公开(公告)号：US20160334356A1

公开(公告)日：2016-11-17

申请号：US15155681

申请日：2016-05-16

申请人： Abbott Diabetes Care Inc.

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： G01N27/327 ,  C12Q1/32 ,  C12Q1/00

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

摘要翻译： 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

公开(公告)号：US09341591B2

公开(公告)日：2016-05-17

申请号：US14281405

申请日：2014-05-19

申请人： Abbott Diabetes Care Inc.

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： G01N27/327 ,  C12Q1/00

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

公开(公告)号：US20160074949A1

公开(公告)日：2016-03-17

申请号：US14784695

申请日：2014-05-09

申请人： YASUNAGA CORPORATION

发明人： Yuji KAIMASU ,  Jungo MATSUI

IPC分类号： B23D31/00 ,  B23P15/00

CPC分类号： B23D31/002 ,  B23D3/02 ,  B23D13/00 ,  B23D2031/005 ,  B23P15/00 ,  B23P2700/04 ,  B26D3/14 ,  Y10T29/49288 ,  Y10T29/49789 ,  Y10T29/4979 ,  Y10T29/49792 ,  Y10T29/49794 ,  Y10T29/49796 ,  Y10T74/2142 ,  Y10T83/0304

摘要： A method of forming a fracture start portion of a con rod for forming fracture start portions of a con rod at opposing positions in an inner peripheral surface of a large end of the con rod made of metal, includes a first step of forming a groove portion at a position corresponding to the fracture start portion by using a first insert tip with a large tip end and a second step of forming the fracture start portion, which has become a V-shaped groove, by machining a bottom portion of the groove portion smaller by using a second insert tip having a tip end smaller than the first insert tip.

摘要翻译： 一种形成用于在由金属制成的杆的大端的内周面的相对位置处形成杆的断裂起始部分的杆的断裂起始部分的方法包括：第一步骤，形成槽部分 通过使用具有大的前端的第一插入端头和形成V形槽的断裂起始部分的第二步骤，通过机械加工凹槽部分的较小的底部，在对应于断裂起始部分的位置处 通过使用具有小于第一插入尖端的尖端的第二插入尖端。

公开(公告)号：US08555495B2

公开(公告)日：2013-10-15

申请号：US13299120

申请日：2011-11-17

申请人： Yong Poo Chia ,  Low Siu Waf ,  Suan Jeung Boon ,  Eng Meow Koon ,  Swee Kwang Chua

发明人： Yong Poo Chia ,  Low Siu Waf ,  Suan Jeung Boon ,  Eng Meow Koon ,  Swee Kwang Chua

IPC分类号： H01K3/10

CPC分类号： H01L21/561 ,  H01L21/56 ,  H01L21/568 ,  H01L21/6835 ,  H01L22/00 ,  H01L23/3114 ,  H01L24/05 ,  H01L24/97 ,  H01L25/0657 ,  H01L25/50 ,  H01L2221/68345 ,  H01L2224/97 ,  H01L2225/06524 ,  H01L2225/06541 ,  H01L2225/06548 ,  H01L2225/06551 ,  H01L2225/06558 ,  H01L2225/06575 ,  H01L2924/12042 ,  H01L2924/14 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49144 ,  Y10T29/49146 ,  Y10T29/49155 ,  Y10T29/49165 ,  Y10T29/49167 ,  Y10T29/49169 ,  Y10T29/49794 ,  H01L2924/00

摘要： A method for packaging integrated circuit chips (die) is described that includes providing a base substrate with package level contacts, coating a base substrate with adhesive, placing dies on the adhesive, electrically connecting the die to the package level contacts, and removing the backside of the base substrate to expose the backside of the package level contacts. Accordingly, an essentially true chip scale package is formed. Multi-chip modules are formed by filling gaps between the chips with an encapsulant. In an embodiment, chips are interconnected by electrical connections between package level contacts in the base substrate. In an embodiment, substrates each having chips are adhered back-to-back with through vias formed in aligned saw streets to interconnect the back-to-back chip assembly.

摘要翻译： 描述了一种用于封装集成电路芯片（裸片）的方法，其包括提供具有封装级触点的基底基板，用粘合剂涂覆基底基板，将模具放置在粘合剂上，将模具电连接到封装级触点，以及去除背面 的基底以露出封装级触点的背面。 因此，形成了基本上真正的芯片级封装。 通过用密封剂填充芯片之间的间隙来形成多芯片模块。 在一个实施例中，芯片通过基底衬底中的封装级触点之间的电连接互连。 在一个实施例中，每个具有芯片的基板通过形成在对准的锯道中的通孔背靠背粘合以互连背对背芯片组件。

公开(公告)号：US08425758B2

公开(公告)日：2013-04-23

申请号：US12568887

申请日：2009-09-29

申请人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

公开(公告)号：US08425743B2

公开(公告)日：2013-04-23

申请号：US12723169

申请日：2010-03-12

申请人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

公开(公告)号：US20130042459A1

公开(公告)日：2013-02-21

申请号：US13584998

申请日：2012-08-14

申请人： Joseph Szuba

发明人： Joseph Szuba

IPC分类号： B23P15/00

CPC分类号： B23P15/00 ,  B23P2700/11 ,  F16D3/38 ,  F16D3/40 ,  F16D2250/00 ,  Y10T29/49794 ,  Y10T29/49796 ,  Y10T29/4984

摘要： A method of making a universal joint from a tube, including forming a plurality of pairs of coaxially aligned holes at longitudinally spaced locations in the tube, cutting the tube along a curvilinear cutting path around the holes forming a pair of projecting arms and U-shaped recesses between the arms forming a plurality of yokes and pivotally interconnecting the yokes using a pivot member received in the holes of adjacent yokes.

摘要翻译： 一种从管形成万向接头的方法，包括在管中的纵向间隔开的位置形成多对同轴对准的孔，沿着围绕孔的曲线切割路径切割管，形成一对突出臂和U形 所述臂之间的凹部形成多个轭，并且使用容纳在相邻轭的孔中的枢转构件枢转地互连轭。

公开(公告)号：US08262996B2

公开(公告)日：2012-09-11

申请号：US12568930

申请日：2009-09-29

申请人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： G01N15/06

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

摘要翻译： 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于测定生物流体如血液或血清中生物分子如葡萄糖或乳酸的浓度，使用诸如库仑法，电流分析法; 和电位法。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

公开(公告)号：US08221685B2

公开(公告)日：2012-07-17

申请号：US12568936

申请日：2009-09-29

申请人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： G01N15/06

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

公开(公告)号：US08211363B2

公开(公告)日：2012-07-03

申请号：US12568892

申请日：2009-09-29

申请人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： G01N15/06

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

摘要翻译： 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于测定生物流体如血液或血清中生物分子如葡萄糖或乳酸的浓度，使用诸如库仑法，电流分析法; 和电位法。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。