公开(公告)号：US06908987B2

公开(公告)日：2005-06-21

申请号：US10439799

申请日：2003-05-16

申请人： Bruce M. Spiegelman ,  Pere Puigserver ,  Zhidan Wu ,  Guillaume Adelmant

发明人： Bruce M. Spiegelman ,  Pere Puigserver ,  Zhidan Wu ,  Guillaume Adelmant

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K48/00 ,  A61P1/14 ,  A61P3/04 ,  A61P3/10 ,  A61P7/00 ,  C07K14/47 ,  C07K14/575 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/58 ,  G01N33/68

CPC分类号： C07K14/5759 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/4702 ,  C12N2799/026 ,  G01N2500/00 ,  Y10S435/81

摘要： The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为PGC-1核酸分子，其编码可调节各种脂肪细胞相关活性的蛋白质，包括例如脂肪细胞例如棕色脂肪细胞中的产热，以及脂肪形成。 本发明还提供了反义核酸分子，含有PGC-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中PGC-1基因被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的PGC-1蛋白，融合蛋白，抗原肽和抗PGC-1抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US07250283B2

公开(公告)日：2007-07-31

申请号：US10482094

申请日：2002-07-03

申请人： Bruce M. Spiegelman ,  Guillaume Adelmant ,  Pere Puigserver

发明人： Bruce M. Spiegelman ,  Guillaume Adelmant ,  Pere Puigserver

IPC分类号： C12N1/20 ,  C12N9/02 ,  C12N15/00 ,  C07H21/04

CPC分类号： C07K14/47 ,  C07K2319/00

摘要： The invention provides isolated nucleic acid molecules, designated PGC-1b and PGC-1c nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码PGC-1家族成员的新型同工型的分离的核酸分子，命名为PGC-1b和PGC-1c核酸分子。 本发明还提供了反义核酸分子，含有PGC-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中PGC-1基因被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的PGC-1蛋白，融合蛋白，抗原肽和抗PGC-1抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US06525178B2

公开(公告)日：2003-02-25

申请号：US09900236

申请日：2001-07-05

申请人： Bruce M. Spiegelman ,  Pere Puigserver ,  Zhidan Wu ,  Guillaume Adelmant

发明人： Bruce M. Spiegelman ,  Pere Puigserver ,  Zhidan Wu ,  Guillaume Adelmant

IPC分类号： A61K3800

CPC分类号： C07K14/5759 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/4702 ,  C12N2799/026 ,  G01N2500/00 ,  Y10S435/81

摘要： The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

公开(公告)号：US20090098569A1

公开(公告)日：2009-04-16

申请号：US11765855

申请日：2007-06-20

申请人： Bruce M. Spiegelman ,  Guillaume Adelmant ,  Pere Puigserver

发明人： Bruce M. Spiegelman ,  Guillaume Adelmant ,  Pere Puigserver

IPC分类号： G01N33/53 ,  G01N33/566

CPC分类号： C07K14/47 ,  C07K2319/00

摘要： The invention provides isolated nucleic acid molecules, designated PGC-1b and PGC-1c nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码PGC-1家族成员的新型同工型的分离的核酸分子，命名为PGC-1b和PGC-1c核酸分子。 本发明还提供了反义核酸分子，含有PGC-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中PGC-1基因被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的PGC-1蛋白，融合蛋白，抗原肽和抗PGC-1抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US06872391B2

公开(公告)日：2005-03-29

申请号：US10256889

申请日：2002-09-27

申请人： Bruce M. Spiegelman ,  Pere Puigserver ,  Zhidan Wu ,  Guillaume Adelmant

发明人： Bruce M. Spiegelman ,  Pere Puigserver ,  Zhidan Wu ,  Guillaume Adelmant

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K48/00 ,  A61P1/14 ,  A61P3/04 ,  A61P3/10 ,  A61P7/00 ,  C07K14/47 ,  C07K14/575 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/58 ,  G01N33/68 ,  A61K39/395

CPC分类号： C07K14/5759 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/4702 ,  C12N2799/026 ,  G01N2500/00 ,  Y10S435/81

摘要： The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为PGC-1核酸分子，其编码可调节各种脂肪细胞相关活性的蛋白质，包括例如脂肪细胞例如棕色脂肪细胞中的产热，以及脂肪形成。 本发明还提供了反义核酸分子，含有PGC-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中PGC-1基因被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的PGC-1蛋白，融合蛋白，抗原肽和抗PGC-1抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US06426411B1

公开(公告)日：2002-07-30

申请号：US09203453

申请日：1998-12-01

申请人： Bruce M. Spiegelman ,  Pere Puigserver ,  Zhidan Wu ,  Guillaume Adelmant

发明人： Bruce M. Spiegelman ,  Pere Puigserver ,  Zhidan Wu ,  Guillaume Adelmant

IPC分类号： C07H2104

CPC分类号： C07K14/5759 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/4702 ,  C12N2799/026 ,  G01N2500/00 ,  Y10S435/81

摘要： The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为PGC-1核酸分子，其编码可调节各种脂肪细胞相关活性的蛋白质，包括例如脂肪细胞例如棕色脂肪细胞中的产热，以及脂肪形成。 本发明还提供了反义核酸分子，含有PGC-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中PGC-1基因被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的PGC-1蛋白，融合蛋白，抗原肽和抗PGC-1抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。