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    Methods using human calcium sensor protein, fragments thereof and DNA encoding same
    1.
    发明授权
    Methods using human calcium sensor protein, fragments thereof and DNA encoding same 失效
    使用人类钙传感蛋白，其片段和编码相同DNA的方法

    公开(公告)号：US06187548B1

    公开(公告)日：2001-02-13

    申请号：US08652877

    申请日：1996-05-23

    申请人： Göran Akerström ,  Claes Juhlin ,  Lars Rask ,  Göran Hjälm ,  Clarence C. Morse ,  Edward M. Murray ,  Gregg R. Crumley

    发明人： Göran Akerström ,  Claes Juhlin ,  Lars Rask ,  Göran Hjälm ,  Clarence C. Morse ,  Edward M. Murray ,  Gregg R. Crumley

    IPC分类号： G01N3353

    CPC分类号： C07K14/4728 ,  A61K38/00 ,  C07K14/705

    摘要： The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.

    摘要翻译： 本发明涉及在人胎盘中分离编码钙传感器的cDNA克隆和随后的Northern印迹，其也证实人甲状旁腺和肾小管细胞中的mRNA表达。 使用大鼠Heymann肾炎抗原（肾小管刷糖蛋白与钙结合能力的糖蛋白）证实了序列相似性。 免疫组织化学证实了钙传感蛋白的组织分布，类似于以前描述的Heymann抗原。 提出鉴定的钙传感器蛋白构成了用于识别细胞外钙的变化的通用传感器，并且其通过不同器官系统对钙调节起关键作用。 钙传感器蛋白属于糖蛋白的LDL超家族，主要作为蛋白质受体起主要作用，但具有功能上重要的钙结合能力。

    Nucleic acids encoding human calcium sensor protein
    3.
    发明授权
    Nucleic acids encoding human calcium sensor protein 失效
    编码人类钙传感蛋白的核酸

    公开(公告)号：US06239270B1

    公开(公告)日：2001-05-29

    申请号：US08476515

    申请日：1995-06-07

    申请人： Göran Akerström ,  Claes Juhlin ,  Lars Rask ,  Göran Hjälm ,  Clarence C. Morse ,  Edward M. Murray ,  Gregg R. Crumley

    发明人： Göran Akerström ,  Claes Juhlin ,  Lars Rask ,  Göran Hjälm ,  Clarence C. Morse ,  Edward M. Murray ,  Gregg R. Crumley

    IPC分类号： A61K317105

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.

    摘要翻译： 本发明涉及在人胎盘中分离编码钙传感器的cDNA克隆和随后的Northern印迹，其也证实人甲状旁腺和肾小管细胞中的mRNA表达。 使用大鼠Heymann肾炎抗原（肾小管刷糖蛋白与钙结合能力的糖蛋白）证实了序列相似性。 免疫组织化学证实了钙传感蛋白的组织分布，类似于以前描述的Heymann抗原。 提出鉴定的钙传感器蛋白构成了用于识别细胞外钙的变化的通用传感器，并且其通过不同器官系统对钙调节起关键作用。 钙传感器蛋白属于糖蛋白的LDL超家族，主要作为蛋白质受体起主要作用，但具有功能上重要的钙结合能力。