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公开(公告)号:US09493800B2
公开(公告)日:2016-11-15
申请号:US13186001
申请日:2011-07-19
CPC分类号: C12N15/62 , C12N15/8243 , C12N15/8251 , C12N15/8257 , C12P13/02 , C12P13/04 , C12P13/14 , Y10T436/174614
摘要: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.
摘要翻译: 提供了可用于合成酰基氨基酸的工程化多肽。 还提供了使用工程改造的多肽制备酰基氨基酸的方法。 在某些实施方案中,使用本发明的组合物和/或方法产生的酰基氨基酸包含椰油酰谷氨酸。
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公开(公告)号:US20130071885A1
公开(公告)日:2013-03-21
申请号:US13186001
申请日:2011-07-19
CPC分类号: C12N15/62 , C12N15/8243 , C12N15/8251 , C12N15/8257 , C12P13/02 , C12P13/04 , C12P13/14 , Y10T436/174614
摘要: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.
摘要翻译: 提供了可用于合成酰基氨基酸的工程化多肽。 还提供了使用工程改造的多肽制备酰基氨基酸的方法。 在某些实施方案中,使用本发明的组合物和/或方法产生的酰基氨基酸包含椰油酰谷氨酸。
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公开(公告)号:US20100093037A1
公开(公告)日:2010-04-15
申请号:US12565449
申请日:2009-09-23
摘要: The present invention provides novel methods of growing of microorganisms in cell culture media comprising soy components (e.g., soy molasses) as a carbon source. The present invention further provides novel cell culture media comprising soy components (e.g., soy molasses) as a carbon source. In certain embodiments, inventive cell culture media substantially lack a carbon source other than soy molasses (e.g., the media substantially lack glucose and glycerol). In certain embodiments, inventive cell culture media comprise soy components (e.g., soy molasses) as the sole carbon source.
摘要翻译: 本发明提供了在包含作为碳源的大豆成分(例如大豆糖蜜)的细胞培养基中生长微生物的新方法。 本发明还提供了包含作为碳源的大豆组分(例如大豆糖蜜)的新型细胞培养基。 在某些实施方案中,本发明的细胞培养基质基本上不含除了大豆糖蜜之外的碳源(例如,培养基基本上不含葡萄糖和甘油)。 在某些实施方案中,本发明的细胞培养基包含作为唯一碳源的大豆成分(例如,大豆糖蜜)。
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公开(公告)号:US20110030103A1
公开(公告)日:2011-02-03
申请号:US12596276
申请日:2008-04-16
摘要: Novel lipopeptides, and engineered polypeptides useful in synthesizing lipopeptides are provided. Also provided are methods of making lipopeptides using engineered polypeptides, and methods of using lipopeptides, e.g., as insecticidal and/or antimicrobial agents.
摘要翻译: 提供了新颖的脂肽和可用于合成脂肽的工程化多肽。 还提供了使用工程改造的多肽制备脂肽的方法,以及使用脂肽(例如杀虫剂和/或抗微生物剂)的方法。
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公开(公告)号:US07981685B2
公开(公告)日:2011-07-19
申请号:US12596272
申请日:2008-04-16
CPC分类号: C12N15/62 , C12N15/8243 , C12N15/8251 , C12N15/8257 , C12P13/02 , C12P13/04 , C12P13/14 , Y10T436/174614
摘要: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.
摘要翻译: 提供了可用于合成酰基氨基酸的工程化多肽。 还提供了使用工程改造的多肽制备酰基氨基酸的方法。 在某些实施方案中,使用本发明的组合物和/或方法产生的酰基氨基酸包括椰油酰谷氨酸。
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公开(公告)号:US20110059487A1
公开(公告)日:2011-03-10
申请号:US12822765
申请日:2010-06-24
CPC分类号: C12P21/02 , C12N1/20 , C12N9/0065 , C12N9/18 , C12N9/2465 , C12Y301/01006 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01022 , C12Y302/01037 , C12Y302/01055 , C12Y302/01074 , C12Y302/01086 , C12Y302/01091 , C12Y302/01139
摘要: The present invention provides, among other things, engineered microorganisms and methods that allow efficient conversion of soy carbohydrates to industrial chemicals by fermentation. In some embodiments, the invention provides microbial cells engineered to have increased efficiency in utilizing a soy carbon source (e.g., soy molasses, soy meal, and/or soy hulls) as compared to a parent cell. In some embodiments, microbial cells are engineered to have altered (e.g., increased) expression or activity of one or more carbohydrate modifying enzymes (e.g., glycosidases). In some embodiments, microbial cells are engineered to have altered localization of carbohydrate modifying enzymes (e.g., glycosidases). In some embodiments, engineered microbial cells provided herein are used to produce industrial chemicals (e.g., surfactin) using soy components as primary or sole carbon sources.
摘要翻译: 本发明尤其提供了工程微生物和允许通过发酵将大豆碳水化合物有效转化成工业化学品的方法。 在一些实施方案中,与亲本细胞相比,本发明提供了工程化以提高利用大豆碳源(例如大豆糖蜜,大豆粉和/或大豆皮)的效率的微生物细胞。 在一些实施方案中,将微生物细胞工程化以改变(例如增加)一种或多种碳水化合物修饰酶(例如糖苷酶)的表达或活性。 在一些实施方案中,将微生物细胞工程化以改变碳水化合物修饰酶(例如糖苷酶)的定位。 在一些实施方案中,本文提供的工程微生物细胞用于使用大豆成分作为主要或唯一碳源来生产工业化学品(例如表面活性素)。
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公开(公告)号:US20100093060A1
公开(公告)日:2010-04-15
申请号:US12565408
申请日:2009-09-23
摘要: The present invention provides novel methods of growing of microorganisms in cell culture media comprising cellulosic material as a carbon source. The present invention further provides novel cell culture media cellulosic material as a carbon source. In certain embodiments, inventive cell culture media substantially lack a carbon source other than cellulosic material (e.g., the media substantially lack glucose and glycerol). In certain embodiments, inventive cell culture media comprise cellulosic material as the sole carbon source.
摘要翻译: 本发明提供了在包含纤维素材料作为碳源的细胞培养基中生长微生物的新方法。 本发明还提供作为碳源的新型细胞培养基纤维素材料。 在某些实施方案中,本发明的细胞培养基质基本上不含除纤维素材料之外的碳源(例如,培养基基本上不含葡萄糖和甘油)。 在某些实施方案中,本发明的细胞培养基包含作为唯一碳源的纤维素材料。
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公开(公告)号:US20090269832A1
公开(公告)日:2009-10-29
申请号:US12264491
申请日:2008-11-04
申请人: Kevin A. Jarrell , Gabriel Reznik
发明人: Kevin A. Jarrell , Gabriel Reznik
CPC分类号: C12N1/20 , C12N1/16 , C12P21/005
摘要: The present invention provides novel methods of growing of microorganisms in cell culture media comprising crude glycerol as a carbon source. The present invention further provides novel cell culture media comprising crude glycerol as a carbon source. In certain embodiments, inventive cell culture media substantially lack refined glycerol. In certain embodiments, inventive cell culture media comprise crude glycerol as the sole carbon source.
摘要翻译: 本发明提供了在包含粗甘油作为碳源的细胞培养基中生长微生物的新方法。 本发明还提供了包含粗甘油作为碳源的新型细胞培养基。 在某些实施方案中,本发明的细胞培养基质基本上不含精制甘油。 在某些实施方案中,本发明的细胞培养基包含粗甘油作为唯一的碳源。
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公开(公告)号:US20110030102A1
公开(公告)日:2011-02-03
申请号:US12596272
申请日:2008-04-16
CPC分类号: C12N15/62 , C12N15/8243 , C12N15/8251 , C12N15/8257 , C12P13/02 , C12P13/04 , C12P13/14 , Y10T436/174614
摘要: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.
摘要翻译: 提供了可用于合成酰基氨基酸的工程化多肽。 还提供了使用工程改造的多肽制备酰基氨基酸的方法。 在某些实施方案中,使用本发明的组合物和/或方法产生的酰基氨基酸包含椰油酰谷氨酸。
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公开(公告)号:US20110034557A1
公开(公告)日:2011-02-10
申请号:US12709270
申请日:2010-02-19
申请人: Kevin A. Jarrell , Gabriel Reznik
发明人: Kevin A. Jarrell , Gabriel Reznik
IPC分类号: A61K31/198 , A61P31/04 , A01N37/46 , A01P1/00
摘要: Antimicrobial compositions and methods of using the compositions are described herein. The compositions include an antibacterial acyl amino acid. In some embodiments, the acyl amino acid is a fatty acylated glutamate. The methods herein include methods of using acyl amino acids for treating and preventing bacterial infections.
摘要翻译: 本文描述了抗微生物组合物和使用组合物的方法。 组合物包括抗菌酰基氨基酸。 在一些实施方案中,酰基氨基酸是脂肪酰化谷氨酸。 本文的方法包括使用酰基氨基酸来治疗和预防细菌感染的方法。
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