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1.发明申请HIGH THROUGHPUT, OPTICAL METHOD AND SYSTEM FOR DETERMINING THE EFFECT OF A TEST SUBSTANCE ON NON-CONTIGUOUS LIVING CELLS 有权用于确定测试物质对非连续生活细胞的影响的高通量，光学方法和系统公开(公告)号：US20120134570A1
公开(公告)日：2012-05-31
申请号：US13294848
申请日：2011-11-11
申请人： Jonathan D. Trumbull , Gary A. Gintant , Stanislaw Kantor , Jeffrey Yen Pan , Gilbert J. Diaz , Jonathon Green , Zhi Su , Jeffrey A. Olson
发明人： Jonathan D. Trumbull , Gary A. Gintant , Stanislaw Kantor , Jeffrey Yen Pan , Gilbert J. Diaz , Jonathon Green , Zhi Su , Jeffrey A. Olson
CPC分类号： G06K9/00127 , B01L3/5027 , C12M1/3446 , G01N15/1475 , G06T7/0012 , G06T7/0016 , G06T2207/10016 , G06T2207/30024
摘要： A rapid and efficient method and apparatus for detecting electrophysiologic, proarrhythmic, contractile, and other effects of substances such as compounds and drugs in native cellular cardiac preparations, the preparations representing an integrated cell-based pharmacologic response is disclosed. More specifically, a method to (1) rapidly and efficiently detect and verify the effects of chemicals, compounds and drugs on cardiac repolarization, contractility, and excitability using optically based techniques and customized simulation protocols, and (2) rapidly and efficiently screen and select compounds for electrophysiologic and proarrhythmic effects on cardiac myocytes is disclosed.
摘要翻译： 公开了一种用于检测天然细胞心脏制剂中化合物和药物等物质如电生理，心律失常，收缩和其他作用的快速有效的方法和装置，所述制剂代表基于细胞的综合药理作用。 更具体地说，一种方法（1）使用基于光学的技术和定制的模拟协议，快速有效地检测和验证化学品，化合物和药物对心脏复极化，收缩性和兴奋性的影响，以及（2）快速有效地筛选和选择 公开了对心肌细胞的电生理和心律失常作用的化合物。
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2.发明授权High throughput, optical method and system for determining the effect of a test substance on non-contiguous living cells 有权高通量，光学方法和系统，用于确定测试物质对非连续活细胞的影响公开(公告)号：US09053352B2
公开(公告)日：2015-06-09
申请号：US13294848
申请日：2011-11-11
申请人： Jonathan D. Trumbull , Gary A. Gintant , Stanislaw Kantor , Jeffrey Yen Pan , Gilbert J. Diaz , Jonathon Green , Zhi Su , Jeffrey A. Olson
发明人： Jonathan D. Trumbull , Gary A. Gintant , Stanislaw Kantor , Jeffrey Yen Pan , Gilbert J. Diaz , Jonathon Green , Zhi Su , Jeffrey A. Olson
CPC分类号： G06K9/00127 , B01L3/5027 , C12M1/3446 , G01N15/1475 , G06T7/0012 , G06T7/0016 , G06T2207/10016 , G06T2207/30024
摘要： A rapid and efficient method and apparatus for detecting electrophysiologic, proarrhythmic, contractile, and other effects of substances such as compounds and drugs in native cellular cardiac preparations, the preparations representing an integrated cell-based pharmacologic response is disclosed. More specifically, a method to (1) rapidly and efficiently detect and verify the effects of chemicals, compounds and drugs on cardiac repolarization, contractility, and excitability using optically based techniques and customized simulation protocols, and (2) rapidly and efficiently screen and select compounds for electrophysiologic and proarrhythmic effects on cardiac myocytes is disclosed.
摘要翻译： 公开了一种用于检测天然细胞心脏制剂中化合物和药物等物质如电生理，心律失常，收缩和其他作用的快速有效的方法和装置，所述制剂代表基于细胞的综合药理作用。 更具体地说，一种方法（1）使用基于光学的技术和定制的模拟协议，快速有效地检测和验证化学品，化合物和药物对心脏复极化，收缩性和兴奋性的影响，以及（2）快速有效地筛选和选择 公开了对心肌细胞的电生理和心律失常作用的化合物。
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