
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10.再颁专利DNA encoding human endothelial cell growth factors and plasmids comprising said DNA 失效编码人内皮细胞生长因子的DNA和包含所述DNA的质粒公开(公告)号：USRE38240E1
公开(公告)日：2003-08-26
申请号：US09538305
申请日：2000-03-28
IPC分类号： C12P2104
CPC分类号： C07K14/501 , A61K38/00 , Y02A50/473 , Y10S930/12
摘要： The present invention is directed to DNA encoding human endothelial cell growth factors, and to plasmids comprising said DNA. In particular, the invention relates to DNA encoding a cleavable signal peptide and an endothelial cell growth factor, wherein removal of said signal peptide yields a mature form of the growth factor.
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