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![Pyrazolo [3,4-d] pyrimidine derivatives and their use in the treatment of h.pylori infection](/abs-image/US/2007/01/04/US20070004761A1/abs.jpg.150x150.jpg)
1.发明申请Pyrazolo [3,4-d] pyrimidine derivatives and their use in the treatment of h.pylori infection 审中-公开吡唑并[3,4-d]嘧啶衍生物及其在治疗幽门螺杆菌感染中的应用公开(公告)号：US20070004761A1
公开(公告)日：2007-01-04
申请号：US10539936
申请日：2003-12-19
申请人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Ohryinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
发明人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Ohryinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds having the structural diagram (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译： 本发明涉及具有结构图（I）及其药物组合物及其使用方法的新型化合物。 这些新型化合物提供治疗或预防幽门螺杆菌感染。
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公开(公告)号：US20100286181A1
公开(公告)日：2010-11-11
申请号：US12377785
申请日：2007-08-16
IPC分类号： A61K31/438 , C07D491/113 , C07D417/14 , A61K31/454 , A61P31/04 , A61P13/02 , A61P11/00
CPC分类号： C07D417/14 , C07D491/113 , C07D491/12
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述式（I）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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公开(公告)号：US20100179150A1
公开(公告)日：2010-07-15
申请号：US11816612
申请日：2006-02-16
申请人： Gregory Basarab , Brian Dangel , Paul Robert Fleming , Michael Barry Gravestock , Oluyinka Green , Sheila Irene Hauck , Pamela Hill , Kenneth Gregory Hull , George Mullen , Brian Sherer , Fei Zhou , Haihong Ni
发明人： Gregory Basarab , Brian Dangel , Paul Robert Fleming , Michael Barry Gravestock , Oluyinka Green , Sheila Irene Hauck , Pamela Hill , Kenneth Gregory Hull , George Mullen , Brian Sherer , Fei Zhou , Haihong Ni
IPC分类号： A61K31/454 , C07D417/14 , C07D401/14 , A61K31/5377 , A61K31/4545 , A61P31/04
CPC分类号： C07D417/14 , C07D401/14 , C07D513/04
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述式（I）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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公开(公告)号：US08071605B2
公开(公告)日：2011-12-06
申请号：US12634809
申请日：2009-12-10
申请人： Gregory Basarab , Pamela Hill , Brian Sherer , Fei Zhou
发明人： Gregory Basarab , Pamela Hill , Brian Sherer , Fei Zhou
IPC分类号： A61K31/4965 , A61K31/425
CPC分类号： C07D417/14 , C07D487/08
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述式（I）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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公开(公告)号：US20100173909A1
公开(公告)日：2010-07-08
申请号：US12634809
申请日：2009-12-10
申请人： Gregory BASARAB , Pamela HILL , Brian SHERER , Fei ZHOU
发明人： Gregory BASARAB , Pamela HILL , Brian SHERER , Fei ZHOU
IPC分类号： A61K31/454 , C07D401/14 , A61K31/497 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61P31/04
CPC分类号： C07D417/14 , C07D487/08
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述式（I）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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公开(公告)号：US20060025472A1
公开(公告)日：2006-02-02
申请号：US09798423
申请日：2001-03-02
申请人： Gregory Basarab , Douglas Jordan , Thomas Lessen , Stephen Hansen
发明人： Gregory Basarab , Douglas Jordan , Thomas Lessen , Stephen Hansen
IPC分类号： C07D333/22 , A01N43/06
CPC分类号： A01N37/20 , A01N37/34 , A01N43/36 , A01N53/00 , C07C233/57 , C07C255/41 , C07C255/60 , C07D207/34 , C07D207/46 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/38
摘要： Compounds of Formula I are disclosed which are useful as fungicides wherein Q is X is —O—, —CH(R11)— or ═C(R11)—; R1 is H or C1-C2 alkyl; R2 is H; C1-C6 alkyl; C3-C6 cycloalkyl; or phenyl optionally substituted with halogen, cyano, C1-C2 alkyl or C1-C2 alkoxy; and R3-R11 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula I.
摘要翻译： 公开了可用作杀真菌剂的式I化合物，其中Q是X是-O-，-CH（R 11） - 或-C（R 11） - 。 R 1是H或C 1 -C 2烷基; R 2是H; C 1 -C 6烷基; C 1 -C 6烷基; C 3 -C 6环烷基; 或任选被卤素，氰基，C 1 -C 2烷基或C 1 -C 2烷氧基取代的苯基 ; R 3和R 3 - 如本公开所定义。 还公开了含有式I化合物的组合物和控制由真菌植物病原体引起的植物病害的方法，其涉及施用有效量的式I化合物。
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公开(公告)号：US20070275954A1
公开(公告)日：2007-11-29
申请号：US11569112
申请日：2005-05-19
申请人： Gregory Basarab , Charles Eyermann , Bolin Geng , Madhusudhan Gowravaram , James Loch III , Lawrence MacPherson , Marshall Morningstar , George Mullen , Alex Staz , Andrew Kiely
发明人： Gregory Basarab , Charles Eyermann , Bolin Geng , Madhusudhan Gowravaram , James Loch III , Lawrence MacPherson , Marshall Morningstar , George Mullen , Alex Staz , Andrew Kiely
IPC分类号： A61K31/5513 , A61P1/04 , A61P31/04 , C07D243/14 , C07D491/02
CPC分类号： A61K31/551 , A61K31/5513 , C07D243/20 , C07D403/04 , C07D409/04 , C07D409/14 , C07D471/04
摘要： This invention relates to novel compounds having the Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译： 本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。 这些新型化合物提供治疗或预防幽门螺杆菌感染。
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公开(公告)号：US20060252781A1
公开(公告)日：2006-11-09
申请号：US10567797
申请日：2004-08-12
申请人： Gregory Basarab , Charles Eyermann , Madhusudhhan Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence Macpherson , Marshall Morningstar , Nguyen Thanh
发明人： Gregory Basarab , Charles Eyermann , Madhusudhhan Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence Macpherson , Marshall Morningstar , Nguyen Thanh
IPC分类号： A61K31/519 , C07D487/14
CPC分类号： C07D487/14
摘要： This invention relates to novel compounds having formula: (I) or (II) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译： 本发明涉及具有式（I）或（II）的新化合物及其药物组合物及其使用方法。 这些新型化合物提供治疗或预防幽门螺杆菌感染。
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公开(公告)号：US20060178425A1
公开(公告)日：2006-08-10
申请号：US09798428
申请日：2001-03-02
申请人： Gregory Basarab , Douglas Jordan , Thomas Lessen , Stephen Hansen
发明人： Gregory Basarab , Douglas Jordan , Thomas Lessen , Stephen Hansen
IPC分类号： A01N43/36 , A01N43/06 , C07D333/38 , C07D207/40 , C07C255/60
CPC分类号： A01N37/20 , A01N37/34 , A01N43/36 , A01N53/00 , C07C233/57 , C07C255/41 , C07C255/60 , C07D207/34 , C07D207/46 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/38
摘要： Compounds of Formula I are disclosed which are useful as fungicides wherein X is —O—, —CH(R11)— or ═C(R11)—; R1 is H or C1-C2 alkyl; R2 is H; C1-C6 alkyl; C3-C6 cycloalkyl; or phenyl optionally substituted with halogen, cyano, C1-C2 alkyl or C1-C2 alkoxy; and R3—R11 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula I.
摘要翻译： 公开了式I化合物，其可用作杀真菌剂，其中X是-O - ， - CH（R 11） - 或-C（R 11） - 。 R 1是H或C 1 -C 2烷基; R 2是H; C 1 -C 6烷基; C 1 -C 6烷基; C 3 -C 6环烷基; 或任选被卤素，氰基，C 1 -C 2烷基或C 1 -C 2烷氧基取代的苯基 ; R 3和R 3 - 如本公开所定义。 还公开了含有式I化合物的组合物和控制由真菌植物病原体引起的植物病害的方法，其涉及施用有效量的式I化合物。
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公开(公告)号：US08399489B2
公开(公告)日：2013-03-19
申请号：US11816612
申请日：2006-02-16
申请人： Gregory Basarab , Brian Dangel , Paul Robert Fleming , Michael Barry Gravestock , Oluyinka Green , Sheila Irene Hauck , Pamela Hill , Kenneth Gregory Hull , George Mullen , Haihong Ni , Brian Sherer , Fei Zhou
发明人： Gregory Basarab , Brian Dangel , Paul Robert Fleming , Michael Barry Gravestock , Oluyinka Green , Sheila Irene Hauck , Pamela Hill , Kenneth Gregory Hull , George Mullen , Haihong Ni , Brian Sherer , Fei Zhou
IPC分类号： A61K31/454 , C07D401/14
CPC分类号： C07D417/14 , C07D401/14 , C07D513/04
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述式（I）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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