利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

158 条记录 (耗时 0.038 秒)

    Polysaccharide composition and methods of isolation of the emulsion stabilizing cationic polyelectrolytic polysaccharide
    1.
    发明授权
    Polysaccharide composition and methods of isolation of the emulsion stabilizing cationic polyelectrolytic polysaccharide 失效
    多糖组成和分离乳液稳定阳离子聚电解多糖的方法

    公开(公告)号：US08609835B2

    公开(公告)日：2013-12-17

    申请号：US12993711

    申请日：2009-05-28

    申请人： David L. Kaplan ,  Bruce Panilaitis ,  Michael Mercaldi ,  Hanna Dams-Kozlowska

    发明人： David L. Kaplan ,  Bruce Panilaitis ,  Michael Mercaldi ,  Hanna Dams-Kozlowska

    IPC分类号： C08B37/00 ,  A61K9/14 ,  A61K31/715 ,  C07H5/04

    CPC分类号： C12P19/04 ,  A61K9/1271 ,  A61K9/5123 ,  A61K47/36 ,  B82Y30/00 ,  C08B37/0003 ,  C08B37/0063

    摘要： The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a high molecular weight polymer with a tri-saccharide repeating unit is disclosed. In one aspect of the invention, methods are directed to isolating and purifying a high molecular weight exopolysaccharide (EPS) from a cell supernatant. In another aspect, methods are disclosed for isolating a lipopolysaccharide (LPS) and a high molecular weight Acinetobacter polyelectrolyte exopolysaccharide (APE) from Acinetobacter bacteria. Compositions are also directed to lipid nanoparticles comprising a therapeutic agent encapsulated by a high molecular weight polysaccharide and nanoparticles comprising a therapeutic agent bound to a cationic polysaccharide cross-linked with a polyanion.

    摘要翻译： 本发明涉及新型乳化稳定多糖的纯化和应用。 特别地，公开了具有高分子量的聚电解质外多糖，其包含具有三糖重复单元的高分子量聚合物。 在本发明的一个方面，方法涉及从细胞上清液中分离和纯化高分子量外多糖（EPS）。 在另一方面，公开了从不动细菌分离脂多糖（LPS）和高分子量不动杆菌聚电解质外多糖（APE）的方法。 组合物还涉及包含由高分子量多糖包封的治疗剂和包含与聚阴离子交联的阳离子多糖结合的治疗剂的纳米颗粒的脂质纳米颗粒。

    POLYSACCHARIDE COMPOSITION AND METHODS OF ISOLATION OF THE EMULSION STABILIZING CATIONIC POLYELECTROLYTIC POLYSACCHARIDE
    2.
    发明申请
    POLYSACCHARIDE COMPOSITION AND METHODS OF ISOLATION OF THE EMULSION STABILIZING CATIONIC POLYELECTROLYTIC POLYSACCHARIDE 失效
    多糖组合物和乳液稳定阳离子聚电解多糖的分离方法

    公开(公告)号：US20110206772A1

    公开(公告)日：2011-08-25

    申请号：US12993711

    申请日：2009-05-28

    申请人： David L. Kaplan ,  Bruce Panilaitis ,  Michael Mercaldi ,  Hanna Dams-Kozlowska

    发明人： David L. Kaplan ,  Bruce Panilaitis ,  Michael Mercaldi ,  Hanna Dams-Kozlowska

    IPC分类号： A61K9/14 ,  C08B37/00 ,  A61K47/36 ,  B32B5/16 ,  B82Y5/00

    CPC分类号： C12P19/04 ,  A61K9/1271 ,  A61K9/5123 ,  A61K47/36 ,  B82Y30/00 ,  C08B37/0003 ,  C08B37/0063

    摘要： The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a high molecular weight polymer with a tri-saccharide repeating unit is disclosed. In one aspect of the invention, methods are directed to isolating and purifying a high molecular weight exopolysaccharide (EPS) from a cell supernatant. In another aspect, methods are disclosed for isolating a lipopolysaccharide (LPS) and a high molecular weight Acinetobacter polyelectrolyte exopolysaccharide (APE) from Acinetobacter bacteria. Compositions are also directed to lipid nanoparticles comprising a therapeutic agent encapsulated by a high molecular weight polysaccharide and nanoparticles comprising a therapeutic agent bound to a cationic polysaccharide cross-linked with a polyanion.

    摘要翻译： 本发明涉及新型乳化稳定多糖的纯化和应用。 特别地，公开了具有高分子量的聚电解质外多糖，其包含具有三糖重复单元的高分子量聚合物。 在本发明的一个方面，方法涉及从细胞上清液中分离和纯化高分子量外多糖（EPS）。 在另一方面，公开了从不动细菌分离脂多糖（LPS）和高分子量不动杆菌聚电解质外多糖（APE）的方法。 组合物还涉及包含由高分子量多糖包封的治疗剂和包含与聚阴离子交联的阳离子多糖结合的治疗剂的纳米颗粒的脂质纳米颗粒。

    Method for Polymer Synthesis Using Microfluidic Enzymatic Cascade
    4.
    发明申请
    Method for Polymer Synthesis Using Microfluidic Enzymatic Cascade 审中-公开
    使用微流控酶级联的聚合物合成方法

    公开(公告)号：US20090298139A1

    公开(公告)日：2009-12-03

    申请号：US12224149

    申请日：2007-02-27

    申请人： Jin Zou ,  David L. Kaplan ,  Jin Zou ,  Peter Y. Wong ,  David L. Kaplan

    发明人： Jin Zou ,  David L. Kaplan ,  Jin Zou ,  Peter Y. Wong ,  David L. Kaplan

    IPC分类号： C12P17/16 ,  B01J19/00

    CPC分类号： C12P17/04

    摘要： The present invention discloses a method for producing polymers in a microscale device. The system utilizes a symmetrically branched system of microchannels interconnecting a plurality of loading decks and re-action chambers. The fluid flow is manipulated by the placement of capillary check valves, mixing areas, and microcomb filters. The system provides for cascading enzymatic biosynthesis pathways wherein any variety of enzymes and reactants can be introduced into the system to produce a final product.

    摘要翻译： 本发明公开了一种在微型装置中制备聚合物的方法。 该系统利用互连多个装载甲板和再作用室的对称分支的微通道系统。 通过放置毛细管止回阀，混合区域和微孔过滤器来操纵流体流动。 该系统提供级联的酶生物合成途径，其中可以将任何多种酶和反应物引入系统以产生最终产物。

    Plasmonic nanoparticle-doped silk materials
    5.
    发明授权
    Plasmonic nanoparticle-doped silk materials 有权
    掺杂等离子体纳米粒子的丝材料

    公开(公告)号：US09517357B2

    公开(公告)日：2016-12-13

    申请号：US13819419

    申请日：2011-09-03

    申请人： Fiorenzo Omenetto ,  David L. Kaplan ,  Hu Tao

    发明人： Fiorenzo Omenetto ,  David L. Kaplan ,  Hu Tao

    IPC分类号： A61N5/00 ,  A61N5/06 ,  A61F7/03 ,  A61L31/00 ,  A61L31/12 ,  A61L31/14 ,  H01L35/30

    CPC分类号： A61N5/0625 ,  A61F7/03 ,  A61L31/005 ,  A61L31/125 ,  A61L31/14 ,  A61L2400/12 ,  A61N5/062 ,  H01L35/30 ,  Y10T428/268 ,  Y10T428/2927

    摘要： Provided herein are silk fibroin-based photothermal elements and uses thereof. The silk fibroin-based photothermal elements comprise a plurality of plasmonic nanoparticle distributed in a silk fibroin matrix, and can generate heat when the plasmonic nanoparticles are exposed to electromagnetic radiation. The silk fibroin-based photothermal elements can be adapted to be conformable and biodegradable, and can further be integrated with various electronic components, such as a thermo-electric device for conversion of heat into electricity. The invention is useful for various in vivo applications, such as photothermal therapy, controlled drug-delivery devices or wireless powering of implanted micro-devices.

    摘要翻译： 本文提供的是丝素蛋白基光热元件及其用途。 基于丝素蛋白的光热元件包括分布在丝素蛋白基质中的多个等离子体激元纳米颗粒，当等离子体激元纳米粒子暴露于电磁辐射时可产生热量。 丝素蛋白的光热元件可以适应和可生物降解，并且可以进一步与各种电子部件集成，例如用于将热量转换成电的热电装置。 本发明可用于各种体内应用，例如光热治疗，受控药物递送装置或植入的微器件的无线供电。

    Diazonium salt modification of silk polymer
    7.
    发明授权
    Diazonium salt modification of silk polymer 有权
    丝绸聚合物的重氮盐改性

    公开(公告)号：US08906444B2

    公开(公告)日：2014-12-09

    申请号：US13479709

    申请日：2012-05-24

    申请人： David L. Kaplan ,  Amanda Murphy

    发明人： David L. Kaplan ,  Amanda Murphy

    IPC分类号： B05D3/00 ,  C12N5/02 ,  A61K38/17 ,  C08L89/00 ,  C08H1/00

    CPC分类号： C09D189/00 ,  C08H1/00 ,  C08L89/00

    摘要： A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These methods are particularly useful when the introduction of cells to a mammal is desired, since modifications to the silk protein affect the physical properties and thus the adhesion, metabolic activity and cell morphology of the desired cells. The silk protein can be modified to produce, or modify, a structure that provides an optimal environment for the desired cells.

    摘要翻译： 本文描述了通过将化学部分偶联到丝聚合物的酪氨酸残基来修饰丝聚合物的方法，用于改变丝蛋白的物理性质。 因此，可以通过本文所述的方法制备具有所需物理性质的丝蛋白。 当需要向哺乳动物引入细胞时，这些方法特别有用，因为对丝蛋白的修饰会影响所需细胞的物理性质，因此影响粘附，代谢活性和细胞形态。 可以修饰丝蛋白以产生或修饰为所需细胞提供最佳环境的结构。