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    METERED-DOSE INHALER AND METHOD OF USING THE SAME
    1.
    发明申请
    METERED-DOSE INHALER AND METHOD OF USING THE SAME 审中-公开
    计量吸入器及其使用方法

    公开(公告)号：US20120055467A1

    公开(公告)日：2012-03-08

    申请号：US13226017

    申请日：2011-09-06

    申请人： Gaetano Brambilla ,  David Andrew Lewis ,  Robert Johnson ,  David Howlett

    发明人： Gaetano Brambilla ,  David Andrew Lewis ,  Robert Johnson ,  David Howlett

    IPC分类号： A61M11/00 ,  A61M16/14

    CPC分类号： A61M15/009 ,  A61J1/2037 ,  A61J1/2089 ,  A61M15/0003 ,  B65D83/54 ,  B65D83/682

    摘要： A metered-dose inhaler includes at least one vessel and an actuator for receiving the at least one vessel. The at least one vessel includes a first reservoir containing a first formulation and a second reservoir containing a second formulation. The metered-dose inhaler is actuable when the at least one vessel is received by the actuator. The metered-dose inhaler is configured to simultaneously deliver a first metered dose of the first formulation and a second metered dose of the second formulation upon actuation.

    摘要翻译： 计量吸入器包括至少一个容器和用于容纳至少一个容器的致动器。 所述至少一个容器包括含有第一制剂的第一储存器和含有第二制剂的第二储存器。 当至少一个容器被致动器接收时，计量吸入器是致动的。 计量吸入器构造成在致动时同时递送第一制剂的第一计量剂量和第二制剂的第二计量剂量。

    Pharmaceutical formulations for dry powder inhalers
    2.
    发明申请
    Pharmaceutical formulations for dry powder inhalers 有权
    干粉吸入器的药物制剂

    公开(公告)号：US20090269412A1

    公开(公告)日：2009-10-29

    申请号：US12386758

    申请日：2009-04-21

    申请人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rajbir Gill ,  Gaetano Brambilla ,  Rossella Musa ,  Lorenzo Ferrarini

    发明人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rajbir Gill ,  Gaetano Brambilla ,  Rossella Musa ,  Lorenzo Ferrarini

    IPC分类号： A61K9/16

    CPC分类号： A61K9/16 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/1682 ,  A61K31/167 ,  A61K31/58

    摘要： A powder for use in a dry powder inhaler comprises: i) a fraction of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation which is freely flowable, can be produced in a simple way, is physically and chemically stable and capable of delivering accurate doses and/or high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.

    摘要翻译： 用于干粉吸入器的粉末包括：i）由生理上可接受的赋形剂和添加剂的混合物构成的细粒度的一部分; ii）一部分粗颗粒; 和iii）至少一种活性成分。 该粉末适用于将有效成分有效递送至患有肺部疾病如哮喘的患者的低呼吸道。 特别地，本发明提供了作为可自由流动的用于吸入的干燥粉末施用的制剂，可以以简单的方式产生，物理和化学稳定并且能够输送精确剂量和/或低强度的高细颗粒级分 使用高或中等阻力装置的活性成分。

    Aerosol inhaler
    3.
    发明申请
    Aerosol inhaler 审中-公开
    气溶胶吸入器

    公开(公告)号：US20050034720A1

    公开(公告)日：2005-02-17

    申请号：US10168546

    申请日：2001-01-02

    申请人： Gaetano Brambilla ,  Isabella Panza ,  Alessandra Ferraris

    发明人： Gaetano Brambilla ,  Isabella Panza ,  Alessandra Ferraris

    IPC分类号： A61K9/00 ,  A61M15/00 ,  A61M11/00

    CPC分类号： A61M15/0086 ,  A61K9/008 ,  A61M15/009 ,  A61M2206/16

    摘要： A device for delivering metered aerosols g an active ingredient in solution in a propellant consisting of a hydrofluoroalkane (HFA), selected from 1,1,1,2-tetrafluoroethane (HFA 134a), 1,1,1,2,3,3,3-heptafluoropropane (HFA 227) or mixtures thereof, a co-solvent such as ethanol and optionally a low-volatility component preferably selected from glycerol, propylene glycol polyethylene glycol, oleic acid and isopropyl myristate, said device comprising a flat body with a seat for housing the can, an inhalation mouthpiece and an expansion chamber shaped to create a vortex flow of the aerosol particles expelled by the actuator, wherein the actuator orifice diameter is in the range between 0.30 and 0.50 mm.

    摘要翻译： 一种用于递送计量气溶胶的装置，其是在由选自1,1,1,2-四氟乙烷（HFA 134a），1,1,1,2,3,3（3））中的氢氟烷烃（HFA）组成的推进剂的溶液中的活性成分 ，3-七氟丙烷（HFA 227）或其混合物，共溶剂如乙醇和任选的低挥发性组分，优选选自甘油，丙二醇聚乙二醇，油酸和肉豆蔻酸异丙酯，所述装置包括具有 用于容纳罐的吸入口和膨胀室，其形成为产生由致动器排出的气溶胶颗粒的涡流，其中致动器孔直径在0.30和0.50mm之间的范围内。

    Pharmaceutical aerosol composition containing HFA 227 and HFA 134a
    4.
    发明授权
    Pharmaceutical aerosol composition containing HFA 227 and HFA 134a 失效
    含有HFA 227和HFA 134a的药物气溶胶组合物

    公开(公告)号：US06713047B1

    公开(公告)日：2004-03-30

    申请号：US09831886

    申请日：2001-07-18

    申请人： David Lewis ,  David Ganderton ,  Brian Meakin ,  Paolo Ventura ,  Gaetano Brambilla ,  Raffaella Garzia

    发明人： David Lewis ,  David Ganderton ,  Brian Meakin ,  Paolo Ventura ,  Gaetano Brambilla ,  Raffaella Garzia

    IPC分类号： A61K912

    CPC分类号： A61K9/008

    摘要： In a solution composition for use in an aerosol inhaler which comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility compound the use of a mixture of HFA 134a and HFA 227 allows to modulate the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler to target specific regions of the respiratory tract. Moreover the fine particle dose (FPD) of the active ingredient in the composition increases by reducing the metering chamber volume.

    摘要翻译： 在用于气溶胶吸入器的溶液组合物中，其包含活性物质，含有氢氟烷烃，助溶剂和任选的低挥发性化合物的推进剂，使用HFA134a和HFA227的混合物允许调节质量中值空气动力学直径（ MMAD）气雾剂颗粒在致动吸入器以靶向呼吸道的特定区域时。 此外，组合物中活性成分的细颗粒剂量（FPD）通过减少计量室体积而增加。

    METERED-DOSE INHALER ACTUATOR, METERED-DOSE INHALER AND METHOD OF USING THE SAME
    6.
    发明申请
    METERED-DOSE INHALER ACTUATOR, METERED-DOSE INHALER AND METHOD OF USING THE SAME 审中-公开
    计量吸入器致动器，计量吸入器及其使用方法

    公开(公告)号：US20120055468A1

    公开(公告)日：2012-03-08

    申请号：US13226005

    申请日：2011-09-06

    申请人： Gaetano Brambilla ,  David Andrew Lewis ,  Robert Johnson

    发明人： Gaetano Brambilla ,  David Andrew Lewis ,  Robert Johnson

    IPC分类号： A61M11/02 ,  A61M15/00

    CPC分类号： A61M15/009 ,  A61M2206/10 ,  A61M2206/16

    摘要： An actuator for a metered-dose inhaler is provided. The actuator comprises a housing having a mouthpiece portion and a canister receiving portion configured to receive a canister. The actuator further comprises a member disposed within the housing and defining a valve stem receptacle configured to receive a valve stem of the canister. An orifice is formed in the member, which is in fluid communication with the valve stem receptacle and extending to a face of the member opposite to the valve stem receptacle. A longitudinal axis of the orifice is aligned with a longitudinal axis of the valve stem receptacle. At least one air inlet opening is provided in an outer shell of the housing so as to be spaced from an opening for receiving the canister and a mouthpiece opening.

    摘要翻译： 提供用于计量吸入器的致动器。 致动器包括具有接口部分的壳体和被配置为容纳罐的罐接收部分。 所述致动器还包括设置在所述壳体内的构件，并且限定构造成容纳所述罐的阀杆的阀杆容置孔。 在所述构件中形成孔口，所述孔口与所述阀杆插座流体连通并且延伸到所述构件的与所述阀杆插座相对的面。 孔口的纵向轴线与阀杆容器的纵向轴线对准。 至少一个空气入口开口设置在壳体的外壳中，以与用于容纳罐的开口和接口开口间隔开。

    DRY POWDER FORMULATION COMPRISING AN ANTICHOLINERGIC DRUG
    9.
    发明申请
    DRY POWDER FORMULATION COMPRISING AN ANTICHOLINERGIC DRUG 审中-公开
    干粉制剂包含抗胆碱药物

    公开(公告)号：US20090192187A1

    公开(公告)日：2009-07-30

    申请号：US12343769

    申请日：2008-12-24

    申请人： Gaetano BRAMBILLA ,  Rossella Musa ,  Daniela Cocconi

    发明人： Gaetano BRAMBILLA ,  Rossella Musa ,  Daniela Cocconi

    IPC分类号： A61K31/439 ,  A61P11/00 ,  A61P11/06

    CPC分类号： C07D409/06 ,  A61K9/0075 ,  A61K9/14 ,  A61K31/137 ,  A61K31/439 ,  C07D453/02

    摘要： Pharmaceutical formulation in the form of inhalable dry powder comprising particles of a pharmaceutically acceptable salt of 3-[[[(3-fluorophenyl)[(3,4,5-trifluoro phenyl)methyl]amino]carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyclo [2.2.2]octane as active ingredient, and particles of a carrier made of a physiologically acceptable pharmacologically-inert material are effective for the prevention and/or treatment of a respiratory disease such as asthma and COPD.

    摘要翻译： 以可吸入干粉形式的药物制剂，其包含3 - [[[（3-氟苯基）[（3,4,5-三氟苯基）甲基]氨基]羰基]氧基] -1- [ 2-氧代-2-（2-噻吩基）乙基] -1-氮鎓双环[2.2.2]辛烷作为活性成分，由生理上可接受的药理惰性材料制成的载体颗粒对于预防和/或治疗是有效的 的呼吸系统疾病如哮喘和COPD。