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公开(公告)号：US20080187532A1
公开(公告)日：2008-08-07
申请号：US11905392
申请日：2007-09-28
申请人： Austin Gurney , Fumiko Axelrod , Tim Hoey , Sanjeev Satyal
发明人： Austin Gurney , Fumiko Axelrod , Tim Hoey , Sanjeev Satyal
IPC分类号： A61K39/395 , C07K16/18 , C12N15/00 , C12N5/06 , G01N33/574 , C12P21/04 , A61P43/00
CPC分类号： A61K39/39558 , A61K31/4745 , A61K31/513 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of treating cancer comprising administering a therapeutically effective amount of an anti-DLL4 antibody.
摘要翻译： 描述了特异性结合人DLL4的细胞外结构域并影响包含癌干细胞的肿瘤生长的分离的抗体。 还描述了治疗癌症的方法，包括施用治疗有效量的抗DLL4抗体。
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公开(公告)号：US20080064049A1
公开(公告)日：2008-03-13
申请号：US11591019
申请日：2006-10-31
申请人： Michael Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gumey , Pierro Dalerba , Grace Chen , Mark Prince
发明人： Michael Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gumey , Pierro Dalerba , Grace Chen , Mark Prince
IPC分类号： G01N33/574 , C12N5/06
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译： 本发明涉及用于表征，治疗和诊断癌症的组合物和方法。 特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。
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公开(公告)号：US09376497B2
公开(公告)日：2016-06-28
申请号：US12782429
申请日：2010-05-18
申请人： Austin Gurney , Fumiko Axelrod , Tim Hoey , Sanjeev Satyal
发明人： Austin Gurney , Fumiko Axelrod , Tim Hoey , Sanjeev Satyal
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , A61K39/00
CPC分类号： A61K39/39558 , A61K31/4745 , A61K31/513 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of treating cancer comprising administering a therapeutically effective amount of an anti-DLL4 antibody.
摘要翻译： 描述了特异性结合人DLL4的细胞外结构域并影响包含癌干细胞的肿瘤生长的分离的抗体。 还描述了治疗癌症的方法，包括施用治疗有效量的抗DLL4抗体。
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公开(公告)号：US07750124B2
公开(公告)日：2010-07-06
申请号：US11905392
申请日：2007-09-28
申请人： Austin Gurney , Fumiko Axelrod , Tim Hoey , Sanjeev Satyal
发明人： Austin Gurney , Fumiko Axelrod , Tim Hoey , Sanjeev Satyal
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04
CPC分类号： A61K39/39558 , A61K31/4745 , A61K31/513 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of treating cancer comprising administering a therapeutically effective amount of an anti-DLL4 antibody.
摘要翻译： 描述了特异性结合人DLL4的细胞外结构域并影响包含癌干细胞的肿瘤生长的分离的抗体。 还描述了治疗癌症的方法，包括施用治疗有效量的抗DLL4抗体。
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公开(公告)号：US20100316637A1
公开(公告)日：2010-12-16
申请号：US12782429
申请日：2010-05-18
申请人： AUSTIN GURNEY , FUMIKO AXELROD , TIM HOEY , SANJEEV SATYAL
发明人： AUSTIN GURNEY , FUMIKO AXELROD , TIM HOEY , SANJEEV SATYAL
IPC分类号： A61K39/395 , C07K16/18 , A61P35/00
CPC分类号： A61K39/39558 , A61K31/4745 , A61K31/513 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of treating cancer comprising administering a therapeutically effective amount of an anti-DLL4 antibody.
摘要翻译： 描述了特异性结合人DLL4的细胞外结构域并影响包含癌干细胞的肿瘤生长的分离的抗体。 还描述了治疗癌症的方法，包括施用治疗有效量的抗DLL4抗体。
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公开(公告)号：US20100169990A1
公开(公告)日：2010-07-01
申请号：US12650873
申请日：2009-12-31
申请人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Grace Chen , Mark Prince
发明人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Grace Chen , Mark Prince
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译： 本发明涉及用于表征，治疗和诊断癌症的组合物和方法。 特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。
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公开(公告)号：US07723112B2
公开(公告)日：2010-05-25
申请号：US11591019
申请日：2006-10-31
申请人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Mark Prince , Grace Chen
发明人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Mark Prince , Grace Chen
IPC分类号： G01N33/53
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译： 本发明涉及用于表征，治疗和诊断癌症的组合物和方法。 特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。
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