公开(公告)号：US4507388A

公开(公告)日：1985-03-26

申请号：US281722

申请日：1981-07-09

申请人： Alessandro Tabacco ,  Franco Meiattini

发明人： Alessandro Tabacco ,  Franco Meiattini

IPC分类号： G01N33/62 ,  C12Q1/58

CPC分类号： C12Q1/58

摘要： In a method for the enzymic-colorimetric determination of urea in clinical analyses, the improvement consisting in that the sample to be tested is admixed with a composite reagent composed by urease, a buffer, an alkali-metal salicylate and a nitroprusside and, after a short incubation, a hypochlorite is added, a short additional incubation is performed and the color is measured photometrically. By this method, two reagent systems are sufficient instead of the usual three.

摘要翻译： 在临床分析中用于尿素比色测定的方法中，改进之处在于将待测样品与由脲酶，缓冲液，碱金属水杨酸盐和硝普钠组成的复合试剂混合，在 短暂孵育，加入次氯酸盐，进行短暂的另外孵育，并用光度测量颜色。 通过这种方法，两种试剂系统是足够的，而不是通常的三种。

公开(公告)号：USRE29498E

公开(公告)日：1977-12-20

申请号：US663248

申请日：1976-03-02

申请人： Franco Meiattini

发明人： Franco Meiattini

IPC分类号： C12Q1/54

CPC分类号： C12Q1/54 ,  C12Q2326/50 ,  C12Q2326/96

摘要： Process for enzymatic determination of glucose with a glucose-oxidase-peroxidase enzyme system involving the use of a reduced acceptor which is oxidized. As reduced acceptor in the enzymatic reaction catalyzed by peroxidase, a ferrocyanide salt is oxidized to ferricyanide; then a further reducing system is introduced, which system is oxidized by the ferricyanide, with the formation of a colored quinone compound, the reaction between ferricyanide and the reducing system taking place spontaneously.

公开(公告)号：US4339317A

公开(公告)日：1982-07-13

申请号：US204220

申请日：1980-11-05

申请人： Franco Meiattini ,  Giorgio Papeschi ,  Paolo Tarli ,  Paolo Neri

发明人： Franco Meiattini ,  Giorgio Papeschi ,  Paolo Tarli ,  Paolo Neri

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B5/15 ,  G01N27/27 ,  G01N27/28 ,  G01N27/403 ,  G01N27/30

CPC分类号： A61B5/157 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1468 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/153 ,  A61B5/150389 ,  A61B5/150503

摘要： For taking measurements on fluids, such as biological fluids (e.g. blood and the like), a device is disclosed which is a cylindrical body insertable in a syringe or a similar sampling container and has on the exposed face a set of electrodes or probes which are connected via appropriate electric leads to processing and displaying devices which permit the taking of immediate readings of important parameters such as pH, temperature, partial pressures of gases and so on.

摘要翻译： 为了对诸如生物流体（例如血液等）的流体进行测量，公开了一种装置，其是可插入注射器或类似取样容器中的圆柱体，并且在暴露面上具有一组电极或探针， 通过适当的电导线连接到处理和显示装置，其允许立即读取诸如pH，温度，气体分压等重要参数的立即读数。

公开(公告)号：US4306020A

公开(公告)日：1981-12-15

申请号：US190794

申请日：1980-09-25

申请人： Franco Meiattini

发明人： Franco Meiattini

IPC分类号： G01N33/50 ,  C12Q1/42

CPC分类号： C12Q1/42 ,  C12Q2334/10

摘要： A novel composition is disclosed for determining the activity of the alkaline phosphatase, which comprises a salt of p-nitrophenylphosphoric acid, a magnesium salt, sodium borate and 2-amino-2-hydroxymethyl-1,3-propanediol. The composition affords advantages over the known composition especially as regards sensitivity.

摘要翻译： 公开了一种用于测定碱性磷酸酶的活性的新型组合物，其包括对硝基苯基磷酸盐，镁盐，硼酸钠和2-氨基-2-羟甲基-1,3-丙二醇的盐。 该组合物优于已知组合物，特别是关于灵敏度。

公开(公告)号：US5183762A

公开(公告)日：1993-02-02

申请号：US544599

申请日：1990-06-27

申请人： Franco Meiattini

发明人： Franco Meiattini

IPC分类号： G01N33/72

CPC分类号： G01N33/728 ,  Y10S436/903 ,  Y10T436/108331 ,  Y10T436/146666

摘要： A reagent containing a buffer suitable for maintaining the Ph of the reagent between 3-7, sulfanilic acid or sulfanilamide, a cupric soluble salt and an alkaline metal nitrite, for the detection and determination of bilirubin in the urine providing precise results and ready automation of the procedure, characterized in that it is a stable combination of all the substances used for such analysis.

公开(公告)号：US5128265A

公开(公告)日：1992-07-07

申请号：US546763

申请日：1990-07-02

申请人： Franco Meiattini

发明人： Franco Meiattini

IPC分类号： C12Q1/28

CPC分类号： C12Q1/28 ,  Y10S436/904 ,  Y10T436/107497 ,  Y10T436/108331

摘要： A reagent for the detection and quantitative determination of leukocytes by measuring the myeloperoxidase (MPO) activity of biological samples, which is sensitive for disclosing even only a few leukocytes, without interferences caused by hemoglobin even in the presence of several erythrocytes, and suitable for photometric readings in the visible spectrum region. The reagent comprises a buffer, a chromogen, a surface-active agent, at least an alkali metal halide, a hydroperoxide compound and optionally a reaction promoter.

公开(公告)号：US5294403A

公开(公告)日：1994-03-15

申请号：US959791

申请日：1992-10-13

申请人： Franco Meiattini

发明人： Franco Meiattini

IPC分类号： G01N33/72

CPC分类号： G01N33/728 ,  Y10S436/903 ,  Y10T436/108331 ,  Y10T436/146666

摘要： A kit including a reagent containing a buffer suitable for maintaining the pH of the reagent between 3-7, sulfanilic acid or sulfanilamide, a cupric soluble salt and an alkaline metal nitrite, for the detection and determination of bilirubin in the urine providing precise results and ready automation of the procedure, characterized in that it is a stable combination of all the substances used for such analysis.

摘要翻译： 一种试剂盒，其包含适于保持3-7，对氨基苯磺酸或磺胺，铜可溶性盐和碱金属亚硝酸盐之间的试剂的pH的缓冲液的试剂，用于检测和测定尿液中的胆红素，从而提供精确的结果，以及 该程序的现成自动化，其特征在于它是用于这种分析的所有物质的稳定组合。

公开(公告)号：US4254220A

公开(公告)日：1981-03-03

申请号：US82174

申请日：1979-10-05

申请人： Franco Meiattini

发明人： Franco Meiattini

IPC分类号： G01N33/66 ,  C12Q1/54 ,  G01N33/52

CPC分类号： C12Q1/54

摘要： A composition for the determination of glucose in the kinetic mode comprising the enzymes glucose-oxidase and peroxidase, a buffer system, a component containing an aromatic ring with a phenolic hydroxyl attached to said ring, a component containing a reactive group containing a structure derived from 1-phenyl-5-pyrazolinone and a substance which inhibits glucose-oxidase but not peroxidase.

摘要翻译： 用于测定葡萄糖的组合物，其包含酶葡萄糖 - 氧化酶和过氧化物酶，缓冲系统，含有与所述环连接的酚羟基的芳环的组分，含有含有衍生自 1-苯基-5-吡唑啉酮和抑制葡萄糖氧化酶而不是过氧化物酶的物质。

公开(公告)号：US4220714A

公开(公告)日：1980-09-02

申请号：US896201

申请日：1978-04-13

申请人： Franco Meiattini ,  Giuliano Giannini ,  Paolo Tarli

发明人： Franco Meiattini ,  Giuliano Giannini ,  Paolo Tarli

IPC分类号： C12Q1/48 ,  A61K31/70 ,  C12N9/12 ,  C12N9/99 ,  C12Q1/50

CPC分类号： C12N9/1229 ,  C12N9/99 ,  C12Q1/50

摘要： A method and a combination of reagents are disclosed for determining the creatine kinase activity by inhibiting the action of creatine kinase, the improvement consisting in that adenosine - 5'- monophosphate is used in combination with an inorganic, preferably an alkali metal, fluoride. By so doing the masking effect of adenylate kinase are efficiently offset.

摘要翻译： 公开了通过抑制肌酸激酶的作用来测定肌酸激酶活性的方法和组合，其改进在于将腺苷-5'-单磷酸酯与无机，优选碱金属氟化物组合使用。 通过这样做，腺苷酸激酶的掩蔽效应被有效地抵消。