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公开(公告)号：US20050084532A1
公开(公告)日：2005-04-21
申请号：US10505441
申请日：2003-03-11
IPC分类号： C12N11/02 , A61K6/083 , A61K6/087 , A61K6/09 , A61K6/097 , A61K8/64 , A61K8/73 , A61K8/96 , A61K8/97 , A61K8/98 , A61K9/16 , A61K35/12 , A61L27/00 , A61L27/38 , A61L27/56 , A61P43/00 , C08J3/20 , A61K9/14
CPC分类号： A61L27/3804 , A61K9/1647 , A61L27/3847 , A61L27/56
摘要： A process for the preparation of a polymer composite loaded with functioning matter wherein the process comprises contacting a polymer substrate and functioning matter with a plasticising fluid or mixture of plasticising fluids under plasticising conditions to plasticise and/or swell the polymer and incorporate the functioning matter, and releasing the plasticising fluid to obtain the polymer composite, wherein contacting is at a pressure in the range 1 to 1000 bar and a temperature in the range −200 to +500C, selected in manner that at least a proportion of functioning matter does not freeze or refreeze during processing, or if at a temperature at which freezing or refreezing may occur, that either matter is desiccated or a pressure constraint is applied whereby pressure is in a range having a maximum pressure less than 1000 bar throughout contact of functioning matter and plasticising fluid, whereby at least a proportion of functioning matter retains its function in the polymer composite; A polymer composite obtained with the process; A scaffold comprising a polymer composite loaded with functioning matter, optionally additionally comprising biofunctional materials; An apparatus for use in the preparation of the polymer composite or with use of the process; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.
摘要翻译： 一种用于制备装载有功能物质的聚合物复合物的方法，其中该方法包括在塑化条件下使聚合物基质和功能物质与塑化流体或塑化流体的混合物接触以使聚合物塑化和/或溶胀并结合功能性物质， 并释放塑化流体以获得聚合物复合材料，其中接触处于1至1000巴的压力和-200至+ 500℃范围内的温度，其选择方式为至少一部分功能物质不会冻结 或在加工过程中重新冻结，或者如果在可能发生冷冻或再冻结的温度下，任何一种物质都被干燥或施加压力约束，从而在功能物质和增塑剂的接触过程中，压力在最大压力小于1000巴的范围内 流体，其中功能物质的至少一部分保留其在聚合物组合物中的功能 现场; 用该方法得到的聚合物复合物; 一种支架，其包含负载功能物质的聚合物复合物，任选地另外包含生物功能材料; 用于制备聚合物复合材料或使用该方法的设备; 以及将复合材料用作药物递送的支持物或支架，用于生物修复，作为用于人或动物或植物物质的生物催化剂或生物保护剂，用作结构成分，例如包含聚合物和任选的其它合成或天然 用于医疗或手术插入的金属，塑料，碳或玻璃纤维网，稀松布，棒或类似的增强物作为固体整体作为骨或组织插入，作为用于湿插入骨或牙齿中的填料或水泥，或作为固体聚集体或整料 用于诸如针或诸如牙冠等牙科植入物的矫形植入物
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公开(公告)号：US20070254035A1
公开(公告)日：2007-11-01
申请号：US10576909
申请日：2004-10-22
申请人： Jianyuan Hao , Martin Whitaker , Kevin Shakesheff , Steven Howdle
发明人： Jianyuan Hao , Martin Whitaker , Kevin Shakesheff , Steven Howdle
CPC分类号： C08J9/12 , B01J3/008 , B29C44/12 , C08J9/14 , C08J2201/03 , C08J2203/06 , C08J2203/08 , C08J2203/12 , C08J2203/14 , C08J2203/142
摘要： Process for preparing active polymer extrudate comprising polymer matrix and guest matter, the process comprising contacting a polymer substrate and guest matter with a plasticising fluid under dense phase, sub critical or supercritical plasticising conditions of elevated temperature and/or pressure to plasticise the polymer substrate and incorporate guest matter and extruding polymer substrate incorporating guest matter under dense phase, sub critical or supercritical conditions via an extrusion orifice into a collection zone or a mould with simultaneous or subsequent release of pressure, whereby extrudate is obtained comprising a solid admixture of polymer matrix and guest matter in form conferred by the orifice or the mould; a novel extrudate; composition thereof and apparatus for the preparation thereof, and use thereof in fibre processing techniques, medical applications such as in delivery of drugs and other agents such as imaging and diagnostic agents, tissue engineering, and as medical devices or aids such as delivery devices or aids for drugs, imaging and diagnostic agents, as tissue engineering devices or aids such as sutures, and the like; as an anti-microbial for example having bacteria-static or -cidal activity; as a natural or synthetic barrier capable of immobilising e.g. naturally occurring or artificially introduced poisons or toxins by e.g. absorption, interaction or reaction; in agrochemical or crop protection applications; in the processing of thermally labile fibres for use in dying, textiles, electronics etc below the polymer Tg, Tm or viscosity; in incorporation of dyes and other thermally labile materials into polymers that cannot be formed by traditional processes e.g. melt extrusion and the like; or in incorporation of surfactants into fibres to control polymer properties.
摘要翻译： 制备包含聚合物基质和客体物质的活性聚合物挤出物的方法，该方法包括在高温和/或高压的密相，亚临界或超临界塑化条件下使聚合物基质和客体物质与增塑流体接触，以塑化聚合物基材和 将客体物质和挤出聚合物基材在密相，亚临界或超临界条件下通过挤出孔引入收集区或模具中，同时或随后释放压力，由此得到包含聚合物基质和固体混合物的固体混合物的挤出物 由孔或模具赋予的形式的客体; 新型挤出物 其制备方法及其制备方法及其在纤维加工技术中的应用，医药应用如药物递送和其它试剂如成像和诊断试剂，组织工程，以及作为医疗装置或辅助剂例如递送装置或助剂 用作药物，成像和诊断剂，作为组织工程装置或诸如缝合线等辅助物品; 作为抗微生物剂，例如具有细菌静止或杀生物活性; 作为能够固定的天然或合成屏障。 天然存在或人为引入的毒素或毒素。 吸收，相互作用或反应; 在农业或作物保护应用中; 在聚合物Tg，Tm或粘度以下的用于染色，纺织品，电子等的热不稳定纤维的加工; 将染料和其他热不稳定材料并入聚合物中，所述聚合物不能通过传统方法形成，例如 熔融挤出等; 或将表面活性剂掺入纤维中以控制聚合物性质。
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公开(公告)号：US20050084533A1
公开(公告)日：2005-04-21
申请号：US10506618
申请日：2003-03-10
CPC分类号： A61K9/0024 , A61K9/1647 , C08J3/203
摘要： A process for the preparation of a polymer composite comprising internally distributed deposition matter wherein the process comprises providing a deposit of deposition matter at the surface of a solid state polymer substrate, contacting the surface deposited polymer with a plasticising fluid or a mixture of plasticising fluids under plasticising conditions to plasticise and/or swell the polymer and internally distribute deposition matter, and releasing the plasticising fluid or fluids to obtain polymer composite.; A polymer composite comprising a porous or non porous polymer throughout which particulate deposition matter as hereinbefore defined is distributed with desired uniformity, preferably with high uniformity in excess of 80% for example in excess of 98%.; A scaffold comprising a polymer composite having internally distributed deposition matter; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.
摘要翻译： 一种用于制备包含内部分布的沉积物质的聚合物复合材料的方法，其中所述方法包括在固态聚合物基材的表面提供沉积物沉积物，使表面沉积聚合物与塑化流体或塑化流体的混合物接触， 增塑和/或溶胀聚合物并内部分散沉积物质，以及释放塑化流体或流体以获得聚合物复合材料的塑化条件; 包含多孔聚合物或非多孔聚合物的聚合物复合材料，其中如上文所定义的颗粒沉积物质以所需的均匀性分布，优选具有超过80％，例如超过98％的高均匀性。 一种支架，其包括具有内部分布的沉积物质的聚合物复合材料; 以及将复合材料用作药物递送的支持物或支架，用于生物修复，作为用于人或动物或植物物质的生物催化剂或生物保护剂，用作结构成分，例如包含聚合物和任选的其它合成或天然 用于医疗或手术插入的金属，塑料，碳或玻璃纤维网，稀松布，棒或类似的增强物作为固体整体作为骨或组织插入，作为用于湿插入骨或牙齿中的填料或水泥，或作为固体聚集体或整料 用于诸如针或诸如牙冠等牙科植入物的矫形植入物
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公开(公告)号：US06855329B1
公开(公告)日：2005-02-15
申请号：US09600502
申请日：1999-01-20
IPC分类号： A61K47/48 , A61L27/00 , A61L27/34 , A61L27/58 , A61L31/00 , A61L31/10 , A61L31/14 , A01N25/08 , A01N43/04 , A61F2/00 , C12Q1/68 , A01N61/90
CPC分类号： A61L31/148 , A61L27/34 , A61L27/58 , A61L31/10 , C08L89/00
摘要： The invention provides a biodegradable and biocompatible polymer article having a surface wherein a biologically active ligand is provided on said surface in a spatially controlled pattern. The pattern may be formed using a poly(dimethyl siloxane) mold. The biologically active ligand may be attached to the polymer article by a biotin-avidin-biotin linkage.
摘要翻译： 本发明提供了具有表面的可生物降解和生物相容的聚合物制品，其中在空间控制图案中在所述表面上提供生物活性配体。 图案可以使用聚（二甲基硅氧烷）模具形成。 生物活性配体可以通过生物素 - 抗生物素蛋白 - 生物素键连接到聚合物制品上。
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5.发明申请Polymer Particles Prepared From Polymerisable Alkylene Glycol (Meth) Acrylate Monomers 有权由可聚合的亚烷基二醇（甲基）丙烯酸酯单体制备的聚合物颗粒公开(公告)号：US20110305767A1
公开(公告)日：2011-12-15
申请号：US13123737
申请日：2009-10-13
申请人： Cameron Alexander , Kevin Shakesheff , Liang He , Martyn Davies , Wenxin Wang , Brian Saunders
发明人： Cameron Alexander , Kevin Shakesheff , Liang He , Martyn Davies , Wenxin Wang , Brian Saunders
IPC分类号： A61K9/14 , A61K35/12 , A61P43/00 , A23L1/22 , A61K38/18 , A61K8/81 , A61Q13/00 , C08F216/04 , A61K47/32
CPC分类号： C12N5/0068 , C08F2220/286 , C08F2220/287 , C12M25/14 , C12N2533/40 , C12N2539/10
摘要： The invention provides polymer particles that are obtainable by a method selected from emulsion methods, diffusion methods and evaporation methods carried out in the presence of surface-engineering surfactant which is one or more polymer that displays a lower critical solution temperature, in aqueous media, that is between 10 to 90° C., this polymer being the polymerisation product of one or more monomer selected from polymerisable alkyleneglycol acrylate monomers and polymerisable alkyleneglycol methacrylate monomers. The polymer particles can be used in controlled release applications, such as flavour release applications, fragrance release applications and biomedical applications. The invention also provides a cell support matrix comprising the polymer particles.
摘要翻译： 本发明提供聚合物颗粒，其可通过选自乳液法，扩散方法和蒸发方法获得的方法，所述方法是在表面工程表面活性剂存在下进行的，所述表面工程表面活性剂是在水介质中显示较低临界溶解温度的一种或多种聚合物， 在10至90℃之间，该聚合物是一种或多种选自可聚合的亚烷基二醇丙烯酸酯单体和可聚合的亚烷基二醇甲基丙烯酸酯单体的单体的聚合产物。 聚合物颗粒可用于控制释放应用，例如香料释放应用，香料释放应用和生物医学应用。 本发明还提供了包含聚合物颗粒的细胞支持基质。
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6.发明授权Polymer particles prepared from polymerisable alkylene glycol (meth) acrylate monomers 有权由可聚合的亚烷基二醇（甲基）丙烯酸酯单体制备的聚合物颗粒公开(公告)号：US08940336B2
公开(公告)日：2015-01-27
申请号：US13123737
申请日：2009-10-13
申请人： Cameron Alexander , Kevin Shakesheff , Liang He , Martyn Davies , Wenxin Wang , Brian Saunders
发明人： Cameron Alexander , Kevin Shakesheff , Liang He , Martyn Davies , Wenxin Wang , Brian Saunders
IPC分类号： A61K9/50 , A61K9/14 , C12N5/00 , C12M1/12 , C08F220/28
CPC分类号： C12N5/0068 , C08F2220/286 , C08F2220/287 , C12M25/14 , C12N2533/40 , C12N2539/10
摘要： The invention provides polymer particles that are obtainable by a method selected from emulsion methods, diffusion methods and evaporation methods carried out in the presence of surface-engineering surfactant which is one or more polymer that displays a lower critical solution temperature, in aqueous media, that is between 10 to 90° C., this polymer being the polymerization product of one or more monomer selected from polymerisable alkyleneglycol acrylate monomers and polymerisable alkyleneglycol methacrylate monomers. The polymer particles can be used in controlled release applications, such as flavour release applications, fragrance release applications and biomedical applications. The invention also provides a cell support matrix comprising the polymer particles.
摘要翻译： 本发明提供聚合物颗粒，其可通过选自乳液法，扩散方法和蒸发方法获得的方法，所述方法是在表面工程表面活性剂存在下进行的，所述表面工程表面活性剂是在水介质中显示较低临界溶解温度的一种或多种聚合物， 在10至90℃之间，该聚合物是一种或多种选自可聚合的亚烷基二醇丙烯酸酯单体和可聚合的亚烷基二醇甲基丙烯酸酯单体的单体的聚合产物。 聚合物颗粒可用于控制释放应用，例如香料释放应用，香料释放应用和生物医学应用。 本发明还提供了包含聚合物颗粒的细胞支持基质。
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公开(公告)号：US20080108551A1
公开(公告)日：2008-05-08
申请号：US11823209
申请日：2007-06-27
申请人： Adele Horobin , Kevin Shakesheff , David Pritchard
发明人： Adele Horobin , Kevin Shakesheff , David Pritchard
CPC分类号： C12N9/6408 , A61K38/00
摘要： The invention generally provides compositions and methods that promote wound healing. Such compositions comprise isolated L. sericata polypeptides having serine protease activity. Desirably, the serine protease degrades fibronectin. The invention further provides biologically active fragments of fibronectin that promote wound healing that are the degradation products of incubation with ES.
摘要翻译： 本发明通常提供促进伤口愈合的组合物和方法。 这种组合物包含具有丝氨酸蛋白酶活性的分离的丝胶多糖。 希望丝氨酸蛋白酶降解纤连蛋白。 本发明还提供促进伤口愈合的纤连蛋白的生物活性片段，其是与ES孵育的降解产物。
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公开(公告)号：US06800296B1
公开(公告)日：2004-10-05
申请号：US09314540
申请日：1999-05-19
IPC分类号： A61K914
CPC分类号： B82Y5/00 , A61K47/665
摘要： The present invention provides a novel surface engineering strategy that uses biomolecular interactions to immobilize surface modifying ligands on biomaterial architectures. The surface modified compositions resulting from the inventive method are useful in many contexts, including, but not limited to, scaffolds for tissue engineering and as vehicles for site specific drug delivery. In one preferred embodiment, the biomolecular interaction is achieved by using an “anchor-adapter-tag” system, in which an adapter which can interact specifically and with high selectivity with an anchor molecule (present on the biodegradable surface) and a tag (bound to the ligand to be immobilized) simultaneously is used in attaching the ligand to the surface in a manner which is stable in vitro or in vivo. In another preferred embodiment, the biomolecular interaction is achieved by using an “anchor-tag” system, in which the anchor simultaneously acts to effect attachment to the architecture and mediate direct interaction with the tag.
摘要翻译： 本发明提供了一种使用生物分子相互作用将表面改性配体固定在生物材料结构上的新型表面工程策略。 由本发明方法得到的表面改性组合物在许多情况下是有用的，包括但不限于用于组织工程的支架和作为位点特异性药物递送的载体。 在一个优选的实施方案中，生物分子相互作用通过使用“锚 - 适配器 - 标签”系统来实现，其中可以与锚定分子（存在于可生物降解的表面上）特异性并且以高选择性相互作用的接头和标签 与待固定的配体同时用于以配体在体外或体内稳定的方式将配体连接到表面。 在另一个优选实施方案中，生物分子相互作用通过使用“锚 - 标签”系统来实现，其中锚同时作用于实现对结构的附着并且介导与标签的直接相互作用。
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