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    Method and Apparatus for Tomographic Imaging of Absolute Optical Absorption Coefficient in Turbid Media Using Combined Photoacoustic and Diffusing Light Measurements
    6.
    发明申请
    Method and Apparatus for Tomographic Imaging of Absolute Optical Absorption Coefficient in Turbid Media Using Combined Photoacoustic and Diffusing Light Measurements 审中-公开
    用于使用组合光声和漫射光测量的混浊介质中绝对光吸收系数的断层摄影的方法和装置

    公开(公告)号：US20100208965A1

    公开(公告)日：2010-08-19

    申请号：US12668976

    申请日：2008-03-05

    申请人： Huabei Jiang ,  Zhen Yuan ,  Qiang Wang ,  Lu Yin ,  Qizhi Zhang

    发明人： Huabei Jiang ,  Zhen Yuan ,  Qiang Wang ,  Lu Yin ,  Qizhi Zhang

    IPC分类号： G06K9/00

    CPC分类号： A61B5/0073 ,  A61B5/0095 ,  A61B5/4528

    摘要： Embodiments of the invention pertain to methods for imaging a light absorption coefficient distribution. Embodiments of the subject method can be implemented without knowing the strength of incident light in advance and without requiring careful calibrations in the non-scattering medium. Embodiments of the method can combine conventional photoacoustic tomography (PAT) with diffusing light measurements coupled with an optimization procedure based on the photon diffusion equation. Images of absorbing targets as small as 0.5 mm in diameter embedded in a 50 mm diameter background medium can be quantitatively recovered. Small targets with various optical contrast levels relative to the background can be detected well. Embodiments of the subject reconstruction method can include first obtaining the map of absorbed optical energy density. Embodiments can obtain the map of absorbed optical energy density through a model-based reconstruction algorithm that is based on a finite element solution to the photoacoustic wave equation in frequency domain subject to the radiation or absorbing boundary conditions (BCs). The distribution of optical fluence can then be obtained. Embodiments can obtain the distribution of optical fluence using the photon diffusion equation based optimization procedure. The distribution of optical absorption coefficient can then be recovered from the distribution of optical fluence and the absorbed energy density.

    摘要翻译： 本发明的实施例涉及用于对光吸收系数分布进行成像的方法。 可以在不知道入射光的强度并且不需要在非散射介质中仔细校准的情况下实现本方法的实施例。 该方法的实施例可以将传统的光声层析成像（PAT）与基于光子扩散方程的优化过程耦合的扩散光测量结合起来。 可以定量地回收直径为50mm的背景介质中直径小于0.5mm的吸收靶的图像。 可以很好地检测到具有相对于背景的各种光学对比度水平的小目标。 被摄体重建方法的实施例可以包括首先获得吸收的光能密度的图。 实施例可以通过基于模型的重建算法获得吸收的光能密度的图，该算法基于经受辐射或吸收边界条件（BC）的频域中的光声波方程的有限元解。 然后可以获得光能的分布。 实施例可以使用基于光子扩散方程的优化程序获得光能的分布。 光吸收系数的分布可以从光能的分布和吸收的能量密度中恢复。