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公开(公告)号：US06582955B2
公开(公告)日：2003-06-24
申请号：US09853184
申请日：2001-05-11
IPC分类号： C12M112
CPC分类号： A61M1/3687 , A61F2/022 , A61M1/3472 , A61M1/3475 , A61M1/3489 , A61M1/3689 , C12M23/34 , C12M25/10 , C12M29/10
摘要： A bioreactor having an outer shell compartment containing many coaxial pairs of hollow microporous fibers. An annular compartment exists between an outer surface of the inner hollow microporous fiver and the inner surface of the outer hollow microporous fiber. The annular compartment preferably contains blood or plasma. The blood or plasma is, thus, exposed to two microporous hollow fibers which have fluids which can purify or otherwise affect the blood through the walls of two different microporous hollow fibers. An artificial liver or kidney can result when liver or kidney cells are placed in the shell compartment.
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公开(公告)号：US20070295651A1
公开(公告)日：2007-12-27
申请号：US11475467
申请日：2006-06-26
IPC分类号： B01D63/00
CPC分类号： B01D61/243 , B01D61/28 , B01D63/06 , B01D2313/08 , B01D2313/243 , Y02A20/131
摘要： A disposable mass transfer system includes a source of dialysis fluid, a waste fluid reservoir, at least one semi-permeable tubular membrane residing in at least one fluid flow channel carrying a flow of a dialysis fluid, and a configurable pump and tubing. The pump and tubing may be configured to pump fresh dialysis fluid into the fluid flow channel, or may be configured to re-circulate partially spent dialysis fluid through the fluid flow channel. The fluid flow channel may be the interior of a flexible sealed reservoir, or may be a semi-rigid or rigid tubular enclosure.
摘要翻译： 一次性传质系统包括透析液源，废液储存器，至少一个位于至少一个流体流动通道中的半渗透管状膜，该流体流动通道承载透析流体流，以及可配置的泵和管道。 泵和管道可以被配置为将新鲜的透析流体泵送到流体流动通道中，或者可以被配置为将部分用过的透析流体再循环通过流体流动通道。 流体流动通道可以是柔性密封容器的内部，或者可以是半刚性或刚性管状外壳。
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公开(公告)号：US5373972A
公开(公告)日：1994-12-20
申请号：US39655
申请日：1993-03-30
IPC分类号： B65D83/00 , A61F9/00 , A61J1/05 , A61J1/14 , B05B11/00 , B05B11/04 , B65D47/18 , B65D81/24 , B65D37/00
CPC分类号： B05B11/047 , A61F9/0008 , B05B11/0021 , B05B11/0075 , B05B11/3052 , B65D47/18 , B65D81/24 , A61J1/145 , A61J1/1468 , Y10T137/7838 , Y10T137/7882
摘要： A fluid dispensing system for delivering sterile preservative-free solution is disclosed. The system uses double self-sealing valves mounted in series inside a tip compartment which fits on the outlet of a multiple dosage squeeze container to prevent undesirable retrograde flow of the dispensed liquid back into the bottle during the decompression cycle. The valves used are either positive acting, normally closed duckbill and/or umbrella valve(s) which open to express solution from the container when squeezing pressure is applied to the bottle and which automatically close when the pressure is released. The fluid dispensing system with an umbrella valve near the system outlet has close to zero dead space volume thereby practically eliminated possible contamination of the sterile fluid under the circumferential seal head portion of the umbrella valve and in the container. A hydrophobic filter is provided to sterilize the replacement air which enters the container upon release of the squeezing pressure.
摘要翻译： 公开了用于输送无菌防腐剂溶液的流体分配系统。 该系统使用双重自密封阀，其串联安装在尖端隔室内，该末端隔室装配在多次剂量挤压容器的出口上，以防止在减压循环期间将分配的液体反向流入瓶中。 所使用的阀是正压作用，常闭鸭嘴和/或伞形阀，当压力施加到瓶子时，该阀门打开以从容器表达溶液，并且当压力释放时自动关闭。 具有靠近系统出口的伞阀的流体分配系统具有接近零的死空间体积，从而实际上消除了在伞形阀的圆周密封头部分和容器内的无菌流体的可能污染。 提供疏水过滤器以在释放挤压压力时对进入容器的置换空气进行消毒。
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公开(公告)号：US5783075A
公开(公告)日：1998-07-21
申请号：US880970
申请日：1997-06-23
申请人： Roy Eddleman , F. Jesus Martinez , William Martin , Dieter Stute
发明人： Roy Eddleman , F. Jesus Martinez , William Martin , Dieter Stute
CPC分类号： B01L3/502 , B01D61/28 , G01N2001/4016
摘要： A disposable dialysis apparatus which floats in a dialysate solution. The apparatus has a membrane support ring with a central opening surrounded by a downwardly extending tube. The open bottom of the tube supports a dialysis membrane. After the membrane has been loaded with a sample, the membrane is closed and the apparatus is suspended in the dialysate solution.
摘要翻译： 透析液一次性透析装置。 该装置具有膜支撑环，其中心开口被向下延伸的管包围。 管的开口底部支撑透析膜。 在膜已经装载样品之后，关闭膜并将该装置悬浮在透析液中。
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公开(公告)号：US5310094A
公开(公告)日：1994-05-10
申请号：US792989
申请日：1991-11-15
CPC分类号： B65D81/24 , B05B11/0021 , B05B11/0075 , B05B11/047 , B65D47/18 , A61J1/145 , Y10T137/7838 , Y10T137/7882
摘要： A fluid dispensing system for delivering sterile preservative free solution is disclosed. The system uses double self-sealing valves mounted in series inside a tip compartment which fits on the outlet of a multiple dosage squeeze container to prevent undesirable retrograde flow of the dispensed liquid back into the bottle during the decompression cycle. The valves used are positive acting, normally closed duckbill valves which open to express solution from the container when squeezing pressure is applied to the bottle and which automatically close when the pressure is released. A hydrophobic filter is provided to sterilize the replacement air which enters the container upon release of the squeezing pressure.
摘要翻译： 公开了用于递送无菌防腐剂溶液的流体分配系统。 该系统使用双重自密封阀，其串联安装在尖端隔室内，该末端隔室装配在多次剂量挤压容器的出口上，以防止在减压循环期间将分配的液体反向流入瓶中。 所使用的阀是正向作用的常闭鸭嘴阀，当挤压压力施加到瓶子上时，打开以从容器表达溶液，并且当压力释放时自动关闭。 提供疏水过滤器以在释放挤压压力时对进入容器的置换空气进行消毒。
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公开(公告)号：US4734198A
公开(公告)日：1988-03-29
申请号：US577387
申请日：1984-02-06
申请人： William H. Harm , Larry E. Fuller , Earnest R. Caine , Raymond F. Cracauer , Louis C. Cosentino , F. Jesus Martinez
发明人： William H. Harm , Larry E. Fuller , Earnest R. Caine , Raymond F. Cracauer , Louis C. Cosentino , F. Jesus Martinez
CPC分类号： B01F15/0254 , A61M1/1656 , A61M1/1666 , B01F1/0022 , B01F1/0038 , B01F5/106
摘要： A system and process for preparation of dialysis solution from dry chemicals and water on a large scale batch basis. The required amount of water is metered into a dialysis solution tank. Water from the tank is pumped into a spray head which is positioned above a shipping drum containing predetermined amounts of chemicals. Water rains down on the chemicals dissolving and/or entraining the same and the resulting slurry is returned to the dialysate tank as a slurry by means of a pickup wand and suction source. The liquid and chemicals in the dialysis solution tank are continually cycled until all the chemicals in the drum have been removed. Typically, an additional drum containing other kinds of chemicals is then added to the dialysis solution tank in the same manner. Circulation of the solution is continued within the tank until a fully uniform solution results. Dialysis solution in the tank is then filtered and checked for conductivity prior to its direct use in hemodialysis or dilution in a conventional proportioning system.
摘要翻译： 一种大规模批量制备干粉和水的透析液系统和方法。 将所需量的水计量到透析溶液罐中。 来自罐的水被泵送到喷雾头中，该喷头位于包含预定量化学品的运输滚筒上方。 在溶解和/或夹带的化学物质上下沉下来，所得到的浆液通过拾取杆和抽吸源作为浆料返回到透析液罐中。 透析溶液罐中的液体和化学物质不断循环，直到滚筒中的所有化学物质被去除。 通常，以相同的方式将含有其它种类化学物质的另外的鼓加入到透析溶液罐中。 溶液的循环在罐内继续进行，直到得到完全均匀的溶液。 然后将透析溶液过滤并检查其电导率，然后直接用于血液透析或常规配比系统中的稀释。
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公开(公告)号：US4016081A
公开(公告)日：1977-04-05
申请号：US462674
申请日：1974-04-22
IPC分类号： A61H20060101 , A61M20060101 , A61M1/04 , A61M1/22 , B01D20060101 , B01D61/24 , B01D63/08 , B01D31/00
CPC分类号： B01D61/28 , B01D63/082 , B01D2313/08
摘要： A diffusion device is disclosed made from a stack of pairs of semi-permeable membrane walls and plate members positioned between adjacent membrane wall pairs for support thereof. Flow conduits extend transversely of the stack in communication with flow passages between the membranes or between each membrane and each adjacent plate member. In accordance with this invention, staging means are provided for directing fluid in the flow passages successively along different membrane wall pairs to lengthen the fluid path of flow for improved diffusion. The staging means comprises an occluding member in the transversely extending flow conduits, positioned to redirect flow received from along one membrane wall pair along another membrane wall pair.
摘要翻译： 公开了一种扩散装置，其由一对半透膜壁和位于相邻膜壁对之间的板构件的堆叠制成，用于支撑它们。 流动导管横向延伸，与膜之间的流动通道或每个膜与每个相邻的板构件之间的流动通道连通。 根据本发明，提供了分级装置，用于沿着不同的膜壁对连续地引导流体在流动通道中以延长流体的流体路径以改善扩散。 分级装置包括在横向延伸的流动管道中的闭塞构件，其被定位成沿着另一个膜壁对沿着沿着一个膜壁对接收的流动。
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