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    Method and compositions for enhancing immune response and for the production of in vitro mabs
    4.
    发明授权
    Method and compositions for enhancing immune response and for the production of in vitro mabs 有权
    用于增强免疫应答和用于体外制备细胞的方法和组合物

    公开(公告)号：US06407218B1

    公开(公告)日：2002-06-18

    申请号：US09189748

    申请日：1998-11-10

    申请人： Lawrence Tamarkin ,  Giulio F. Paciotti

    发明人： Lawrence Tamarkin ,  Giulio F. Paciotti

    IPC分类号： C07K1618

    CPC分类号： C07K16/241 ,  A61K47/64 ,  A61K47/645 ,  A61K47/665 ,  A61K47/6923 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/55522 ,  B82Y5/00 ,  C07K2317/77 ,  Y10S530/806 ,  Y10S530/808

    摘要： The methods and compositions of the present invention are directed to enhancing an immune response and increasing vaccine efficacy through the simultaneous or sequential targeting of specific immune system components. More particularly, specific immune components, such as macrophages, dendritic cells, B cells and T cells, are individually activated by component-specific immunostimulating agents. One such component-specific immunostimulating agent is an antigen-specific, species-specific monoclonal antibody. The invention is also directed to a method for the in vitro production of the antigen-specific, species-specific monoclonal antibodies which relies upon the in vitro conversion of blood-borne immune cells, such as macrophages and lymphocytes. Vaccine efficacy is enhanced by the administration of compositions containing component-specific immunostimulating agents and other elements, such as antigens or carrier particles, such as colloidal methods, such as gold.

    摘要翻译： 本发明的方法和组合物旨在通过特异性免疫系统组分的同时或连续靶向增强免疫应答和增加疫苗功效。 更具体地，特异性免疫组分如巨噬细胞，树突状细胞，B细胞和T细胞被组分特异性免疫刺激剂单独激活。 一种这样的组分特异性免疫刺激剂是抗原特异性物种特异性单克隆抗体。 本发明还涉及用于体外产生依赖于血液传播的免疫细胞如巨噬细胞和淋巴细胞的体外转化的抗原特异性物种特异性单克隆抗体的方法。 通过施用含有组分特异性免疫刺激剂和其它元件（例如抗原或载体颗粒，例如胶体方法，例如金）的组合物来提高疫苗功效。

    Compositions and methods for generating antibodies
    7.
    发明申请
    Compositions and methods for generating antibodies 有权
    用于产生抗体的组合物和方法

    公开(公告)号：US20110275123A1

    公开(公告)日：2011-11-10

    申请号：US13106745

    申请日：2011-05-12

    申请人： Giulio F. Paciotti ,  Ramadevi Raghunandan ,  Marja S. Huhta ,  Lawrence Tamarkin

    发明人： Giulio F. Paciotti ,  Ramadevi Raghunandan ,  Marja S. Huhta ,  Lawrence Tamarkin

    IPC分类号： C12P21/08

    CPC分类号： C07K16/241 ,  C07K16/1282 ,  C07K16/22 ,  C07K16/2866 ,  C07K2317/21

    摘要： The compositions and methods of the present invention comprise the efficient and effective presentation of antigens to the appropriate components of the immune system resulting in the production of species-specific antibodies in vitro. In general, these compositions comprise one or more antigenic components together with a colloidal metal, optionally combined with derivatized PEG (polyethylene glycol) or other agents. The invention also comprises methods and compositions for making such colloidal metal compositions.

    摘要翻译： 本发明的组合物和方法包括有效和有效地将抗原呈递给免疫系统的合适组分，导致体外物种特异性抗体的产生。 通常，这些组合物包含一种或多种抗原成分以及胶体金属，任选地与衍生化的PEG（聚乙二醇）或其它试剂组合。 本发明还包括制备这种胶体金属组合物的方法和组合物。

    COMPOSITIONS AND METHODS FOR GENERATING ANTIBODIES
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR GENERATING ANTIBODIES 有权
    用于产生抗体的组合物和方法

    公开(公告)号：US20090148908A1

    公开(公告)日：2009-06-11

    申请号：US12267847

    申请日：2008-11-10

    申请人： Giulio F. PACIOTTI ,  Ramadevi Raghunandan ,  Marja S. Huhta ,  Lawrence Tamarkin

    发明人： Giulio F. PACIOTTI ,  Ramadevi Raghunandan ,  Marja S. Huhta ,  Lawrence Tamarkin

    IPC分类号： C12P21/00

    CPC分类号： C07K16/241 ,  C07K16/1282 ,  C07K16/22 ,  C07K16/2866 ,  C07K2317/21

    摘要： The compositions and methods of the present invention comprise the efficient and effective presentation of antigens to the appropriate components of the immune system resulting in the production of species-specific antibodies in vitro. In general, these compositions comprise one or more antigenic components together with a colloidal metal, optionally combined with derivatized PEG (polyethylene glycol) or other agents. The invention also comprises novel cytokine cocktails for generating desired antibodies.

    摘要翻译： 本发明的组合物和方法包括有效和有效地将抗原呈递给免疫系统的合适组分，导致体外物种特异性抗体的产生。 通常，这些组合物包含一种或多种抗原成分以及胶体金属，任选地与衍生化的PEG（聚乙二醇）或其它试剂组合。 本发明还包括用于产生所需抗体的新型细胞因子鸡尾酒。