利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

29 条记录 (耗时 0.024 秒)

    Process for making microneedles, microneedle arrays, masters, and replication tools
    1.
    发明授权
    Process for making microneedles, microneedle arrays, masters, and replication tools 有权
    制造微针，微针阵列，主机和复制工具的过程

    公开(公告)号：US08858807B2

    公开(公告)日：2014-10-14

    申请号：US12293012

    申请日：2007-03-23

    申请人： Robert J. DeVoe ,  Dennis E. Ferguson ,  Franklyn L. Frederickson ,  Mitchell A. F. Johnson ,  Mikhail L. Pekurovsky ,  Craig R. Sykora ,  Jeremy K. Larsen

    发明人： Robert J. DeVoe ,  Dennis E. Ferguson ,  Franklyn L. Frederickson ,  Mitchell A. F. Johnson ,  Mikhail L. Pekurovsky ,  Craig R. Sykora ,  Jeremy K. Larsen

    IPC分类号： B44C1/22 ,  C08F2/50 ,  A61M37/00

    CPC分类号： A61M37/0015 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053 ,  C08F2/50

    摘要： A process for making a microneedle array master comprises: (a) providing a photoreactive composition, the photoreactive composition comprising: (1) at least one reactive species that is capable of undergoing an acid- or radical-initiated chemical reaction, and (2) at least one multiphoton photoinitiator system; and (b) imagewise exposing at least a portion of the composition to light sufficient to cause simultaneous absorption of at least two photons, thereby inducing at least one acid- or radical-initiated chemical reaction where the composition is exposed to the light, the imagewise exposing being carried out in a pattern that is effective to define at least the surface of a plurality of microneedles. The microneedles may be solid and the outer surface of the microneedles may be characterized by at least one concave area. The master may be used to fabricate a tool for replication.

    摘要翻译： 制备微针阵列母版的方法包括：（a）提供光反应性组合物，所述光反应性组合物包含：（1）能够经历酸或自由基引发的化学反应的至少一种反应性物质，和（2） 至少一种多光子光引发剂体系; 和（b）将组合物的至少一部分成像曝光至足以引起同时吸收至少两个光子的光，从而诱导至少一种酸或自由基引发的化学反应，其中组合物暴露于光，成像 以能有效地限定多个微针的表面的图案进行曝光。 微针可以是固体，并且微针的外表面可以由至少一个凹入区域表征。 主人可能用于制作复制工具。

    METHOD OF MOLDING A MICRONEEDLE
    2.
    发明申请
    METHOD OF MOLDING A MICRONEEDLE 有权
    模制麦克风的方法

    公开(公告)号：US20120280428A1

    公开(公告)日：2012-11-08

    申请号：US13549694

    申请日：2012-07-16

    申请人： Dennis E. FERGUSON ,  Satinder K. NAYAR ,  Donald L. POCHARDT

    发明人： Dennis E. FERGUSON ,  Satinder K. NAYAR ,  Donald L. POCHARDT

    IPC分类号： B29C45/40

    CPC分类号： B29C45/568 ,  A61M37/0015 ,  A61M2037/0053 ,  B29C45/2669 ,  B29C45/34 ,  B29C45/561 ,  B29C2045/0094 ,  B29C2791/008 ,  B29L2031/7544 ,  B29L2031/756

    摘要： A method of molding a microneedle including providing a mold apparatus having a mold insert having the negative image of at least one microneedle, a compression core, a mold housing configured to allow a reciprocal motion between the mold insert and the compression core. The method includes placing the mold apparatus in a closed position, injecting polymeric material into the closed mold apparatus, compressing the injected polymeric material between the mold insert and the compression core by a reciprocal motion between the compression core and the mold insert, opening the mold, and removing a molded microneedle from the mold. The mold insert has a mold insert height and the molded microneedle has a height that is from about 90% of the mold insert height to about 115% of the mold insert height.

    摘要翻译： 一种成型微针的方法，包括提供具有模具插入件的模具装置，所述模具插入件具有至少一个微针的负像，压缩芯，模具壳体，其构造成允许模具插入件和压缩芯之间的往复运动。 该方法包括将模具设备放置在关闭位置，将聚合物材料注入封闭的模具设备中，通过在压缩芯和模具插入件之间的往复运动来压缩在模具插入件和压缩芯之间的注入的聚合材料，打开模具 并从模具中取出模制的微针。 模具插入件具有模具插入件高度，并且模制的微针具有从模具插入件高度的大约90％到模具插入件高度的大约115％的高度。

    MOLDED ARTICLES COMPRISING MICRONEEDLE ARRAYS
    3.
    发明申请
    MOLDED ARTICLES COMPRISING MICRONEEDLE ARRAYS 审中-公开
    包含麦克风阵列的模制文章

    公开(公告)号：US20090171314A1

    公开(公告)日：2009-07-02

    申请号：US12295645

    申请日：2007-04-20

    申请人： Dennis E. Ferguson

    发明人： Dennis E. Ferguson

    IPC分类号： A61M5/32 ,  B29C45/00 ,  B32B37/00

    CPC分类号： B29C45/0003 ,  A61M37/0015 ,  A61M2037/0023

    摘要： A molded article comprising at least one chain of microneedle arrays wherein adjacent arrays in the chain are interconnected by integrally formed runners. Such a molded article may further comprise two or more chains of microneedle arrays, wherein adjacent chains are interconnected to each other by integrally formed runners. Also, methods of making molded articles and positioning them for delivery to a patient.

    摘要翻译： 一种模制品，其包括至少一个微针阵列链，其中所述链中的相邻阵列通过整体形成的流道相互连接。 这样的模制品还可以包括两个或更多个微针阵列链，其中相邻的链通过整体形成的流道彼此互连。 此外，制造模制品并将其定位以输送给患者的方法。

    PROCESS FOR MAKING MICRONEEDLES, MICRONEEDLE ARRAYS, MASTERS, AND REPLICATION TOOLS
    4.
    发明申请
    PROCESS FOR MAKING MICRONEEDLES, MICRONEEDLE ARRAYS, MASTERS, AND REPLICATION TOOLS 有权
    制作麦克风，麦克风阵列，主机和复印工具的方法

    公开(公告)号：US20090099537A1

    公开(公告)日：2009-04-16

    申请号：US12293012

    申请日：2007-03-23

    申请人： Robert J. DeVoe ,  Dennis E. Ferguson ,  Franklyn L. Frederickson ,  Mitchell A.F. Johnson ,  Mikhail L. Pekurovsky ,  Craig R. Sykora ,  Jeremy K. Larsen

    发明人： Robert J. DeVoe ,  Dennis E. Ferguson ,  Franklyn L. Frederickson ,  Mitchell A.F. Johnson ,  Mikhail L. Pekurovsky ,  Craig R. Sykora ,  Jeremy K. Larsen

    IPC分类号： A61M5/32 ,  G03F7/20

    CPC分类号： A61M37/0015 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053 ,  C08F2/50

    摘要： A process for making a microneedle array master comprises: (a) providing a photoreactive composition, the photoreactive composition comprising: (1) at least one reactive species that is capable of undergoing an acid- or radical-initiated chemical reaction, and (2) at least one multiphoton photoinitiator system; and (b) imagewise exposing at least a portion of the composition to light sufficient to cause simultaneous absorption of at least two photons, thereby inducing at least one acid- or radical-initiated chemical reaction where the composition is exposed to the light, the imagewise exposing being carried out in a pattern that is effective to define at least the surface of a plurality of microneedles. The microneedles may be solid and the outer surface of the microneedles may be characterized by at least one concave area. The master may be used to fabricate a tool for replication.

    摘要翻译： 制备微针阵列母版的方法包括：（a）提供光反应性组合物，所述光反应性组合物包含：（1）能够经历酸或自由基引发的化学反应的至少一种反应性物质，和（2） 至少一种多光子光引发剂体系; 和（b）将组合物的至少一部分成像曝光至足以引起同时吸收至少两个光子的光，从而诱导至少一种酸或自由基引发的化学反应，其中组合物暴露于光，成像 以能有效地限定多个微针的表面的图案进行曝光。 微针可以是固体，并且微针的外表面可以由至少一个凹入区域表征。 主人可能用于制作复制工具。

    Ultrasonic-assisted molding of precisely-shaped articles and methods
    5.
    发明授权
    Ultrasonic-assisted molding of precisely-shaped articles and methods 有权
    超声波辅助成型精确成型的物品和方法

    公开(公告)号：US09289931B2

    公开(公告)日：2016-03-22

    申请号：US14003045

    申请日：2012-03-14

    申请人： Stanley Rendon ,  Dennis E. Ferguson ,  Donald L. Pochardt ,  Joseph S. Warner ,  Timothy J. Rowell ,  Peter T. Benson ,  Satinder K. Nayar

    发明人： Stanley Rendon ,  Dennis E. Ferguson ,  Donald L. Pochardt ,  Joseph S. Warner ,  Timothy J. Rowell ,  Peter T. Benson ,  Satinder K. Nayar

    IPC分类号： B29C45/56 ,  B29C45/73 ,  B29C45/72 ,  B29C45/00 ,  C08F220/06 ,  B29L11/00

    CPC分类号： B29C45/73 ,  B29C45/0025 ,  B29C45/568 ,  B29C45/7207 ,  B29C2045/7393 ,  B29L2011/00 ,  C08F220/06

    摘要： An ultrasonic-assisted injection molding system and method for making precisely-shaped articles. A source of ultrasonic energy is positioned to apply vibrational energy to a mold cavity connected to at least one gate in flow communication with a source of molten (co)polymer. The mold is heated to a temperature of 104-116° C., and the molten (co)polymer is injected into the mold cavity. After cooling the mold until the molten (co)polymer within the gate has solidified, ultrasonic energy is applied to the mold without remelting the solidified (co)polymer within the gate until the temperature increases to 116-122° C., thereby substantially relieving flow induced stresses. The mold is then cooled until the temperature decreases to 101-107° C., and is thereafter heated until the temperature increases to 116-122° C., thereby substantially relieving any thermally induced stresses. The mold is cooled until the molten (co)polymer has solidified, thereby forming a precision molded plastic optical element.

    摘要翻译： 超声波辅助注射成型系统及制造精密成形制品的方法。 定位超声波能源，以将振动能施加到与熔融（共）聚合物源流动连通的至少一个浇口连接的模腔上。 将模具加热到104-116℃的温度，并将熔融的（共）聚合物注入模腔中。 在模具冷却之后，门内的熔融（共）聚合物已经固化，超声波能量被施加到模具上，而不使固化的（共）聚合物在浇口内重熔，直到温度升至116-122℃，从而基本上缓解 流动应力。 然后将模具冷却直到温度降至101-107℃，然后加热直到温度升至116-122℃，从而基本上减轻任何热诱导的应力。 将模具冷却直到熔融（共）聚合物固化，从而形成精密模塑塑料光学元件。