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1.
公开(公告)号:US10588858B2
公开(公告)日:2020-03-17
申请号:US16443649
申请日:2019-06-17
发明人: Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
IPC分类号: A61K9/12 , A61K8/46 , A61K47/38 , A61K47/20 , A61Q19/00 , A61K47/14 , A61K47/26 , A61K9/00 , A61K8/04
摘要: The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
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2.
公开(公告)号:US10363216B2
公开(公告)日:2019-07-30
申请号:US16236704
申请日:2018-12-31
发明人: Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
IPC分类号: A61K9/12 , A61K47/26 , A61K8/46 , A61K9/00 , A61K47/14 , A61K47/38 , A61K47/20 , A61Q19/00 , A61K8/04
摘要: The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
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公开(公告)号:US09101662B2
公开(公告)日:2015-08-11
申请号:US14045528
申请日:2013-10-03
发明人: Dov Tamarkin , Meir Eini , Doron Friedman , Tal Berman , David Schuz
IPC分类号: A61K9/00 , A61K47/00 , A61K47/12 , A61K31/573 , A61K31/593 , A61K31/341 , A61K31/167 , A61K47/18 , A61K9/12 , A61K31/375 , A61K47/26 , A61K47/32
CPC分类号: A61K47/12 , A61K9/0014 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K9/0056 , A61K9/122 , A61K31/167 , A61K31/341 , A61K31/375 , A61K31/56 , A61K31/573 , A61K31/593 , A61K47/18 , A61K47/183 , A61K47/26 , A61K47/32
摘要: The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.
摘要翻译: 本发明涉及作为载体的无水组合物和泡沫,其中活性药物或化妆品在添加时稳定或稳定化或其不稳定性受到调节剂的存在的阻碍。 药物或化妆品组合物和泡沫体包括:无水溶剂,调节剂和一种或多种活性药物或化妆品。 本发明还涉及给予无水组合物和泡沫的治疗方法。
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公开(公告)号:US20150118164A1
公开(公告)日:2015-04-30
申请号:US14504942
申请日:2014-10-02
发明人: Dov Tamarkin , Helena Shifrin , Rita Keynan , Enbal Ziv , Tal Berman , David Schuz , Elana Gazal
CPC分类号: A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要: A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
摘要翻译: 公开了一种适用于外用的无水可发泡药物组合物。 组合物包括可发泡载体至少一种液化或压缩气体推进剂。 可发泡载体包括至少一种液体油; 至少一种硅氧烷和至少一种至少一种稳定剂; 其中所述稳定剂选自约0.01%至约25%重量的至少一种表面活性剂单独或与泡沫佐剂组合; 和约0%至约5%重量的至少一种聚合物单体或与泡沫佐剂组合; 及其混合物。 进一步描述包含活性剂的药物组合物,其制备方法,适用于载体的推进剂及其用途。
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公开(公告)号:US11033491B2
公开(公告)日:2021-06-15
申请号:US17072243
申请日:2020-10-16
发明人: Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
IPC分类号: A61K9/00 , A01N25/16 , A61K8/34 , A61K8/42 , A61K8/92 , A61K8/73 , A61Q17/02 , A61K8/81 , A61K8/87 , A61Q19/00 , A61K8/362 , A61K8/37 , A61K8/49 , A61K8/86 , A61K8/04 , A61K9/12 , A61Q17/04 , A61Q19/02 , A61Q19/08
摘要: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
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公开(公告)号:US20190247310A9
公开(公告)日:2019-08-15
申请号:US15903275
申请日:2018-02-23
发明人: Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
IPC分类号: A61K9/12 , A61K8/04 , A01N25/16 , A61Q19/00 , A61K8/362 , A61K8/86 , A61K8/49 , A61K8/37 , A61K9/00
摘要: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
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公开(公告)号:US10322085B2
公开(公告)日:2019-06-18
申请号:US16189767
申请日:2018-11-13
发明人: Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
IPC分类号: A61K9/12 , A61K8/362 , A61K8/37 , A61K8/49 , A61K8/86 , A61K9/00 , A61Q19/00 , A01N25/16 , A61K8/04
摘要: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
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公开(公告)号:US20190091149A1
公开(公告)日:2019-03-28
申请号:US15999088
申请日:2018-08-17
发明人: Dov Tamarkin , Helena Shifrin , Rita Keynan , Enbal Ziv , Tal Berman , David Schuz , Elana Gazal
IPC分类号: A61K9/12 , A61K45/06 , A61K31/59 , A61K31/522 , A61K31/355 , A61K47/34 , A61K31/7056 , A61K47/44 , A61K8/04 , A61K9/00 , A61K31/65 , A61K47/06 , A61K47/14 , A61K47/24 , A61K31/20
摘要: A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
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9.
公开(公告)号:US10213384B2
公开(公告)日:2019-02-26
申请号:US15883134
申请日:2018-01-30
发明人: Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
IPC分类号: A61K9/12 , A61Q19/00 , A61K47/38 , A61K47/26 , A61K8/04 , A61K47/14 , A61K9/00 , A61K8/46 , A61K47/20
摘要: The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
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公开(公告)号:US20200078298A1
公开(公告)日:2020-03-12
申请号:US16386710
申请日:2019-04-17
发明人: Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
IPC分类号: A61K9/12 , A61Q19/00 , A61K9/00 , A61K8/86 , A61K8/49 , A61K8/37 , A61K8/362 , A61K8/04 , A01N25/16
摘要: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
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