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公开(公告)号：US20070141076A1
公开(公告)日：2007-06-21
申请号：US11586694
申请日：2006-10-26
IPC分类号： A61K39/00 , G01N33/569 , C07H21/04 , C12N15/74 , G01N33/53 , A61K39/002 , C07K14/45 , C12N1/10
CPC分类号： C07K14/45 , A61K39/00 , C07K2319/00
摘要： The invention described herein relates to a method for identifying antigen fragments of Toxoplasma gondii proteins, and their use as diagnostic and immunogenic agents. Said method is implemented by means of selection of DNA fragments libraries of the parasite with sera of subjects who have been infected, using the phage display technique, and is characterised in that it uses the expression/exposure vector λKM4. The method allows also to identify antigen fragments related to the time of the infection.
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公开(公告)号：US07176286B2
公开(公告)日：2007-02-13
申请号：US10508622
申请日：2003-03-18
IPC分类号： C07K1/00 , A61K38/00 , A61K39/012 , C12N15/09 , C12N7/00
CPC分类号： C07K14/45 , A61K39/00 , C07K2319/00
摘要： The invention described herein relates to a method for identifying antigen fragments of Toxoplasma gondii proteins, and their use as diagnostic and immunogenic agents. Said method is implemented by means of selection of DNA fragments libraries of the parasite with sera of subjects who have been infected, using the phage display technique, and is characterised in that it uses the expression/exposure vector λKM4. The method allows also to identify antigen fragments related to the time of the infection.
摘要翻译： 本文描述的本发明涉及用于鉴定弓形虫蛋白质的抗原片段的方法及其作为诊断和免疫原性试剂的用途。 所述方法通过使用噬菌体展示技术选择具有被感染的受试者血清的寄生虫的DNA片段文库，并且其特征在于其使用表达/暴露载体λKM4来实现。 该方法还可以鉴定与感染时间相关的抗原片段。
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公开(公告)号：US20050089867A1
公开(公告)日：2005-04-28
申请号：US10508622
申请日：2003-03-18
CPC分类号： C07K14/45 , A61K39/00 , C07K2319/00
摘要： The invention described herein relates to a method for identifying antigen fragments of Toxoplasma gondii proteins, and their use as diagnostic and immunogenic agents. Said method is implemented by means of selection of DNA fragments libraries of the parasite with sera of subjects who have been infected, using the phage display technique, and is characterised in that it uses the expression/exposure vector λKM4. The method allows also to identify antigen fragments related to the time of the infection.
摘要翻译： 本文描述的本发明涉及用于鉴定弓形虫蛋白质的抗原片段的方法及其作为诊断和免疫原性试剂的用途。 所述方法通过使用噬菌体展示技术选择具有被感染的受试者血清的寄生虫的DNA片段文库，并且其特征在于其使用表达/暴露载体λKM4来实现。 该方法还可以鉴定与感染时间相关的抗原片段。
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公开(公告)号：US20100068229A1
公开(公告)日：2010-03-18
申请号：US12525800
申请日：2008-02-05
IPC分类号： A61K39/245 , C07K14/045 , C07H21/00 , C12N15/63 , C12N1/00 , C12P21/00 , C12Q1/70 , A61K31/7052 , A61P31/12
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/23 , C07K2319/43 , C12N15/1037 , C12N2710/16122 , G01N33/569 , G01N2333/045
摘要： The invention described herein relates to a method for identifying the antigenic regions of HCMV proteins involved in the human B-cell response to HCMV infection, for combining such antigenic regions in the form of chimeric fusion products, and their use as diagnostic and immunogenic agents.
摘要翻译： 本文描述的本发明涉及用于鉴定涉及HCMV感染的人B细胞应答的HCMV蛋白的抗原性区域的方法，用于将这些抗体区域以嵌合融合产物的形式组合，以及它们作为诊断和免疫原性试剂的用途。
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公开(公告)号：US20090092630A1
公开(公告)日：2009-04-09
申请号：US11899754
申请日：2007-09-06
申请人： Nicola Gargano , Elisa Beghetto , Andrea Spadoni
发明人： Nicola Gargano , Elisa Beghetto , Andrea Spadoni
IPC分类号： A61K39/00
CPC分类号： A61K39/002 , A61K38/00 , A61K2039/53 , C07K14/45
摘要： A method for treatment or prevention of Toxoplasma gondii infections pharmaceutical composition comprising an antigen fragments of Toxoplasma gondii in the form of a chimeric fusion product or a nucleotide sequence coding for the chimeric fusion product and a method of using the chimeric fusion product or nucleotide sequence coding therefor.
摘要翻译： 用于治疗或预防弓形虫感染药物组合物的方法，其包含嵌合融合产物形式的弓形体的抗原片段或编码嵌合融合物的核苷酸序列的方法，以及使用嵌合融合产物或核苷酸序列编码 因此。
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公开(公告)号：US20110027810A1
公开(公告)日：2011-02-03
申请号：US12829367
申请日：2010-07-01
申请人： NICOLA GARGANO , ELISA BEGHETTO , ANDREA SPADONI
发明人： NICOLA GARGANO , ELISA BEGHETTO , ANDREA SPADONI
IPC分类号： G01N33/566 , C07K14/45 , C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： A61K39/002 , A61K38/00 , A61K2039/53 , C07K14/45
摘要： The invention described herein relates to a method for combining antigen fragments of Toxoplasma gondii proteins, in the form of chimeric fusion products, and their use as diagnostic and immunogenic agents.
摘要翻译： 本文描述的本发明涉及以嵌合融合产物的形式组合弓形体弓形体蛋白的抗原片段及其用作诊断和免疫原性试剂的方法。
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公开(公告)号：US07867503B2
公开(公告)日：2011-01-11
申请号：US11899754
申请日：2007-09-06
申请人： Nicola Gargano , Elisa Beghetto , Andrea Spadoni
发明人： Nicola Gargano , Elisa Beghetto , Andrea Spadoni
IPC分类号： A61K39/012
CPC分类号： A61K39/002 , A61K38/00 , A61K2039/53 , C07K14/45
摘要： A method for treatment or prevention of Toxoplasma gondii infections pharmaceutical composition comprising an antigen fragments of Toxoplasma gondii in the form of a chimeric fusion product or a nucleotide sequence coding for the chimeric fusion product and a method of using the chimeric fusion product or nucleotide sequence coding therefor.
摘要翻译： 用于治疗或预防弓形虫感染药物组合物的方法，其包含嵌合融合产物形式的弓形体的抗原片段或编码嵌合融合物的核苷酸序列的方法，以及使用嵌合融合产物或核苷酸序列编码 因此。
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公开(公告)号：US07790187B2
公开(公告)日：2010-09-07
申请号：US11885951
申请日：2006-02-27
申请人： Nicola Gargano , Elisa Beghetto , Andrea Spadoni
发明人： Nicola Gargano , Elisa Beghetto , Andrea Spadoni
IPC分类号： A61K39/012 , C07H21/04 , C12N15/00 , C12P21/04 , C07K14/00
CPC分类号： A61K39/002 , A61K38/00 , A61K2039/53 , C07K14/45
摘要： The invention described herein relates to a method for combining antigen fragments of Toxoplasma gondii proteins, in the form of chimeric fusion products, and their use as diagnostic and immunogenic agents.
摘要翻译： 本文描述的本发明涉及以嵌合融合产物的形式组合弓形体弓形体蛋白的抗原片段及其用作诊断和免疫原性试剂的方法。
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公开(公告)号：US20080280307A1
公开(公告)日：2008-11-13
申请号：US11885951
申请日：2006-02-27
申请人： Nicola Gargano , Elisa Beghetto , Andrea Spadoni
发明人： Nicola Gargano , Elisa Beghetto , Andrea Spadoni
CPC分类号： A61K39/002 , A61K38/00 , A61K2039/53 , C07K14/45
摘要： The invention described herein relates to a method for combining antigen fragments of Toxoplasma gondii proteins, in the form of chimeric fusion products, and their use as diagnostic and immunogenic agents.
摘要翻译： 本文描述的本发明涉及以嵌合融合产物的形式组合弓形体弓形体蛋白的抗原片段及其用作诊断和免疫原性试剂的方法。
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