公开(公告)号：US08814785B2

公开(公告)日：2014-08-26

申请号：US12966234

申请日：2010-12-13

申请人： Michael P. Whitman ,  Gerald Dorros ,  Jeremy Hill

发明人： Michael P. Whitman ,  Gerald Dorros ,  Jeremy Hill

IPC分类号： A61B1/00

CPC分类号： A61B17/3439 ,  A61B17/3421 ,  A61B17/3468 ,  A61B2090/08021

摘要： An orifice introducer device for introducing, e.g., a surgical device, into, e.g., an orifice of a body, includes a tubular member having a distal end and a proximal end. The distal end is adjustable between a first position for insertion into an orifice and a second position once inserted into the orifice. Alternatively, the orifice introducer device includes a distal portion having a proximal end configured to be detachably secured to the distal end of the tubular member. The distal portion is selectively detachable when the orifice introducer device is positioned in the orifice.

摘要翻译： 用于将例如手术装置引入例如身体的孔的孔口导引器装置包括具有远端和近端的管状构件。 远端可以在插入孔中的第一位置和一旦插入孔中的第二位置之间是可调节的。 或者，孔口引导器装置包括远端部分，其具有被配置为可拆卸地固定到管状构件的远端的近端。 当孔口引导器装置定位在孔口中时，远端部分可选择性地拆卸。

公开(公告)号：US20110319976A1

公开(公告)日：2011-12-29

申请号：US13015571

申请日：2011-01-27

申请人： Sriram Iyer ,  Gerald Dorros

发明人： Sriram Iyer ,  Gerald Dorros

IPC分类号： A61F2/84 ,  A61F2/82

摘要： The present invention relates to treating or preventing stenosis at an anastomosis site. In one embodiment, the present invention is a stent is curved along the longitudinal axis for placement in and adjacent to the graft orifice. In a further embodiment, the stent is drug coated to allow delivery of antivasculoproliferative drugs directly to the vicinity of the graft orifice. In a further embodiment, the stent is expandable by use of an external wire. In another embodiment, the present invention is a kit comprising the specially configured stent together with a sleeve comprising a biocompatible matrix material and a pharmaceutical agent, wherein the sleeve is applied to the external surface of the vessel or graft, resulting in extravascular delivery of a pharmaceutical agent. Methods for treating or preventing stenosis at an anastomosis site by applying the extravascular sleeve and the intravascular stent are also provided.

摘要翻译： 本发明涉及治疗或预防吻合部位的狭窄。 在一个实施例中，本发明是一种支架沿着纵向轴线弯曲以放置在移植孔口中并邻近移植孔。 在另一个实施方案中，支架被药物涂覆以允许抗血管增生药物直接递送到移植物孔附近。 在另一个实施例中，支架通过使用外部电线可扩张。 在另一个实施方案中，本发明是一种试剂盒，其包括特别配置的支架以及包含生物相容性基质材料和药剂的套管，其中将套管施加到血管或移植物的外表面，导致血管外递送 药剂。 还提供了通过应用血管外套管和血管内支架治疗或预防吻合部位狭窄的方法。

公开(公告)号：US07029488B2

公开(公告)日：2006-04-18

申请号：US10278183

申请日：2002-10-21

申请人： Claudio Javier Schönholz ,  Gerald Dorros ,  Michael Hogendijk

发明人： Claudio Javier Schönholz ,  Gerald Dorros ,  Michael Hogendijk

IPC分类号： A61M29/00

CPC分类号： A61B17/22 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/22031 ,  A61B17/221 ,  A61B17/3207 ,  A61B2017/22034 ,  A61B2017/22044 ,  A61B2017/22094 ,  A61B2017/3435 ,  A61M25/1002 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/09166 ,  A61M2025/1052

摘要： Apparatus and methods for treating cerebral occlusions are provided, including a thrombectomy device having at least one deployable element. The deployable element is advanced through the occlusion in a contracted state, then self-deploys distal of the occlusion or, alternatively, may be deployed to a wide range of configurations using a physician-actuated deployment knob. The thrombectomy device then may be retracted to cause the deployable element to snare the occlusion, and/or rotated circumferentially to cause the fibrin strands of the occlusion to be wrapped around the deployable element.

摘要翻译： 提供了用于治疗脑闭塞的装置和方法，包括具有至少一个可展开元件的血栓切除装置。 可部署元件在收缩状态下通过闭塞进行，然后自身部署闭塞的远端，或者替代地，可以使用医师致动的展开旋钮部署到宽范围的构​​造。 然后可以将血栓切除装置缩回以使可展开元件圈绕闭塞，和/或周向旋转，以使闭塞的纤维蛋白束缠绕在可部署元件周围。

公开(公告)号：US06902540B2

公开(公告)日：2005-06-07

申请号：US09972231

申请日：2001-10-04

申请人： Gerald Dorros ,  Juan Carlos Parodi ,  Claudio Javier Schönholz ,  Michael Hogendijk

发明人： Gerald Dorros ,  Juan Carlos Parodi ,  Claudio Javier Schönholz ,  Michael Hogendijk

IPC分类号： A61B17/12 ,  A61B17/22 ,  A61B17/34 ,  A61F2/958 ,  A61M37/00 ,  A61B17/00

CPC分类号： A61B17/3207 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12172 ,  A61B17/22 ,  A61B17/221 ,  A61B2017/22034 ,  A61B2017/3435 ,  A61M25/1002 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/09166 ,  A61M2025/1052

摘要： Apparatus and methods for treatment of stroke are provided. In a preferred embodiment, the present invention disposes at least one catheter having a distal occlusive member in either the common carotid artery (CCA) or both the vertebral artery (VA) and the CCA on the hemisphere of the cerebral occlusion. Blood flow in the opposing carotid and/or vertebral arteries may be inhibited. Retrograde or antegrade flow may be provided through either catheter independently to effectively control cerebral flow characteristics. Under such controlled flow conditions, a thrombectomy device may be used to treat the occlusion, and any emboli generated are directed into the catheter(s).

公开(公告)号：US20110082342A1

公开(公告)日：2011-04-07

申请号：US12966234

申请日：2010-12-13

申请人： Michael P. Whitman ,  Gerald Dorros ,  Jeremy Hill

发明人： Michael P. Whitman ,  Gerald Dorros ,  Jeremy Hill

IPC分类号： A61B1/32

CPC分类号： A61B17/3439 ,  A61B17/3421 ,  A61B17/3468 ,  A61B2090/08021

摘要： An orifice introducer device for introducing, e.g., a surgical device, into, e.g., an orifice of a body, includes a tubular member having a distal end and a proximal end. The distal end is adjustable between a first position for insertion into an orifice and a second position once inserted into the orifice. Alternatively, the orifice introducer device includes a distal portion having a proximal end configured to be detachably secured to the distal end of the tubular member. The distal portion is selectively detachable when the orifice introducer device is positioned in the orifice.

摘要翻译： 用于将例如手术装置引入例如身体的孔的孔口导引器装置包括具有远端和近端的管状构件。 远端可以在插入孔中的第一位置和一旦插入孔中的第二位置之间是可调节的。 或者，孔口引导器装置包括远端部分，其具有被配置为可拆卸地固定到管状构件的远端的近端。 当孔口引导器装置定位在孔口中时，远端部分可选择性地拆卸。

公开(公告)号：US07874981B2

公开(公告)日：2011-01-25

申请号：US10632271

申请日：2003-07-31

申请人： Michael P. Whitman ,  Gerald Dorros ,  Jeremy Hill

发明人： Michael P. Whitman ,  Gerald Dorros ,  Jeremy Hill

IPC分类号： A61B1/00

CPC分类号： A61B17/3439 ,  A61B17/3421 ,  A61B17/3468 ,  A61B2090/08021

摘要： An orifice introducer device for introducing, e.g., a surgical device, into, e.g., an orifice of a body, includes a tubular member having a distal end and a proximal end. The distal end is adjustable between a first position for insertion into an orifice and a second position once inserted into the orifice. Alternatively, the orifice introducer device includes a distal portion having a proximal end configured to be detachably secured to the distal end of the tubular member. The distal portion is selectively detachable when the orifice introducer device is positioned in the orifice.

摘要翻译： 用于将例如手术装置引入例如身体的孔的孔口导引器装置包括具有远端和近端的管状构件。 远端可以在插入孔中的第一位置和一旦插入孔中的第二位置之间是可调节的。 或者，孔口引导器装置包括远端部分，其具有被配置为可拆卸地固定到管状构件的远端的近端。 当孔口引导器装置定位在孔口中时，远端部分可选择性地拆卸。

公开(公告)号：US20050277979A1

公开(公告)日：2005-12-15

申请号：US11204891

申请日：2005-08-15

申请人： Gerald Dorros ,  Juan Parodi ,  Mark Bates

发明人： Gerald Dorros ,  Juan Parodi ,  Mark Bates

IPC分类号： A61B17/12 ,  A61B17/22 ,  A61B17/34 ,  A61F2/958 ,  A61M29/00

CPC分类号： A61B17/22031 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/22 ,  A61B17/221 ,  A61B17/3207 ,  A61B2017/22034 ,  A61B2017/2217 ,  A61B2017/3435 ,  A61M25/1002 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/09166 ,  A61M2025/1052

摘要： Apparatus and methods for treatment of stroke are provided. In a preferred embodiment, the present invention disposes at least one catheter having a distal occlusive member in the common carotid artery of the hemisphere of the cerebral occlusion. Retrograde flow may be provided through the catheter to effectively control cerebral flow characteristics. Under such controlled flow conditions, a thrombectomy device may be used to treat the occlusion, and any emboli generated are directed into the catheter.

摘要翻译： 提供了用于治疗中风的装置和方法。 在优选实施例中，本发明将至少一个具有远端闭塞构件的导管配置在大脑闭塞半球的颈总动脉中。 可以通过导管提供逆行流，以有效控制脑流动特征。 在这种受控的流动条件下，可以使用血栓切除装置来治疗闭塞，并且所产生的任何栓塞被引导到导管中。

公开(公告)号：US06855136B2

公开(公告)日：2005-02-15

申请号：US10134237

申请日：2002-04-25

申请人： Gerald Dorros ,  Michael Hogendijk ,  Mark C. Bates

发明人： Gerald Dorros ,  Michael Hogendijk ,  Mark C. Bates

IPC分类号： A61B17/22 ,  A61F2/958 ,  A61M25/00 ,  A61M31/00

CPC分类号： A61B17/22 ,  A61B2017/22042 ,  A61B2017/22084 ,  A61B2017/320716 ,  A61M25/007 ,  A61M25/04 ,  A61M25/10 ,  A61M2025/0081 ,  A61M2025/0681 ,  A61M2025/1047 ,  A61M2025/1052 ,  A61M2025/1079 ,  A61M2025/1093

摘要： The present invention is directed to apparatus and methods for treating a vascular occlusion by providing an infusion catheter having an atraumatic tip and at least one delivery port configured to infuse fluid into the occlusion. The fluid that is infused dilutes the occlusion and reduces adhesion of the occlusion to an intima of the vessel wall, thereby causing the occlusion to dislodge. Emboli generated in the process are directed into an emboli removal catheter for removal.

摘要翻译： 本发明涉及通过提供具有无创尖端的输注导管和配置成将流体注入到闭塞中的至少一个输送口来治疗血管闭塞的装置和方法。 注入的液体会减少闭塞并减少闭塞与血管壁内膜的粘附，从而导致闭塞。 在该过程中产生的栓塞被导入用于移除的栓塞移除导管。

公开(公告)号：US06325823B1

公开(公告)日：2001-12-04

申请号：US09430589

申请日：1999-10-29

申请人： Michael J. Horzewski ,  Gerald Dorros

发明人： Michael J. Horzewski ,  Gerald Dorros

IPC分类号： A61F206

CPC分类号： A61F2/90 ,  A61F2/07 ,  A61F2002/067 ,  A61F2002/075 ,  A61F2002/826 ,  A61F2230/0054 ,  A61F2250/0007 ,  A61F2250/0065

摘要： A prosthesis is provided comprising a plurality of telescoping tubular members that are deployed and assembled in vivo to define a lumen through a diseased portion of a vascular system. The individual tubular members are capable of accommodating torsional and longitudinal displacements caused by relative motion of the healthy portions on either side of the diseased portion of vessel.

摘要翻译： 提供了一种假体，其包括多个伸缩管状构件，其在体内部署和组装以限定通过血管系统的病变部分的内腔。 各个管状构件能够容纳由容器的病变部分两侧的健康部分的相对运动引起的扭转和纵向位移。

公开(公告)号：US20170020651A1

公开(公告)日：2017-01-26

申请号：US15284234

申请日：2016-10-03

申请人： Sriram Iyer ,  Gerald Dorros

发明人： Sriram Iyer ,  Gerald Dorros

IPC分类号： A61F2/06 ,  A61L31/16 ,  A61L31/12 ,  A61F2/954 ,  A61F2/962 ,  A61F2/856 ,  A61F2/90 ,  A61K31/436 ,  A61F2/844

摘要： The present invention relates to treating or preventing stenosis at an anastomosis site. In one embodiment, the present invention is a stent is curved along the longitudinal axis for placement in and adjacent to the graft orifice. In a further embodiment, the stent is drug coated to allow delivery of antivasculoproliferative drugs directly to the vicinity of the graft orifice. In a further embodiment, the stent is expandable by use of an external wire. In another embodiment, the present invention is a kit comprising the specially configured stent together with a sleeve comprising a biocompatible matrix material and a pharmaceutical agent, wherein the sleeve is applied to the external surface of the vessel or graft, resulting in extravascular delivery of a pharmaceutical agent. Methods for treating or preventing stenosis at an anastomosis site by applying the extravascular sleeve and the intravascular stent are also provided.

摘要翻译： 本发明涉及治疗或预防吻合部位的狭窄。 在一个实施例中，本发明是一种支架沿着纵向轴线弯曲以放置在移植孔口中并邻近移植孔。 在另一个实施方案中，支架被药物涂覆以允许抗血管增生药物直接递送到移植物孔附近。 在另一个实施例中，支架通过使用外部电线可扩张。 在另一个实施方案中，本发明是一种试剂盒，其包括特别配置的支架以及包含生物相容性基质材料和药剂的套管，其中将套管施加到血管或移植物的外表面，导致血管外递送 药剂。 还提供了通过应用血管外套管和血管内支架治疗或预防吻合部位狭窄的方法。