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    DEVICE AND METHOD FOR PREVENTING STENOSIS AT AN ANASTOMOSIS SITE
    1.
    发明申请
    DEVICE AND METHOD FOR PREVENTING STENOSIS AT AN ANASTOMOSIS SITE 审中-公开
    用于在分析现场防止STENOSIS的装置和方法

    公开(公告)号：US20170020651A1

    公开(公告)日：2017-01-26

    申请号：US15284234

    申请日：2016-10-03

    申请人： Sriram Iyer ,  Gerald Dorros

    发明人： Sriram Iyer ,  Gerald Dorros

    IPC分类号： A61F2/06 ,  A61L31/16 ,  A61L31/12 ,  A61F2/954 ,  A61F2/962 ,  A61F2/856 ,  A61F2/90 ,  A61K31/436 ,  A61F2/844

    摘要： The present invention relates to treating or preventing stenosis at an anastomosis site. In one embodiment, the present invention is a stent is curved along the longitudinal axis for placement in and adjacent to the graft orifice. In a further embodiment, the stent is drug coated to allow delivery of antivasculoproliferative drugs directly to the vicinity of the graft orifice. In a further embodiment, the stent is expandable by use of an external wire. In another embodiment, the present invention is a kit comprising the specially configured stent together with a sleeve comprising a biocompatible matrix material and a pharmaceutical agent, wherein the sleeve is applied to the external surface of the vessel or graft, resulting in extravascular delivery of a pharmaceutical agent. Methods for treating or preventing stenosis at an anastomosis site by applying the extravascular sleeve and the intravascular stent are also provided.

    摘要翻译： 本发明涉及治疗或预防吻合部位的狭窄。 在一个实施例中，本发明是一种支架沿着纵向轴线弯曲以放置在移植孔口中并邻近移植孔。 在另一个实施方案中，支架被药物涂覆以允许抗血管增生药物直接递送到移植物孔附近。 在另一个实施例中，支架通过使用外部电线可扩张。 在另一个实施方案中，本发明是一种试剂盒，其包括特别配置的支架以及包含生物相容性基质材料和药剂的套管，其中将套管施加到血管或移植物的外表面，导致血管外递送 药剂。 还提供了通过应用血管外套管和血管内支架治疗或预防吻合部位狭窄的方法。

    DEVICE AND METHOD FOR PREVENTING STENOSIS AT AN ANASTOMOSIS SITE
    2.
    发明申请
    DEVICE AND METHOD FOR PREVENTING STENOSIS AT AN ANASTOMOSIS SITE 审中-公开
    用于在分析现场防止STENOSIS的装置和方法

    公开(公告)号：US20140088681A1

    公开(公告)日：2014-03-27

    申请号：US13850450

    申请日：2013-03-26

    申请人： Sriram Iyer ,  Gerald Dorros

    发明人： Sriram Iyer ,  Gerald Dorros

    IPC分类号： A61L27/54 ,  A61F2/966 ,  A61F2/82

    摘要： The present invention relates to treating or preventing stenosis at an anastomosis site. In one embodiment, the present invention is a stent is curved along the longitudinal axis for placement in and adjacent to the graft orifice. In a further embodiment, the stent is drug coated to allow delivery of antivasculoproliferative drugs directly to the vicinity of the graft orifice. In a further embodiment, the stent is expandable by use of an external wire. In another embodiment, the present invention is a kit comprising the specially configured stent together with a sleeve comprising a biocompatible matrix material and a pharmaceutical agent, wherein the sleeve is applied to the external surface of the vessel or graft, resulting in extravascular delivery of a pharmaceutical agent. Methods for treating or preventing stenosis at an anastomosis site by applying the extravascular sleeve and the intravascular stent are also provided.

    摘要翻译： 本发明涉及在吻合部位处理或预防狭窄。 在一个实施例中，本发明是一种支架沿着纵向轴线弯曲以放置在移植孔口中并邻近移植孔。 在另一个实施方案中，支架被药物涂覆以允许抗血管增生药物直接递送到移植物孔附近。 在另一个实施例中，支架通过使用外部电线可扩张。 在另一个实施方案中，本发明是一种试剂盒，其包括特别配置的支架以及包含生物相容性基质材料和药剂的套管，其中将套管施加到血管或移植物的外表面，导致血管外递送 药剂。 还提供了通过应用血管外套管和血管内支架治疗或预防吻合部位狭窄的方法。

    DEVICE AND METHOD FOR PREVENTING STENOSIS AT AN ANASTOMOSIS SITE
    3.
    发明申请
    DEVICE AND METHOD FOR PREVENTING STENOSIS AT AN ANASTOMOSIS SITE 审中-公开
    用于在分析现场防止STENOSIS的装置和方法

    公开(公告)号：US20110319976A1

    公开(公告)日：2011-12-29

    申请号：US13015571

    申请日：2011-01-27

    申请人： Sriram Iyer ,  Gerald Dorros

    发明人： Sriram Iyer ,  Gerald Dorros

    IPC分类号： A61F2/84 ,  A61F2/82

    摘要： The present invention relates to treating or preventing stenosis at an anastomosis site. In one embodiment, the present invention is a stent is curved along the longitudinal axis for placement in and adjacent to the graft orifice. In a further embodiment, the stent is drug coated to allow delivery of antivasculoproliferative drugs directly to the vicinity of the graft orifice. In a further embodiment, the stent is expandable by use of an external wire. In another embodiment, the present invention is a kit comprising the specially configured stent together with a sleeve comprising a biocompatible matrix material and a pharmaceutical agent, wherein the sleeve is applied to the external surface of the vessel or graft, resulting in extravascular delivery of a pharmaceutical agent. Methods for treating or preventing stenosis at an anastomosis site by applying the extravascular sleeve and the intravascular stent are also provided.

    摘要翻译： 本发明涉及治疗或预防吻合部位的狭窄。 在一个实施例中，本发明是一种支架沿着纵向轴线弯曲以放置在移植孔口中并邻近移植孔。 在另一个实施方案中，支架被药物涂覆以允许抗血管增生药物直接递送到移植物孔附近。 在另一个实施例中，支架通过使用外部电线可扩张。 在另一个实施方案中，本发明是一种试剂盒，其包括特别配置的支架以及包含生物相容性基质材料和药剂的套管，其中将套管施加到血管或移植物的外表面，导致血管外递送 药剂。 还提供了通过应用血管外套管和血管内支架治疗或预防吻合部位狭窄的方法。

    Medical implants and methods for regulating the tissue response to vascular closure devices
    4.
    发明申请
    Medical implants and methods for regulating the tissue response to vascular closure devices 审中-公开
    用于调节血管闭合装置的组织反应的医用植入物和方法

    公开(公告)号：US20050004158A1

    公开(公告)日：2005-01-06

    申请号：US10871902

    申请日：2004-06-18

    申请人： Sriram Iyer ,  Nicholas Kipshidze ,  Victor Nikolaychik ,  Gary Roubin

    发明人： Sriram Iyer ,  Nicholas Kipshidze ,  Victor Nikolaychik ,  Gary Roubin

    IPC分类号： A61B17/00 ,  A61K31/4745 ,  A61M20060101

    CPC分类号： A61L31/125 ,  A61B17/0057 ,  A61B2017/00641 ,  A61B2017/00659 ,  A61B2017/00893 ,  A61K9/7007 ,  A61K31/436 ,  A61K31/4745 ,  A61L31/044 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

    摘要： Devices and methods for reducing, eliminating, preventing, suppressing, or treating tissue responses to hemostatic devices e.g., biological sealants or vascular procedures are disclosed. The invention employs a combination of resorbable, biocompatible matrix materials and a variety of therapeutic agents, such as antiproliferatives or antibiotics, applied to a vascular puncture or incision to achieve hemostasis following diagnostic or interventional vascular catheterizations and to treat neointimal hyperplasia and stenosis. A matrix of a material such as collagen provides a reservoir of a therapeutic agent such as rapamycin (sirolimus) and its derivatives and analogs for delivery at a tissue site at risk for vasculoproliferation, infection, inflammation, fibrosis or other tissue responses.

    摘要翻译： 公开了用于减少，消除，预防，抑制或治疗止血装置（例如生物密封剂或血管程序）的组织反应的装置和方法。 本发明采用可再吸收的生物相容性基质材料和多种治疗剂（例如抗增生剂或抗生素）的组合，应用于血管穿刺或切口以在诊断或介入性血管导管插入术后实现止血并治疗新生内膜增生和狭窄。 诸如胶原的材料的基质提供治疗剂的储库，例如雷帕霉素（西罗莫司）及其衍生物和类似物，用于在血管增生，感染，炎症，纤维化或其它组织应答风险的组织部位递送。

    Non-foreshortening intraluminal prosthesis
    8.
    发明申请
    Non-foreshortening intraluminal prosthesis 审中-公开
    非缩短腔内假体

    公开(公告)号：US20070213808A1

    公开(公告)日：2007-09-13

    申请号：US11726660

    申请日：2007-03-21

    申请人： Gary Roubin ,  Geoffrey White ,  Sriram Iyer ,  Russell Redmond ,  Claude Vidal

    发明人： Gary Roubin ,  Geoffrey White ,  Sriram Iyer ,  Russell Redmond ,  Claude Vidal

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/07 ,  A61F2/915 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2210/0019 ,  A61F2230/0054 ,  A61F2250/0029 ,  A61F2250/0039

    摘要： An intraluminal prosthesis is provided with a plurality of annular elements. Each annular element includes a plurality of struts and apices connected to form an annular configuration. Each annular element has a compressed state and an expanded state, and has a longitudinal dimension which is smaller in the expanded state than in the compressed state. A plurality of connecting members connect the apices of adjacent annular elements. The connecting members have a plurality of alternating segments that function to compensate for the smaller longitudinal dimension of each annular element in the expanded state. The stent may be provided with varying flexibility along its length and/or circumference, and may include segments that have different diameters.

    摘要翻译： 管腔内假体设置有多个环形元件。 每个环形元件包括连接以形成环形构造的多个支柱和顶点。 每个环形元件具有压缩状态和膨胀状态，并且在膨胀状态下具有比在压缩状态下更小的纵向尺寸。 多个连接构件连接相邻环形元件的顶点。 连接构件具有多个交替的部分，其用于补偿处于膨胀状态的每个环形元件的较小的纵向尺寸。 支架可以沿着其长度和/或周长具有变化的柔性，并且可以包括具有不同直径的段。

    METHODS AND DEVICES FOR USING DRUG-ELUTING EMBOLIZATION
    10.
    发明申请
    METHODS AND DEVICES FOR USING DRUG-ELUTING EMBOLIZATION 审中-公开
    用于使用药物灌注的方法和装置

    公开(公告)号：US20080086156A1

    公开(公告)日：2008-04-10

    申请号：US11745203

    申请日：2007-05-07

    申请人： Robert Rosen ,  Nicholas Kipshidze ,  Sriram Iyer ,  Gary Roubin

    发明人： Robert Rosen ,  Nicholas Kipshidze ,  Sriram Iyer ,  Gary Roubin

    IPC分类号： A61B17/03

    CPC分类号： A61B17/12022 ,  A61B17/12118 ,  A61B17/12131 ,  A61B17/1214 ,  A61F2002/823

    摘要： A method and system of embolizing an organ or vessel is disclosed. An embolization device such as a coil, balloon, spheres, stents or occlusive plaques is used. The embolization device has a surface, which may be coated with composition retaining material such as a polymer, bio-polymer or non-polymer based technology that allows sustained release of drug or material from drug eluting occlusive device. For example, an anti-angiogenic composition is coated on the application surface. The embolization device is then inserted in the vessel and embolization is enhanced by the composition.

    摘要翻译： 公开了栓塞器官或血管的方法和系统。 使用栓塞装置，例如线圈，球囊，球体，支架或闭塞斑块。 栓塞装置具有可以用组合物保持材料如聚合物，生物聚合物或基于非聚合物的技术涂覆的表面，其允许药物或药物从药物洗脱闭塞装置中持续释放。 例如，抗血管生成组合物涂覆在施用表面上。 然后将栓塞装置插入血管并通过组合物增强栓塞。