Oil and Liquid Silicone Foamable Carriers and Formulations
    4.
    发明申请
    Oil and Liquid Silicone Foamable Carriers and Formulations 有权
    油和液体硅胶可发泡载体和配方

    公开(公告)号:US20150118164A1

    公开(公告)日:2015-04-30

    申请号:US14504942

    申请日:2014-10-02

    摘要: A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.

    摘要翻译: 公开了一种适用于外用的无水可发泡药物组合物。 组合物包括可发泡载体至少一种液化或压缩气体推进剂。 可发泡载体包括至少一种液体油; 至少一种硅氧烷和至少一种至少一种稳定剂; 其中所述稳定剂选自约0.01%至约25%重量的至少一种表面活性剂单独或与泡沫佐剂组合; 和约0%至约5%重量的至少一种聚合物单体或与泡沫佐剂组合; 及其混合物。 进一步描述包含活性剂的药物组合物,其制备方法,适用于载体的推进剂及其用途。

    DICARBOXYLIC ACID FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF

    公开(公告)号:US20190247310A9

    公开(公告)日:2019-08-15

    申请号:US15903275

    申请日:2018-02-23

    摘要: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

    Dicarboxylic Acid Foamable Vehicle and Pharmaceutical Compositions Thereof

    公开(公告)号:US20200078298A1

    公开(公告)日:2020-03-12

    申请号:US16386710

    申请日:2019-04-17

    摘要: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.