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25 条记录 (耗时 0.027 秒)

    DPI formulation containing sulfoalkyl ether cyclodextrin
    1.
    发明授权
    DPI formulation containing sulfoalkyl ether cyclodextrin 审中-公开

    公开(公告)号：US10668160B2

    公开(公告)日：2020-06-02

    申请号：US13335780

    申请日：2011-12-22

    申请人： James D. Pipkin ,  Gerold L. Mosher ,  Douglas B. Hecker

    发明人： James D. Pipkin ,  Gerold L. Mosher ,  Douglas B. Hecker

    IPC分类号： A61K9/16 ,  A61P29/00 ,  B32B5/16 ,  A61P11/00 ,  A61K47/40 ,  A61K9/00

    摘要： An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.

    R-cefuroxime axetil
    5.
    发明授权
    R-cefuroxime axetil 失效
    R-头孢呋辛酯

    公开(公告)号：US5063224A

    公开(公告)日：1991-11-05

    申请号：US550005

    申请日：1990-07-09

    申请人： Gerold L. Mosher ,  Michael V. Mullen

    发明人： Gerold L. Mosher ,  Michael V. Mullen

    IPC分类号： C07D501/00 ,  C07D501/34

    CPC分类号： C07D501/00

    摘要： R-Cefuroxime axetil which is substantially free of the S-isomer is readily absorbed from the stomach and gastro-intestinal track of animals, and is therefore ideally suited to oral therapy of bacterial infections.

    摘要翻译： 基本上不含S-异构体的R-头孢呋辛酯可从动物的胃和胃肠道中容易地吸收，因此理想地适用于细菌感染的口服治疗。

    Inhalant Formulation Containing Sulfoalkyl Ether Cyclodextrin and Corticosteroid Prepared from a Unit Dose Suspension
    8.
    发明申请
    Inhalant Formulation Containing Sulfoalkyl Ether Cyclodextrin and Corticosteroid Prepared from a Unit Dose Suspension 审中-公开
    含有单体剂量悬浮液制备的磺基烷基醚环糊精和皮质类固醇的吸入制剂

    公开(公告)号：US20110008325A1

    公开(公告)日：2011-01-13

    申请号：US12835174

    申请日：2010-07-13

    申请人： James D. Pipkin ,  Rupert O. Zimmerer ,  Diane O. Thompson ,  Gerold L. Mosher

    发明人： James D. Pipkin ,  Rupert O. Zimmerer ,  Diane O. Thompson ,  Gerold L. Mosher

    IPC分类号： A61K31/724 ,  A61K39/395 ,  A61P11/00

    CPC分类号： A61K47/40 ,  A61K9/0078 ,  A61K31/137 ,  A61K31/47

    摘要： An inhalable unit dose liquid formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of corticosteroid, such as budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus. The formulation is prepared by mixing SAE-CD, in solid or liquid (dissolved) form, with an inhalable suspension-based unit dose formulation.

    摘要翻译： 提供含有SAE-CD和皮质类固醇的可吸入单位剂量液体制剂。 该制剂适于用任何已知的喷雾器通过雾化给予受试者。 制剂可以包含在试剂盒中。 制剂以水溶液或浓缩组合物的形式给药。 该制剂用于通过吸入施用皮质类固醇的改进的雾化系统。 配方中的SAE-CD显着提高了皮质类固醇（如布地奈德）的化学稳定性。 提供了通过吸入给药该制剂的方法。 制剂也可以通过常规的鼻输送装置来施用。 通过将固体或液体（溶解）形式的SAE-CD与可吸入悬浮液的单位剂量制剂混合来制备制剂。