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    NOVEL METHOD FOR THE ASYMMETRIC SYNTHESIS OF BETA-LACTONE COMPOUNDS
    1.
    发明申请
    NOVEL METHOD FOR THE ASYMMETRIC SYNTHESIS OF BETA-LACTONE COMPOUNDS 失效
    用于不对称合成BETA-LACTONE化合物的新方法

    公开(公告)号：US20100173982A1

    公开(公告)日：2010-07-08

    申请号：US12620412

    申请日：2009-11-17

    申请人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel ,  Daniel Romo ,  Vikram Purohit ,  Gil Ma

    发明人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel ,  Daniel Romo ,  Vikram Purohit ,  Gil Ma

    IPC分类号： A61K31/335 ,  C07D305/12

    CPC分类号： A61K31/336 ,  A61K31/335 ,  A61K31/337 ,  A61K31/365 ,  A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/445 ,  A61K31/585 ,  G01N33/5011 ,  G01N2333/91057

    摘要： The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

    摘要翻译： 本发明的特征在于通过向受试者施用有效量的β-内酯来治疗受试者的癌症的方法。 本发明还具有通过向受试者施用有效量的脂肪酸合酶抑制剂来抑制受试者血管生成的方法。 这些方法可用于治疗各种癌症和其他疾病和病症。 本发明还涉及鉴定可用于本发明治疗肿瘤，抑制血管发生以及涉及病理性血管生成的疾病和病症的治疗的β-内酯和其它化合物的方法。 本发明还具有合成β-内酯并具有新型β-内酯化合物特征的方法。

    Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
    3.
    发明授权
    Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation 失效
    通过β-内酯和其他化合物抑制脂肪酸合酶抑制细胞增殖

    公开(公告)号：US07799826B2

    公开(公告)日：2010-09-21

    申请号：US10418513

    申请日：2003-04-16

    申请人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel

    发明人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel

    IPC分类号： A61K31/335

    CPC分类号： A61K31/337 ,  A61K31/335 ,  A61K31/336 ,  A61K31/365 ,  A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/445 ,  A61K31/585 ,  G01N33/5011 ,  G01N2333/91057

    摘要： The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis.

    摘要翻译： 本发明的特征在于通过向受试者施用有效量的β-内酯来治疗受试者的癌症的方法。 本发明还具有通过向受试者施用有效量的脂肪酸合酶抑制剂来抑制受试者血管生成的方法。 这些方法可用于治疗各种癌症和其他疾病和病症。 本发明还涉及鉴定可用于本发明治疗肿瘤，抑制血管发生以及涉及病理性血管生成的疾病和病症的治疗的β-内酯和其它化合物的方法。

    Method for the asymmetric synthesis of beta-lactone compounds
    4.
    发明授权
    Method for the asymmetric synthesis of beta-lactone compounds 失效
    β-内酯化合物的不对称合成方法

    公开(公告)号：US08124794B2

    公开(公告)日：2012-02-28

    申请号：US12620412

    申请日：2009-11-17

    申请人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel ,  Daniel Romo ,  Vikram Purohit ,  Gil Ma

    发明人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel ,  Daniel Romo ,  Vikram Purohit ,  Gil Ma

    IPC分类号： C07D305/00

    CPC分类号： A61K31/336 ,  A61K31/335 ,  A61K31/337 ,  A61K31/365 ,  A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/445 ,  A61K31/585 ,  G01N33/5011 ,  G01N2333/91057

    摘要： The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

    摘要翻译： 本发明的特征在于通过向受试者施用有效量的β-内酯来治疗受试者的癌症的方法。 本发明还具有通过向受试者施用有效量的脂肪酸合酶抑制剂来抑制受试者血管生成的方法。 这些方法可用于治疗各种癌症和其他疾病和病症。 本发明还涉及鉴定可用于本发明治疗肿瘤，抑制血管发生以及涉及病理性血管生成的疾病和病症的治疗的β-内酯和其它化合物的方法。 本发明还具有合成β-内酯并具有新型β-内酯化合物特征的方法。

    Method for the asymmetric synthesis of beta-lactone compounds
    6.
    发明授权
    Method for the asymmetric synthesis of beta-lactone compounds 失效
    β-内酯化合物的不对称合成方法

    公开(公告)号：US07728153B2

    公开(公告)日：2010-06-01

    申请号：US11378961

    申请日：2006-03-16

    申请人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel ,  Daniel Romo ,  Vikram Purohit ,  Gil Ma

    发明人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel ,  Daniel Romo ,  Vikram Purohit ,  Gil Ma

    IPC分类号： C07D305/00

    CPC分类号： A61K31/336 ,  A61K31/335 ,  A61K31/337 ,  A61K31/365 ,  A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/445 ,  A61K31/585 ,  G01N33/5011 ,  G01N2333/91057

    摘要： The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

    摘要翻译： 本发明的特征在于通过向受试者施用有效量的β-内酯来治疗受试者的癌症的方法。 本发明还具有通过向受试者施用有效量的脂肪酸合酶抑制剂来抑制受试者血管生成的方法。 这些方法可用于治疗各种癌症和其他疾病和病症。 本发明还涉及鉴定可用于本发明治疗肿瘤，抑制血管发生以及涉及病理性血管生成的疾病和病症的治疗的β-内酯和其它化合物的方法。 本发明还具有合成β-内酯并具有新型β-内酯化合物特征的方法。

    Novel method for the asymmetric synthesis of beta-lactone compounds
    8.
    发明申请
    Novel method for the asymmetric synthesis of beta-lactone compounds 失效
    β-内酯化合物的不对称合成的新方法

    公开(公告)号：US20060258620A1

    公开(公告)日：2006-11-16

    申请号：US11378961

    申请日：2006-03-16

    申请人： Jeffrey Smith ,  Fumiko Axelrod ,  Steven Kridel ,  Daniel Romo ,  Vikram Purohit ,  Gil Ma

    发明人： Jeffrey Smith ,  Fumiko Axelrod ,  Steven Kridel ,  Daniel Romo ,  Vikram Purohit ,  Gil Ma

    IPC分类号： A61K31/695 ,  A61K31/337 ,  A61K31/365

    CPC分类号： A61K31/336 ,  A61K31/335 ,  A61K31/337 ,  A61K31/365 ,  A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/445 ,  A61K31/585 ,  G01N33/5011 ,  G01N2333/91057

    摘要： The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

    摘要翻译： 本发明的特征在于通过向受试者施用有效量的β-内酯来治疗受试者的癌症的方法。 本发明还具有通过向受试者施用有效量的脂肪酸合酶抑制剂来抑制受试者血管生成的方法。 这些方法可用于治疗各种癌症和其他疾病和病症。 本发明还涉及鉴定可用于本发明治疗肿瘤，抑制血管发生以及涉及病理性血管生成的疾病和病症的治疗的β-内酯和其它化合物的方法。 本发明还具有合成β-内酯并具有新型β-内酯化合物特征的方法。