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1.发明申请公开(公告)号：US20100043883A1
公开(公告)日：2010-02-25
申请号：US12491014
申请日：2009-06-24
CPC分类号： C12M37/00 , C12M33/00 , G01N1/2035 , Y10T137/0318 , Y10T137/8593
摘要： An automatic sterile sampling system for sampling fluid includes a steam valve, a sampling valve, a processing system, an isolation valve, and a controller. The inner diameters of the valve ports and fluid lines are less than about 8 mm. The system has tapered transitions between an outlet port of the sampling valve and an inlet port of the isolation valve and between a sample transfer port of the isolation valve and a sample transfer channel. An isolation valve drain outlet port protrudes upwardly from the isolation valve and has a longitudinal axis that is angled less than about 45° with from vertical.
摘要翻译： 用于采样流体的自动无菌取样系统包括蒸汽阀，取样阀，处理系统，隔离阀和控制器。 阀口和流体管线的内径小于约8mm。 该系统在采样阀的出口和隔离阀的入口之间以及隔离阀的样品传送端口和样品传送通道之间具有锥形过渡。 隔离阀排出口从隔离阀向上突出并且具有与垂直方向成小于约45°角度的纵向轴线。
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公开(公告)号：US20080308494A1
公开(公告)日：2008-12-18
申请号：US12156441
申请日：2008-05-29
CPC分类号： G01N1/14 , G01N2001/1006
摘要： A sampling apparatus and method for sampling is provided that achieves automatic, aseptic, extractive sampling of fluid samples from fluid sources containing high solids and/or high viscosity fluid without failing due to adverse interactions between the fluid and the sampling device such as clogging or fouling due to mechanical means or to physicochemical reactions between the fluid and the materials of construction of the sample device.
摘要翻译： 提供了一种采样设备和采样方法，其实现了对来自含有高固体和/或高粘度流体的流体源的流体样品的自动，无菌抽取采样，而不会由于流体和取样装置之间的不利相互作用而导致例如堵塞或结垢 由于机械手段或液体与样品装置结构材料之间的物理化学反应。
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公开(公告)号：US07341652B2
公开(公告)日：2008-03-11
申请号：US10601181
申请日：2003-06-20
IPC分类号： G01N27/447
CPC分类号： G01N35/1097 , B01D61/14 , B01D61/142 , B01D61/16 , B01D61/18 , B01D2311/04 , G01N27/44704 , Y10T436/25375 , B01D2311/12 , B01D2311/16 , B01D2311/2603
摘要： A system and method for capillary electrophoresis are provided for analyzing a macromolecule prepared from a complex liquid mixture. In particular applications, methods and apparatus are provided for separating and analyzing a solution containing a denatured macromolecule by employing a stationary capillary electrophoresis apparatus. An apparatus for capillary electrophoresis includes an inlet chamber and a capillary electrophoresis column. One end of the column is fixed at the interior of the inlet chamber. The column has a length of at least about 20 centimeters. Also included is a liquid source adapted for automatic control. The liquid source supplies a liquid sample through an input valve into the inlet chamber so that the sample is in fluid communication with the end of the column. A method for capillary electrophoresis includes automatically supplying the liquid sample to the apparatus.
摘要翻译： 提供毛细管电泳的系统和方法，用于分析由复合液体混合物制备的大分子。 特别是应用中，提供了一种使用固定式毛细管电泳装置分离和分析含有变性大分子的溶液的方法和装置。 毛细管电泳装置包括入口室和毛细管电泳柱。 塔的一端固定在入口室的内部。 该柱具有至少约20厘米的长度。 还包括适用于自动控制的液体源。 液体源通过输入阀将液体样品提供到入口室中，使得样品与柱的端部流体连通。 毛细管电泳的方法包括将液体样品自动供应给设备。
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公开(公告)号：US07955843B2
公开(公告)日：2011-06-07
申请号：US11604440
申请日：2006-11-27
CPC分类号： G01N35/1097 , B01D61/142 , B01D61/16 , B01D61/18 , B01D2311/04 , G01N1/2035 , G01N27/44704 , Y10T137/4259 , Y10T137/4266 , B01D2311/12 , B01D2311/16
摘要： An apparatus and method for an aseptic fluidic interface between bioprocess systems is provided. The apparatus includes an inlet valve, adapted for automatic control, that is coupled to a biofluid source site. A sampling conduit extends from the inlet valve to an outlet valve. The outlet valve is adapted for automatic control and is coupled to a biofluid process site. A trap is at the sampling conduit. A waste valve, adapted for automatic control, is located at a waste conduit extending from the sampling conduit to a waste site. Also included is a wash fluid source that is coupled to at least one of the inlet or outlet valves. In the method, the sample is automatically directed to the biofluid process site by opening the outlet valve, and closing the waste valve. Also included is isolating the biofluid sites by closing the inlet and outlet valves, and opening the waste valve to drain biofluid from the trap to the waste site. Another step is cleaning the sampling conduit before sample collection by directing the wash fluid through at least one valve selected from the inlet and outlet valves, and subsequently through the waste valve to the waste site.
摘要翻译： 提供了用于生物处理系统之间的无菌流体界面的装置和方法。 该装置包括适于自动控制的入口阀，其连接到生物流体源部位。 取样导管从入口阀延伸到出口阀。 出口阀适用于自动控制，并连接到生物流体过程现场。 陷阱位于采样管道处。 适用于自动控制的废气阀位于从采样管道延伸到废物处所的废料管道处。 还包括与至少一个入口阀或出口阀联接的洗涤流体源。 在该方法中，通过打开出口阀并关闭废气阀，将样品自动导向生物流体过程现场。 还包括通过关闭入口和出口阀来隔离生物流体位置，并打开废气阀以将生物流体从捕集器排出到废物处。 另一步骤是在采样之前通过将洗涤流体引导至少一个选自入口阀和出口阀的阀，然后通过废气阀到废物部位来清洗取样管。
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5.发明申请Method and apparatus for operating an automated biomolecular preparation system 审中-公开用于操作自动化生物分子制备系统的方法和装置公开(公告)号：US20090204264A1
公开(公告)日：2009-08-13
申请号：US12321890
申请日：2009-01-27
IPC分类号： G05D7/06
CPC分类号： G01N35/00584 , G01N27/44756
摘要： A system automatically prepares and analyzes a macromolecule prepared from a complex liquid mixture. To prepare the macromolecule, a controller executing executable instructions, such as compiled software or firmware, operates a hydraulic subsystem in response to operational input, which may be interpreted by the executable instructions at run-time. To analyze the prepared macromolecule, an apparatus for capillary electrophoresis includes a liquid source, inlet chamber, capillary electrophoresis column, and controller that may operate under control of executable instructions and operational input in a similar manner. The system may require validation and approval by a regulatory body, such as the FDA. Based on the de-coupled configuration of the executable instructions and operational input, the system can be validated and approved with the executable instructions independent of the operational input, and vice-versa. A method for distributing the system based on this feature is also provided.
摘要翻译： 系统自动制备和分析由复杂液体混合物制备的大分子。 为了准备大分子，执行诸如编译的软件或固件的可执行指令的控制器响应于可运行时可执行指令来解释的操作输入操作液压子系统。 为了分析制备的高分子，用于毛细管电泳的装置包括液体源，入口室，毛细管电泳柱和控制器，其可以以类似的方式在可执行指令和操作输入的控制下操作。 该系统可能需要由FDA等监管机构进行验证和批准。 基于可执行指令和操作输入的去耦合配置，系统可以与独立于操作输入的可执行指令进行验证和批准，反之亦然。 还提供了一种基于该特征分发系统的方法。
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公开(公告)号：US07601545B2
公开(公告)日：2009-10-13
申请号：US10601277
申请日：2003-06-20
CPC分类号： G01N35/1097 , B01D61/14 , B01D61/142 , B01D61/16 , B01D61/18 , B01D2311/04 , G01N1/2035 , G01N1/4077 , G01N27/44704 , Y10S436/808 , Y10T436/25 , Y10T436/25375 , B01D2311/16 , B01D2311/18
摘要： An apparatus for preparing a macromolecule sample from a complex liquid mixture includes a hydraulic system adapted for control by an automated controller, comprising a pump and one or more valves. The hydraulic system can be controlled by an automated controller to apply the liquid mixture to one or more filters with a pressure differential across each filter. The filters include a rough filter selected to separate, from a macromolecule in a liquid mixture, at least a portion of one or more rough components in the mixture that are larger than the macromolecule. Further included is a fine filter selected to separate from the macromolecule at least a portion of one or more fine components in the mixture that are smaller than the macromolecule. A method for preparing a macromolecule sample includes automatically acquiring a liquid mixture, the mixture including a macromolecule. At least a portion of the other components in the mixture are automatically separated from the macromolecule by applying the mixture to each of one or more filters, with a pressure differential across each filter.
摘要翻译： 用于从复杂液体混合物制备大分子样品的装置包括适于由自动控制器控制的液压系统，包括泵和一个或多个阀。 液压系统可以由自动控制器控制，以将液体混合物施加到一个或多个过滤器上，并在每个过滤器上具有压差。 过滤器包括粗选择的过滤器，其选择为从液体混合物中的大分子中分离混合物中大于大分子的一种或多种粗组分的至少一部分。 进一步包括精选过滤器，其被选择为与大分子分离混合物中的一种或多种细小成分的至少一部分小于大分子。 制备高分子样品的方法包括自动获取液体混合物，该混合物包括大分子。 通过将混合物施加到一个或多个过滤器中的每一个上，通过每个过滤器上的压力差，将混合物中的至少一部分其它组分自动地与大分子分离。
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7.发明申请METHODS AND SYSTEMS FOR IDENTIFICATION, EXTRACTION, AND TRANSFER OF ANALYTICAL DATA FOR PROCESS CONTROL 审中-公开用于识别，提取和转移分析数据进行过程控制的方法和系统公开(公告)号：US20110027892A1
公开(公告)日：2011-02-03
申请号：US12826048
申请日：2010-06-29
IPC分类号： G01N35/00
CPC分类号： G01N30/86 , G01N30/88 , Y10T436/11
摘要： Disclosed are methods, apparatuses, and systems, for (1) providing reliable identification of analytes from an HPLC or other analytical instrument, (2) ensuring data integrity during transfer of analytical data from the instrument to, for example, a control application or other destination, and (3) near-immediate transfer of the data after analysis. Embodiments include methods, apparatuses, and systems that automatically identify a subset of analytes from a plurality of analytes able to be analyzed by a liquid chromatograph (or similar instrument) and that automatically extract a subset of result data from the instrument, where the result data relates to a liquid mixture sample from a reactor (or other source) and where the subset of data corresponds to the subset of analytes. The subset of data may then be used to control a reactor process, or other process, by, for example, transferring the subset of data to a control application.
摘要翻译： 公开了方法，装置和系统，用于（1）提供来自HPLC或其他分析仪器的分析物的可靠识别，（2）在将分析数据从仪器转移到例如控制应用或其他方面时确保数据完整性 目的地，以及（3）分析后数据的即时转移。 实施方案包括自动鉴定能够通过液相色谱仪（或类似仪器）分析的多种分析物的分析物的子集的方法，装置和系统，并自动从仪器中提取结果数据的子集，其中结果数据 涉及来自反应器（或其他源）的液体混合物样品，其中数据子集对应于分析物的子集。 然后可以将数据子集用于控制反应器过程或其他过程，例如通过将数据子集传送到控制应用程序。
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8.发明申请公开(公告)号：US20100047122A1
公开(公告)日：2010-02-25
申请号：US12490960
申请日：2009-06-24
CPC分类号： C12M37/00 , C12M33/00 , G01N1/10 , G01N2001/1037 , G01N2001/205
摘要： A sampling system includes a steam source, a steam valve connected the steam source, a sampling valve connected to the fluid sample source, an isolation valve, a processing module, a drain valve, a drain, and a controller. The controller to passes cleaning fluid from the processing module through the isolation valve to the drain, passes steam through the steam valve, sampling valve, and isolation valve to the drain for a duration sufficient to sterilize the sampling valve, the isolation valve, and a fluid path therebetween, and passes fluid samples from the fluid sample source through the sampling valve and isolation valve to the processing module. The system and a method described delivers safer, more consistent sampling, while reducing the risk of contamination during extraction of a sample from a vessel and minimizing waste of the sample.
摘要翻译： 采样系统包括蒸汽源，连接蒸汽源的蒸汽阀，连接到流体样品源的采样阀，隔离阀，处理模块，排水阀，排水管和控制器。 控制器将清洁液从处理模块通过隔离阀传送到排水管，使蒸汽通过蒸汽阀，取样阀和隔离阀到达排水管，持续时间足以消除取样阀，隔离阀和 并且将来自流体样品源的流体样品通过采样阀和隔离阀传递到处理模块。 所述系统和所述方法提供更安全，更一致的取样，同时降低了从容器中提取样品时的污染风险，并最大限度地减少了样品的浪费。
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公开(公告)号：US20100021880A1
公开(公告)日：2010-01-28
申请号：US12573438
申请日：2009-10-05
CPC分类号： G01N35/1097 , B01D61/14 , B01D61/142 , B01D61/16 , B01D61/18 , B01D2311/04 , G01N1/2035 , G01N1/4077 , G01N27/44704 , Y10S436/808 , Y10T436/25 , Y10T436/25375 , B01D2311/16 , B01D2311/18
摘要： An apparatus for preparing a macromolecule sample from a complex liquid mixture includes a hydraulic system adapted for control by an automated controller, comprising a pump and one or more valves. The hydraulic system can be controlled by an automated controller to apply the liquid mixture to one or more filters with a pressure differential across each filter. The filters include a rough filter selected to separate, from a macromolecule in a liquid mixture, at least a portion of one or more rough components in the mixture that are larger than the macromolecule. Further included is a fine filter selected to separate from the macromolecule at least a portion of one or more fine components in the mixture that are smaller than the macromolecule. A method for preparing a macromolecule sample includes automatically acquiring a liquid mixture, the mixture including a macromolecule. At least a portion of the other components in the mixture are automatically separated from the macromolecule by applying the mixture to each of one or more filters, with a pressure differential across each filter.
摘要翻译： 用于从复杂液体混合物制备大分子样品的装置包括适于由自动控制器控制的液压系统，包括泵和一个或多个阀。 液压系统可以由自动控制器控制，以将液体混合物施加到一个或多个过滤器上，并在每个过滤器上具有压差。 过滤器包括粗选择的过滤器，其选择为从液体混合物中的大分子中分离混合物中大于大分子的一种或多种粗组分的至少一部分。 进一步包括精选过滤器，其被选择为与大分子分离混合物中的一种或多种细小成分的至少一部分小于大分子。 制备高分子样品的方法包括自动获取液体混合物，该混合物包括大分子。 通过将混合物施加到一个或多个过滤器中的每一个上，通过每个过滤器上的压力差，将混合物中的至少一部分其它组分自动地与大分子分离。
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公开(公告)号：US20080210560A1
公开(公告)日：2008-09-04
申请号：US12011015
申请日：2008-01-23
申请人： George E. Barringer
发明人： George E. Barringer
IPC分类号： C07K1/26
CPC分类号： G01N35/1097 , B01D61/14 , B01D61/142 , B01D61/16 , B01D61/18 , B01D2311/04 , G01N27/44704 , Y10T436/25375 , B01D2311/12 , B01D2311/16 , B01D2311/2603
摘要： A system and method for capillary electrophoresis are provided for analyzing a macromolecule prepared from a complex liquid mixture. In particular applications, methods and apparatus are provided for separating and analyzing a solution containing a denatured macromolecule by employing a stationary capillary electrophoresis apparatus. An apparatus for capillary electrophoresis includes an inlet chamber and a capillary electrophoresis column. One end of the column is fixed at the interior of the inlet chamber. The column has a length of at least about 20 centimeters. Also included is a liquid source adapted for automatic control. The liquid source supplies a liquid sample through an input valve into the inlet chamber so that the sample is in fluid communication with the end of the column. A method for capillary electrophoresis includes automatically supplying the liquid sample to the apparatus.
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