公开(公告)号：US20180221449A1

公开(公告)日：2018-08-09

申请号：US15506392

申请日：2015-08-25

申请人： Antonio E. CIVITARESE ,  Frank L. GREENWAY

发明人： Antonio E. CIVITARESE ,  Frank L. GREENWAY

IPC分类号： A61K38/22 ,  A61K31/137 ,  A61P21/06 ,  A61P3/10 ,  A61P3/06

CPC分类号： A61K38/22 ,  A61K31/137 ,  A61K45/06 ,  A61P3/06 ,  A61P3/10 ,  A61P21/06 ,  A61K2300/00

摘要： The present disclosure provides compositions including an amylin receptor agonist and a beta-2-adreno-receptor agonist (e.g., an anti-hyperglycemia agent), compositions including at least two different anti-catabolic agents, compositions including at least two different anti-adiposity agents, methods of treating a condition (e.g., muscle wasting, muscle wasting-related condition, excess adiposity, an excess adiposity-related condition, and the like), methods of increasing muscle mass, formation of thermogenic brown adipose tissue (BAT), and/or decreasing white adipose tissue (WAT) content, methods of treating muscle wasting, methods of treating excess adiposity, and the like.

公开(公告)号：US20180055848A1

公开(公告)日：2018-03-01

申请号：US15565367

申请日：2016-01-28

申请人： Frank L. Greenway

发明人： Frank L. Greenway

IPC分类号： A61K31/522 ,  A61K31/137 ,  A61K9/00

CPC分类号： A61K31/522 ,  A61K9/0053 ,  A61K31/137 ,  A61K2300/00

摘要： A combination of albuterol and caffeine can be used to reduce fat body mass or to increase lean body mass. The combination may be used to treat conditions such as obesity or sarcopenia. There is a substantial synergy in the combinations: The combined effect of albuterol and caffeine is significantly greater than would be expected from the known properties of the individual components.

公开(公告)号：US20160128363A1

公开(公告)日：2016-05-12

申请号：US14895397

申请日：2014-06-04

申请人： John W. FINLEY ,  Thomas GETTYS ,  Frank L. GREENWAY

发明人： John W. Finley ,  Thomas Gettys ,  Frank L. Greenway

IPC分类号： A23L1/015

CPC分类号： A23L5/25 ,  A23G9/32 ,  A23K20/147 ,  A23L2/66 ,  A23L5/27 ,  A23L5/276 ,  A23L7/109 ,  A23L7/196 ,  A23L13/40 ,  A23L13/50 ,  A23L15/30 ,  A23L19/12 ,  A23L33/10 ,  A23L33/17 ,  A23L33/175 ,  A23L33/19 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2200/332 ,  A23V2250/0632 ,  A23V2250/54246

摘要： A method is disclosed for making palatable methionine-restricted foods, to deliver a methionine-restricted diet to human or veterinary patients. A protein or a food product containing protein is partially oxidized, preferably with ozone, to oxidize nearly all of the methionine and cysteine. After oxidation, tryptophan and lysine are optionally added back since they tend to be oxidized also. Optionally, a small amount of methionine is also added back so that the final methionine is within a preferred range of about 0.85 to about 1.8 gram methionine per 100 gram total protein, preferably about 1.2 gram per 100 gram total protein.

摘要翻译： 公开了一种制备可食用甲硫氨酸限制食品的方法，以将甲硫氨酸限制性饮食递送给人或兽医患者。 蛋白质或含有蛋白质的食品部分被氧化，优选用臭氧氧化几乎所有的甲硫氨酸和半胱氨酸。 氧化后，任选地加入色氨酸和赖氨酸，因为它们也倾向于被氧化。 任选地，还加入少量的甲硫氨酸，使得最终甲硫氨酸在每100克总蛋白质约0.85至约1.8克甲硫氨酸的优选范围内，优选约1.2克/ 100克总蛋白质。

公开(公告)号：US5952026A

公开(公告)日：1999-09-14

申请号：US125504

申请日：1993-09-22

申请人： Frank L. Greenway ,  George A. Bray

发明人： Frank L. Greenway ,  George A. Bray

IPC分类号： A23L19/12 ,  A23L19/18 ,  A23L1/217

CPC分类号： A23L19/18 ,  A23L19/14 ,  Y10S426/808

摘要： A potato chip having no added fat and process for preparation thereof, wherein a slice of undehydrated fresh potato having no added fat and no coating of globular protein and having a thickness of about 1 to about 3 millimeters is heated in a microwave oven at high intensity, with periodic heating separated by periodic cooling for a period of time sufficient to produce a product having essentially the same flavor, color and crispness as potato slices fried in deep fat. The resulting potato chip has substantially reduced calories as compared with potato chips fried in deep fat or oil, and has essentially the same low fat content as uncooked potatoes. Optionally, the slice may be coated with a non-globular protein coating prior to microwave heating. Such a coating may include salt, non-globular protein, flavorants, spices, and/or vitamin additives, as desired, but preferably does not contain any fat which would increase the fat and calorie content of the finished potato chip.

摘要翻译： 一种没有添加脂肪的马铃薯片及其制备方法，其中将未添加脂肪并且没有球状蛋白的包衣并且具有约1至约3毫米厚度的未脱水的新鲜马铃薯切片在高强度的微波炉中加热 ，周期性加热通过周期性冷却分离足以产生具有与深部脂肪中油炸的马铃薯切片基本相同的风味，颜色和脆度的产品。 所得到的马铃薯片与在深脂肪或油中煎炸的薯片相比具有显着降低的热量，并且具有与未煮过的马铃薯基本相同的低脂肪含量。 任选地，在微波加热之前，切片可以用非球形蛋白质涂层涂覆。 根据需要，这样的涂层可以包括盐，非球形蛋白质，调味剂，香料和/或维生素添加剂，但优选不含任何能增加成品马铃薯片的脂肪和热量含量的脂肪。

公开(公告)号：US08334000B2

公开(公告)日：2012-12-18

申请号：US12718148

申请日：2010-03-22

申请人： Frank L. Greenway ,  Zhijun Liu ,  Eugene A. Woltering

发明人： Frank L. Greenway ,  Zhijun Liu ,  Eugene A. Woltering

IPC分类号： A61K36/00 ,  A61K51/00 ,  A61K39/395 ,  A61K38/21

CPC分类号： A61K31/192 ,  A61K31/454 ,  A61K31/7024 ,  A61K36/40 ,  A61K36/44 ,  A61K36/708 ,  A61K36/73

摘要： An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.

摘要翻译： 已经发现中国黑莓（Rubus suavissimus）的提取物抑制血管生成，并分离出两种活性级分。 没食子酸通过体外人血管生成模型显示为活性抗血管生成化合物之一。 已知或发现有没食子酸的其他植物的水提取物也被发现具有抗血管生成活性。 发现没食子酸的各种衍生物抑制血管生成。 中国黑莓的提取物也减缓了大鼠胰腺肿瘤和角膜新血管形成的发生。 石榴提取物显示抑制脂肪组织中的血管发生。 来自红豆杉和其他具有没食子酸的植物和没食子酸及其衍生物的提取物可用于治疗与新生血管形成相关的各种疾病，包括糖尿病性视网膜病变，牛皮癣，肿瘤，肥胖症，癌症，类风湿性关节炎等。

公开(公告)号：US07709031B2

公开(公告)日：2010-05-04

申请号：US10559091

申请日：2004-05-27

申请人： Frank L. Greenway ,  Zhijun Liu ,  Eugene A. Woltering

发明人： Frank L. Greenway ,  Zhijun Liu ,  Eugene A. Woltering

IPC分类号： A61K36/00 ,  A61K51/00 ,  A61K39/395 ,  A61K38/21

CPC分类号： A61K31/192 ,  A61K31/454 ,  A61K31/7024 ,  A61K36/40 ,  A61K36/44 ,  A61K36/708 ,  A61K36/73

摘要： An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.

摘要翻译： 已经发现中国黑莓（Rubus suavissimus）的提取物抑制血管生成，并分离出两种活性级分。 没食子酸通过体外人血管生成模型显示为活性抗血管生成化合物之一。 已知或发现有没食子酸的其他植物的水提取物也被发现具有抗血管生成活性。 发现没食子酸的各种衍生物抑制血管生成。 中国黑莓的提取物也减缓了大鼠胰腺肿瘤和角膜新血管形成的发生。 石榴提取物显示抑制脂肪组织中的血管发生。 来自红豆杉和其他具有没食子酸的植物和没食子酸及其衍生物的提取物可用于治疗与新生血管形成相关的各种疾病，包括糖尿病性视网膜病变，牛皮癣，肿瘤，肥胖症，癌症，类风湿性关节炎等。

公开(公告)号：US07150141B1

公开(公告)日：2006-12-19

申请号：US10713518

申请日：2003-11-14

申请人： Frank L. Greenway ,  Andrew T. Roberts

发明人： Frank L. Greenway ,  Andrew T. Roberts

IPC分类号： A44C11/00 ,  A61B5/11 ,  B21L1/00 ,  G01G19/44

CPC分类号： A44C11/002 ,  A44C15/0045

摘要： Presented in one embodiment is a waist chain comprising a plurality of links; a plurality of coupling members which connect the plurality of links, thereby forming a chain with two ends; and at least one end connection member which is connectable to both ends of the chain such that the chain becomes continuous. The waist chain is positioned tightly around the waist of a person such that as the person's weight increases, the waist chain becomes increasingly tight. Presented in another embodiment is a waist chain comprising a plurality of links; a plurality of coupling members which connect the plurality of links, thereby forming a chain with two ends; at least one end connection member which is connectable to both ends of the chain such that the chain becomes continuous and at least one end link which is connectable to one or both ends of the chain and to the end connection member. The end connection member is a hollow cylinder comprising a side wall. Presented in another embodiment is a weight loss method comprising altering a person's food intake such that the person experiences weight loss; fitting the person tightly with a waist chain such that as the person's weight increases, the waist chain becomes increasingly tight. The waist chain comprises a plurality of links; a plurality of coupling members which connect the plurality of links, thereby forming a chain with two ends; at least one end connection member which is connectable to both of the ends of the chain such that the chain becomes continuous.

摘要翻译： 在一个实施例中呈现的是包括多个连杆的腰链; 多个联接构件，其连接多个连杆，从而形成具有两个端部的链条; 以及至少一个端部连接构件，其可连接到链条的两端，使得链条变得连续。 腰链紧紧地定位于人的腰部，使得随着人的体重增加，腰链变得越来越紧。 在另一实施例中呈现的是包括多个连杆的腰链; 多个联接构件，其连接多个连杆，从而形成具有两个端部的链条; 至少一个端部连接构件，其可链接到所述链条的两端，使得所述链条变得连续，以及至少一个可连接到所述链条的一端或两端以及所述端部连接构件的端部连接件。 端部连接构件是包括侧壁的中空圆柱体。 在另一个实施方案中呈现的减肥方法包括改变人的食物摄入，使得人体重减轻; 使人紧紧地配合腰链，使得随着人的体重增加，腰链越来越紧。 腰链包括多个连杆; 多个联接构件，其连接多个连杆，从而形成具有两个端部的链条; 至少一个端部连接构件，其能够连接到链条的两端，使得链条变得连续。

公开(公告)号：US06417231B1

公开(公告)日：2002-07-09

申请号：US08992852

申请日：1997-12-18

申请人： Frank L. Greenway ,  Jennifer C. Rood

发明人： Frank L. Greenway ,  Jennifer C. Rood

IPC分类号： A61K3122

CPC分类号： A61K31/22 ,  A23L33/10

摘要： A method and composition are disclosed for administering pyruvate in high doses to mammals, including humans. The method and composition do not produce an excessive acid load, salt load, or nitrogen load. Bioavailability of pyruvate from the composition is high. The composition has been named “tripyruvin” (tripyruvyl glycerol, or glycerol tripyruvate), and has the following structure:

摘要翻译： 公开了用于向包括人在内的哺乳动物施用高剂量丙酮酸的方法和组合物。 该方法和组合物不会产生过多的酸负荷，盐负荷或氮负荷。 来自组合物的丙酮酸的生物利用度高。 该组合物被命名为“tripyruvin”（tripyruvyl glycerol，或者tripyruvate甘油），具有以下结构：

公开(公告)号：US4525359A

公开(公告)日：1985-06-25

申请号：US448836

申请日：1982-12-10

申请人： Frank L. Greenway, III ,  George A. Bray

发明人： Frank L. Greenway, III ,  George A. Bray

IPC分类号： A61K8/41 ,  A61K8/49 ,  A61K9/00 ,  A61K31/13 ,  A61K31/135 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/475 ,  A61K31/48 ,  A61K31/495 ,  A61K31/52 ,  A61K45/00 ,  A61K47/00 ,  A61P3/06 ,  A61Q19/06 ,  C07D233/24 ,  C07D311/74 ,  C07D319/20 ,  C07D459/00 ,  C07D473/08 ,  C07D519/02 ,  A61K31/245

CPC分类号： A61K9/0014 ,  A61K31/135 ,  A61K31/41 ,  A61K31/475 ,  A61K31/48 ,  A61K31/52 ,  A61K8/41 ,  A61K8/4953 ,  A61K8/498 ,  A61K9/0019 ,  A61Q19/06

摘要： A treatment for accelerating regional weight reduction in humans, wherein an active ingredient encouraging elimination of fatty deposits, preferably a beta adrenergic stimulator or an alpha-2 adrenergic inhibitor, is selectively delivered to a regional fat deposit prior to commencing or during a general weight control program, whereby body weight is preferentially reduced in the selected area. The beta adrenergic stimulator, preferably isoproterenol or forskolin, or the alpha-2 adrenergic inhibitor, preferably yohimbine, or combinations thereof may be delivered by any means accomplishing specific delivery to the selected area, including injection, implantation, and topical application to the skin as in an ointment or creme.

摘要翻译： 用于加速人体局部体重减轻的治疗方法，其中鼓励消除脂肪沉积物的活性成分，优选β-肾上腺素能刺激剂或α-2肾上腺素能抑制剂在开始之前或在一般体重控制期间被选择性递送至区域脂肪沉积物 程序，从而在所选区域中优先减少体重。 β肾上腺素能刺激剂，优选异丙肾上腺素或毛喉素，或α-2肾上腺素能抑制剂，优选育亨宾，或其组合可以通过任何实现特定递送到所选区域的方式递送，包括注射，植入和局部施用于皮肤，作为 在一个软膏或奶油。

公开(公告)号：US10897921B2

公开(公告)日：2021-01-26

申请号：US14895397

申请日：2014-06-04

申请人： John W. Finley ,  Thomas Gettys ,  Frank L. Greenway

发明人： John W. Finley ,  Thomas Gettys ,  Frank L. Greenway

IPC分类号： A23L5/20 ,  A23G9/32 ,  A23L2/66 ,  A23K20/147 ,  A23L13/50 ,  A23L33/00 ,  A23L33/10 ,  A23L33/175 ,  A23L7/109 ,  A23L7/196 ,  A23L33/17 ,  A23L19/12 ,  A23L13/40 ,  A23L15/00 ,  A23L33/19

摘要： A method is disclosed for making palatable methionine-restricted foods, to deliver a methionine-restricted diet to human or veterinary patients. A protein or a food product containing protein is partially oxidized, preferably with ozone, to oxidize nearly all of the methionine and cysteine. After oxidation, tryptophan and lysine are optionally added back since they tend to be oxidized also. Optionally, a small amount of methionine is also added back so that the final methionine is within a preferred range of about 0.85 to about 1.8 gram methionine per 100 gram total protein, preferably about 1.2 gram per 100 gram total protein.