摘要:
Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.
摘要:
The invention describes poly(ortho ester) polymers that include at least one therapeutic compound in the polymer backbone. The therapeutic compound includes at least one phenol residue and an aliphatic alcohol residue or two or more phenolic residues.
摘要:
Methods for preparing polymers from multifunctional azides and multifunctional azide-reactants are described in the present disclosure. Exemplary multifunctional azide-reactants include multifunctional alkynes and/or multifunctional α-phosphine esters. In certain embodiments, such polymers can be prepared in vivo. Such polymers can be useful in a wide variety of biomedical applications.
摘要:
Heteroatom-containing polymers such as polyketals, and methods of making and using such heteroatom-containing polymers are disclosed herein. The heteroatom-containing polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the heteroatom-containing polymers are polyketals that are biodegradable.
摘要:
A method of repairing a housing for a machine system includes returning an inner diameter of at least one bearing bore of the housing to a uniform diameter state. The at least one bearing bore is prepared for resurfacing via removing deeply entrapped grease from within pores in cast surface material of the housing subsequent to returning the inner diameter to a uniform diameter state. Subsequent to preparing the at least one bearing bore for resurfacing, it is resurfaced with a material different from cast material of the housing and bonded therewith, for example via thermal spray coating. Resurfacing a cast metallic component, of iron, steel, or the like with metal spray coating may include removing deeply embedded grease from pores of cast surface material of a cast component, in preparation for spraying the cast component with metal spray resurfacing material.
摘要:
Liposome complexes are provided for site-specific delivery of pharmaceutical agents with improved targeting efficiency. The liposome complexes include a pharmaceutical agent associated with the liposome; a sialic acid-containing molecule associated with the liposome; and optionally a targeting agent attached to the sialic acid-containing molecule. The invention also provides methods of making liposome complexes and their in vivo administration.
摘要:
Compounds that include diorgano groups having quaternary carbons and optionally urethane groups, urea groups, or combinations thereof (i.e., polyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.
摘要:
A method of repairing a housing for a machine system includes returning an inner diameter of at least one bearing bore of the housing to a uniform diameter state. The at least one bearing bore is prepared for resurfacing via removing deeply entrapped grease from within pores in cast surface material of the housing subsequent to returning the inner diameter to a uniform diameter state. Subsequent to preparing the at least one bearing bore for resurfacing, it is resurfaced with a material different from cast material of the housing and bonded therewith, for example via thermal spray coating. Resurfacing a cast metallic component, of iron, steel, or the like with metal spray coating may include removing deeply embedded grease from pores of cast surface material of a cast component, in preparation for spraying the cast component with metal spray resurfacing material.
摘要:
Polyketal polymers, and methods of making and using such polyketal polymers are disclosed herein. The polyketal poylmers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the polyketal polymers are biodegradable.
摘要:
Polymers, compositions, and medical devices useful for delivering (e.g., by local and/or sustained delivery) a haloacetate (e.g., dichoroacetate) to a tissue are disclosed herein. Such methods can be useful for treatment of diseases such as cancer.