公开(公告)号：US06635634B2

公开(公告)日：2003-10-21

申请号：US10074020

申请日：2002-02-14

Applicant: Kiyoshi Taniguchi ,  Minoru Sakurai ,  Naoaki Fujii ,  Kumi Hosoi ,  Yasuyo Tomishima ,  Hisashi Takasugi ,  Hajime Sogabe ,  Hirofumi Ishikawa ,  Naomi Hanioka

Inventor： Kiyoshi Taniguchi ,  Minoru Sakurai ,  Naoaki Fujii ,  Kumi Hosoi ,  Yasuyo Tomishima ,  Hisashi Takasugi ,  Hajime Sogabe ,  Hirofumi Ishikawa ,  Naomi Hanioka

IPC: A61K3154

Abstract: This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic, anti-urinary incontinence and anti-pollakiuria activities, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.

公开(公告)号：US20080275095A1

公开(公告)日：2008-11-06

申请号：US11579507

申请日：2005-03-28

Applicant: Hajime Sogabe ,  Masayuki Tomita ,  Shoko Nakazato

Inventor： Hajime Sogabe ,  Masayuki Tomita ,  Shoko Nakazato

IPC: A61K31/421 ,  A61P13/12

CPC classification number: A61K45/06 ,  A61K31/401 ,  A61K31/421 ,  A61K2300/00

Abstract: This invention relates to methods for treating renal diseases by using combination of prostaglandin E2 receptor antagonist and renin-angiotensin system inhibitor and pharmaceutical compositions for treating renal diseases comprising prostaglandin E2 receptor antagonist and renin-angiotensin system inhibitor.

Abstract translation: 本发明涉及通过使用前列腺素E2受体拮抗剂和肾素 - 血管紧张素系统抑制剂的组合治疗肾病的方​​法和用于治疗包含前列腺素E2受体拮抗剂和肾素 - 血管紧张素系统抑制剂的肾病的药物组合物。

公开(公告)号：US07217706B2

公开(公告)日：2007-05-15

申请号：US10074020

申请日：2002-02-14

Applicant: Kiyoshi Taniguchi ,  Minoru Sakurai ,  Naoaki Fujii ,  Kumi Hosoi ,  Yasuyo Tomishima ,  Hisashi Takasugi ,  Hajime Sogabe ,  Hirofumi Ishikawa ,  Naomi Hanioka

Inventor： Kiyoshi Taniguchi ,  Minoru Sakurai ,  Naoaki Fujii ,  Kumi Hosoi ,  Yasuyo Tomishima ,  Hisashi Takasugi ,  Hajime Sogabe ,  Hirofumi Ishikawa ,  Naomi Hanioka

IPC: A61K31/54 ,  A61K31/24 ,  C09D211/06 ,  C09D211/70 ,  C07C233/00

CPC classification number: C07D213/40 ,  A61K31/165 ,  A61K31/223 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4468 ,  A61K31/495 ,  A61K31/501 ,  A61K31/5375 ,  C07C215/46 ,  C07C217/30 ,  C07C217/74 ,  C07C219/24 ,  C07C229/18 ,  C07C229/50 ,  C07C233/25 ,  C07C233/43 ,  C07C233/80 ,  C07C235/20 ,  C07C235/24 ,  C07C237/48 ,  C07C271/24 ,  C07C271/30 ,  C07C271/58 ,  C07C275/22 ,  C07C279/22 ,  C07C307/02 ,  C07C307/10 ,  C07C311/08 ,  C07C311/18 ,  C07C317/32 ,  C07C323/25 ,  C07C323/41 ,  C07C2601/06 ,  C07C2601/14 ,  C07C2602/12 ,  C07D209/08 ,  C07D209/16 ,  C07D211/26 ,  C07D213/73 ,  C07D213/85 ,  C07D233/60 ,  C07D235/26 ,  C07D277/46 ,  C07D295/185 ,  C07D401/04 ,  C07D417/14

Abstract: This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic, anti-urinary incontinence and anti-pollakiuria activities, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.

Abstract translation: 本发明涉及由下式[I]表示的新的丙醇胺衍生物或其盐：其中每个符号如说明书中所定义或其盐，其具有肠选择性交感神经兴奋剂，抗溃疡性，抗胰腺炎，脂肪分解，抗尿液 失禁和抗尿频活动，其制备方法，包含其的药物组合物，以及用于预防和/或治疗本说明书中对人或动物表示的疾病的方法。

公开(公告)号：US06495546B1

公开(公告)日：2002-12-17

申请号：US09646878

申请日：2000-11-22

Applicant: Kiyoshi Taniguchi ,  Minoru Sakurai ,  Naoaki Fujii ,  Kumi Hosoi ,  Yasuyo Tomishima ,  Hisashi Takasugi ,  Hajime Sogabe ,  Hirofumi Ishikawa ,  Naomi Hanioka

Inventor： Kiyoshi Taniguchi ,  Minoru Sakurai ,  Naoaki Fujii ,  Kumi Hosoi ,  Yasuyo Tomishima ,  Hisashi Takasugi ,  Hajime Sogabe ,  Hirofumi Ishikawa ,  Naomi Hanioka

IPC: A61K3154

CPC classification number: C07D213/40 ,  A61K31/165 ,  A61K31/223 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4468 ,  A61K31/495 ,  A61K31/501 ,  A61K31/5375 ,  C07C215/46 ,  C07C217/30 ,  C07C217/74 ,  C07C219/24 ,  C07C229/18 ,  C07C229/50 ,  C07C233/25 ,  C07C233/43 ,  C07C233/80 ,  C07C235/20 ,  C07C235/24 ,  C07C237/48 ,  C07C271/24 ,  C07C271/30 ,  C07C271/58 ,  C07C275/22 ,  C07C279/22 ,  C07C307/02 ,  C07C307/10 ,  C07C311/08 ,  C07C311/18 ,  C07C317/32 ,  C07C323/25 ,  C07C323/41 ,  C07C2601/06 ,  C07C2601/14 ,  C07C2602/12 ,  C07D209/08 ,  C07D209/16 ,  C07D211/26 ,  C07D213/73 ,  C07D213/85 ,  C07D233/60 ,  C07D235/26 ,  C07D277/46 ,  C07D295/185 ,  C07D401/04 ,  C07D417/14

Abstract: Propanolamine derivatives represented by the following formula (I): These derivatives may be &bgr;3 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria activities. Pharmaceutical compositions containing such propanolamine derivatives, methods for the prevention and/or treatment diseases using these propanolamine derivatives, and processes for their preparation are also described.

Abstract translation: 由下式（I）表示的丙醇胺衍生物：这些衍生物可以是β3激动剂，并且发挥拟交感神经，抗溃疡，抗胰腺炎，脂肪分解和抗尿失禁和抗尿频活性。 还描述了含有这种丙醇胺衍生物的药物组合物，使用这些丙醇胺衍生物预防和/或治疗疾病的方法及其制备方法。