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公开(公告)号：US07540948B2
公开(公告)日：2009-06-02
申请号：US11216041
申请日：2005-09-01
申请人： G. Bruce Collier , Eric Brouwer , Anjulia Wong
发明人： G. Bruce Collier , Eric Brouwer , Anjulia Wong
摘要： A BUN (blood urea nitrogen) sensor containing immobilized carbonic anhydrase and immobilized urease for the in vitro detection of urea nitrogen in blood and biological samples with improved performance and precision characteristics.
摘要翻译： 含有固定化碳酸酐酶和固定脲酶的BUN（血尿素氮）传感器用于体外检测血液和生物样品中的尿素氮，具有改进的性能和精密特性。
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2.发明申请Beverages and foodstuffs resistant to light induced flavour changes, processes for making the same, and compositions for imparting such resistance 有权对光诱导的风味变化的饮料和食品，制造它们的方法和赋予这种抵抗力的组合物公开(公告)号：US20070071850A1
公开(公告)日：2007-03-29
申请号：US10573348
申请日：2004-09-29
申请人： Richard Van Der Ark , Peter Blokker , Louise Bolshaw , Eric Brouwer , Paul Hughes , Henk Kessels , Fred Olierook , Marcel Van Veen
发明人： Richard Van Der Ark , Peter Blokker , Louise Bolshaw , Eric Brouwer , Paul Hughes , Henk Kessels , Fred Olierook , Marcel Van Veen
IPC分类号： C12C11/00
CPC分类号： A23C9/152 , A23G3/32 , A23G3/346 , A23G3/36 , A23G2200/00 , A23L3/3526 , A23L3/3544 , A23L29/045 , C12C5/02 , C12C5/04
摘要： One aspect of the present invention is concerned with a composition that can suitably be used as an additive in beverages and foodstuffs, which composition: i. contains at least 0.5%, preferably at least 1.0%, by weight of dry matter, of pyrazine derivatives according to formula (I): wherein R1-R4 independently represent hydrogen; a hydroxyhydrocarbyl residue; an ester of a hydroxyhydrocarbyl residue; or an ether of a hydroxyhydrocarbyl residue; and at least one R1-R4 is a hydroxyhydrocarbyl residue or an ester or an ether thereof, and ii. exhibits an absorption ratio A280/560 of at least 80, preferably of at least 250. The invention also relates to a method of manufacturing a beverage or a foodstuff that is resistant to light induced flavour changes, said method comprising introducing into said beverage or foodstuff the aforementioned light stabilising composition and to a process for the manufacture of such a light stabilising composition.
摘要翻译： 本发明的一个方面涉及可适当地用作饮料和食品中的添加剂的组合物，其组成如下：i。 含有至少0.5重量％，优选至少1.0重量％的干物质，根据式（I）的吡嗪衍生物：其中R 1 -R 4独立地表示 氢; 羟基烃基残基; 羟基烃基残基的酯; 或羟基烃基残基的醚; 并且至少一个R 1 -R 4是羟基烃基残基或其酯或醚，和ii。 表现出至少80，优选至少250的吸收比A 280/560。本发明还涉及制造对光诱导的风味变化具有抗性的饮料或食品的方法，所述方法 方法，包括向所述饮料或食品中引入前述的光稳定化组合物和制造这种光稳定组合物的方法。
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3.发明申请AUTOMATED METHOD AND APPARATUS FOR DETECTING ERRONEOUS SAMPLE COLLECTION IN CLINICAL ASSAYS 有权用于检测临床测试中的错误样本采集的自动化方法和装置公开(公告)号：US20120295359A1
公开(公告)日：2012-11-22
申请号：US13565930
申请日：2012-08-03
IPC分类号： G01N35/00
CPC分类号： G01N35/00603
摘要： An automatic method for identifying biological samples that are collected using the wrong blood preservative for subsequent analytical testing. The method also provides for identification and/or suppression of certain analytical test results that are substantially or partly adversely affected. The invention is particularly suited for use in point-of-care medical diagnostic testing.
摘要翻译： 一种用于识别使用错误的防腐剂收集的生物样品进行后续分析测试的自动方法。 该方法还提供对基本或部分不利影响的某些分析测试结果的识别和/或抑制。 本发明特别适用于护理点医疗诊断测试。
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公开(公告)号：US08182663B2
公开(公告)日：2012-05-22
申请号：US12392511
申请日：2009-02-25
申请人： G. Bruce Collier , Eric Brouwer , Anjulia Wong
发明人： G. Bruce Collier , Eric Brouwer , Anjulia Wong
摘要： A BUN (blood urea nitrogen) sensor containing immobilized carbonic anhydrase and immobilized urease for the in vitro detection of urea nitrogen in blood and biological samples with improved performance and precision characteristics.
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公开(公告)号：US20060046275A1
公开(公告)日：2006-03-02
申请号：US11216041
申请日：2005-09-01
申请人： G. Collier , Eric Brouwer , Anjulia Wong
发明人： G. Collier , Eric Brouwer , Anjulia Wong
IPC分类号： G01N33/542 , G01N33/53
摘要： A BUN (blood urea nitrogen) sensor containing immobilized carbonic anhydrase and immobilized urease for the in vitro detection of urea nitrogen in blood and biological samples with improved performance and precision characteristics.
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6.发明授权Automated method and apparatus for detecting erroneous sample collection in clinical assays 有权用于检测临床测定中错误样本收集的自动化方法和装置公开(公告)号：US08548772B2
公开(公告)日：2013-10-01
申请号：US13565930
申请日：2012-08-03
CPC分类号： G01N35/00603
摘要： An automatic method for identifying biological samples that are collected using the wrong blood preservative for subsequent analytical testing. The method also provides for identification and/or suppression of certain analytical test results that are substantially or partly adversely affected. The invention is particularly suited for use in point-of-care medical diagnostic testing.
摘要翻译： 一种用于识别使用错误的防腐剂收集的生物样品进行后续分析测试的自动方法。 该方法还提供对基本或部分不利影响的某些分析测试结果的识别和/或抑制。 本发明特别适用于护理点医疗诊断测试。
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7.发明申请AUTOMATED METHOD AND APPARATUS FOR DETECTING ERRONEOUS SAMPLE COLLECTION IN CLINICAL ASSAYS 有权用于检测临床测试中的错误样本采集的自动化方法和装置公开(公告)号：US20090173641A1
公开(公告)日：2009-07-09
申请号：US12339886
申请日：2008-12-19
CPC分类号： G01N35/00603
摘要： A method for identifying biological samples that are collected using the wrong anticoagulant for subsequent analytical testing. The method also provides for identification of certain analytical test results that are substantially or partly adversely affected.
摘要翻译： 用于鉴定使用错误的抗凝剂收集的生物样品用于随后的分析测试的方法。 该方法还提供对基本或部分不利影响的某些分析测试结果的鉴定。
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公开(公告)号：US20090119047A1
公开(公告)日：2009-05-07
申请号：US12210700
申请日：2008-09-15
申请人： Michael P. ZELIN , Eric BROUWER , Steven BREEZE
发明人： Michael P. ZELIN , Eric BROUWER , Steven BREEZE
CPC分类号： G01N27/4163 , G01K3/04 , G01N27/3274 , G01N31/229 , G01N2035/00089
摘要： An improved quality assurance system and method for point-of-care testing are disclosed. The present invention provides quality assurance for laboratory quality tests performed by a blood analysis system or the like at the point of patient care without the need for running liquid-based quality control materials on the analysis system. Quality assurance of a quantitative physiological sample test system is performed without using a quality control sample by monitoring the thermal and temporal stress of a component used with the test system. Alert information is generated that indicates that the component has failed quality assurance when the thermal and temporal stress exceeds a predetermined thermal-temporal stress threshold. Alternatively, the present invention provides quality assurance for laboratory quality tests performed by a blood analysis system or the like at the point of patient care by minimizing the need for running liquid-based quality control materials on the analysis system.
摘要翻译： 公开了改进的质量保证体系和护理点测试方法。 本发明提供了在患者护理时由血液分析系统等进行的实验室质量测试的质量保证，而不需要在分析系统上运行基于液体的质量控制材料。 通过监测与测试系统一起使用的组件的热和时间应力，不使用质量控制样品来进行定量生理样品测试系统的质量保证。 产生警报信息，其指示当热和时间应力超过预定的热 - 时间应力阈值时该部件质量失效。 或者，本发明通过最小化在分析系统上运行基于液体的质量控制材料的需要来提供在患者护理时由血液分析系统等进行的实验室质量测试的质量保证。
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公开(公告)号：US08510067B2
公开(公告)日：2013-08-13
申请号：US12210700
申请日：2008-09-15
申请人： Michael P. Zelin , Eric Brouwer , Steven Breeze
发明人： Michael P. Zelin , Eric Brouwer , Steven Breeze
CPC分类号： G01N27/4163 , G01K3/04 , G01N27/3274 , G01N31/229 , G01N2035/00089
摘要： An improved quality assurance system and method for point-of-care testing are disclosed. The present invention provides quality assurance for laboratory quality tests performed by a blood analysis system or the like at the point of patient care without the need for running liquid-based quality control materials on the analysis system. Quality assurance of a quantitative physiological sample test system is performed without using a quality control sample by monitoring the thermal and temporal stress of a component used with the test system. Alert information is generated that indicates that the component has failed quality assurance when the thermal and temporal stress exceeds a predetermined thermal-temporal stress threshold. Alternatively, the present invention provides quality assurance for laboratory quality tests performed by a blood analysis system or the like at the point of patient care by minimizing the need for running liquid-based quality control materials on the analysis system.
摘要翻译： 公开了改进的质量保证体系和护理点测试方法。 本发明提供了在患者护理时由血液分析系统等进行的实验室质量测试的质量保证，而不需要在分析系统上运行基于液体的质量控制材料。 通过监测与测试系统一起使用的组件的热和时间应力，不使用质量控制样品来进行定量生理样品测试系统的质量保证。 产生警报信息，其指示当热和时间应力超过预定的热 - 时间应力阈值时该部件质量失效。 或者，本发明通过最小化在分析系统上运行基于液体的质量控制材料的需要来提供在患者护理时由血液分析系统等进行的实验室质量测试的质量保证。
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10.发明授权Automated methods for detecting sample collection with erroneous anticoagulant in clinical assays 有权用于在临床测定中检测带有错误抗凝剂的样品采集的自动方法公开(公告)号：US08265904B2
公开(公告)日：2012-09-11
申请号：US12339886
申请日：2008-12-19
CPC分类号： G01N35/00603
摘要： An automatic method for identifying biological samples that are collected using the wrong blood preservative for subsequent analytical testing. The method also provides for identification and/or suppression of certain analytical test results that are substantially or partly adversely affected. The invention is particularly suited for use in point-of-care medical diagnostic testing.
摘要翻译： 一种用于识别使用错误的防腐剂收集的生物样品进行后续分析测试的自动方法。 该方法还提供对基本或部分不利影响的某些分析测试结果的识别和/或抑制。 本发明特别适用于护理点医疗诊断测试。
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