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1.发明授权公开(公告)号：US08846102B2
公开(公告)日：2014-09-30
申请号：US11694852
申请日：2007-03-30
申请人： Anthony T. Cheung , Eric C. Hsu
发明人： Anthony T. Cheung , Eric C. Hsu
CPC分类号： C12N5/0679 , A61K9/5161 , A61K47/36 , A61K48/0041 , A61K48/005 , A61K48/0058
摘要： The present invention provides chitosan-based nanoparticles that can protect nucleic acids and deliver the same into gut mucosal cells. Compositions and methods for the expression of therapeutic nucleic acids in cells of the gut mucosa are provided. Compositions and methods for delivering therapeutic proteins systemically from cells of the gut mucosa are also provided.
摘要翻译： 本发明提供了可以保护核酸并将其输送到肠粘膜细胞中的基于壳聚糖的纳米颗粒。 提供了在肠粘膜细胞中表达治疗性核酸的组合物和方法。 还提供了从肠粘膜细胞全身递送治疗性蛋白质的组合物和方法。
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公开(公告)号：US20090041740A1
公开(公告)日：2009-02-12
申请号：US12017902
申请日：2008-01-22
申请人： SCOTT POWNALL , Anthony T. Cheung , Eric C. Hsu , Bruno Doiron
发明人： SCOTT POWNALL , Anthony T. Cheung , Eric C. Hsu , Bruno Doiron
IPC分类号： A61K38/43 , C12N5/06 , C12N15/85 , C12N15/86 , A61K38/46 , A61P35/00 , A61K38/45 , A61K31/7088 , A61K38/17
CPC分类号： A61K38/45 , A61K38/47 , A61K45/06 , A61K48/005 , C12N9/16 , C12N15/86 , C12N2710/10343 , C12Q1/25 , C12Q1/34 , C12Y301/03016 , G01N33/5011 , G01N33/5023
摘要： The invention provides compositions and methods for inhibiting the growth or proliferation of hyperproliferative cells or inducing regression of hyperproliferative cells. More specifically, the invention provides compositions and methods for stimulating glycogen accumulation in target cells (e.g., hyperproliferative cells) in order to increase glycogen to a level that is toxic to the target cell.
摘要翻译： 本发明提供了抑制过度增殖细胞生长或增殖或诱导过度增殖细胞退化的组合物和方法。 更具体地，本发明提供了用于刺激靶细胞（例如，过度增殖细胞）中的糖原积累的组合物和方法，以便将糖原增加至对靶细胞有毒性的水平。
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公开(公告)号：US09404088B2
公开(公告)日：2016-08-02
申请号：US13070988
申请日：2011-03-24
申请人： Anthony T. Cheung , Eric C. Hsu
发明人： Anthony T. Cheung , Eric C. Hsu
CPC分类号： C12N5/0679 , A61K9/5161 , A61K47/36 , A61K48/0041 , A61K48/005 , A61K48/0058
摘要： The present invention provides chitosan-based nanoparticles that can protect nucleic acids and deliver the same into gut mucosal cells. Compositions and methods for the expression of therapeutic nucleic acids in cells of the gut mucosa are provided. Compositions and methods for delivering therapeutic proteins systemically from cells of the gut mucosa are also provided.
摘要翻译： 本发明提供了可以保护核酸并将其输送到肠粘膜细胞中的基于壳聚糖的纳米颗粒。 提供了在肠粘膜细胞中表达治疗性核酸的组合物和方法。 还提供了从肠粘膜细胞全身递送治疗性蛋白质的组合物和方法。
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4.发明申请公开(公告)号：US20110171314A1
公开(公告)日：2011-07-14
申请号：US11694852
申请日：2007-03-30
申请人： Anthony T. CHEUNG , Eric C. Hsu
发明人： Anthony T. CHEUNG , Eric C. Hsu
IPC分类号： A61K9/50 , A61K31/7088 , C12N5/071 , A61P37/08
CPC分类号： C12N5/0679 , A61K9/5161 , A61K47/36 , A61K48/0041 , A61K48/005 , A61K48/0058
摘要： The present invention provides chitosan-based nanoparticles that can protect nucleic acids and deliver the same into gut mucosal cells. Compositions and methods for the expression of therapeutic nucleic acids in cells of the gut mucosa are provided. Compositions and methods for delivering therapeutic proteins systemically from cells of the gut mucosa are also provided.
摘要翻译： 本发明提供了可以保护核酸并将其输送到肠粘膜细胞中的基于壳聚糖的纳米颗粒。 提供了在肠粘膜细胞中表达治疗性核酸的组合物和方法。 还提供了从肠粘膜细胞全身递送治疗性蛋白质的组合物和方法。
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公开(公告)号：US20110039917A1
公开(公告)日：2011-02-17
申请号：US12680527
申请日：2008-09-26
申请人： Eric C Hsu , Carlos Fleet , Anthony Cheung , Jun Gao
发明人： Eric C Hsu , Carlos Fleet , Anthony Cheung , Jun Gao
IPC分类号： A61K31/7088
CPC分类号： C08B37/0063 , A61K31/7088 , C07H17/02 , C12N15/87 , Y10T428/2982
摘要： The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provided are methods for altering the diameter of chitosan-nucleic acid polyplexes.
摘要翻译： 本发明提供高度浓缩的壳聚糖 - 核酸复合物组合物和分散体，以及用于制备组合物和分散体的方法。 混合壳聚糖 - 核酸复合物的方法包括壳聚糖溶液和核酸溶液的在线混合，然后任选地与聚集抑制剂进一步浓缩壳聚糖 - 核酸复合物的分散体。 还提供了改变壳聚糖 - 核酸复合物直径的方法。
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公开(公告)号：US20110171276A1
公开(公告)日：2011-07-14
申请号：US13070988
申请日：2011-03-24
申请人： Anthony T. Cheung , Eric C. Hsu
发明人： Anthony T. Cheung , Eric C. Hsu
CPC分类号： C12N5/0679 , A61K9/5161 , A61K47/36 , A61K48/0041 , A61K48/005 , A61K48/0058
摘要： The present invention provides chitosan-based nanoparticles that can protect nucleic acids and deliver the same into gut mucosal cells. Compositions and methods for the expression of therapeutic nucleic acids in cells of the gut mucosa are provided. Compositions and methods for delivering therapeutic proteins systemically from cells of the gut mucosa are also provided.
摘要翻译： 本发明提供了可以保护核酸并将其输送到肠粘膜细胞中的壳聚糖基纳米颗粒。 提供了在肠粘膜细胞中表达治疗性核酸的组合物和方法。 还提供了从肠粘膜细胞全身递送治疗性蛋白质的组合物和方法。
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