公开(公告)号：US20050084532A1

公开(公告)日：2005-04-21

申请号：US10505441

申请日：2003-03-11

申请人： Steven Howdle ,  Kevin Shakesheff ,  Martin Whitaker ,  Felicity Rosamari Rose

发明人： Steven Howdle ,  Kevin Shakesheff ,  Martin Whitaker ,  Felicity Rosamari Rose

IPC分类号： C12N11/02 ,  A61K6/083 ,  A61K6/087 ,  A61K6/09 ,  A61K6/097 ,  A61K8/64 ,  A61K8/73 ,  A61K8/96 ,  A61K8/97 ,  A61K8/98 ,  A61K9/16 ,  A61K35/12 ,  A61L27/00 ,  A61L27/38 ,  A61L27/56 ,  A61P43/00 ,  C08J3/20 ,  A61K9/14

CPC分类号： A61L27/3804 ,  A61K9/1647 ,  A61L27/3847 ,  A61L27/56

摘要： A process for the preparation of a polymer composite loaded with functioning matter wherein the process comprises contacting a polymer substrate and functioning matter with a plasticising fluid or mixture of plasticising fluids under plasticising conditions to plasticise and/or swell the polymer and incorporate the functioning matter, and releasing the plasticising fluid to obtain the polymer composite, wherein contacting is at a pressure in the range 1 to 1000 bar and a temperature in the range −200 to +500C, selected in manner that at least a proportion of functioning matter does not freeze or refreeze during processing, or if at a temperature at which freezing or refreezing may occur, that either matter is desiccated or a pressure constraint is applied whereby pressure is in a range having a maximum pressure less than 1000 bar throughout contact of functioning matter and plasticising fluid, whereby at least a proportion of functioning matter retains its function in the polymer composite; A polymer composite obtained with the process; A scaffold comprising a polymer composite loaded with functioning matter, optionally additionally comprising biofunctional materials; An apparatus for use in the preparation of the polymer composite or with use of the process; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.

摘要翻译： 一种用于制备装载有功能物质的聚合物复合物的方法，其中该方法包括在塑化条件下使聚合物基质和功能物质与塑化流体或塑化流体的混合物接触以使聚合物塑化和/或溶胀并结合功能性物质， 并释放塑化流体以获得聚合物复合材料，其中接触处于1至1000巴的压力和-200至+ 500℃范围内的温度，其选择方式为至少一部分功能物质不会冻结 或在加工过程中重新冻结，或者如果在可能发生冷冻或再冻结的温度下，任何一种物质都被干燥或施加压力约束，从而在功能物质和增塑剂的接触过程中，压力在最大压力小于1000巴的范围内 流体，其中功能物质的至少一部分保留其在聚合物组合物中的功能 现场; 用该方法得到的聚合物复合物; 一种支架，其包含负载功能物质的聚合物复合物，任选地另外包含生物功能材料; 用于制备聚合物复合材料或使用该方法的设备; 以及将复合材料用作药物递送的支持物或支架，用于生物修复，作为用于人或动物或植物物质的生物催化剂或生物保护剂，用作结构成分，例如包含聚合物和任选的其它合成或天然 用于医疗或手术插入的金属，塑料，碳或玻璃纤维网，稀松布，棒或类似的增强物作为固体整体作为骨或组织插入，作为用于湿插入骨或牙齿中的填料或水泥，或作为固体聚集体或整料 用于诸如针或诸如牙冠等牙科植入物的矫形植入物