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公开(公告)号：US20230360415A1
公开(公告)日：2023-11-09
申请号：US18214874
申请日：2023-06-27
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Michael A. Brasch , Curtis M. Gosnell , Timothy M. Wiles , Raphael Rodolphe Marcelpoil , Bas Nieuwenhuis , Trienko Marten Van Der Kaap , Michael Bois
CPC classification number: G06V20/698 , G06F16/5866 , C12M1/3446 , C12M41/36 , G06T7/0016 , G06N7/01 , G06T2207/10056 , G06T2207/30024 , G06V2201/03
Abstract: A system and method for developing applications (Apps) for automated assessment and analysis of processed biological samples. Such samples are obtained, combined with nutrient media and incubated. The incubated samples are imaged and the image information is classified according to predetermined criteria. The classified image information is then evaluated according to Apps derived from classified historical image information in a data base. The classified historical image information is compared with the classified image information to provide guidance on further processing of the biological sample through Apps tailored to process provide sample process guidance tailored to the classifications assigned to the image information.
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公开(公告)号：US20180142193A1
公开(公告)日：2018-05-24
申请号：US15576228
申请日：2016-03-25
Inventor： Masami SUZUKI , Norio NISHI , Junichi MATSUMOTO , Kimio SUMARU , Toshiyuki KANAMORI
IPC: C12M1/42 , C12N5/00 , C12M1/00 , C12M1/12 , C12M1/26 , C12N1/02 , C12N13/00 , C12M1/34 , C12M1/32
CPC classification number: C12M1/42 , C12M1/005 , C12M1/3446 , C12M23/20 , C12M25/06 , C12M31/02 , C12M33/06 , C12M33/10 , C12M47/04 , C12N1/00 , C12N1/02 , C12N5/0081 , C12N13/00
Abstract: A method of killing specific cells from among a group of cells cultured in a culture vessel by quick and brief laser treatment, the cell culture vessel comprising a main body and a to-be-irradiated layer attached to the main body, the to-be-irradiated layer containing an ingredient capable of absorbing laser light upon laser irradiation, the group of cells being cultured on the surface of the to-be-irradiated layer, the method comprising: applying laser light to a partial area of the to-be-irradiated layer directly below the specific cells.
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公开(公告)号：US20170006790A1
公开(公告)日：2017-01-12
申请号：US15273356
申请日：2016-09-22
Applicant: GreenOnyx LTD
Inventor： Tsipi SHOHAM , Benjamin SHOHAM
CPC classification number: A01G31/02 , A01G7/02 , A01G27/003 , A01G33/00 , A01K61/00 , A01K61/10 , A01K61/54 , A01K61/59 , A01K63/00 , A01K63/003 , B01D46/00 , C12M1/34 , C12M1/3446 , C12M21/02 , C12M41/48 , G06K9/00 , G06T7/0004 , G06T7/0016 , G06T7/90 , G06T2207/10016 , G06T2207/10024 , G06T2207/10152 , G06T2207/30004 , G06T2207/30128 , Y02A40/81 , Y02P60/642
Abstract: System and methods for monitoring the growth of an aquatic plant culture and detecting real-time characteristics associated with the aquatic plant culture aquatic plants. The systems and methods may include a control unit configured to perform an analysis of at least one image of an aquatic plant culture. The analysis may include processing at least one collected image to determine at least one physical characteristic or state of an aquatic plant culture. Systems and methods for distributing aquatic plant cultures are also provided. The distribution systems and methods may track and control the distribution of an aquatic plant culture based on information received from various sources. Systems and methods for growing and harvesting aquatic plants in a controlled and compact environment are also provided. The systems may include a bioreactor having a plurality of vertically stacked modules designed to contain the aquatic plants and a liquid growth medium.
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公开(公告)号：US20170313965A1
公开(公告)日：2017-11-02
申请号：US15653967
申请日：2017-07-19
Applicant: OLYMPUS CORPORATION
Inventor： Yasunobu IGA , Yohei TANIKAWA , Shinichi TAKIMOTO , Yoshinobu AKAHORI
CPC classification number: C12M1/3446 , C12M41/46 , C12M41/48 , G01N21/8851 , G01N2021/0143
Abstract: A cell analysis apparatus including: a cell image acquisition unit that acquires an image of cells in a culture vessel in which cells are cultured; a smoothing processing unit that smooths luminance values in the image acquired by the cell image acquisition unit; a minimum-value detecting unit that detects minimum values of the luminance values smoothed by the smoothing processing unit; a smallest-minimum-value extracting unit that extracts smallest minimum values which are the smallest in regions according to the sizes of the cells, from the minimum values detected by the minimum-value detecting unit; a counting unit that counts the number of smallest minimum values extracted by the smallest-minimum-value extracting unit; and a cell-count calculating unit that calculates the number of cells in the culture vessel on the basis of the number of smallest minimum values counted by the counting unit.
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5.发明授权Detection device for detecting biological microparticles such as bacteria, viruses, spores, pollen or biological toxins, and detection method 有权用于检测细菌，病毒，孢子，花粉或生物毒素等生物微粒的检测装置及检测方法公开(公告)号：US09029082B2
公开(公告)日：2015-05-12
申请号：US13207197
申请日：2011-08-10
Applicant: Alois Friedberger , Ulrich Reidt , Gerhard Müller
Inventor： Alois Friedberger , Ulrich Reidt , Gerhard Müller
IPC: C12Q1/68 , C12P19/34 , C12M1/34 , G01N33/569
CPC classification number: C12M1/3446 , C12Q1/6888 , G01N33/56911 , G01N33/56983
Abstract: A device for the detection of micro particles that can be marked by probes or antibodies capable of being detected by radiation has a filter, a supply system, and a detection system. Fluid to be examined is passed over a filter to filter out the micro particles and to perform the marking steps by supplying corresponding marking substances to the filter.
Abstract translation: 用于检测可被能够被辐射检测的探针或抗体标记的微粒的装置具有过滤器，供给系统和检测系统。 要检查的流体通过过滤器以过滤出微粒子，并通过向过滤器提供相应的标记物质来执行标记步骤。
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Patent Agency Ranking
6.发明申请HIGH THROUGHPUT, OPTICAL METHOD AND SYSTEM FOR DETERMINING THE EFFECT OF A TEST SUBSTANCE ON NON-CONTIGUOUS LIVING CELLS 有权用于确定测试物质对非连续生活细胞的影响的高通量，光学方法和系统公开(公告)号：US20120134570A1
公开(公告)日：2012-05-31
申请号：US13294848
申请日：2011-11-11
Applicant: Jonathan D. Trumbull , Gary A. Gintant , Stanislaw Kantor , Jeffrey Yen Pan , Gilbert J. Diaz , Jonathon Green , Zhi Su , Jeffrey A. Olson
Inventor： Jonathan D. Trumbull , Gary A. Gintant , Stanislaw Kantor , Jeffrey Yen Pan , Gilbert J. Diaz , Jonathon Green , Zhi Su , Jeffrey A. Olson
CPC classification number: G06K9/00127 , B01L3/5027 , C12M1/3446 , G01N15/1475 , G06T7/0012 , G06T7/0016 , G06T2207/10016 , G06T2207/30024
Abstract: A rapid and efficient method and apparatus for detecting electrophysiologic, proarrhythmic, contractile, and other effects of substances such as compounds and drugs in native cellular cardiac preparations, the preparations representing an integrated cell-based pharmacologic response is disclosed. More specifically, a method to (1) rapidly and efficiently detect and verify the effects of chemicals, compounds and drugs on cardiac repolarization, contractility, and excitability using optically based techniques and customized simulation protocols, and (2) rapidly and efficiently screen and select compounds for electrophysiologic and proarrhythmic effects on cardiac myocytes is disclosed.
Abstract translation: 公开了一种用于检测天然细胞心脏制剂中化合物和药物等物质如电生理，心律失常，收缩和其他作用的快速有效的方法和装置，所述制剂代表基于细胞的综合药理作用。 更具体地说，一种方法（1）使用基于光学的技术和定制的模拟协议，快速有效地检测和验证化学品，化合物和药物对心脏复极化，收缩性和兴奋性的影响，以及（2）快速有效地筛选和选择 公开了对心肌细胞的电生理和心律失常作用的化合物。
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公开(公告)号：US11727699B2
公开(公告)日：2023-08-15
申请号：US16753667
申请日：2018-10-04
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Michael A. Brasch , Curtis M. Gosnell , Timothy M. Wiles , Raphael Rodolphe Marcelpoil , Bas Nieuwenhuis , Trienko Marten Van Der Kaap , Michael Bois
CPC classification number: G06V20/698 , C12M1/3446 , C12M41/36 , G06F16/5866 , G06N7/01 , G06T7/0016 , G06T2207/10056 , G06T2207/30024 , G06V2201/03
Abstract: A system and method for developing applications (Apps) for automated assessment and analysis of processed biological samples. Such samples are obtained, combined with nutrient media and incubated. The incubated samples are imaged and the image information is classified according to predetermined criteria. The classified image information is then evaluated according to Apps derived from classified historical image information in a data base. The classified historical image information is compared with the classified image information to provide guidance on further processing of the biological sample through Apps tailored to process provide sample process guidance tailored to the classifications assigned to the image information.
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8.发明申请METHOD AND SYSTEM FOR CHARACTERIZING THE AGGLOMERATION OR SPEED OF PARTICLES CONTAINED IN A LIQUID, SUCH AS BLOOD PARTICLES 审中-公开用于表征液体中包含的颗粒的聚集或速度的方法和系统，例如血液颗粒公开(公告)号：US20160299158A1
公开(公告)日：2016-10-13
申请号：US15094565
申请日：2016-04-08
Inventor： Vincent POHER , Myriam-Laure CUBIZOLLES , Patrick POUTEAU , Cédric ALLIER , Johanna SPIACZKA
CPC classification number: G01N33/86 , C12M1/3446 , C12Q1/04 , C12Q1/56 , G01N15/0227 , G01N15/1434 , G01N15/1436 , G01N15/1463 , G01N21/253 , G01N21/6452 , G01N21/77 , G01N33/4905 , G01N33/80 , G01N2015/0073 , G01N2015/0084 , G01N2015/0092 , G01N2015/0693 , G01N2015/1075 , G01N2015/144 , G01N2015/1454 , G01N2015/1486 , G01N2015/1497 , G01N2021/7769 , G01N2201/06113 , G01N2201/062 , G01N2201/12 , G03H2001/0447
Abstract: The method is provided for characterizing agglomeration of particles in a liquid containing an analyte, including introducing liquid into a fluid chamber; mixing the liquid with a bifunctional reagent, lighting the fluid chamber using an excitation light beam extending through the fluid chamber in a longitudinal direction (X); acquiring at least one image using a matrix photodetector, each image including pixels (In(x,y), x,y representing the coordinates of a pixel of an image, the image (I(x,y)) being formed by radiation transmitted by the lighted fluid chamber; and calculating from at least one acquired image (I(x,y)), at least one indicator (Ind2) characterizing the particle agglomeration. The photodetector can be positioned less than 1 cm from the fluid chamber, and during the calculation step, the calculated indicator (Ind2) is representative of the intensity of the pixels of the image. The method advantageously allows for charactering the agglomeration of particles in a liquid.
Abstract translation: 该方法用于表征包含分析物的液体中的颗粒的聚集，包括将液体引入流体室中; 将液体与双功能试剂混合，使用沿纵向（X）延伸穿过流体室的激发光束照亮流体室; 使用矩阵光电检测器获取至少一个图像，每个图像包括表示图像的像素的坐标的像素（In（x，y），x，y），由透射的辐射形成的图像（I（x，y）） 通过点亮的流体室;以及从至少一个获取的图像（I（x，y））计算出至少一个表征颗粒聚集的指示器（Ind2），光电检测器可以定位在离流体室小于1cm处，以及 在计算步骤中，计算的指示符（Ind2）代表图像像素的强度，该方法有利于表征液体中颗粒的聚集。
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公开(公告)号：US20160135380A1
公开(公告)日：2016-05-19
申请号：US15008012
申请日：2016-01-27
Applicant: GreenOnyx LTD
Inventor： Tsipi SHOHAM , Benjamin SHOHAM
CPC classification number: A01K63/00 , A01G33/00 , A01K61/00 , A01K61/10 , A01K61/54 , A01K61/59 , A01K63/003 , B01D46/00 , C12M1/34 , C12M1/3446 , C12M41/48 , G06K9/00 , G06T7/0016 , G06T7/90 , G06T2207/10016 , G06T2207/10024 , G06T2207/10152 , G06T2207/30004 , G06T2207/30128 , Y02A40/81 , Y02P60/642
Abstract: System and methods for monitoring the growth of an aquatic plant culture and detecting real-time characteristics associated with the aquatic plant culture aquatic plants. The systems and methods may include a control unit configured to perform an analysis of at least one image of an aquatic plant culture. The analysis may include processing at least one collected image to determine at least one physical characteristic or state of an aquatic plant culture. Systems and methods for distributing aquatic plant cultures are also provided. The distribution systems and methods may track and control the distribution of an aquatic plant culture based on information received from various sources. Systems and methods for growing and harvesting aquatic plants in a controlled and compact environment are also provided. The systems may include a bioreactor having a plurality of vertically stacked modules designed to contain the aquatic plants and a liquid growth medium.
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10.发明授权Method and system for characterizing the movement speed of particles contained in a liquid, such as blood particles 有权用于表征包含在诸如血液颗粒的液体中的颗粒的移动速度的方法和系统公开(公告)号：US09341636B2
公开(公告)日：2016-05-17
申请号：US13905727
申请日：2013-05-30
Inventor： Vincent Poher , Myriam-Laure Cubizolles , Patrick Pouteau , Cédric Allier , Johanna Spiaczka
IPC: G01N33/80 , G01N15/02 , G01N33/49 , G01N15/14 , G01N21/64 , C12M1/34 , C12Q1/04 , C12Q1/56 , G01N21/25 , G01N15/00 , G01N15/06 , G01N15/10
CPC classification number: G01N33/86 , C12M1/3446 , C12Q1/04 , C12Q1/56 , G01N15/0227 , G01N15/1434 , G01N15/1436 , G01N15/1463 , G01N21/253 , G01N21/6452 , G01N21/77 , G01N33/4905 , G01N33/80 , G01N2015/0073 , G01N2015/0084 , G01N2015/0092 , G01N2015/0693 , G01N2015/1075 , G01N2015/144 , G01N2015/1454 , G01N2015/1486 , G01N2015/1497 , G01N2021/7769 , G01N2201/06113 , G01N2201/062 , G01N2201/12
Abstract: The method according to the invention is capable of characterizing a variation in the speed of particles or agglomeration of particles, the particles, such as blood particles, being contained in a liquid (12).The characterization method includes the following steps: introducing the liquid (12) into a fluid chamber (14); lighting the fluid chamber (14) using an excitation light beam (18) emitted by a light source (16), the light beam (18) extending through the fluid chamber (14) in a longitudinal direction (X); acquiring at least one image using a matrix photodetector (20), the image being formed by radiation transmitted by the lighted fluid chamber (14); and calculating, from at least one acquired image, at least one indicator characterizing the variation of the speed or agglomeration of the particles. During the acquisition step, the photodetector (20) is positioned at a distance (D2) smaller than 1 cm from the fluid chamber (14) in the longitudinal direction (X).
Abstract translation: 根据本发明的方法能够表征颗粒速度的变化或粒子的聚集，颗粒（例如血液颗粒）被包含在液体（12）中。 表征方法包括以下步骤：将液体（12）引入流体室（14）中; 使用由光源（16）发射的激发光束（18）照亮流体室（14），所述光束（18）沿纵向方向（X）延伸穿过流体室（14）; 使用矩阵光电检测器（20）获取至少一个图像，所述图像由所述点亮的流体室（14）透射的辐射形成; 以及从至少一个获取的图像计算表征所述粒子的速度或聚集的变化的至少一个指示符。 在采集步骤期间，光电检测器（20）位于距离流体室（14）在纵向方向（X）上小于1cm的距离（D2）处。
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