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公开(公告)号：US20190298894A1
公开(公告)日：2019-10-03
申请号：US16445799
申请日：2019-06-19
发明人： Martin Friedrich
IPC分类号： A61M1/00
摘要： The invention relates to a suction tip (1) for suctioning a biological fluid, comprising a main body (12) having a main shaft (3) and a wall (4), a connection (5) for a suction line (2) formed on the main shaft (3) on the main body (12) and defining a free connection cross-section (6) of the suction tip (1), and multiple decentralized suction holes (7) laterally entering the main body (12), running through the wall (4) of the main body (12) and communicating with the connection (5) in the main body (12), wherein, with the continuous extension of its path (13) through the wall (4) of the main body (12), a free minimum cross-section (10) of each decentralized suction hole (7) overlaps completely with the free connection cross-section (6) of the connection (5).
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公开(公告)号：US20230242914A1
公开(公告)日：2023-08-03
申请号：US17917958
申请日：2021-03-11
申请人： Michaael ZEISBERG , Gerd HASENFUSS , Elisabeth ZEISBERG , GEORG-AUGUST-UNIVERSITAET GOETTINGEN STIFTUNG OEFFENTLICHEN RECHTS,UNIVERSITAETSMEDIZIN
IPC分类号： C12N15/113 , C12N15/86 , A61K31/713 , A61K9/00 , A61P31/14
CPC分类号： C12N15/1131 , C12N15/86 , A61K31/713 , A61K9/0012 , A61P31/14 , C12N2710/10041 , C12N2750/14141
摘要： The present invention relates to a novel approach for treating coronavirus infections, particularly infections caused by MERS-CoV, SARS-CoV and SARS-CoV-2 variants. Based on effectively targeting and cleaving single stranded RNA viruses, the present invention provides Cas13d guide RNAs, to guide the Cas13d protein to a target site in the genome of humanized Coronaviridae that is conserved between MERS-CoV, SARS-CoV and SARS-CoV-2. The disclosed invention further provides an AAV vector comprising such a Cas13d guide RNA expression cassette as well as a Cas13d for treating coronavirus infections, especially COVID-19 infections.
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公开(公告)号：US20230282011A1
公开(公告)日：2023-09-07
申请号：US18174971
申请日：2023-02-27
申请人： Siemens Healthcare GmbH , Georg-August-Universitaet Goettingen Stiftung oeffentlichen Rechts Universitaetsmedizin Goettingen
IPC分类号： G06V20/70 , G06V10/774 , G06V10/84 , G06V10/26 , G06V10/764 , G06V10/776
CPC分类号： G06V20/70 , G06V10/774 , G06V10/84 , G06V10/26 , G06V10/764 , G06V10/776 , G06V2201/03
摘要： A set of pre-annotated medical images is received, and the received set is processed by automatically: training an AI-based uncertainty model using the received set as training data; processing medical images of the received set by determining classified segments and/or uncertainty regions in the medical images using the trained AI-based uncertainty model; selecting at least a part of the processed medical images including classified segments and/or uncertainty regions based on the processing result; and presenting the selected part of processed medical images to a human expert. Furthermore, a modified received set including additional annotations created by the human expert is received.
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公开(公告)号：US11643626B2
公开(公告)日：2023-05-09
申请号：US16207392
申请日：2018-12-03
CPC分类号： C12M23/12 , C12M21/08 , C12M23/10 , C12M23/48 , C12M25/14 , C12M35/02 , C12M41/46 , C12N13/00
摘要： A well plate comprises a plate main body and at least one cavity in an upper side of the plate main body. An upwardly open annular channel is formed in the at least one cavity, the annular channel being delimited at an inner circumference thereof by a closed circumferential wall. A horizontal outer circumference of the circumferential wall decreases from bottom to top up to an upper edge of the circumferential wall. Within the horizontal circumference of the circumferential wall, at its upper edge, at least two retaining elements connect upwardly to the upper edge of the circumferential wall. The at least two retaining elements are at a free horizontal distance to one another, and at least one of the at least two retaining elements is elastically supported at the plate main body in horizontal direction.
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5.发明授权公开(公告)号：US11628065B2
公开(公告)日：2023-04-18
申请号：US16828444
申请日：2020-03-24
发明人： Arndt F. Schilling , Shahed Taheri
摘要： The present invention relates to the diagnosis and treatment of joint-related diseases, in particular osteoarthritis. Based on the analysis of the microarchitecture, such as microchannels, of the subchondral bone, the present invention provides methods for evaluating the health state of a joint as well as determining whether a joint is prone to develop or has already developed a disease correlated to joint and cartilage destruction. The invention further provides for membranes and other implants mimicking healthy subchondral bone structure suitable for promoting regeneration of joint structure and function.
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公开(公告)号：US20230024933A1
公开(公告)日：2023-01-26
申请号：US17714500
申请日：2022-04-06
申请人： Georg-August-Universitaet Goettingen Stiftung Oeffentlichen Rechts, Universitaetsmedizin , Board of Regents, The University of Texas System
发明人： Michael ZEISBERG , Elisabeth ZEISBERG , Bjoern TAMPE , Gerhard Anton MUELLER , Xingbo XU , Desiree TAMPE , Raghu KALLURI
IPC分类号： A61K31/713 , C12Q1/6869 , C07K14/47 , C12N15/113
摘要： Provided is a method of preventing, treating or delaying progression of a disease involving aberrant fibroblast proliferation. The method involves using a compound that reduces the level of tyrosine phosphatase activity effected by the protein EYA1A in the parenchymal organ, a nucleic acid ligase IV inhibitor, or an antisense oligonucleotide against the p53-binding protein 1 (53BP1).
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公开(公告)号：US11331333B2
公开(公告)日：2022-05-17
申请号：US16678398
申请日：2019-11-08
申请人： Georg August Universitaet Goettingen Stiftung Oeffentlichen Rechts, Universitaetsmedizin , The University of Texas MD Anderson Cancer Center
发明人： Michael Zeisberg , Elisabeth Zeisberg , Bjoern Tampe , Gerhard Anton Mueller , Xu Xingbo , Desiree Tampe , Raghu Kalluri
IPC分类号： C07H21/02 , A61K31/713 , C12Q1/6869 , C07K14/47 , C12N15/113
摘要： Provided is a method of preventing, treating or delaying progression of a disease involving aberrant fibroblast proliferation. The method involves using a compound that reduces the level of tyrosine phosphatase activity effected by the protein EYA1A in the parenchymal organ, a nucleic acid ligase IV inhibitor, or an antisense oligonucleotide against the p53-binding protein 1 (53BP1).
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公开(公告)号：US20210008044A1
公开(公告)日：2021-01-14
申请号：US17042027
申请日：2019-03-27
申请人： GEORG-AUGUST-UNIVERSITAET GOETTINGEN, STIFTUNG OEFFENTLICHEN RECHTS, UNIVERSITAETSMEDIZIN , THE UNIVERSITY OF TEXAS
发明人： Michael ZEISBERG , Elisabeth ZEISBERG , Björn TAMPE , Désiree TAMPE , Gerhard Anton MUELLER , Raghu KALLURI
IPC分类号： A61K31/436 , A61P13/12 , C12N15/113 , A61K31/4439 , A61P9/00 , A61P1/16 , A61K31/35 , A61K31/496
摘要： The present disclosure is directed to novel therapeutic approaches for the prevention, treatment and/or delaying progression of chronic injury, progressive loss of functional parenchymal cells, or fibrosis of an organ. Specifically disclosed are agents for use in increasing homodimer-formation of ARNT in an organ in the prevention, treatment and/or delaying progression of chronic injury, progressive loss of functional parenchymal cells, or fibrosis of said organ, as further defined in the claims. In embodiments, said agent may be (i) an inhibitor of protein phosphatase 2A (PP2A) activity, (ii) an inhibitor of the transcriptional repressor complex FKBP12/YY1, or (iii) an expression construct, which is capable of over-expressing ARNT in said organ, as well as combinations of (i), (ii), and/or (iii).
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9.发明授权公开(公告)号：US11662332B2
公开(公告)日：2023-05-30
申请号：US16430997
申请日：2019-06-04
CPC分类号： G01N27/44743 , A01N1/0294 , C12M1/42 , C12N13/00 , G01N1/30 , G01N27/447 , C07K1/14 , C07K1/26 , G01N27/44704
摘要： In a method for producing transparent biological preparations for examination by light microscopy biological tissue is electrophoretically clarified in that the tissue is immersed in an aqueous alkaline electrophoresis solution and is exposed to an electric field in the electrophoresis solution. The electrophoresis solution contains a buffer base, the cations of which have a molecular weight of at least 50 Da, at a concentration of 5 to 100 mol/m3 and a non-ionic detergent at a concentration of 0.1 to 10% (w/v).
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10.发明申请公开(公告)号：US20210298907A1
公开(公告)日：2021-09-30
申请号：US16828444
申请日：2020-03-24
发明人： ARNDT F. SCHILLING , SHAHED TAHERI
摘要： The present invention relates to the diagnosis and treatment of joint-related diseases, in particular osteoarthritis. Based on the analysis of the microarchitecture, such as microchannels, of the subchondral bone, the present invention provides methods for evaluating the health state of a joint as well as determining whether a joint is prone to develop or has already developed a disease correlated to joint and cartilage destruction. The invention further provides for membranes and other implants mimicking healthy subchondral bone structure suitable for promoting regeneration of joint structure and function.
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