公开(公告)号：US08093024B2

公开(公告)日：2012-01-10

申请号：US12786434

申请日：2010-05-25

申请人： Gary Strobel ,  Denise C. Manker ,  Julien Mercier

发明人： Gary Strobel ,  Denise C. Manker ,  Julien Mercier

IPC分类号： C12P3/00 ,  A01N63/00

CPC分类号： A01N63/02 ,  A01N63/04 ,  C12N1/14 ,  Y02E50/17 ,  Y02E50/343

摘要： This invention provides a novel endophytic fungus, Muscodor, that produces a mixture of volatile antibiotics with activity on specific plant pathogens, bacteria, nematodes and insects. Also provided is a method for treating or protecting plants, soil and seeds from microbial infections comprising applying an effective amount of a volatile antibiotic producing Muscodor sp. The invention also relates to fungicidal, bactericidal, insecticidal and nematicidal compositions comprising this novel Muscodor strain and the antibiotics and metabolites produced by this strain either alone, or in combination with other chemical and biological pesticides. Also provided is a method for identifying and isolating related gas producing fungi.

摘要翻译： 本发明提供了一种新颖的内生真菌Muscodor，其产生具有对特定植物病原体，细菌，线虫和昆虫的活性的挥发性抗生素的混合物。 还提供了一种治疗或保护植物，土壤和种子免受微生物感染的方法，包括施用有效量的挥发性抗生素产生的Muscodor sp。 本发明还涉及杀真菌，杀菌，杀虫剂和杀线虫剂组合物，其包含该新颖的Muscodor菌株以及该菌株单独或与其它化学和生物农药组合产生的抗生素和代谢物。 还提供了鉴定和分离相关产气真菌的方法。

公开(公告)号：US20100285543A1

公开(公告)日：2010-11-11

申请号：US12786434

申请日：2010-05-25

申请人： Gary Strobel ,  Denise C. Manker ,  Julien Mercier

发明人： Gary Strobel ,  Denise C. Manker ,  Julien Mercier

IPC分类号： C12P5/00 ,  C12P5/02 ,  C12P7/28 ,  C12P7/62 ,  C12P7/06 ,  C12P7/16 ,  C12P17/04

CPC分类号： A01N63/02 ,  A01N63/04 ,  C12N1/14 ,  Y02E50/17 ,  Y02E50/343

摘要： This invention provides a novel endophytic fungus, Muscodor, that produces a mixture of volatile antibiotics with activity on specific plant pathogens, bacteria, nematodes and insects. Also provided is a method for treating or protecting plants, soil and seeds from microbial infections comprising applying an effective amount of a volatile antibiotic producing Muscodor sp. The invention also relates to fungicidal, bactericidal, insecticidal and nematicidal compositions comprising this novel Muscodor strain and the antibiotics and metabolites produced by this strain either alone, or in combination with other chemical and biological pesticides. Also provided is a method for identifying and isolating related gas producing fungi.

摘要翻译： 本发明提供了一种新颖的内生真菌Muscodor，其产生具有对特定植物病原体，细菌，线虫和昆虫的活性的挥发性抗生素的混合物。 还提供了一种治疗或保护植物，土壤和种子免受微生物感染的方法，包括施用有效量的挥发性抗生素产生的Muscodor sp。 本发明还涉及杀真菌，杀菌，杀虫剂和杀线虫剂组合物，其包含该新颖的Muscodor菌株以及该菌株单独或与其它化学和生物农药组合产生的抗生素和代谢物。 还提供了鉴定和分离相关产气真菌的方法。

公开(公告)号：US07267975B2

公开(公告)日：2007-09-11

申请号：US10687546

申请日：2003-10-15

申请人： Gary Strobel ,  Bryn Daisy

发明人： Gary Strobel ,  Bryn Daisy

IPC分类号： A01N25/00 ,  A01N63/00 ,  A01N63/04 ,  A01N65/00 ,  C12N1/00 ,  C12P1/02 ,  C12P7/00 ,  C07C409/44

CPC分类号： C12R1/645 ,  A01N63/04 ,  C12P5/005 ,  Y10S435/911

摘要： The present invention relates to the discovery of a novel endophytic fungus, Muscodor vitigenus, from the liana, Paullinia paullinioides. This fungus produces naphthalene under certain cultural conditions that has chromatographic and mass spectral properties that are identical to authentic naphthalene. In a preferred embodiment, the naphthalene in the gas phase of M. vitigenus is useful in the repellency of unwanted insect pests. The unique biological activity of the novel endophyte suggests a wide range of potential practical applications, particularly in the area of insect repellents, insecticides, antimicrobials, anthelmintics and vermicides.

摘要翻译： 本发明涉及一种新颖的内生真菌，来自木犀草的保护性痢疾杆菌（Paillinia paullinioides）。 这种真菌在某些文化条件下产生萘，其色谱和质谱光谱性质与真正的萘相同。 在优选的实施方案中，维生素M.的气相中的萘可用于不期望的害虫的排斥。 新型内生真菌的独特生物活性表明广泛的潜在实际应用，特别是在驱虫剂，杀虫剂，抗微生物剂，驱肠虫剂和杀真菌剂方面。

公开(公告)号：US07192939B2

公开(公告)日：2007-03-20

申请号：US10356320

申请日：2003-01-30

申请人： Gary Strobel ,  Eugene Ford ,  James K. Harper

发明人： Gary Strobel ,  Eugene Ford ,  James K. Harper

IPC分类号： A01N57/00 ,  C07D305/12 ,  C07D307/93

CPC分类号： C07D307/87 ,  A61K31/343 ,  C07D307/88 ,  C12P17/04 ,  C12R1/645 ,  Y02A50/492

摘要： The present invention relates to the novel isolated 12–30 strain of Pestalotiopsis microspora capable of producing novel antioxidant and antimycotic agents. The present invention also relates to the novel isolated 3,5,7 trisubstituted isobenzofuranone and derivatives thereof, methods of isolating the novel isobenzofuranone from cultures P. microspora 12–30, and to novel uses of the compound as an antioxidant and antimycotic agent. The present invention further relates to a novel 1,5,7 trisubstituted 1,3-dihydroisobenzofuran and derivatives thereof, methods of isolating this novel compound from cultures of Pestalotiopsis microspora 12–30, and to uses thereof.

摘要翻译： 本发明涉及能够生产新型抗氧化剂和抗真菌剂的新型分离的Pestalotiopsis microspora的12-30菌株。 本发明还涉及新型分离的3,5,7三取代异苯并呋喃酮及其衍生物，从培养物微孢子菌属12-30中分离出新的异苯并呋喃酮的方法，以及该化合物作为抗氧化剂和抗真菌剂的新用途。 本发明还涉及一种新的1,5,7三取代1,3-二氢异苯并呋喃及其衍生物，其从Pestalotiopsis microspora 12-30的培养物中分离出该新化合物的方法及其应用。

公开(公告)号：US20060127346A1

公开(公告)日：2006-06-15

申请号：US11344768

申请日：2006-02-01

申请人： Gary Strobel ,  David Ezra

发明人： Gary Strobel ,  David Ezra

IPC分类号： A61L9/015 ,  A61K35/74

CPC分类号： A01N63/04 ,  A01N63/02 ,  C12N1/14

摘要： This invention relates to the discovery of a novel endophytic fungus, Muscodor albus, which produces volatile antibiotics that have been shown to be effective in the treatment of human and animal waste products. Through experimentation, this invention confirms that Muscodor albus can be used in disposable bags in connection with portable toilets to solve the problem of degradation of waste products in situations where humans are removed from sanitary facilities. This invention includes the discovery of non-volatile inhibitors that are also produced by Muscodor albus and that are similarly effective in treating human and animal wastes. This invention covers a unique and novel method for preparing Muscodor albus for commercial use in the treatment of human and animal wastes, which involves infesting barley seeds with Muscodor albus and then storing them under conditions that will allow the fungus to remain viable for up to nine months.

公开(公告)号：US20050260182A1

公开(公告)日：2005-11-24

申请号：US11064486

申请日：2005-02-24

申请人： Gary Strobel ,  Debbie Yaver ,  Uvidelio Castillo ,  David Ezra

发明人： Gary Strobel ,  Debbie Yaver ,  Uvidelio Castillo ,  David Ezra

IPC分类号： A01N63/00 ,  A01N63/02 ,  A61K38/00 ,  A61K38/54 ,  C07K14/36 ,  C12N1/20 ,  C12N9/99 ,  C12P21/00 ,  C12R1/465

CPC分类号： C12R1/465 ,  A01N63/00 ,  A01N63/02 ,  A61K38/00 ,  C07K14/36 ,  C12P21/00

摘要： The present invention relates to isolated strains of a Streptomyces spp. which are endophytes of dicotyledonous plants and to methods for selecting such strains. The present invention also relates to a biologically active compound called coronamycin obtained from endophytic Streptomycetes isolated from higher plants. The present invention further relates to compositions of such compounds and to methods of protecting plants against attack by a plant pathogen and methods of inhibiting bacterial growth, fungal growth, viral infection, growth of parasitic organisms, and cancer cell growth with such compositions.

摘要翻译： 本发明涉及链霉菌属（Streptomyces spp。）的分离菌株。 其是双子叶植物的内生真菌和选择这些菌株的方法。 本发明还涉及从高等植物分离的内生菌链球菌获得的称为冠状病毒的生物活性化合物。 本发明进一步涉及这些化合物的组合物以及保护植物免受植物病原体攻击的方法以及用这些组合物抑制细菌生长，真菌生长，病毒感染，寄生生物生长和癌细胞生长的方法。

公开(公告)号：US20060127347A1

公开(公告)日：2006-06-15

申请号：US11344769

申请日：2006-02-01

申请人： Gary Strobel ,  David Ezra

发明人： Gary Strobel ,  David Ezra

IPC分类号： A61L9/015 ,  A61K35/74

CPC分类号： A01N63/04 ,  A01N63/02 ,  C12N1/14

摘要： This invention relates to the discovery of a novel endophytic fungus, Muscodor albus, which produces volatile antibiotics that have been shown to be effective in the treatment of human and animal waste products. Through experimentation, this invention confirms that Muscodor albus can be used in disposable bags in connection with portable toilets to solve the problem of degradation of waste products in situations where humans are removed from sanitary facilities. This invention includes the discovery of non-volatile inhibitors that are also produced by Muscodor albus and that are similarly effective in treating human and animal wastes. This invention covers a unique and novel method for preparing Muscodor albus for commercial use in the treatment of human and animal wastes, which involves infesting barley seeds with Muscodor albus and then storing them under conditions that will allow the fungus to remain viable for up to nine months.

摘要翻译： 本发明涉及一种新颖的内生真菌Muscodor albus的发现，它产生已被证明在人和动物废物处理方面有效的挥发性抗生素。 通过实验，本发明证实了Muscodor albus可以用于与便携式厕所相关的一次性袋中，以解决在人类从卫生设施中移除的情况下废物降解的问题。 本发明包括还发现也由Muscodor albus生产并且类似地有效治疗人和动物废物的非挥发性抑制剂。 本发明涵盖了用于制备用于人和动物废物的商业用途的Muscodor albus的独特和新颖的方法，其涉及用Muscodor albus侵染大麦种子，然后在允许真菌保持最多9种条件的条件下储存 几个月。

公开(公告)号：US6013493A

公开(公告)日：2000-01-11

申请号：US979942

申请日：1997-11-26

申请人： Andrea Stierle ,  Donald Stierle ,  Gary Strobel

发明人： Andrea Stierle ,  Donald Stierle ,  Gary Strobel

IPC分类号： C07D305/14 ,  C12N1/14 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/645

CPC分类号： C12R1/645 ,  C07D305/14 ,  C12P17/02 ,  C12Q1/04 ,  G01N2407/02 ,  Y10S435/911

摘要： Taxol is produced from taxol-producing micro-organisms. Methods of obtain the taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatment of leukemia and cancer cells are described.

摘要翻译： 紫杉醇是由紫杉醇生产微生物产生的。 描述获得紫杉醇生产微生物的方法。 描述了放射性标记的紫杉醇产品和使用放射性标记的紫杉醇和用于治疗白血病和癌细胞的方法。

公开(公告)号：US5861302A

公开(公告)日：1999-01-19

申请号：US258105

申请日：1994-06-10

申请人： Andrea Stierle ,  Donald Stierle ,  Gary Strobel

发明人： Andrea Stierle ,  Donald Stierle ,  Gary Strobel

IPC分类号： C07D305/14 ,  C12N1/14 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/645 ,  C07D305/00 ,  C12N1/16

CPC分类号： C12R1/645 ,  C07D305/14 ,  C12P17/02 ,  C12Q1/04 ,  G01N2407/02 ,  Y10S435/911

摘要： Taxol is produced from taxol-producing micro-organisms. Methods of obtain the taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatment of leukemia and cancer cells are described.

公开(公告)号：US07754203B2

公开(公告)日：2010-07-13

申请号：US11131659

申请日：2005-05-17

申请人： Gary Strobel ,  Denise C. Manker ,  Julien Mercier

发明人： Gary Strobel ,  Denise C. Manker ,  Julien Mercier

IPC分类号： A01N63/00

CPC分类号： A01N63/02 ,  A01N63/04 ,  C12N1/14 ,  Y02E50/17 ,  Y02E50/343

摘要： This invention provides a novel endophytic fungus, Muscodor, that produces a mixture of volatile antibiotics with activity on specific plant pathogens, bacteria, nematodes and insects. Also provided is a method for treating or protecting plants, soil and seeds from microbial infections comprising applying an effective amount of a volatile antibiotic producing Muscodor sp. The invention also relates to fungicidal, bactericidal, insecticidal and nematicidal compositions comprising this novel Muscodor strain and the antibiotics and metabolites produced by this strain either alone, or in combination with other chemical and biological pesticides. Also provided is a method for identifying and isolating related gas producing fungi.

摘要翻译： 本发明提供了一种新颖的内生真菌Muscodor，其产生具有对特定植物病原体，细菌，线虫和昆虫的活性的挥发性抗生素的混合物。 还提供了一种治疗或保护植物，土壤和种子免受微生物感染的方法，包括施用有效量的挥发性抗生素产生的Muscodor sp。 本发明还涉及杀真菌，杀菌，杀虫剂和杀线虫剂组合物，其包含该新颖的Muscodor菌株以及该菌株单独或与其它化学和生物农药组合产生的抗生素和代谢物。 还提供了鉴定和分离相关产气真菌的方法。