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1.发明申请NEAR-IR INDOCYANINE GREEN DOPED MULTIMODAL SILICA NANOPARTICLES AND METHODS FOR MAKING THE SAME 审中-公开近红外吲哚啉绿色多糖多元二氧化硅纳米颗粒及其制备方法公开(公告)号：US20130108552A1
公开(公告)日：2013-05-02
申请号：US13582226
申请日：2011-02-24
申请人： Parvesh Sharma , Scott Chang Brown , Niclas Bengtsson , Glenn A. Walter , Nobutaka Iwakuma , Edward W. Scott , Stephen R. Grobmyer , Swadeshmukul Santra , Brij M. Moudgil
发明人： Parvesh Sharma , Scott Chang Brown , Niclas Bengtsson , Glenn A. Walter , Nobutaka Iwakuma , Edward W. Scott , Stephen R. Grobmyer , Swadeshmukul Santra , Brij M. Moudgil
CPC分类号： A61N5/062 , A61K49/001 , B82Y5/00 , B82Y15/00 , C09K11/02 , C09K11/06 , G01N21/6486
摘要： The subject invention provides novel fluorescent core-shell nanoparticles comprising an encapsulated fluorescent core comprising an ionically bound fluorescent dye and a metal oxide shell. In one exemplary embodiment of the invention a core containing indocyanine green (ICG) with a silica shell that displays excellent photostability for generation of a near infrared fluorescence signal. The fluorescent core-shell nanoparticle can be further modified to act as an MRI, x-ray, or PAT contrast agent. The ICG nanoparticles can also be used as photodynamic therapeutic agent. Other embodiments of the invention directed to methods of making the novel core-shell nanoparticles and to the use of the core-shell nanoparticles for in vitro or in vivo imaging.
摘要翻译： 本发明提供了新颖的荧光核 - 壳纳米颗粒，其包含包含离子键的荧光染料和金属氧化物壳的包封的荧光核心。 在本发明的一个示例性实施方案中，含有具有二氧化硅壳的吲哚菁绿（ICG）的核心，其显示出用于产生近红外荧光信号的优异的光稳定性。 荧光核 - 壳纳米颗粒可进一步修饰为MRI，X射线或PAT造影剂。 ICG纳米颗粒也可以用作光动力治疗剂。 本发明的其它实施方案涉及制备新型核 - 壳纳米颗粒的方法以及使用核 - 壳纳米颗粒进行体外或体内成像。
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公开(公告)号：US08128908B2
公开(公告)日：2012-03-06
申请号：US10590590
申请日：2005-05-02
CPC分类号： A61K49/0423 , A61K49/0002 , A61K49/0067 , A61K49/085 , A61K49/14 , A61K49/183 , B82Y5/00 , Y10S977/774
摘要： The present invention relates to fluorescent, radio-opaque and magnetic quantum nanoparticles, useful as multifunctional contrast agents or probes for in vivo bioimaging, and methods of their use. The invention provides for multifaceted bioimaging (e.g., intra-arterial pre-operative brain mapping and broad based in vivo diagnostic imaging), including imaging of various cell types, such as stem cells.
摘要翻译： 本发明涉及可用作体内生物成像的多功能造影剂或探针的荧光，不透射线和磁性量子纳米粒子及其使用方法。 本发明提供了多方面的生物成像（例如，动脉内术前脑图谱和广泛的体内诊断成像），包括各种细胞类型如干细胞的成像。
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公开(公告)号：US20100254911A1
公开(公告)日：2010-10-07
申请号：US12675633
申请日：2008-08-28
申请人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
发明人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.
摘要翻译： 多峰纳米颗粒是含有PAT造影剂和发光成像，X射线成像和/或MRI中的一种或多种的纳米颗粒。 多峰纳米颗粒可以具有包含在芯上具有金属涂层的氧化物的介电芯。 颗粒可以是金属斑点。 多模式纳米颗粒可用于治疗目的，例如肿瘤的消融或中子捕获以及用作成像的造影剂。
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公开(公告)号：US08361437B2
公开(公告)日：2013-01-29
申请号：US12675633
申请日：2008-08-28
申请人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
发明人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.
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