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1.发明授权公开(公告)号：US08609835B2
公开(公告)日：2013-12-17
申请号：US12993711
申请日：2009-05-28
IPC分类号： C08B37/00 , A61K9/14 , A61K31/715 , C07H5/04
CPC分类号： C12P19/04 , A61K9/1271 , A61K9/5123 , A61K47/36 , B82Y30/00 , C08B37/0003 , C08B37/0063
摘要： The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a high molecular weight polymer with a tri-saccharide repeating unit is disclosed. In one aspect of the invention, methods are directed to isolating and purifying a high molecular weight exopolysaccharide (EPS) from a cell supernatant. In another aspect, methods are disclosed for isolating a lipopolysaccharide (LPS) and a high molecular weight Acinetobacter polyelectrolyte exopolysaccharide (APE) from Acinetobacter bacteria. Compositions are also directed to lipid nanoparticles comprising a therapeutic agent encapsulated by a high molecular weight polysaccharide and nanoparticles comprising a therapeutic agent bound to a cationic polysaccharide cross-linked with a polyanion.
摘要翻译： 本发明涉及新型乳化稳定多糖的纯化和应用。 特别地，公开了具有高分子量的聚电解质外多糖，其包含具有三糖重复单元的高分子量聚合物。 在本发明的一个方面，方法涉及从细胞上清液中分离和纯化高分子量外多糖（EPS）。 在另一方面，公开了从不动细菌分离脂多糖（LPS）和高分子量不动杆菌聚电解质外多糖（APE）的方法。 组合物还涉及包含由高分子量多糖包封的治疗剂和包含与聚阴离子交联的阳离子多糖结合的治疗剂的纳米颗粒的脂质纳米颗粒。
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2.发明申请公开(公告)号：US20110206772A1
公开(公告)日：2011-08-25
申请号：US12993711
申请日：2009-05-28
CPC分类号： C12P19/04 , A61K9/1271 , A61K9/5123 , A61K47/36 , B82Y30/00 , C08B37/0003 , C08B37/0063
摘要： The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a high molecular weight polymer with a tri-saccharide repeating unit is disclosed. In one aspect of the invention, methods are directed to isolating and purifying a high molecular weight exopolysaccharide (EPS) from a cell supernatant. In another aspect, methods are disclosed for isolating a lipopolysaccharide (LPS) and a high molecular weight Acinetobacter polyelectrolyte exopolysaccharide (APE) from Acinetobacter bacteria. Compositions are also directed to lipid nanoparticles comprising a therapeutic agent encapsulated by a high molecular weight polysaccharide and nanoparticles comprising a therapeutic agent bound to a cationic polysaccharide cross-linked with a polyanion.
摘要翻译： 本发明涉及新型乳化稳定多糖的纯化和应用。 特别地，公开了具有高分子量的聚电解质外多糖，其包含具有三糖重复单元的高分子量聚合物。 在本发明的一个方面，方法涉及从细胞上清液中分离和纯化高分子量外多糖（EPS）。 在另一方面，公开了从不动细菌分离脂多糖（LPS）和高分子量不动杆菌聚电解质外多糖（APE）的方法。 组合物还涉及包含由高分子量多糖包封的治疗剂和包含与聚阴离子交联的阳离子多糖结合的治疗剂的纳米颗粒的脂质纳米颗粒。
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公开(公告)号：US20090010872A1
公开(公告)日：2009-01-08
申请号：US11596753
申请日：2005-05-20
IPC分类号： A61K45/00 , C12N15/11 , C12N15/00 , C12N5/06 , C12N1/20 , C12N1/19 , A61P43/00 , C12N15/87 , C12P21/04 , C07K14/00 , C07K16/18 , A61K35/12
CPC分类号： C07K14/5431 , A61K38/00 , C07K14/7155 , C07K2319/32
摘要： The present invention concerns a new designer cytokine termed H11, which is constructed by fusion of two soluble components, soluble interleukin 11 receptor (sIL-11 R) and interleukin 11 (IL-11) using their natural sequence and its use for the production of a medicament for treating or preventing a disease selected from the group consisting of a proliferative disease, a cytopathy, radiation damage, an IL-11 dependent inflammatory disorder, IL-11 dependent degenerative disorder and IL-11 dependent or mediated soft tissue disorder.
摘要翻译： 本发明涉及一种称为H11的新设计者细胞因子，其通过使用其天然序列融合两种可溶性成分，可溶性白细胞介素11受体（sIL-11R）和白介素11（IL-11）及其用于生产 用于治疗或预防选自增殖性疾病，细胞病变，辐射损伤，IL-11依赖性炎性病症，IL-11依赖性退行性病症和IL-11依赖性或介导性软组织病症的疾病的药物。
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