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公开(公告)号：US10047040B2
公开(公告)日：2018-08-14
申请号：US15502512
申请日：2015-08-27
发明人： Noelle Gauvry , Chouaib Tahtaoui
IPC分类号： C07C311/08 , C07F7/08 , C07F5/02 , C07D295/155 , C07D333/24 , C07D231/12 , C07D213/61 , C07D231/56 , C07D213/56 , C07D239/30 , C07D239/26 , C07D277/30 , C07D213/84 , C07D333/28 , C07C311/21 , C07C311/14 , C07D309/06 , C07D249/08 , C07D277/64 , C07D277/60 , C07D277/56 , C07D285/135 , C07D333/78 , C07D277/46 , C07D277/54 , C07D263/50 , C07D275/03 , C07D317/66 , C07D209/08 , C07D215/06 , C07D487/04 , C07D237/26
CPC分类号： C07C311/08 , C07C235/56 , C07C307/10 , C07C311/09 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/40 , C07C2602/42 , C07D209/08 , C07D213/26 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/84 , C07D215/06 , C07D231/12 , C07D231/20 , C07D231/56 , C07D237/26 , C07D239/26 , C07D239/30 , C07D239/34 , C07D249/08 , C07D249/12 , C07D263/50 , C07D275/03 , C07D277/30 , C07D277/46 , C07D277/54 , C07D277/56 , C07D277/60 , C07D277/62 , C07D277/64 , C07D279/12 , C07D285/135 , C07D295/155 , C07D295/185 , C07D295/26 , C07D309/06 , C07D317/66 , C07D333/24 , C07D333/28 , C07D333/78 , C07D487/04 , C07F5/025 , C07F7/081 , C07F7/0812
摘要： The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.
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公开(公告)号：US20220064159A1
公开(公告)日：2022-03-03
申请号：US17415309
申请日：2019-12-13
IPC分类号： C07D471/04 , C07D405/12 , C07D215/42 , C07D311/74
摘要： The present invention provides compounds of formula (I): which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.
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公开(公告)号：US20220008366A1
公开(公告)日：2022-01-13
申请号：US17281914
申请日：2019-09-30
发明人： Sarah George , Peter Rolfe , Chouaib Tahtaoui
IPC分类号： A61K31/167 , A61K31/63 , A61P33/10
摘要： The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of clorsulon.
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公开(公告)号：US11938103B2
公开(公告)日：2024-03-26
申请号：US17281914
申请日：2019-09-30
发明人： Sarah George , Peter Rolfe , Chouaib Tahtaoui
IPC分类号： A61K31/167 , A61K31/63 , A61P33/10
CPC分类号： A61K31/167 , A61K31/63 , A61P33/10
摘要： The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of clorsulon.
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公开(公告)号：US10464889B2
公开(公告)日：2019-11-05
申请号：US16037396
申请日：2018-07-17
发明人： Noelle Gauvry , Chouaib Tahtaoui
IPC分类号： C07C311/08 , C07D277/62 , C07D213/61 , C07D213/84 , C07D231/12 , C07D231/20 , C07D231/56 , C07C307/10 , C07D333/24 , C07D333/28 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/29 , C07D239/26 , C07D239/30 , C07D239/34 , C07D249/12 , C07D277/30 , C07D277/64 , C07D279/12 , C07D295/155 , C07D295/185 , C07D295/26 , C07D213/26 , C07D213/64 , C07D213/65 , C07C311/09 , C07C235/56 , C07F5/02 , C07F7/08 , C07D209/08 , C07D213/56 , C07D215/06 , C07D237/26 , C07D249/08 , C07D263/50 , C07D275/03 , C07D277/46 , C07D277/54 , C07D277/56 , C07D277/60 , C07D285/135 , C07D309/06 , C07D317/66 , C07D333/78 , C07D487/04
摘要： The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.
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公开(公告)号：US10370375B2
公开(公告)日：2019-08-06
申请号：US16055560
申请日：2018-08-06
发明人： Noelle Gauvry , Chouaib Tahtaoui , Pascal Furet , Pierre Ducray
IPC分类号： C07D471/14 , C07D239/46 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D239/42 , C07D239/48
摘要： The invention relates to a compound of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful as therapeutic agent for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis. Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, inflammatory bowel diseases, Crohn's disease, Alzheimer's disease, leukemia, osteoarthritis, control of pruritus, chronic respiratory disease or keratoconjunctivitis in mammals.
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公开(公告)号：US20190142795A1
公开(公告)日：2019-05-16
申请号：US16099590
申请日：2017-05-03
发明人： Chouaib Tahtaoui
IPC分类号： A61K31/381 , A23K50/80 , A23K20/137
CPC分类号： A61K31/381 , A01N43/80 , A23K20/137 , A23K50/80
摘要： The present invention provides a dihydroisoxazole of formula: or a salt thereof, for use in the control of sea lice in fish.
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公开(公告)号：US10059709B2
公开(公告)日：2018-08-28
申请号：US15119800
申请日：2015-03-25
发明人： Noelle Gauvry , Chouaib Tahtaoui , Pascal Furet , Pierre Ducray
IPC分类号： C07D471/14 , C07D239/46 , C07D471/04 , A61K31/44 , C07D473/34 , C07D487/04 , C07D495/04 , C07D239/42 , C07D239/48
CPC分类号： C07D471/14 , C07D239/42 , C07D239/46 , C07D239/48 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04
摘要： The invention relates to a compound of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful as therapeutic agent for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, inflammatory bowel diseases, Crohn's disease, Alzheimer's disease, leukemia, osteoarthritis, control of pruritus, chronic respiratory disease or keratoconjunctivitis in mammals.
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公开(公告)号：US20220064160A1
公开(公告)日：2022-03-03
申请号：US17415323
申请日：2019-12-13
IPC分类号： C07D471/04 , C07D495/04 , C07D493/04 , C07D405/12 , C07D311/68 , A61P33/10
摘要： The present invention provides compounds of formula (I): which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.
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公开(公告)号：US10537549B2
公开(公告)日：2020-01-21
申请号：US16099590
申请日：2017-05-03
发明人： Chouaib Tahtaoui
IPC分类号： A61K31/381 , A23K50/80 , A23K20/137 , A01N43/80
摘要： The present invention provides a dihydroisoxazole of formula: or a salt thereof, for use in the control of sea lice in fish.
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