公开(公告)号：US20050084532A1

公开(公告)日：2005-04-21

申请号：US10505441

申请日：2003-03-11

Applicant: Steven Howdle ,  Kevin Shakesheff ,  Martin Whitaker ,  Felicity Rosamari Rose

Inventor： Steven Howdle ,  Kevin Shakesheff ,  Martin Whitaker ,  Felicity Rosamari Rose

IPC: C12N11/02 ,  A61K6/083 ,  A61K6/087 ,  A61K6/09 ,  A61K6/097 ,  A61K8/64 ,  A61K8/73 ,  A61K8/96 ,  A61K8/97 ,  A61K8/98 ,  A61K9/16 ,  A61K35/12 ,  A61L27/00 ,  A61L27/38 ,  A61L27/56 ,  A61P43/00 ,  C08J3/20 ,  A61K9/14

CPC classification number: A61L27/3804 ,  A61K9/1647 ,  A61L27/3847 ,  A61L27/56

Abstract: A process for the preparation of a polymer composite loaded with functioning matter wherein the process comprises contacting a polymer substrate and functioning matter with a plasticising fluid or mixture of plasticising fluids under plasticising conditions to plasticise and/or swell the polymer and incorporate the functioning matter, and releasing the plasticising fluid to obtain the polymer composite, wherein contacting is at a pressure in the range 1 to 1000 bar and a temperature in the range −200 to +500C, selected in manner that at least a proportion of functioning matter does not freeze or refreeze during processing, or if at a temperature at which freezing or refreezing may occur, that either matter is desiccated or a pressure constraint is applied whereby pressure is in a range having a maximum pressure less than 1000 bar throughout contact of functioning matter and plasticising fluid, whereby at least a proportion of functioning matter retains its function in the polymer composite; A polymer composite obtained with the process; A scaffold comprising a polymer composite loaded with functioning matter, optionally additionally comprising biofunctional materials; An apparatus for use in the preparation of the polymer composite or with use of the process; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.

Abstract translation: 一种用于制备装载有功能物质的聚合物复合物的方法，其中该方法包括在塑化条件下使聚合物基质和功能物质与塑化流体或塑化流体的混合物接触以使聚合物塑化和/或溶胀并结合功能性物质， 并释放塑化流体以获得聚合物复合材料，其中接触处于1至1000巴的压力和-200至+ 500℃范围内的温度，其选择方式为至少一部分功能物质不会冻结 或在加工过程中重新冻结，或者如果在可能发生冷冻或再冻结的温度下，任何一种物质都被干燥或施加压力约束，从而在功能物质和增塑剂的接触过程中，压力在最大压力小于1000巴的范围内 流体，其中功能物质的至少一部分保留其在聚合物组合物中的功能 现场; 用该方法得到的聚合物复合物; 一种支架，其包含负载功能物质的聚合物复合物，任选地另外包含生物功能材料; 用于制备聚合物复合材料或使用该方法的设备; 以及将复合材料用作药物递送的支持物或支架，用于生物修复，作为用于人或动物或植物物质的生物催化剂或生物保护剂，用作结构成分，例如包含聚合物和任选的其它合成或天然 用于医疗或手术插入的金属，塑料，碳或玻璃纤维网，稀松布，棒或类似的增强物作为固体整体作为骨或组织插入，作为用于湿插入骨或牙齿中的填料或水泥，或作为固体聚集体或整料 用于诸如针或诸如牙冠等牙科植入物的矫形植入物

公开(公告)号：US20070254035A1

公开(公告)日：2007-11-01

申请号：US10576909

申请日：2004-10-22

Applicant: Jianyuan Hao ,  Martin Whitaker ,  Kevin Shakesheff ,  Steven Howdle

Inventor： Jianyuan Hao ,  Martin Whitaker ,  Kevin Shakesheff ,  Steven Howdle

IPC: C08J7/12 ,  A61K9/14 ,  B01J3/00 ,  C08J3/205

CPC classification number: C08J9/12 ,  B01J3/008 ,  B29C44/12 ,  C08J9/14 ,  C08J2201/03 ,  C08J2203/06 ,  C08J2203/08 ,  C08J2203/12 ,  C08J2203/14 ,  C08J2203/142

Abstract: Process for preparing active polymer extrudate comprising polymer matrix and guest matter, the process comprising contacting a polymer substrate and guest matter with a plasticising fluid under dense phase, sub critical or supercritical plasticising conditions of elevated temperature and/or pressure to plasticise the polymer substrate and incorporate guest matter and extruding polymer substrate incorporating guest matter under dense phase, sub critical or supercritical conditions via an extrusion orifice into a collection zone or a mould with simultaneous or subsequent release of pressure, whereby extrudate is obtained comprising a solid admixture of polymer matrix and guest matter in form conferred by the orifice or the mould; a novel extrudate; composition thereof and apparatus for the preparation thereof, and use thereof in fibre processing techniques, medical applications such as in delivery of drugs and other agents such as imaging and diagnostic agents, tissue engineering, and as medical devices or aids such as delivery devices or aids for drugs, imaging and diagnostic agents, as tissue engineering devices or aids such as sutures, and the like; as an anti-microbial for example having bacteria-static or -cidal activity; as a natural or synthetic barrier capable of immobilising e.g. naturally occurring or artificially introduced poisons or toxins by e.g. absorption, interaction or reaction; in agrochemical or crop protection applications; in the processing of thermally labile fibres for use in dying, textiles, electronics etc below the polymer Tg, Tm or viscosity; in incorporation of dyes and other thermally labile materials into polymers that cannot be formed by traditional processes e.g. melt extrusion and the like; or in incorporation of surfactants into fibres to control polymer properties.

Abstract translation: 制备包含聚合物基质和客体物质的活性聚合物挤出物的方法，该方法包括在高温和/或高压的密相，亚临界或超临界塑化条件下使聚合物基质和客体物质与增塑流体接触，以塑化聚合物基材和 将客体物质和挤出聚合物基材在密相，亚临界或超临界条件下通过挤出孔引入收集区或模具中，同时或随后释放压力，由此得到包含聚合物基质和固体混合物的固体混合物的挤出物 由孔或模具赋予的形式的客体; 新型挤出物 其制备方法及其制备方法及其在纤维加工技术中的应用，医药应用如药物递送和其它试剂如成像和诊断试剂，组织工程，以及作为医疗装置或辅助剂例如递送装置或助剂 用作药物，成像和诊断剂，作为组织工程装置或诸如缝合线等辅助物品; 作为抗微生物剂，例如具有细菌静止或杀生物活性; 作为能够固定的天然或合成屏障。 天然存在或人为引入的毒素或毒素。 吸收，相互作用或反应; 在农业或作物保护应用中; 在聚合物Tg，Tm或粘度以下的用于染色，纺织品，电子等的热不稳定纤维的加工; 将染料和其他热不稳定材料并入聚合物中，所述聚合物不能通过传统方法形成，例如 熔融挤出等; 或将表面活性剂掺入纤维中以控制聚合物性质。

公开(公告)号：US20050058835A1

公开(公告)日：2005-03-17

申请号：US10496425

申请日：2002-11-20

Applicant: Steven Howdle ,  Roger Bayston ,  Paul Webb

Inventor： Steven Howdle ,  Roger Bayston ,  Paul Webb

IPC: A61L2/232 ,  A61L2/238 ,  A61L15/44 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2/00

CPC classification number: A61L29/16 ,  A61L2/232 ,  A61L2/238 ,  A61L15/44 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/624 ,  Y10T428/31504

Abstract: A method of impregnating a polymeric substrate with an antimicrobial substance or precursor thereto, in which said substance is impregnated into said substrate as a solution, an emulsion or a suspension in a supercritical fluid. Additionally, there is provided a method of impregnating a substantially transparent polymeric substrate with an antimicrobial substance or precursor thereto, wherein the polymeric substrate is capable of being swelled by a swelling agent which contains dissolved, suspended or emulsified therein said antimicrobial substance or precursor thereto, so as to permit impregnation of the polymeric substrate with the antimicrobial substance or precursor thereto. There is also provided a device obtained by such methods.

Abstract translation: 一种用抗微生物物质或其前体浸渍聚合物基质的方法，其中所述物质作为溶液浸渍在所述基质中，乳液或悬浮液在超临界流体中。 此外，提供了一种用抗微生物物质或其前体浸渍基本上透明的聚合物基质的方法，其中聚合物基质能够被其中含有溶解，悬浮或乳化在其中的抗微生物物质或其前体的溶胀剂溶胀， 以便允许用抗微生物物质或其前体浸渍聚合物基质。 还提供了通过这种方法获得的装置。

公开(公告)号：US20070273055A1

公开(公告)日：2007-11-29

申请号：US10595323

申请日：2004-10-08

Applicant: Pier Sazio ,  John Badding ,  Dan Hewak ,  Steven Howdle

Inventor： Pier Sazio ,  John Badding ,  Dan Hewak ,  Steven Howdle

IPC: B29D11/00

CPC classification number: G02B6/02385 ,  C03B19/00 ,  C03B37/0122 ,  C03B2201/58 ,  C03B2203/42 ,  C03C13/04 ,  C03C25/104 ,  G02B1/007 ,  G02B6/0229 ,  G02B6/02352 ,  G02B6/02357 ,  G02B6/02371 ,  G02B6/0238

Abstract: A method of fabricating a metamaterial is provided, comprising providing a sample of engineered microstructured material that is transparent to electromagnetic radiation and comprises one or more voids, passing through the voids a high pressure fluid comprising a functional material carried in a carrier fluid, and causing the functional material to deposit or otherwise integrate into the engineered microstructured material to form the metamaterial. Many microstructured materials and functional materials can be used, together with various techniques for controlling the location of the integration of the functional material within the microstructured material, so that a wide range of different metamaterials can be produced.

Abstract translation: 提供了一种制造超材料的方法，包括提供对电磁辐射透明的工程化微结构材料的样品，并且包括一个或多个空隙，通过空隙将包含承载在载体流体中的功能材料的高压流体引入， 功能材料沉积或以其他方式整合到工程化微结构材料中以形成超材料。 可以使用许多微结构材料和功能材料，以及用于控制功能材料在微结构材料内的整合位置的各种技术，从而可以产生宽范围的不同的超材料。

公开(公告)号：US20050084533A1

公开(公告)日：2005-04-21

申请号：US10506618

申请日：2003-03-10

Applicant: Steven Howdle ,  Kevin Shakesheff ,  Martin Whitaker ,  Michael Watson

Inventor： Steven Howdle ,  Kevin Shakesheff ,  Martin Whitaker ,  Michael Watson

IPC: A61K47/30 ,  A61K9/00 ,  A61K9/16 ,  A61L27/00 ,  C08J3/20 ,  D06M23/00 ,  A61K9/14 ,  C08L1/00

CPC classification number: A61K9/0024 ,  A61K9/1647 ,  C08J3/203

Abstract: A process for the preparation of a polymer composite comprising internally distributed deposition matter wherein the process comprises providing a deposit of deposition matter at the surface of a solid state polymer substrate, contacting the surface deposited polymer with a plasticising fluid or a mixture of plasticising fluids under plasticising conditions to plasticise and/or swell the polymer and internally distribute deposition matter, and releasing the plasticising fluid or fluids to obtain polymer composite.; A polymer composite comprising a porous or non porous polymer throughout which particulate deposition matter as hereinbefore defined is distributed with desired uniformity, preferably with high uniformity in excess of 80% for example in excess of 98%.; A scaffold comprising a polymer composite having internally distributed deposition matter; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.

Abstract translation: 一种用于制备包含内部分布的沉积物质的聚合物复合材料的方法，其中所述方法包括在固态聚合物基材的表面提供沉积物沉积物，使表面沉积聚合物与塑化流体或塑化流体的混合物接触， 增塑和/或溶胀聚合物并内部分散沉积物质，以及释放塑化流体或流体以获得聚合物复合材料的塑化条件; 包含多孔聚合物或非多孔聚合物的聚合物复合材料，其中如上文所定义的颗粒沉积物质以所需的均匀性分布，优选具有超过80％，例如超过98％的高均匀性。 一种支架，其包括具有内部分布的沉积物质的聚合物复合材料; 以及将复合材料用作药物递送的支持物或支架，用于生物修复，作为用于人或动物或植物物质的生物催化剂或生物保护剂，用作结构成分，例如包含聚合物和任选的其它合成或天然 用于医疗或手术插入的金属，塑料，碳或玻璃纤维网，稀松布，棒或类似的增强物作为固体整体作为骨或组织插入，作为用于湿插入骨或牙齿中的填料或水泥，或作为固体聚集体或整料 用于诸如针或诸如牙冠等牙科植入物的矫形植入物