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    Automated process line
    2.
    发明授权
    Automated process line 有权
    自动化生产线

    公开(公告)号：US06730517B1

    公开(公告)日：2004-05-04

    申请号：US09680581

    申请日：2000-10-05

    Applicant: Hubert Köster ,  Ping Yip ,  Jhobe Steadman ,  Dirk Reuter ,  Richard MacDonald

    Inventor： Hubert Köster ,  Ping Yip ,  Jhobe Steadman ,  Dirk Reuter ,  Richard MacDonald

    IPC: G01N3502

    CPC classification number: G01N35/0099 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/203332 ,  Y10T436/24 ,  Y10T436/25875

    Abstract: Fully automated modular analytical systems with integrated instrumentation for analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates, are provided. Analytical methods of detection and analysis, such as mass spectrometry, radiolabeling, mass tags, chemical tags and fluorescence chemiluminescence, are integrated with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate Automated Process Line (APL).

    Abstract translation: 提供了具有用于分析生物聚合物样品（如核酸，蛋白质，肽和碳水化合物）的集成仪器的全自动模块化分析系统。 检测和分析的分析方法，如质谱，放射性标记，质量标签，化学标签和荧光化学发光，与机器人技术和自动化学反应系统集成，提供高通量，精确的自动生产线（APL）。

    Method and apparatus for MALDI analysis
    4.
    发明授权
    Method and apparatus for MALDI analysis 失效
    MALDI分析方法和装置

    公开(公告)号：US06812455B2

    公开(公告)日：2004-11-02

    申请号：US10117558

    申请日：2002-04-03

    Applicant: Franz Hillenkamp ,  David M. Lough ,  G. Scott Higgins ,  Dirk Reuter

    Inventor： Franz Hillenkamp ,  David M. Lough ,  G. Scott Higgins ,  Dirk Reuter

    IPC: H01L4904

    CPC classification number: H01J49/164 ,  B01J2219/00387 ,  C40B60/14 ,  H01J49/0418

    Abstract: Matrix assisted laser desorption/ionization (MALDI) is performed in a manner that thermalizes large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpening the spectral peaks. In one embodiment the light is delivered to a matrix or sample holder having a cover, baffle or compartment. The baffle or compartment impedes or contains a plume of desorbed material and the analyte undergoes collisions to lower its mean velocity and directionality. Thus “thermalized” the analyte ions are passed to a mass analysis instrument.

    Abstract translation: 矩阵辅助激光解吸/离子化（MALDI）以对散射物质的大分子离子进行热分解的方式进行光谱分析。 热化离子具有低或零平均速度，并且以明确的时间瞬间呈现，减少伪像并锐化光谱峰。 在一个实施例中，光被传送到具有盖，挡板或隔室的基质或样品保持器。 挡板或隔室阻碍或包含一束解吸材料，分析物经受碰撞以降低其平均速度和方向性。 因此，“热化”的分析物离子被传递到质量分析仪器。

    Method and apparatus for maldi analysis
    5.
    发明授权
    Method and apparatus for maldi analysis 有权

    公开(公告)号：US06423966B1

    公开(公告)日：2002-07-23

    申请号：US09483629

    申请日：2000-01-14

    Applicant: Franz Hillenkamp ,  David M. Lough ,  G. Scott Higgins ,  Dirk Reuter

    Inventor： Franz Hillenkamp ,  David M. Lough ,  G. Scott Higgins ,  Dirk Reuter

    IPC: H01J4904

    Abstract: Matrix assisted laser desorption/ionization is performed,in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpening the spectral peaks. In one embodiment the light is delivered to a matrix or sample holder having a cover, baffle or compartment. The baffle or compartment impedes or contains a plume of desorbed material and the analyte undergoes collisions to lower its mean velocity and directionality. Thus “thermalized” the analyte ions are passed to a mass analysis instrument. In a preferred embodiment an optical fiber butts up against a thin transparent plate on which the specimen resides, with the matrix side in a vacuum acceleration chamber. A mechanical stage moves the specimen in both the x- and y-directions to select a point on the specimen which is to receive the radiation. The use of a fiber optic illuminator allows the entire stage assembly to be subsumed essentially within the dimensions of a conventional stage. In other embodiments, a thermalizing compartment is provided in a capillary tube about the end of the illumination fiber and the sample matrix is deposited along the inner cylindrical wall of the tube, so the capillary forms a migration path to the outlet for thermalization of the desorbed analyte. In other embodiments microstructures having the shape of a small lean-to, overhang or perforated cover plate, or providing a high aspect surface texture, provide the necessary containment to promote thermalization of the released analyte. A thin layer or cover of fibrous or permeable material may also be used to thermalize the analyte before mass analysis, and in other embodiment this material may also act as the substrate. An automated instrument may include a fixed array of illumination fibers which are illuminated at different times to eject samples from a corresponding array of points on the specimen.

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