公开(公告)号：US20170196862A2

公开(公告)日：2017-07-13

申请号：US14876525

申请日：2015-10-06

申请人： Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Ciemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

发明人： Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Ciemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

IPC分类号： A61K31/506 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/44 ,  C07D213/84 ,  C07D231/14 ,  A61K31/415 ,  C07D209/42 ,  A61K31/404 ,  C07D401/12 ,  A61K31/4439 ,  C07D401/14 ,  C07D231/12 ,  A61K31/497 ,  C07D417/12 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4525 ,  A61J1/03 ,  C07D213/82

CPC分类号： A61K31/506 ,  A61J1/035 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  C07D209/18 ,  C07D209/42 ,  C07D209/49 ,  C07D213/64 ,  C07D213/73 ,  C07D213/82 ,  C07D213/84 ,  C07D231/12 ,  C07D231/14 ,  C07D231/20 ,  C07D235/24 ,  C07D239/34 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.