公开(公告)号：US07408044B2

公开(公告)日：2008-08-05

申请号：US10815320

申请日：2004-04-01

Applicant: Hans Binz ,  Thierry Baussant ,  Jean-François Haeuw ,  Thien Ngoc Nguyen

Inventor： Hans Binz ,  Thierry Baussant ,  Jean-François Haeuw ,  Thien Ngoc Nguyen

IPC: C07K1/00 ,  A61K39/385 ,  A61K39/00 ,  A61K39/02 ,  A61K45/00 ,  A61K39/108 ,  C12P21/04 ,  C12N15/09

CPC classification number: C07K14/005 ,  A61K39/385 ,  A61K2039/6068 ,  C07K14/26 ,  C07K2319/00 ,  C12N2760/18522 ,  Y10S530/806 ,  Y10S530/807 ,  Y10S530/825

Abstract: The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homology with the P40 protein of Klebsiella pneumoniae. The invention also relates to nucleotide sequences which encode these peptides or proteins and to the use of these sequences as a medicament. More particularly, such DNA sequences can be used in compositions which are intended for immunization by the intramuscular or intradermal route.

Abstract translation: 本发明涉及一种佐剂产品，其旨在在施用于宿主时改善分子的活性，其特征在于其包含至少一部分肺炎克雷伯杆菌的P40蛋白或与其中至少80％的同源性的蛋白质 肺炎克雷伯杆菌的P40蛋白。 本发明还涉及编码这些肽或蛋白质的核苷酸序列以及这些序列作为药物的用途。 更具体地，这样的DNA序列可以用于旨在通过肌内或皮内途径免疫的组合物中。

公开(公告)号：US20060034870A1

公开(公告)日：2006-02-16

申请号：US10815320

申请日：2004-04-01

Applicant: Hans Binz ,  Thierry Baussant ,  Jean-Francois Haeuw ,  Thien Nguyen

Inventor： Hans Binz ,  Thierry Baussant ,  Jean-Francois Haeuw ,  Thien Nguyen

IPC: A61K39/108 ,  C07K14/195

CPC classification number: C07K14/005 ,  A61K39/385 ,  A61K2039/6068 ,  C07K14/26 ,  C07K2319/00 ,  C12N2760/18522 ,  Y10S530/806 ,  Y10S530/807 ,  Y10S530/825

Abstract: The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homology with the P40 protein of Klebsiella pneumoniae. The invention also relates to nucleotide sequences which encode these peptides or proteins and to the use of these sequences as a medicament. More particularly, such DNA sequences can be used in compositions which are intended for immunization by the intramuscular or intradermal route.

Abstract translation: 本发明涉及一种佐剂产品，其旨在在施用于宿主时改善分子的活性，其特征在于其包含至少一部分肺炎克雷伯杆菌的P40蛋白或与其中至少80％的同源性的蛋白质 肺炎克雷伯杆菌的P40蛋白。 本发明还涉及编码这些肽或蛋白质的核苷酸序列以及这些序列作为药物的用途。 更具体地，这样的DNA序列可以用于旨在通过肌内或皮内途径免疫的组合物中。

公开(公告)号：US20050250933A1

公开(公告)日：2005-11-10

申请号：US10655855

申请日：2003-09-05

Applicant: Hans Binz ,  Thien N'Guyen ,  Thierry Baussant ,  Michel Trudel

Inventor： Hans Binz ,  Thien N'Guyen ,  Thierry Baussant ,  Michel Trudel

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/155 ,  A61K47/48 ,  A61P31/12 ,  C07H21/04 ,  C07K14/08 ,  C07K14/115 ,  C07K14/135 ,  C07K14/26 ,  C07K14/705 ,  C07K14/765 ,  C07K19/00 ,  C12N15/45 ,  C12P21/02 ,  C12R1/19

CPC classification number: A61K39/155 ,  A61K38/00 ,  A61K39/12 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6081 ,  C07K14/005 ,  C07K14/26 ,  C07K14/765 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2760/18522 ,  C12N2760/18534

Abstract: A polypeptide useful as an immunogen element and characterised in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80% homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and a method for preparing same, are also disclosed.

Abstract translation: 可用作免疫原元件的多肽，其特征在于其携带在亚组A和B之间的人呼吸道合胞病毒的G蛋白序列的氨基酸残基130-230或牛呼吸道合胞体之间的肽序列上 或与至少80％同源的序列上。 还公开了含有所述多肽的免疫原性试剂或药物组合物及其制备方法。

公开(公告)号：US06558673B1

公开(公告)日：2003-05-06

申请号：US09626830

申请日：2000-07-27

Applicant: Hans Binz ,  Thien Ngoc Nguyen ,  Christine Andreoni ,  Ake Per Nygren ,  Stefan Stahl ,  Mathias Uhlen

Inventor： Hans Binz ,  Thien Ngoc Nguyen ,  Christine Andreoni ,  Ake Per Nygren ,  Stefan Stahl ,  Mathias Uhlen

IPC: A61K39155

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K39/385 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/6037 ,  A61K2039/6068 ,  C12N2760/18522 ,  C12N2760/18534

Abstract: A complex of an immunogen and a support molecule, characterized in that the immunogen is coupled covalently to a support molecule, wherein the support molecule is a polypeptide fragment which is able to bind specifically to mammalian serum albumin is disclosed. The invention also relates to the use of such complexes to treat RSV infection, as well as vaccines derived from such complexes.

Abstract translation: 免疫原和支持分子的复合物，其特征在于所述免疫原共价偶联至支持分子，其中所述载体分子是能够特异性结合哺乳动物血清白蛋白的多肽片段。 本发明还涉及这种复合物用于治疗RSV感染的用途，以及衍生自这种复合物的疫苗。

公开(公告)号：US6113911A

公开(公告)日：2000-09-05

申请号：US721979

申请日：1996-10-04

Applicant: Hans Binz ,  Thien N'Guyen Ngoc ,  Thierry Baussant ,  Michel Trudel

Inventor： Hans Binz ,  Thien N'Guyen Ngoc ,  Thierry Baussant ,  Michel Trudel

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/155 ,  A61K47/48 ,  A61P31/12 ,  C07H21/04 ,  C07K14/08 ,  C07K14/115 ,  C07K14/135 ,  C07K14/26 ,  C07K14/705 ,  C07K14/765 ,  C07K19/00 ,  C12N15/45 ,  C12P21/02 ,  C12R1/19 ,  A61K39/12

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K47/4833 ,  C07K14/005 ,  C07K14/26 ,  C07K14/765 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6081 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2760/18522 ,  C12N2760/18534

Abstract: A polypeptide useful as an immunogen element and characterized in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80% homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and methods for preparing and using the same, are also disclosed.

Abstract translation: PCT No.PCT / FR95 / 00444 Sec。 371日期1996年10月4日第 102（e）日期1996年10月4日PCT提交1995年4月6日PCT公布。 WO95 / 27787 PCT出版物 1995年10月19日的日期可用作免疫原元件的多肽，其特征在于其携带在亚组A和B组的人呼吸道合胞病毒的G蛋白序列的氨基酸残基130-230之间的肽序列上，或 的牛呼吸道合胞病毒，或与至少80％同源的序列。 还公开了含有所述多肽的免疫原性试剂或药物组合物及其制备和使用方法。

公开(公告)号：US06780420B1

公开(公告)日：2004-08-24

申请号：US09679750

申请日：2000-10-05

Applicant: Hans Binz ,  Thierry Baussant ,  Jean-François Haeuw ,  Thien Nguyen Ngoc

Inventor： Hans Binz ,  Thierry Baussant ,  Jean-François Haeuw ,  Thien Nguyen Ngoc

IPC: A61K39108

CPC classification number: C07K14/005 ,  A61K39/385 ,  A61K2039/6068 ,  C07K14/26 ,  C07K2319/00 ,  C12N2760/18522 ,  Y10S530/806 ,  Y10S530/807 ,  Y10S530/825

Abstract: The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homology with the P40 protein of Klebsiella pneumoniae. The invention also relates to nucleotide sequences which encode these peptides or proteins and to the use of these sequences as a medicament. More particularly, such DNA sequences can be used in compositions which are intended for immunization by the intramuscular or intradermal route.

Abstract translation: 本发明涉及一种佐剂产品，其旨在在施用于宿主时改善分子的活性，其特征在于其包含至少一部分肺炎克雷伯杆菌的P40蛋白或与其中至少80％的同源性的蛋白质 肺炎克雷伯杆菌的P40蛋白。 本发明还涉及编码这些肽或蛋白质的核苷酸序列以及这些序列作为药物的用途。 更具体地，这样的DNA序列可以用于旨在通过肌内或皮内途径免疫的组合物中。

公开(公告)号：US06197929B1

公开(公告)日：2001-03-06

申请号：US08836500

申请日：1997-08-11

Applicant: Hans Binz ,  Thierry Baussant ,  Jean-François Haeuw ,  Thien Nguyen Ngoc

Inventor： Hans Binz ,  Thierry Baussant ,  Jean-François Haeuw ,  Thien Nguyen Ngoc

IPC: C07K100

CPC classification number: C07K14/005 ,  A61K39/385 ,  A61K2039/6068 ,  C07K14/26 ,  C07K2319/00 ,  C12N2760/18522 ,  Y10S530/806 ,  Y10S530/807 ,  Y10S530/825

Abstract: The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homology with the P40 protein of Klebsiella pneumoniae. The invention also relates to nucleotide sequences which encode these peptides or proteins and to the use of these sequences as a medicament. More particularly, such DNA sequences can be used in compositions which are intended for immunization by the intramuscular or intradermal route.

Abstract translation: 本发明涉及一种佐剂产品，其旨在在施用于宿主时改善分子的活性，其特征在于其包含至少一部分肺炎克雷伯杆菌的P40蛋白或与其中至少80％的同源性的蛋白质 肺炎克雷伯杆菌的P40蛋白。 本发明还涉及编码这些肽或蛋白质的核苷酸序列以及这些序列作为药物的用途。 更具体地，这样的DNA序列可以用于旨在通过肌内或皮内途径免疫的组合物中。

公开(公告)号：US6130091A

公开(公告)日：2000-10-10

申请号：US836504

申请日：1997-07-01

Applicant: Hans Binz ,  Thien Nguyen Ngoc ,  Stefan Stahl ,  Mathias Uhlen ,  Per Ake Nygren

Inventor： Hans Binz ,  Thien Nguyen Ngoc ,  Stefan Stahl ,  Mathias Uhlen ,  Per Ake Nygren

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/00 ,  A61K39/155 ,  A61P31/12 ,  C07K14/135 ,  C07K14/31 ,  C12N1/21 ,  C12N15/45 ,  C12P21/02 ,  C12R1/44 ,  C12N7/00 ,  C12N1/00 ,  C12N15/00

CPC classification number: C07K14/005 ,  C07K14/31 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C12N2760/18522 ,  Y10S435/882

Abstract: A method for obtaining a Staphylococcus carnosus bacterium expressing at its membrane surface a recombinant polypeptide derived from RSV protein G, said polypeptide having a sequence which is a modification of SEQ ID No. 1 and SEQ ID No. 2 (sequence encompassed between residues 130 and 230 of RSV A and RSV B protein G respectively) wherein at least one of position 44 and 57 is serine is disclosed.

Abstract translation: PCT No.PCT / FR95 / 01465 Sec。 371日期1997年7月1日 102（e）日期1997年7月1日PCT提交1995年11月7日PCT公布。 公开号WO96 / 14418 PCT 日期1996年5月17日一种用于获得在其膜表面表达来自RSV蛋白G的重组多肽的葡萄球菌属细菌的方法，所述多肽具有作为SEQ ID No.1和SEQ ID No.2的修饰（序列包括 在分别为RSV A和RSV B蛋白G的残基130和230之间），其中位置44和57中的至少一个是丝氨酸。

公开(公告)号：US06616930B2

公开(公告)日：2003-09-09

申请号：US10091257

申请日：2002-03-05

Applicant: Hans Binz ,  Thien Ngoc N'Guyen ,  Thierry Baussant ,  Michel Trudel

Inventor： Hans Binz ,  Thien Ngoc N'Guyen ,  Thierry Baussant ,  Michel Trudel

IPC: A61K39155

CPC classification number: A61K39/155 ,  A61K38/00 ,  A61K39/12 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6081 ,  C07K14/005 ,  C07K14/26 ,  C07K14/765 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2760/18522 ,  C12N2760/18534

Abstract: A polypeptide useful as an immunogen element and characterized in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80% homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and methods for preparing and using the same, are also disclosed.

Abstract translation: 可用作免疫原元件的多肽，其特征在于其携带在亚组A和B之间的人呼吸道合胞病毒的G蛋白序列的氨基酸残基130-230或牛呼吸道合胞体之间的肽序列上 或与至少80％同源的序列上。 还公开了含有所述多肽的免疫原性试剂或药物组合物及其制备和使用方法。

公开(公告)号：US06537556B1

公开(公告)日：2003-03-25

申请号：US09582876

申请日：2000-06-30

Applicant: Hans Binz ,  Thien N'Guyen Ngoc ,  Thierry Baussant ,  Michel Trudel

Inventor： Hans Binz ,  Thien N'Guyen Ngoc ,  Thierry Baussant ,  Michel Trudel

IPC: A61K39155

CPC classification number: A61K39/155 ,  A61K38/00 ,  A61K39/12 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6081 ,  C07K14/005 ,  C07K14/26 ,  C07K14/765 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2760/18522 ,  C12N2760/18534

Abstract: A polypeptide useful as an immunogen element and characterized in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80% homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and methods for preparing and using the same, are also disclosed.