公开(公告)号：US20120316492A1

公开(公告)日：2012-12-13

申请号：US13578711

申请日：2011-02-07

申请人： Eric Chappel

发明人： Eric Chappel

IPC分类号： A61M5/14

CPC分类号： A61M5/16881 ,  A61M5/14276 ,  A61M5/145 ,  A61M5/16813 ,  A61M27/006 ,  A61M2039/2413 ,  A61M2205/0244 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0057 ,  F16K2099/008 ,  F16K2099/0088 ,  G05D7/0635 ,  G05D7/0694 ,  Y10T137/7791 ,  Y10T137/86734

摘要： The invention concerns a flow regulator, made of a stack of 3 plates, respectively a top plate including a flexible membrane (1), a middle plate (2) with pillars and through holes and a bottom plate (3) with fluidic ports, micro channels and through holes (8,9,12). The principle is based on the deformation of the membrane due to the pressure of the liquid. The membrane goes in contact with the pillars of the middle plate, obstructing gradually the through holes of the pillars. The device is designed to keep the flow constant in a predefined range of pressure. The device is dedicated to ultra low flow rate up to 1 ml per day or below, typically for drug infusion. Plastic flow regulators comprise preferably several independent valves coupled in parallel. The membrane plate is therefore made of several flexible membranes obstructing gradually the flow by increasing the pressure. Stress limiters are used to avoid plastic deformation of the membrane. For implanted pump, the use of a flow regulator instead of a flow restrictor has several advantages, including the possibility to reduce significantly the reservoir pressure and to generate directly the pressure during the pump filling by using an elastic drug reservoir.

摘要翻译： 本发明涉及一种流量调节器，由三个板组成，分别是包括柔性膜（1），具有支柱和通孔的中间板（2）和具有流体端口的底板（3）的顶板，微板 通道和通孔（8,9,12）。 该原理是基于液体由于压力引起的膜的变形。 膜与中间板的支柱接触，逐渐阻塞柱的通孔。 设备旨在使流量保持在预定的压力范围内。 该设备专用于每天或以下超过1毫升的超低流速，通常用于药物输注。 塑料流量调节器优选并联连接多个独立的阀。 因此，膜片由几个柔性膜制成，通过增加压力逐渐阻塞流动。 应力限制器用于避免膜的塑性变形。 对于植入式泵，使用流量调节器代替限流器具有若干优点，包括显着降低储层压力并通过使用弹性药物储存器在泵填充期间直接产生压力的可能性。

公开(公告)号：US10286144B2

公开(公告)日：2019-05-14

申请号：US14128925

申请日：2012-06-22

申请人： Eric Chappel ,  Stephan Proennecke ,  Frédéric Neftel

发明人： Eric Chappel ,  Stephan Proennecke ,  Frédéric Neftel

IPC分类号： A61M5/14 ,  A61M5/142 ,  A61M5/145 ,  A61M5/168 ,  A61M5/50 ,  F04D15/00

摘要： Method for detecting failure including possible under or over delivery of a micropump having at least an inlet valve, a pumping chamber with an inner pressure sensor and an outlet valve, said method comprising the determination of the pump tightness via the measurement of the pressure by said inner pressure sensor in said pumping chamber at least at certain intervals when the pump is inactive and the comparison with a value of reference.

公开(公告)号：US09822774B2

公开(公告)日：2017-11-21

申请号：US13512463

申请日：2010-11-19

申请人： Niklaus Schneeberger ,  Eric Chappel

发明人： Niklaus Schneeberger ,  Eric Chappel

IPC分类号： F04B43/04 ,  F04B19/00

CPC分类号： F04B43/046 ,  F04B19/006 ,  F04B43/043

摘要： A micropump in the form of a stack comprising, in succession, a flexible diaphragm, a pumping chamber and a closing-off plate, said pumping chamber communicating with the outside, for example via the flexible diaphragm; said diaphragm being furthermore secured to an actuator arranged outside the micropump, characterized in that said diaphragm is secured to the actuator by way of at least one element in the form of a strip, which is rigid along its main axis and flexible in the direction perpendicular to its main axis.

公开(公告)号：US20140147246A1

公开(公告)日：2014-05-29

申请号：US14128925

申请日：2012-06-22

申请人： Eric Chappel ,  Stephan Proennecke ,  Frédéric Neftel

发明人： Eric Chappel ,  Stephan Proennecke ,  Frédéric Neftel

IPC分类号： F04D15/00

CPC分类号： A61M5/14244 ,  A61M5/14593 ,  A61M5/16859 ,  A61M5/16881 ,  A61M5/5086 ,  F04D15/0005

摘要： Method for detecting failure including possible under or over delivery of a micropump having at least an inlet valve, a pumping chamber with an inner pressure sensor and an outlet valve, said method comprising the determination of the pump tightness via the measurement of the pressure by said inner pressure sensor in said pumping chamber at least at certain intervals when the pump is inactive and the comparison with a value of reference.

摘要翻译： 用于检测故障的方法，包括可能在至少具有入口阀的微型泵，或具有内部压力传感器的泵送室和出口阀之间或之后输送的方法，所述方法包括通过所述压力的测量来确定泵的紧度 至少在泵不活动的情况下至少以一定的间隔和与参考值的比较，所述泵送室中的内部压力传感器。

公开(公告)号：US20120048403A1

公开(公告)日：2012-03-01

申请号：US13318669

申请日：2010-05-20

申请人： Eric Chappel ,  Frédéric Neftel

发明人： Eric Chappel ,  Frédéric Neftel

IPC分类号： F16K15/06 ,  F16K15/02

CPC分类号： A61M27/006 ,  A61M5/16881 ,  A61M2205/3344 ,  F16K15/026 ,  F16K15/063 ,  Y10T137/7792 ,  Y10T137/7933

摘要： The regulator comprises at least a cylinder (2) with a fluid inlet connector (1) for receiving fluid at an inlet pressure and a fluid outlet connector (4) for delivering fluid, at least one chamber (3), a rod (5) in said cylinder with one side submitted to the inlet pressure and the other side submitted to the outlet pressure generating a net force counter-balanced by at least one spring means (7) acting on one side of said rod (5) against said inlet pressure, wherein a fluidic pathway is formed between said rod (5) and said cylinder (2) as the major fluidic resistance of the device, wherein a change of the inlet pressure induces a move of the rod along the axis of the cylinder thereby modifying the fluidic resistance of said fluidic pathway, wherein the fluidic resistance of said pathway varies with the applied pressure at the inlet in a predefined range of pressure, inducing a regulated flow rate in the considered range of pressure.

摘要翻译： 调节器至少包括具有用于接收入口压​​力的流体的流体入口连接器（1）和用于输送流体的流体出口连接器（4）的至少一个气缸（2），至少一个腔室（3），杆（5） 在所述气缸中，一侧承受入口压力，另一侧承受出口压力，产生由至少一个弹簧装置（7）反平衡的净力，所述弹簧装置（7）抵抗所述入口压力作用在所述杆（5）的一侧上 ，其中在所述杆（5）和所述气缸（2）之间形成流体通道作为所述装置的主要流体阻力，其中所述入口压力的变化引起所述杆沿着所述气缸的轴线的移动，从而改变 所述流体路径的流体阻力，其中所述通路的流体阻力随预定压力范围内入口处的施加压力而变化，从而在所考虑的压力范围内引起调节流量。

公开(公告)号：US20100324504A1

公开(公告)日：2010-12-23

申请号：US12866840

申请日：2009-02-06

申请人： Eric Chappel ,  Stephan Gamper

发明人： Eric Chappel ,  Stephan Gamper

IPC分类号： A61M5/168 ,  B23P17/00

CPC分类号： A61M5/16881 ,  A61M2205/0244 ,  G05D7/0113 ,  Y10T29/494

摘要： Flow regulator for the infusion of medicaments, comprising, in succession, a substrate (1), a channel (5), a spacer (3) and a membrane (4), the latter having at least one hole (6) communicating with the channel (5), characterized in that the regulator is produced from at least two separate elements (1-4), the first element comprising the membrane (4) and the second element comprising the spacer (3).

摘要翻译： 用于输注药物的流量调节器，包括依次包括基底（1），通道（5），间隔物（3）和膜（4），后者具有至少一个孔（6），与孔 通道（5），其特征在于，所述调节器由至少两个分离的元件（1-4）制成，所述第一元件包括所述膜（4），所述第二元件包括所述间隔物（3）。

公开(公告)号：US20090097037A1

公开(公告)日：2009-04-16

申请号：US11814661

申请日：2006-01-24

申请人： Eric Chappel

发明人： Eric Chappel

IPC分类号： G01B11/02 ,  G01B11/24

CPC分类号： G01F22/00

摘要： The invention relates to a method of measuring a volume in a fluid flow micromechanical device (100) by optically measuring the profile of a surface therein, the method comprising the following steps: a) providing and positioning an optical apparatus (10; 50; 30; 70) for measuring the profile of a surface; b) providing means (24; 44; 64; 84) for acquiring and processing the images coming from the optical apparatus for measuring a profile; c) placing said moving member (133) in a first position and then in a second position, and activating said optical apparatus for measuring the profile of the surface to direct a light beam on said reference face, and activating the image acquisition and processor means to obtain a first image in said first position of the moving member (133) and a second image in said second position; and d) comparing said second image with said first image of said reference face to determine the variation in the volume of the cavity (138) generated by the deformation of the moving member.

摘要翻译： 本发明涉及一种通过光学测量其表面轮廓来测量流体微机械装置（100）中的体积的方法，该方法包括以下步骤：a）提供和定位光学装置（10; 50; 30） ; 70）用于测量表面的轮廓; b）提供用于获取和处理来自光学装置的用于测量轮廓的图像的装置（24; 44; 64; 84） c）将所述移动构件（133）放置在第一位置然后处于第二位置，并且激活所述光学装置以测量所述表面的轮廓以将光束引导到所述参考面上，以及激活所述图像采集和处理器装置 以在所述移动部件（133）的所述第一位置和所述第二位置的第二图像中获得第一图像; 以及d）将所述第二图像与所述参考面的所述第一图像进行比较，以确定由所述移动构件的变形产生的空腔（138）的体积的变化。

公开(公告)号：US20140199181A1

公开(公告)日：2014-07-17

申请号：US14235090

申请日：2012-07-27

申请人： Eric Chappel

发明人： Eric Chappel

IPC分类号： F04B19/00

CPC分类号： F04B19/006 ,  A61M5/14224 ,  F04B43/02 ,  F04B43/043 ,  F04B43/046

摘要： The present invention describes the improvements due to alternated actuation cycles to reduce the delivery errors related to the pumping chamber elasticity, the actuator relaxation or hysteresis. The method actuates a pumping device with an optimal driving voltage profile, wherein the pumping device comprises a pumping chamber including a pumping membrane and a voltage controlled actuator connected to said membrane; the movement of said membrane being defined by three positions, namely a rest, a bottom and a top position. The method includes the actuation of the membrane with a pumping pattern including at least two different cycles: Cycle A: rest-bottom-rest-top-rest Cycle B: rest-top-rest-bottom-rest. The invention also relates to a device to carry out the method.

摘要翻译： 本发明描述了由于交替的致动循环引起的改进，以减少与泵室弹性，致动器松弛或滞后有关的输送误差。 该方法致动具有最佳驱动电压分布的泵送装置，其中泵送装置包括泵送室，泵送室包括泵送膜和连接到所述膜的电压控制致动器; 所述膜的运动由三个位置限定，即休息，底部和顶部位置。 该方法包括用包括至少两个不同循环的泵送模式来致动膜：循环A：休息 - 休息 - 休息 - 休息循环B：休息 - 休息 - 休息 - 休息。 本发明还涉及一种用于执行该方法的装置。

公开(公告)号：US20130272902A1

公开(公告)日：2013-10-17

申请号：US13997523

申请日：2011-12-19

申请人： André Noth ,  Eric Chappel

发明人： André Noth ,  Eric Chappel

IPC分类号： F04B49/00

CPC分类号： F04B49/00 ,  F04B43/0081 ,  F04B43/046 ,  F04B49/065

摘要： A method for actuating a pumping device with an optimal driving voltage, wherein the pumping device comprises a pumping chamber (4) having a pumping membrane (1), an inlet (3) and an outlet chamber (5), a voltage controlled actuator (6) connected to said pumping membrane (1), said pumping membrane reaching a stop position defined by a mechanical stop (2) a sensor for determining whether the pumping membrane has reached said mechanical stop (2); said method comprising a learning and working phase, wherein the learning phase comprises the following steps actuation of the pumping membrane (1) by applying a predetermined actuation voltage Vact to the actuator (6) said pumping membrane (1) reaching said position in an over-actuation step or not reaching said mechanical stop (2) position in an under-actuation process; after the over-actuation step, decreasing the voltage so that the pumping membrane (1) has left said mechanical stop (2) position and storing as the optimal voltage Vact optimal or in the under-actuation step, increasing the voltage so that the pumping membrane (1) reaches said mechanical stop (2) position and storing as the optimal voltage Vact optimal actuating the pumping device in the working phase with the determined optimal voltage value Vact optimal.

摘要翻译： 一种用于以最佳驱动电压致动泵送装置的方法，其中所述泵送装置包括具有泵送膜（1），入口（3）和出口室（5）的泵送室（4），电压控制致动器 6）连接到所述泵送膜（1），所述泵送膜达到由机械止动件（2）限定的停止位置，传感器用于确定泵膜是否到达所述机械止动件（2）; 所述方法包括学习和工作阶段，其中所述学习阶段包括以下步骤：通过将预定的致动电压Vact施加到所述致动器（6）来致动所述泵送膜（1），所述泵送膜（1）到达所述位置 在未致动过程中没有达到所述机械止挡（2）位置; 在过度致动步骤之后，降低电压使得泵膜（1）已经离开所述机械停止（2）位置并且存储为最佳电压Vact最佳或者在低致动步骤中，增加电压使得泵送 膜（1）到达所述机械停止位置（2）并且存储为在确定的最佳电压值Vact最优的工作阶段中使泵送装置致动的最佳电压Vact。

公开(公告)号：US09192720B2

公开(公告)日：2015-11-24

申请号：US13059507

申请日：2008-10-22

申请人： Eric Chappel ,  Niklaus Schneeberger ,  Frédéric Neftel

发明人： Eric Chappel ,  Niklaus Schneeberger ,  Frédéric Neftel

IPC分类号： F04B17/00 ,  A61M5/168 ,  F04B43/04 ,  A61M5/142

CPC分类号： F04B51/00 ,  A61M5/14224 ,  A61M5/168 ,  A61M5/16854 ,  A61M5/365 ,  A61M2005/16863 ,  A61M2005/16868 ,  A61M2205/0244 ,  A61M2205/0294 ,  A61M2205/3355 ,  A61M2205/70 ,  F04B43/043

摘要： The invention concerns a pumping device that includes a pump having a pumping chamber with a variable volume, an inlet that communicates with the pumping chamber and a valve, an outlet that communicates with the pumping chamber and a valve, and an actuator adapted to change the volume of the pumping chamber. A fluidic pathway in the pumping device includes the inlet, the pumping chamber, the outlet, and a downstream line situated downstream of the outlet valve. The pumping device also includes a pressure sensor for measuring the pressure between the valves of the pathway, and a processing means for processing the received pressure data from the pressure sensor. The invention also concerns a method for detecting a dysfunction in the pumping device.

摘要翻译： 本发明涉及一种泵送装置，其包括具有可变容积的泵送室的泵，与泵送室连通的入口和阀，与泵送室连通的出口和阀，以及适于改变 抽水室的体积。 泵送装置中的流体路径包括入口，泵送室，出口以及位于出口阀下游的下游管线。 泵送装置还包括用于测量通道的阀之间的压力的压力传感器和用于处理来自压力传感器的接收的压力数据的处理装置。 本发明还涉及一种用于检测泵送装置中的功能障碍的方法。